BindingDB PrimarySearch

Found 2 hits Enz. Inhib. hit(s) with Target = 'Histone-lysine N-methyltransferase EZH2 [Y641N]'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Histone-lysine N-methyltransferase EZH2 [Y641N] (Homo sapiens (Human))	BDBM50009672 (AdoHcy \| CHEMBL418052 \| S-(5'-adenosyl)-L-homocyst...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB US Patent	n/a	n/a	380	n/a	n/a	n/a	n/a	7.6	n/a
Epizyme, Inc. US Patent					Assay Description S-Adenosyl-L-homocysteine (SAH) was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive c...				US Patent US9175331 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JQP
Epizyme, Inc. US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Histone-lysine N-methyltransferase EZH2 [Y641N] (Homo sapiens (Human))	BDBM190225 (US9175331, 75) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.10E+3	n/a	n/a	n/a	n/a	7.6	n/a
Epizyme, Inc. US Patent					Assay Description Compound 75 was serially diluted 3 fold in DMSO for 10 points and 1 μL , was plated in a 384 well microtiter plate. Positive control (100% inhib...				US Patent US9175331 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JQP
Epizyme, Inc. US Patent					More data for this Ligand-Target Pair