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Target
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Compile Data Set for Download or QSAR
Found
4
hits Enz. Inhib. hit(s) with Target = 'Probable JmjC domain-containing histone demethylation protein 2C'
Target/Host
(Institution)
Ligand
Target/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
k
off
s
-1
k
on
M
-1
s
-1
pH
Temp
°C
Probable JmjC domain-containing histone demethylation protein 2C
(Homo sapiens (Human))
BDBM50163389
(CHEMBL3793278)
Show SMILES
NNc1nccc(n1)C(O)=O
Show InChI
InChI=1S/C5H6N4O2/c6-9-5-7-2-1-3(8-5)4(10)11/h1-2H,6H2,(H,10,11)(H,7,8,9)
PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
CHEMBL
MMDB
PC cid
PC sid
UniChem
Patents
Similars
Article
PubMed
n/a
n/a
1.90E+3
n/a
n/a
n/a
n/a
n/a
n/a
Sichuan University
Curated by
ChEMBL
Assay Description
Inhibition of KDM3C (unknown origin) using substrate peptide/ascorbate/2-OG/ Fe(2) as substrate preincubated for 15 mins followed by addition of subs...
Bioorg Med Chem Lett
26:
2284
-
8
(2016)
Article DOI:
10.1016/j.bmcl.2016.03.048
BindingDB Entry DOI:
10.7270/Q2XP76TS
More data for this
Ligand-Target Pair
Probable JmjC domain-containing histone demethylation protein 2C
(Homo sapiens (Human))
BDBM50594964
(CHEMBL5193187)
Show SMILES
[H][C@]12OC[C@H](NS(=O)(=O)c3ccc(NC(C)=O)cc3)[C@@]1([H])OC[C@@H]2Nc1nccc(n1)-c1ccccc1 |r|
Show InChI
PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
n/a
2.70E+3
n/a
n/a
n/a
n/a
n/a
TBA
Citation and Details
Article DOI:
10.1016/j.ejmech.2022.114143
BindingDB Entry DOI:
10.7270/Q28W3J9V
More data for this
Ligand-Target Pair
Probable JmjC domain-containing histone demethylation protein 2C
(Homo sapiens (Human))
BDBM50594965
(CHEMBL5173150)
Show SMILES
[H][C@]12OC[C@H](NS(=O)(=O)c3ccc(NC(C)=O)cc3)[C@@]1([H])OC[C@@H]2Nc1nccc(n1)-c1cccc(c1)C(C)(C)C |r|
Show InChI
PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
n/a
8.06E+3
n/a
n/a
n/a
n/a
n/a
TBA
Citation and Details
Article DOI:
10.1016/j.ejmech.2022.114143
BindingDB Entry DOI:
10.7270/Q28W3J9V
More data for this
Ligand-Target Pair
Probable JmjC domain-containing histone demethylation protein 2C
(Homo sapiens (Human))
BDBM50594963
(CHEMBL5191875)
Show SMILES
[H][C@]12OC[C@H](NS(=O)(=O)c3ccc(NC(C)=O)cc3)[C@@]1([H])OC[C@@H]2Nc1nccc(n1)-c1cccc(F)c1 |r|
Show InChI
PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
n/a
2.67E+4
n/a
n/a
n/a
n/a
n/a
TBA
Citation and Details
Article DOI:
10.1016/j.ejmech.2022.114143
BindingDB Entry DOI:
10.7270/Q28W3J9V
More data for this
Ligand-Target Pair
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