Found 31 hits Enz. Inhib. hit(s) with Target = 'Protein arginine N-methyltransferase 7' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Protein arginine N-methyltransferase 7
(Homo sapiens (Human)) | BDBM50597884
(CHEMBL5185202)Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CSCCCCNCc2cccc(c2)-c2ccc(Cl)cc2)[C@@H](O)[C@H]1O |r| | PDB
UniProtKB/SwissProt
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| PC cid
PC sid
PDB
UniChem
| PDB
Article
PubMed
| n/a | n/a | <2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01208
BindingDB Entry DOI: 10.7270/Q25X2DZR |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Protein arginine N-methyltransferase 7
(Homo sapiens (Human)) | BDBM50009672
(AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...)Show SMILES N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O Show InChI InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1 | PDB
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MCE
KEGG
MMDB
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UniChem
Patents
Similars
| PDB
Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human PRMT7 using GST-GAR as substrate by hotspot assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2019.112023
BindingDB Entry DOI: 10.7270/Q2TB1BJ6 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Protein arginine N-methyltransferase 7
(Homo sapiens (Human)) | BDBM50598017
(CHEMBL5206272)Show SMILES COC(=O)c1cc(O)c2cc(NC(=O)NCCCCCNC(=N)NC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c(N)ncnc34)ccc2c1 |r| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
| Article
PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00252
BindingDB Entry DOI: 10.7270/Q2DF6W8F |
More data for this
Ligand-Target Pair | |
Protein arginine N-methyltransferase 7
(Homo sapiens (Human)) | BDBM50598020
(CHEMBL5202088)Show SMILES COC(=O)c1cc(O)c2cc(NC(=O)NCCCCNC(=N)NCC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c(N)ncnc34)ccc2c1 |r| | PDB
UniProtKB/SwissProt
GoogleScholar
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| PC cid
PC sid
PDB
UniChem
| Article
PubMed
| n/a | n/a | 226 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00252
BindingDB Entry DOI: 10.7270/Q2DF6W8F |
More data for this
Ligand-Target Pair | |
Protein arginine N-methyltransferase 7
(Homo sapiens (Human)) | BDBM50598015
(CHEMBL5199380)Show SMILES COC(=O)c1cc(O)c2cc(NC(=O)NCCCNC(=N)NC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c(N)ncnc34)ccc2c1 |r| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
| Article
PubMed
| n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00252
BindingDB Entry DOI: 10.7270/Q2DF6W8F |
More data for this
Ligand-Target Pair | |
Protein arginine N-methyltransferase 7
(Homo sapiens (Human)) | BDBM50598018
(CHEMBL5180108)Show SMILES COC(=O)c1cc(O)c2ccc(NC(=O)NCCCCCCNC(=N)NC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c(N)ncnc34)cc2c1 |r| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00252
BindingDB Entry DOI: 10.7270/Q2DF6W8F |
More data for this
Ligand-Target Pair | |
Protein arginine N-methyltransferase 7
(Homo sapiens (Human)) | BDBM50598016
(CHEMBL5170047)Show SMILES COC(=O)c1cc(O)c2cc(NC(=O)NCCCCNC(=N)NC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c(N)ncnc34)ccc2c1 |r| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
| Article
PubMed
| n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00252
BindingDB Entry DOI: 10.7270/Q2DF6W8F |
More data for this
Ligand-Target Pair | |
Protein arginine N-methyltransferase 7
(Homo sapiens (Human)) | BDBM50598019
(CHEMBL5186617)Show SMILES COC(=O)c1cc(O)c2cc(NC(=O)NCCCCCCCNC(=N)NC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c(N)ncnc34)ccc2c1 |r| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 631 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00252
BindingDB Entry DOI: 10.7270/Q2DF6W8F |
More data for this
Ligand-Target Pair | |
Protein arginine N-methyltransferase 7
(Homo sapiens (Human)) | BDBM50598022
(CHEMBL5173678)Show SMILES COC(=O)c1cc(O)c2cc(NC(=O)NCCCCNC(=N)NC\C=C\[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c(N)ncnc34)ccc2c1 |r| | PDB
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MCE
PC cid
PC sid
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UniChem
| Article
PubMed
| n/a | n/a | 1.68E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00252
BindingDB Entry DOI: 10.7270/Q2DF6W8F |
More data for this
Ligand-Target Pair | |
Protein arginine N-methyltransferase 7
(Homo sapiens (Human)) | BDBM50598021
(CHEMBL5191769)Show SMILES COC(=O)c1cc(O)c2cc(NC(=O)NCCCCNC(=N)NCCC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c(N)ncnc34)ccc2c1 |r| | PDB
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| PC cid
PC sid
PDB
UniChem
| Article
PubMed
| n/a | n/a | 4.68E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00252
BindingDB Entry DOI: 10.7270/Q2DF6W8F |
More data for this
Ligand-Target Pair | |
Protein arginine N-methyltransferase 7
(Homo sapiens (Human)) | BDBM50089221
(CHEMBL3577854)Show SMILES CCNC(=O)NCCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r| Show InChI InChI=1S/C15H23N7O4S/c1-2-17-15(25)18-3-4-27-5-8-10(23)11(24)14(26-8)22-7-21-9-12(16)19-6-20-13(9)22/h6-8,10-11,14,23-24H,2-5H2,1H3,(H2,16,19,20)(H2,17,18,25)/t8-,10-,11-,14-/m1/s1 | PDB
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| Article
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| n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto
Curated by ChEMBL
| Assay Description
Inhibition of human full length PRMT7 expressed in Sf9 cells assessed as inhibition of H2B[23-37] methylation |
ACS Med Chem Lett 6: 408-12 (2015)
Article DOI: 10.1021/ml500467h
BindingDB Entry DOI: 10.7270/Q2Q81FSZ |
More data for this
Ligand-Target Pair | |
Protein arginine N-methyltransferase 7
(Homo sapiens (Human)) | BDBM50396023
(CHEMBL2169919)Show SMILES CC(C)N(CCCNC(=O)Nc1ccc(cc1)C(C)(C)C)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc2c(N)ncnc12 |r| Show InChI InChI=1S/C28H41N7O4/c1-17(2)34(13-6-12-30-27(38)33-19-9-7-18(8-10-19)28(3,4)5)15-21-22(36)23(37)26(39-21)35-14-11-20-24(29)31-16-32-25(20)35/h7-11,14,16-17,21-23,26,36-37H,6,12-13,15H2,1-5H3,(H2,29,31,32)(H2,30,33,38)/t21-,22-,23-,26-/m1/s1 | PDB
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| Article
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| n/a | n/a | 7.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto
Curated by ChEMBL
| Assay Description
Inhibition of human full length PRMT7 expressed in Sf9 cells |
ACS Med Chem Lett 6: 408-12 (2015)
Article DOI: 10.1021/ml500467h
BindingDB Entry DOI: 10.7270/Q2Q81FSZ |
More data for this
Ligand-Target Pair | |
Protein arginine N-methyltransferase 7
(Homo sapiens (Human)) | BDBM50247634
(CHEMBL4067973)Show SMILES N[C@@H](CCCN(CCc1cccc(c1)C(N)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O |r| Show InChI InChI=1S/C24H32N8O6/c25-15(24(36)37)5-2-7-31(8-6-13-3-1-4-14(9-13)21(27)35)10-16-18(33)19(34)23(38-16)32-12-30-17-20(26)28-11-29-22(17)32/h1,3-4,9,11-12,15-16,18-19,23,33-34H,2,5-8,10,25H2,(H2,27,35)(H,36,37)(H2,26,28,29)/t15-,16+,18+,19+,23+/m0/s1 | PDB
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| PC cid
PC sid
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UniChem
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| Article
PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
| Assay Description
Inhibition of PRMT7 (unknown origin) using [3H]-SAM as co-factor by scintillation proximity assay |
J Med Chem 61: 1541-1551 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01422
BindingDB Entry DOI: 10.7270/Q2FT8PF2 |
More data for this
Ligand-Target Pair | |
Protein arginine N-methyltransferase 7
(Homo sapiens (Human)) | BDBM50550092
(CHEMBL4740128)Show SMILES CNC(=N)N\N=C(\C)c1ccc2oc3ccc(cc3c2c1)C(\C)=N\NC(=N)NC | PDB
UniProtKB/SwissProt
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AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.33E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant GST-tagged PRMT7 (unknown origin) expressed in Escherichia coli using biotin-labeled SMD1 as substrate incubated for 120 mi... |
Citation and Details
Article DOI: 10.1039/d0md00259c
BindingDB Entry DOI: 10.7270/Q29P3583 |
More data for this
Ligand-Target Pair | |
Protein arginine N-methyltransferase 7
(Homo sapiens (Human)) | BDBM50550091
(CHEMBL4648477)Show SMILES NC(=N)c1ccc(Nc2ccc(cc2)-c2cc3ccc(cc3[nH]2)C(N)=N)cc1 | PDB
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PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.36E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant GST-tagged PRMT7 (unknown origin) expressed in Escherichia coli using biotin-labeled SMD1 as substrate incubated for 120 mi... |
Citation and Details
Article DOI: 10.1039/d0md00259c
BindingDB Entry DOI: 10.7270/Q29P3583 |
More data for this
Ligand-Target Pair | |
Protein arginine N-methyltransferase 7
(Homo sapiens (Human)) | BDBM50525201
(CHEMBL4463124)Show SMILES CNC[C@@H](O)CN1CCc2c(C1)cccc2OCc1ccc(cc1)-c1nccs1 |r| Show InChI InChI=1S/C23H27N3O2S/c1-24-13-20(27)15-26-11-9-21-19(14-26)3-2-4-22(21)28-16-17-5-7-18(8-6-17)23-25-10-12-29-23/h2-8,10,12,20,24,27H,9,11,13-16H2,1H3/t20-/m1/s1 | PDB
UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of recombinant full-length human PRMT7 expressed in Sf9 insect cells using Ac-KKDGKKRKRSRKESYK-biotin as substrate measured after 30 mins ... |
J Med Chem 62: 5414-5433 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00297
BindingDB Entry DOI: 10.7270/Q289199B |
More data for this
Ligand-Target Pair | |
Protein arginine N-methyltransferase 7
(Homo sapiens (Human)) | BDBM50009672
(AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...)Show SMILES N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O Show InChI InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1 | PDB
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| PDB
Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto
Curated by ChEMBL
| Assay Description
Inhibition of human full length PRMT7 expressed in Sf9 cells |
ACS Med Chem Lett 6: 408-12 (2015)
Article DOI: 10.1021/ml500467h
BindingDB Entry DOI: 10.7270/Q2Q81FSZ |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Protein arginine N-methyltransferase 7
(Homo sapiens (Human)) | CHEMBL5266562
| PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
UniChem
| | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Protein arginine N-methyltransferase 7
(Homo sapiens (Human)) | BDBM50089221
(CHEMBL3577854)Show SMILES CCNC(=O)NCCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r| Show InChI InChI=1S/C15H23N7O4S/c1-2-17-15(25)18-3-4-27-5-8-10(23)11(24)14(26-8)22-7-21-9-12(16)19-6-20-13(9)22/h6-8,10-11,14,23-24H,2-5H2,1H3,(H2,16,19,20)(H2,17,18,25)/t8-,10-,11-,14-/m1/s1 | PDB
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CHEMBL
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| Article
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| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto
Curated by ChEMBL
| Assay Description
Inhibition of human full length PRMT7 expressed in Sf9 cells |
ACS Med Chem Lett 6: 408-12 (2015)
Article DOI: 10.1021/ml500467h
BindingDB Entry DOI: 10.7270/Q2Q81FSZ |
More data for this
Ligand-Target Pair | |
Protein arginine N-methyltransferase 7
(Homo sapiens (Human)) | BDBM50551136
(CHEMBL4757320)Show SMILES CC(C)(C)c1ccc(NC(=O)c2ncn(CC(=O)NCc3ccc4c(N)nccc4c3)n2)cc1 | PDB
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.15E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human PRMT7 using GST-GAR as substrate by hotspot assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2019.112023
BindingDB Entry DOI: 10.7270/Q2TB1BJ6 |
More data for this
Ligand-Target Pair | |
Protein arginine N-methyltransferase 7
(Homo sapiens (Human)) | BDBM50551131
(CHEMBL4787257)Show SMILES Cc1ccc(NC(=O)c2ncn(CC(=O)NCc3ccc4c(N)nccc4c3)n2)cc1C | PDB
UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.94E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human PRMT7 using GST-GAR as substrate by hotspot assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2019.112023
BindingDB Entry DOI: 10.7270/Q2TB1BJ6 |
More data for this
Ligand-Target Pair | |
Protein arginine N-methyltransferase 7
(Homo sapiens (Human)) | BDBM50529897
(CHEMBL4468383)Show SMILES O[C@@H](CNC(=O)c1ccc2CN(CCc2c1)C(=O)c1ccc(Br)cc1)CN1CCc2ccccc2C1 |r| Show InChI InChI=1S/C29H30BrN3O3/c30-26-9-7-21(8-10-26)29(36)33-14-12-22-15-23(5-6-25(22)18-33)28(35)31-16-27(34)19-32-13-11-20-3-1-2-4-24(20)17-32/h1-10,15,27,34H,11-14,16-19H2,(H,31,35)/t27-/m0/s1 | PDB
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| PC cid
PC sid
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| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica
Curated by ChEMBL
| Assay Description
Inhibition of recombinant full length human N-terminal FLAG-tagged PRMT7 expressed in Sf9 insect cells preincubated for 15 mins followed by substrate... |
Eur J Med Chem 164: 317-333 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.065
BindingDB Entry DOI: 10.7270/Q2RR22Q1 |
More data for this
Ligand-Target Pair | |
Protein arginine N-methyltransferase 7
(Homo sapiens (Human)) | BDBM223137
(P5i-6)Show InChI InChI=1S/C12H10ClN3O2/c13-9-3-1-8(2-4-9)11-6-5-10(18-11)7-15-16-12(14)17/h1-7H,(H3,14,16,17)/b15-7+ | PDB
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| Article
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | 25 |
Sichuan University
| Assay Description
All in vitro enzymatic assays were carried out by Shanghai ChemPartner Co. (998 Halei Road, Pudong New Area, Shanghai, 201203, China). To measure the... |
Chem Biol Drug Des 89: 585-598 (2017)
Article DOI: 10.1111/cbdd.12881
BindingDB Entry DOI: 10.7270/Q21V5CTR |
More data for this
Ligand-Target Pair | |
Protein arginine N-methyltransferase 7
(Homo sapiens (Human)) | BDBM50238541
(CHEMBL4092336)Show SMILES COC(=O)c1ccccc1NC(=O)CSc1nc2cc(OC)ccc2[nH]1 Show InChI InChI=1S/C18H17N3O4S/c1-24-11-7-8-14-15(9-11)21-18(20-14)26-10-16(22)19-13-6-4-3-5-12(13)17(23)25-2/h3-9H,10H2,1-2H3,(H,19,22)(H,20,21) | PDB
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human N-terminal His-tagged full length PRMT7 expressed in baculovirus using of histone H4 as substrate preincubated for 15... |
J Med Chem 60: 6289-6304 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00587
BindingDB Entry DOI: 10.7270/Q2D220XW |
More data for this
Ligand-Target Pair | |
Protein arginine N-methyltransferase 7
(Homo sapiens (Human)) | BDBM50532859
(CHEMBL4436627)Show SMILES Cl.C[C@H](N)C(=O)NCc1ccc(Oc2cc(C)cc(C)c2)c(C)c1 |r| Show InChI InChI=1S/C19H24N2O2.ClH/c1-12-7-13(2)9-17(8-12)23-18-6-5-16(10-14(18)3)11-21-19(22)15(4)20;/h5-10,15H,11,20H2,1-4H3,(H,21,22);1H/t15-;/m0./s1 | PDB
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto
Curated by ChEMBL
| Assay Description
Inhibition of PRMT7 (unknown origin) |
J Med Chem 59: 6838-47 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00668
BindingDB Entry DOI: 10.7270/Q2445QZC |
More data for this
Ligand-Target Pair | |
Protein arginine N-methyltransferase 7
(Homo sapiens (Human)) | BDBM50529897
(CHEMBL4468383)Show SMILES O[C@@H](CNC(=O)c1ccc2CN(CCc2c1)C(=O)c1ccc(Br)cc1)CN1CCc2ccccc2C1 |r| Show InChI InChI=1S/C29H30BrN3O3/c30-26-9-7-21(8-10-26)29(36)33-14-12-22-15-23(5-6-25(22)18-33)28(35)31-16-27(34)19-32-13-11-20-3-1-2-4-24(20)17-32/h1-10,15,27,34H,11-14,16-19H2,(H,31,35)/t27-/m0/s1 | PDB
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica
Curated by ChEMBL
| Assay Description
Inhibition of recombinant full length human N-terminal FLAG-tagged PRMT7 expressed in Sf9 insect cells preincubated for 15 mins followed by substrate... |
Eur J Med Chem 164: 317-333 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.065
BindingDB Entry DOI: 10.7270/Q2RR22Q1 |
More data for this
Ligand-Target Pair | |
Protein arginine N-methyltransferase 7
(Homo sapiens (Human)) | BDBM50532859
(CHEMBL4436627)Show SMILES Cl.C[C@H](N)C(=O)NCc1ccc(Oc2cc(C)cc(C)c2)c(C)c1 |r| Show InChI InChI=1S/C19H24N2O2.ClH/c1-12-7-13(2)9-17(8-12)23-18-6-5-16(10-14(18)3)11-21-19(22)15(4)20;/h5-10,15H,11,20H2,1-4H3,(H,21,22);1H/t15-;/m0./s1 | PDB
UniProtKB/SwissProt
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto
Curated by ChEMBL
| Assay Description
Inhibition of PRMT7 (unknown origin) |
J Med Chem 59: 6838-47 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00668
BindingDB Entry DOI: 10.7270/Q2445QZC |
More data for this
Ligand-Target Pair | |
Protein arginine N-methyltransferase 7
(Homo sapiens (Human)) | BDBM50550095
(CHEMBL4792295) | PDB
UniProtKB/SwissProt
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PC sid
UniChem
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PubMed
| n/a | n/a | 1.26E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant GST-tagged PRMT7 (unknown origin) expressed in Escherichia coli using biotin-labeled SMD1 as substrate incubated for 120 mi... |
Citation and Details
Article DOI: 10.1039/d0md00259c
BindingDB Entry DOI: 10.7270/Q29P3583 |
More data for this
Ligand-Target Pair | |
Protein arginine N-methyltransferase 7
(Homo sapiens (Human)) | BDBM50550093
(CHEMBL4755950)Show SMILES C1CN=C(N1)c1cc2cc(ccc2o1)-c1cc2ccc(cc2[nH]1)C1=NCCN1 |c:2,t:28| | PDB
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| n/a | n/a | 2.48E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant GST-tagged PRMT7 (unknown origin) expressed in Escherichia coli using biotin-labeled SMD1 as substrate incubated for 120 mi... |
Citation and Details
Article DOI: 10.1039/d0md00259c
BindingDB Entry DOI: 10.7270/Q29P3583 |
More data for this
Ligand-Target Pair | |
Protein arginine N-methyltransferase 7
(Homo sapiens (Human)) | BDBM50550094
(CHEMBL4740956)Show SMILES CNCC(=O)NC1=CC2C(C=C1)C(=O)c1cc(NC(=O)CNC)ccc1C2=O |c:10,t:6| | PDB
UniProtKB/SwissProt
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UniChem
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PubMed
| n/a | n/a | 2.88E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant GST-tagged PRMT7 (unknown origin) expressed in Escherichia coli using biotin-labeled SMD1 as substrate incubated for 120 mi... |
Citation and Details
Article DOI: 10.1039/d0md00259c
BindingDB Entry DOI: 10.7270/Q29P3583 |
More data for this
Ligand-Target Pair | |
Protein arginine N-methyltransferase 7
(Homo sapiens (Human)) | BDBM50089221
(CHEMBL3577854)Show SMILES CCNC(=O)NCCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r| Show InChI InChI=1S/C15H23N7O4S/c1-2-17-15(25)18-3-4-27-5-8-10(23)11(24)14(26-8)22-7-21-9-12(16)19-6-20-13(9)22/h6-8,10-11,14,23-24H,2-5H2,1H3,(H2,16,19,20)(H2,17,18,25)/t8-,10-,11-,14-/m1/s1 | PDB
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Similars
| Article
PubMed
| n/a | n/a | n/a | 3.70E+4 | n/a | n/a | n/a | n/a | n/a |
University of Toronto
Curated by ChEMBL
| Assay Description
Binding affinity to human full length PRMT7 by Surface plasmon resonance method |
ACS Med Chem Lett 6: 408-12 (2015)
Article DOI: 10.1021/ml500467h
BindingDB Entry DOI: 10.7270/Q2Q81FSZ |
More data for this
Ligand-Target Pair | |
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