Found 13 hits Enz. Inhib. hit(s) with Target = 'Guanine deaminase' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Guanine deaminase
(Homo sapiens (Human)) | BDBM50208879
(2,6-diaminopurine | 9H-Purine-2,6-diamine0.5M H2SO...)Show InChI InChI=1S/C5H6N6/c6-3-2-4(9-1-8-2)11-5(7)10-3/h1H,(H5,6,7,8,9,10,11) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 1.88E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The State University of New Jersey
Curated by ChEMBL
| Assay Description Inhibition of GDA by colorimetric assay |
Bioorg Med Chem 18: 6748-55 (2010)
Article DOI: 10.1016/j.bmc.2010.07.054 BindingDB Entry DOI: 10.7270/Q25T3KPK |
More data for this Ligand-Target Pair | |
Guanine deaminase
(Homo sapiens (Human)) | BDBM82009
(CAS_1188 | CHEMBL1424 | NSC_1188 | Xanthine)Show InChI InChI=1S/C5H4N4O2/c10-4-2-3(7-1-6-2)8-5(11)9-4/h1H,(H3,6,7,8,9,10,11) | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| 1.96E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The State University of New Jersey
Curated by ChEMBL
| Assay Description Inhibition of GDA by colorimetric assay |
Bioorg Med Chem 18: 6748-55 (2010)
Article DOI: 10.1016/j.bmc.2010.07.054 BindingDB Entry DOI: 10.7270/Q25T3KPK |
More data for this Ligand-Target Pair | |
Guanine deaminase
(Homo sapiens (Human)) | BDBM50325823
(CHEMBL1224659 | N-2-Acetylguanine)Show InChI InChI=1S/C7H7N5O2/c1-3(13)10-7-11-5-4(6(14)12-7)8-2-9-5/h2H,1H3,(H3,8,9,10,11,12,13,14) | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| 3.44E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The State University of New Jersey
Curated by ChEMBL
| Assay Description Inhibition of GDA by colorimetric assay |
Bioorg Med Chem 18: 6748-55 (2010)
Article DOI: 10.1016/j.bmc.2010.07.054 BindingDB Entry DOI: 10.7270/Q25T3KPK |
More data for this Ligand-Target Pair | |
Guanine deaminase
(Homo sapiens (Human)) | BDBM50325824
(1H-purine-2,6,8(3H,7H,9H)-trione | 7,9-Dihydro-3H-...)Show InChI InChI=1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12) | PDB MMDB
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| Article PubMed
| 4.34E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The State University of New Jersey
Curated by ChEMBL
| Assay Description Inhibition of GDA by colorimetric assay |
Bioorg Med Chem 18: 6748-55 (2010)
Article DOI: 10.1016/j.bmc.2010.07.054 BindingDB Entry DOI: 10.7270/Q25T3KPK |
More data for this Ligand-Target Pair | |
Guanine deaminase
(Homo sapiens (Human)) | BDBM7957
(4-amino-1H-imidazole-5-carboxamide | 5-Amino-3H-im...)Show InChI InChI=1S/C4H6N4O/c5-3-2(4(6)9)7-1-8-3/h1H,5H2,(H2,6,9)(H,7,8) | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| 4.44E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The State University of New Jersey
Curated by ChEMBL
| Assay Description Inhibition of GDA by colorimetric assay |
Bioorg Med Chem 18: 6748-55 (2010)
Article DOI: 10.1016/j.bmc.2010.07.054 BindingDB Entry DOI: 10.7270/Q25T3KPK |
More data for this Ligand-Target Pair | |
Guanine deaminase
(Homo sapiens (Human)) | BDBM82522
(7-MethylX | 7-Methylxanthine | CAS_552-62-5 | CHEM...)Show InChI InChI=1S/C6H6N4O2/c1-10-2-7-4-3(10)5(11)9-6(12)8-4/h2H,1H3,(H2,8,9,11,12) | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| 5.55E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The State University of New Jersey
Curated by ChEMBL
| Assay Description Inhibition of GDA by colorimetric assay |
Bioorg Med Chem 18: 6748-55 (2010)
Article DOI: 10.1016/j.bmc.2010.07.054 BindingDB Entry DOI: 10.7270/Q25T3KPK |
More data for this Ligand-Target Pair | |
Guanine deaminase
(Homo sapiens (Human)) | BDBM10849
(1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| 1.02E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The State University of New Jersey
Curated by ChEMBL
| Assay Description Inhibition of GDA by colorimetric assay |
Bioorg Med Chem 18: 6748-55 (2010)
Article DOI: 10.1016/j.bmc.2010.07.054 BindingDB Entry DOI: 10.7270/Q25T3KPK |
More data for this Ligand-Target Pair | |
Guanine deaminase
(Homo sapiens (Human)) | BDBM50378883
(CHEMBL1645489)Show SMILES OCC1(NC(=O)OCc2ccccc2)NC(=O)c2ncn(Cc3ccccc3)c2NC1=O Show InChI InChI=1S/C22H21N5O5/c28-13-22(26-21(31)32-12-16-9-5-2-6-10-16)20(30)24-18-17(19(29)25-22)23-14-27(18)11-15-7-3-1-4-8-15/h1-10,14,28H,11-13H2,(H,24,30)(H,25,29)(H,26,31) | PDB MMDB
Reactome pathway KEGG
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| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 1.67E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Competitive inhibition of guanase by Lineweaver-Burk plot analysis |
Bioorg Med Chem Lett 21: 756-9 (2011)
Article DOI: 10.1016/j.bmcl.2010.11.109 BindingDB Entry DOI: 10.7270/Q2XK8GJV |
More data for this Ligand-Target Pair | |
Guanine deaminase
(Homo sapiens (Human)) | BDBM50193757
(3-benzyl-4,5,7,8-tetrahydro-6-hydroxymethyl-6H-imi...)Show InChI InChI=1S/C14H14N4O3/c19-7-10-13(20)17-12-11(14(21)16-10)15-8-18(12)6-9-4-2-1-3-5-9/h1-5,8,10,19H,6-7H2,(H,16,21)(H,17,20) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 2.01E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Maryland
Curated by ChEMBL
| Assay Description Inhibition of rabbit liver guanase |
Bioorg Med Chem Lett 16: 5551-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.033 BindingDB Entry DOI: 10.7270/Q2FB52J0 |
More data for this Ligand-Target Pair | |
Guanine deaminase
(Homo sapiens (Human)) | BDBM50106015
(2-(4,6-Diamino-8-imino-8,8a-dihydro-3aH-1,3,5,7-te...)Show InChI InChI=1S/C9H15N7O2/c10-7-5-6(8(11)15-9(12)14-7)16(3-13-5)4-18-2-1-17/h13,17H,1-4H2,(H5,10,11,12,14,15) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| 2.97E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Maryland
Curated by ChEMBL
| Assay Description Binding affinity against Guanine deaminase (guanase) from rabbit liver was determined |
Bioorg Med Chem Lett 11: 2893-6 (2001)
BindingDB Entry DOI: 10.7270/Q28K79MD |
More data for this Ligand-Target Pair | |
Guanine deaminase
(Homo sapiens (Human)) | BDBM50193756
(4,5,7,8-tetrahydro-6-hydroxymethyl-6H-imidazo[4,5-...)Show InChI InChI=1S/C7H8N4O3/c12-1-3-6(13)11-5-4(7(14)10-3)8-2-9-5/h2-3,12H,1H2,(H,8,9)(H,10,14)(H,11,13) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 5.36E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Maryland
Curated by ChEMBL
| Assay Description Inhibition of rabbit liver guanase |
Bioorg Med Chem Lett 16: 5551-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.033 BindingDB Entry DOI: 10.7270/Q2FB52J0 |
More data for this Ligand-Target Pair | |
Guanine deaminase
(Homo sapiens (Human)) | BDBM50073384
(3-Benzyl-3H-imidazo[4,5-e][1,4]diazepine-6,8-dione...)Show InChI InChI=1S/C13H10N4O2/c18-10-6-14-12-11(13(19)16-10)15-8-17(12)7-9-4-2-1-3-5-9/h1-6,8H,7H2,(H,16,18,19) | PDB MMDB
Reactome pathway KEGG
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| CHEMBL PC cid PC sid UniChem
| PubMed
| 2.27E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Maryland
Curated by ChEMBL
| Assay Description Compound was tested for its inhibitory effect on rabbit liver guanase |
Bioorg Med Chem Lett 8: 3649-52 (1999)
BindingDB Entry DOI: 10.7270/Q2BV7FR7 |
More data for this Ligand-Target Pair | |
Guanine deaminase
(Homo sapiens (Human)) | BDBM50401837
(CHEMBL2203870)Show InChI InChI=1S/C6H8N4O2/c11-3-1-7-5-4(6(12)10-3)8-2-9-5/h2-3,7,11H,1H2,(H,8,9)(H,10,12) | PDB MMDB
Reactome pathway KEGG
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CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Maryland
Curated by ChEMBL
| Assay Description Inhibition of guanase |
Bioorg Med Chem Lett 22: 7214-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.09.053 BindingDB Entry DOI: 10.7270/Q2MC916H |
More data for this Ligand-Target Pair | |