Found 6 hits Enz. Inhib. hit(s) with Target = 'Potassium channel subfamily K member 18' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Potassium channel subfamily K member 18
(Homo sapiens (Human)) | BDBM50017662
(2-(Diethylamino)-2',6'-acetoxylidide | 2-(Diethyla...)Show InChI InChI=1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17) | UniProtKB/SwissProt
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Channel blocking activity at human TRESK channel |
Bioorg Med Chem Lett 26: 4919-4924 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.020 BindingDB Entry DOI: 10.7270/Q2T72KDN |
More data for this Ligand-Target Pair | |
Potassium channel subfamily K member 18
(Homo sapiens (Human)) | BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)Show InChI InChI=1S/C14H10F3NO2/c15-14(16,17)9-4-3-5-10(8-9)18-12-7-2-1-6-11(12)13(19)20/h1-8,18H,(H,19,20) | UniProtKB/SwissProt
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 4.74E+5 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Activation of human TRESK channel expressed in HEK293 cells assessed as induction of channel current by whole cell patch clamp assay |
Bioorg Med Chem Lett 26: 4919-4924 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.020 BindingDB Entry DOI: 10.7270/Q2T72KDN |
More data for this Ligand-Target Pair | |
Potassium channel subfamily K member 18
(Homo sapiens (Human)) | BDBM50197058
(CHEMBL3970106)Show InChI InChI=1S/C17H19NO2/c1-17(2,3)12-7-6-8-13(11-12)18-15-10-5-4-9-14(15)16(19)20/h4-11,18H,1-3H3,(H,19,20) | UniProtKB/SwissProt
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CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 4.50E+4 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Activation of human TRESK channel relative to control |
Bioorg Med Chem Lett 26: 4919-4924 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.020 BindingDB Entry DOI: 10.7270/Q2T72KDN |
More data for this Ligand-Target Pair | |
Potassium channel subfamily K member 18
(Homo sapiens (Human)) | BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)Show InChI InChI=1S/C14H10F3NO2/c15-14(16,17)9-4-3-5-10(8-9)18-12-7-2-1-6-11(12)13(19)20/h1-8,18H,(H,19,20) | UniProtKB/SwissProt
GoogleScholar AffyNet
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Activation of human TRESK channel relative to control |
Bioorg Med Chem Lett 26: 4919-4924 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.020 BindingDB Entry DOI: 10.7270/Q2T72KDN |
More data for this Ligand-Target Pair | |
Potassium channel subfamily K member 18
(Homo sapiens (Human)) | BDBM50197061
(CHEMBL3965023)Show InChI InChI=1S/C17H19N5/c1-17(2,3)12-7-6-8-13(11-12)18-15-10-5-4-9-14(15)16-19-21-22-20-16/h4-11,18H,1-3H3,(H,19,20,21,22) | UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.88E+4 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Activation of human TRESK channel expressed in HEK293 cells assessed as induction of channel current by whole cell patch clamp assay |
Bioorg Med Chem Lett 26: 4919-4924 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.020 BindingDB Entry DOI: 10.7270/Q2T72KDN |
More data for this Ligand-Target Pair | |
Potassium channel subfamily K member 18
(Homo sapiens (Human)) | BDBM50197060
(CHEMBL1417584)Show InChI InChI=1S/C17H17N5/c1-2-8-13-12(6-1)7-5-11-15(13)18-16-10-4-3-9-14(16)17-19-21-22-20-17/h3-5,7,9-11,18H,1-2,6,8H2,(H,19,20,21,22) | UniProtKB/SwissProt
GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Activation of human TRESK channel relative to control |
Bioorg Med Chem Lett 26: 4919-4924 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.020 BindingDB Entry DOI: 10.7270/Q2T72KDN |
More data for this Ligand-Target Pair | |