Found 2511 hits Enz. Inhib. hit(s) with Target = 'S-adenosylmethionine synthase isoform type-2' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
S-adenosylmethionine synthase isoform type-2
(Rattus norvegicus) | BDBM18134
(({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-...)Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C10H17N6O12P3/c11-8-5-9(13-2-12-8)16(3-14-5)10-7(18)6(17)4(27-10)1-26-31(24,25)28-30(22,23)15-29(19,20)21/h2-4,6-7,10,17-18H,1H2,(H,24,25)(H2,11,12,13)(H4,15,19,20,21,22,23)/t4-,6-,7-,10-/m1/s1 | PDB MMDB
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Similars
| PubMed
| 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory constant against rat kidney Methionine adenosyltransferase II |
J Med Chem 29: 318-22 (1986)
BindingDB Entry DOI: 10.7270/Q2DF6RSH |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Rattus norvegicus) | BDBM85447
(Epoxy analogue, I(a))Show InChI InChI=1S/C5H9NO3/c6-4(5(7)8)1-3-2-9-3/h3-4H,1-2,6H2,(H,7,8)/t3-,4-/m0/s1 | PDB MMDB
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| MMDB PC cid PC sid PDB UniChem
| PDB Article PubMed
| 7.00E+3 | -30.6 | 5.00E+4 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Laboratoire de chimie bioorganique
| Assay Description AdoMet synthetase activity was measured by a radioactive assay using (14C-methyl)-L-methionine as described by Sullivan and Hoffman with minor modifi... |
J Enzym Inhib 13: 361-7 (1998)
Article DOI: 10.3109/14756369809021481 BindingDB Entry DOI: 10.7270/Q2668BQ4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
S-adenosylmethionine synthase isoform type-2
(Rattus norvegicus) | BDBM50367328
(CHEMBL1791415)Show SMILES NC(CCSC(CP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O |r| Show InChI InChI=1S/C15H26N7O13P3S/c16-6(15(25)26)1-2-39-7(3-36(27,28)35-38(32,33)21-37(29,30)31)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,27,28)(H2,17,18,19)(H4,21,29,30,31,32,33)/t6?,7?,9-,10+,11+,14+/m0/s1 | PDB MMDB
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UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition constant was evaluated with kidney Methionine adenosyltransferase II form of rat methionine adenosyltransferase, when ATP was the variable... |
J Med Chem 29: 1030-8 (1986)
BindingDB Entry DOI: 10.7270/Q2CF9QN4 |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Rattus norvegicus) | BDBM50367329
(CHEMBL1791416)Show SMILES NC(CCSC(CP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O |r| Show InChI InChI=1S/C15H25N6O14P3S/c16-6(15(24)25)1-2-39-7(3-36(26,27)34-38(31,32)35-37(28,29)30)11-9(22)10(23)14(33-11)21-5-20-8-12(17)18-4-19-13(8)21/h4-7,9-11,14,22-23H,1-3,16H2,(H,24,25)(H,26,27)(H,31,32)(H2,17,18,19)(H2,28,29,30)/t6?,7?,9-,10+,11+,14+/m0/s1 | PDB MMDB
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UniProtKB/SwissProt
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| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 3.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition constant was evaluated with kidney Methionine adenosyltransferase II form of rat methionine adenosyltransferase, when ATP was the variable... |
J Med Chem 29: 1030-8 (1986)
BindingDB Entry DOI: 10.7270/Q2CF9QN4 |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Rattus norvegicus) | BDBM50367329
(CHEMBL1791416)Show SMILES NC(CCSC(CP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O |r| Show InChI InChI=1S/C15H25N6O14P3S/c16-6(15(24)25)1-2-39-7(3-36(26,27)34-38(31,32)35-37(28,29)30)11-9(22)10(23)14(33-11)21-5-20-8-12(17)18-4-19-13(8)21/h4-7,9-11,14,22-23H,1-3,16H2,(H,24,25)(H,26,27)(H,31,32)(H2,17,18,19)(H2,28,29,30)/t6?,7?,9-,10+,11+,14+/m0/s1 | PDB MMDB
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UniProtKB/SwissProt
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| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 3.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition constant was evaluated with kidney Methionine adenosyltransferase II form of rat methionine adenosyltransferase, when ATP was the variable... |
J Med Chem 29: 1030-8 (1986)
BindingDB Entry DOI: 10.7270/Q2CF9QN4 |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Rattus norvegicus) | BDBM50452293
(CHEMBL2092766)Show SMILES CCC[C@]1(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r| Show InChI InChI=1S/C13H22N5O13P3/c1-2-3-13(4-28-33(24,25)31-34(26,27)30-32(21,22)23)9(20)8(19)12(29-13)18-6-17-7-10(14)15-5-16-11(7)18/h5-6,8-9,12,19-20H,2-4H2,1H3,(H,24,25)(H,26,27)(H2,14,15,16)(H2,21,22,23)/t8-,9+,12-,13-/m1/s1 | PDB MMDB
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UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 4.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition constant was evaluated with kidney Methionine adenosyltransferase II form of rat methionine adenosyltransferase, when ATP was the variable... |
J Med Chem 29: 1030-8 (1986)
BindingDB Entry DOI: 10.7270/Q2CF9QN4 |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Rattus norvegicus) | BDBM50367301
(CHEMBL1791432)Show SMILES CCCC(OP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r| Show InChI InChI=1S/C13H22N5O13P3/c1-2-3-6(29-33(24,25)31-34(26,27)30-32(21,22)23)10-8(19)9(20)13(28-10)18-5-17-7-11(14)15-4-16-12(7)18/h4-6,8-10,13,19-20H,2-3H2,1H3,(H,24,25)(H,26,27)(H2,14,15,16)(H2,21,22,23)/t6?,8-,9+,10+,13+/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 4.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory constant against rat kidney Methionine adenosyltransferase II, activity expressed as Ki |
J Med Chem 29: 318-22 (1986)
BindingDB Entry DOI: 10.7270/Q2DF6RSH |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Rattus norvegicus) | BDBM50452293
(CHEMBL2092766)Show SMILES CCC[C@]1(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r| Show InChI InChI=1S/C13H22N5O13P3/c1-2-3-13(4-28-33(24,25)31-34(26,27)30-32(21,22)23)9(20)8(19)12(29-13)18-6-17-7-10(14)15-5-16-11(7)18/h5-6,8-9,12,19-20H,2-4H2,1H3,(H,24,25)(H,26,27)(H2,14,15,16)(H2,21,22,23)/t8-,9+,12-,13-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 4.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition constant was evaluated with kidney Methionine adenosyltransferase II form of rat methionine adenosyltransferase, when ATP was the variable... |
J Med Chem 29: 1030-8 (1986)
BindingDB Entry DOI: 10.7270/Q2CF9QN4 |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Rattus norvegicus) | BDBM85448
(Epoxy analogue, I(b))Show InChI InChI=1S/C6H11NO3/c1-3-5(10-3)2-4(7)6(8)9/h3-5H,2,7H2,1H3,(H,8,9)/t3-,4+,5+/m1/s1 | PDB MMDB
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UniProtKB/SwissProt
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| KEGG PC cid PC sid UniChem
Similars
| Article PubMed
| 6.10E+4 | -25.0 | 1.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Laboratoire de chimie bioorganique
| Assay Description AdoMet synthetase activity was measured by a radioactive assay using (14C-methyl)-L-methionine as described by Sullivan and Hoffman with minor modifi... |
J Enzym Inhib 13: 361-7 (1998)
Article DOI: 10.3109/14756369809021481 BindingDB Entry DOI: 10.7270/Q2668BQ4 |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Rattus norvegicus) | BDBM50367042
(CHEMBL606221)Show SMILES Nc1ncnc2n(cnc12)C1O[C@H](CCOP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C11H18N5O13P3/c12-9-6-10(14-3-13-9)16(4-15-6)11-8(18)7(17)5(27-11)1-2-26-31(22,23)29-32(24,25)28-30(19,20)21/h3-5,7-8,11,17-18H,1-2H2,(H,22,23)(H,24,25)(H2,12,13,14)(H2,19,20,21)/t5-,7-,8-,11?/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 7.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory constant against rat kidney Methionine adenosyltransferase II |
J Med Chem 29: 318-22 (1986)
BindingDB Entry DOI: 10.7270/Q2DF6RSH |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Rattus norvegicus) | BDBM85450
(Epithioamino acid analogue, II(a))Show InChI InChI=1S/C5H9NO2S/c6-4(5(7)8)1-3-2-9-3/h3-4H,1-2,6H2,(H,7,8)/t3-,4+/m1/s1 | PDB MMDB
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| PC cid PC sid UniChem
Similars
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| 1.00E+5 | -23.7 | 1.40E+5 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Laboratoire de chimie bioorganique
| Assay Description AdoMet synthetase activity was measured by a radioactive assay using (14C-methyl)-L-methionine as described by Sullivan and Hoffman with minor modifi... |
J Enzym Inhib 13: 361-7 (1998)
Article DOI: 10.3109/14756369809021481 BindingDB Entry DOI: 10.7270/Q2668BQ4 |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Rattus norvegicus) | BDBM85449
(Epoxy analogue, I(c))Show InChI InChI=1S/C6H11NO3/c1-3-5(10-3)2-4(7)6(8)9/h3-5H,2,7H2,1H3,(H,8,9)/t3-,4-,5-/m0/s1 | PDB MMDB
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UniProtKB/SwissProt
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| KEGG PC cid PC sid UniChem
Similars
| Article PubMed
| 1.05E+5 | -23.6 | 1.10E+5 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Laboratoire de chimie bioorganique
| Assay Description AdoMet synthetase activity was measured by a radioactive assay using (14C-methyl)-L-methionine as described by Sullivan and Hoffman with minor modifi... |
J Enzym Inhib 13: 361-7 (1998)
Article DOI: 10.3109/14756369809021481 BindingDB Entry DOI: 10.7270/Q2668BQ4 |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Rattus norvegicus) | BDBM85451
(Epithioamino acid analogue, II(b))Show InChI InChI=1S/C6H11NO2S/c1-3-5(10-3)2-4(7)6(8)9/h3-5H,2,7H2,1H3,(H,8,9)/t3-,4+,5-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
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| PC cid PC sid UniChem
Similars
| Article PubMed
| 1.40E+5 | -22.9 | 3.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Laboratoire de chimie bioorganique
| Assay Description AdoMet synthetase activity was measured by a radioactive assay using (14C-methyl)-L-methionine as described by Sullivan and Hoffman with minor modifi... |
J Enzym Inhib 13: 361-7 (1998)
Article DOI: 10.3109/14756369809021481 BindingDB Entry DOI: 10.7270/Q2668BQ4 |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Rattus norvegicus) | BDBM85452
(Epithioamino acid analogue, II(c))Show InChI InChI=1S/C6H11NO2S/c1-3-5(10-3)2-4(7)6(8)9/h3-5H,2,7H2,1H3,(H,8,9)/t3-,4-,5+/m0/s1 | PDB MMDB
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UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 1.40E+5 | -22.9 | 4.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Laboratoire de chimie bioorganique
| Assay Description AdoMet synthetase activity was measured by a radioactive assay using (14C-methyl)-L-methionine as described by Sullivan and Hoffman with minor modifi... |
J Enzym Inhib 13: 361-7 (1998)
Article DOI: 10.3109/14756369809021481 BindingDB Entry DOI: 10.7270/Q2668BQ4 |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Rattus norvegicus) | BDBM50367331
(CHEMBL1791417)Show SMILES NC(CCS(=O)C(CP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O |r| Show InChI InChI=1S/C15H25N6O15P3S/c16-6(15(24)25)1-2-40(33)7(3-37(26,27)35-39(31,32)36-38(28,29)30)11-9(22)10(23)14(34-11)21-5-20-8-12(17)18-4-19-13(8)21/h4-7,9-11,14,22-23H,1-3,16H2,(H,24,25)(H,26,27)(H,31,32)(H2,17,18,19)(H2,28,29,30)/t6?,7?,9-,10+,11+,14+,40?/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 1.40E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition constant was evaluated with kidney Methionine adenosyltransferase II form of rat methionine adenosyltransferase, when ATP was the variable... |
J Med Chem 29: 1030-8 (1986)
BindingDB Entry DOI: 10.7270/Q2CF9QN4 |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Rattus norvegicus) | BDBM50026197
(Adenosine 5'-triphosphate derivative | CHEMBL31428...)Show SMILES CO[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1cnc2c(N)ncnc12 |r| Show InChI InChI=1S/C11H18N5O13P3/c1-25-8-7(17)5(2-26-31(21,22)29-32(23,24)28-30(18,19)20)27-11(8)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17H,2H2,1H3,(H,21,22)(H,23,24)(H2,12,13,14)(H2,18,19,20) | PDB MMDB
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| 1.40E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory constant against rat kidney Methionine adenosyltransferase II, activity expressed as Ki |
J Med Chem 29: 318-22 (1986)
BindingDB Entry DOI: 10.7270/Q2DF6RSH |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Rattus norvegicus) | BDBM50026193
(Adenosine 5'-triphosphate derivative | CHEMBL31428...)Show SMILES CO[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1cnc2c(N)ncnc12 |r| Show InChI InChI=1S/C11H18N5O13P3/c1-25-8-5(2-26-31(21,22)29-32(23,24)28-30(18,19)20)27-11(7(8)17)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17H,2H2,1H3,(H,21,22)(H,23,24)(H2,12,13,14)(H2,18,19,20) | PDB MMDB
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Similars
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| 1.70E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory constant against rat kidney Methionine adenosyltransferase II, activity expressed as Ki |
J Med Chem 29: 318-22 (1986)
BindingDB Entry DOI: 10.7270/Q2DF6RSH |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Rattus norvegicus) | BDBM50367305
(CHEMBL1791430)Show SMILES CC(OP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r| Show InChI InChI=1S/C11H18N5O13P3/c1-4(27-31(22,23)29-32(24,25)28-30(19,20)21)8-6(17)7(18)11(26-8)16-3-15-5-9(12)13-2-14-10(5)16/h2-4,6-8,11,17-18H,1H3,(H,22,23)(H,24,25)(H2,12,13,14)(H2,19,20,21)/t4?,6-,7+,8+,11+/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
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| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 1.90E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory constant against rat kidney Methionine adenosyltransferase II, activity expressed as Ki |
J Med Chem 29: 318-22 (1986)
BindingDB Entry DOI: 10.7270/Q2DF6RSH |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Rattus norvegicus) | BDBM50367307
(CHEMBL1791431)Show SMILES CCCSC(OP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r| Show InChI InChI=1S/C13H22N5O13P3S/c1-2-3-35-13(29-33(24,25)31-34(26,27)30-32(21,22)23)9-7(19)8(20)12(28-9)18-5-17-6-10(14)15-4-16-11(6)18/h4-5,7-9,12-13,19-20H,2-3H2,1H3,(H,24,25)(H,26,27)(H2,14,15,16)(H2,21,22,23)/t7-,8+,9-,12+,13?/m0/s1 | PDB MMDB
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UniProtKB/SwissProt
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| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 2.70E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory constant against rat kidney Methionine adenosyltransferase II, activity expressed as Ki |
J Med Chem 29: 318-22 (1986)
BindingDB Entry DOI: 10.7270/Q2DF6RSH |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Rattus norvegicus) | BDBM50118221
(9H-purine derivative | CHEMBL132722 | DIPHOSPHOMET...)Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)CP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Show InChI InChI=1S/C11H18N5O12P3/c12-9-6-10(14-2-13-9)16(3-15-6)11-8(18)7(17)5(27-11)1-26-29(19,20)4-30(21,22)28-31(23,24)25/h2-3,5,7-8,11,17-18H,1,4H2,(H,19,20)(H,21,22)(H2,12,13,14)(H2,23,24,25)/t5-,7-,8-,11-/m1/s1 | PDB MMDB
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| 3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory constant against rat kidney Methionine adenosyltransferase II |
J Med Chem 29: 318-22 (1986)
BindingDB Entry DOI: 10.7270/Q2DF6RSH |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Rattus norvegicus) | BDBM50367300
(CHEMBL610977)Show SMILES CCCCSc1ncnc2n(cnc12)C1O[C@H](OP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C13H21N4O13P3S/c1-2-3-4-34-11-7-10(14-5-15-11)17(6-16-7)12-8(18)9(19)13(27-12)28-32(23,24)30-33(25,26)29-31(20,21)22/h5-6,8-9,12-13,18-19H,2-4H2,1H3,(H,23,24)(H,25,26)(H2,20,21,22)/t8-,9+,12?,13-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 3.10E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory constant against rat kidney Methionine adenosyltransferase II, activity expressed as Ki |
J Med Chem 29: 318-22 (1986)
BindingDB Entry DOI: 10.7270/Q2DF6RSH |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Rattus norvegicus) | BDBM50367303
(CHEMBL1791433)Show SMILES CSC(OP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r| Show InChI InChI=1S/C11H18N5O13P3S/c1-33-11(27-31(22,23)29-32(24,25)28-30(19,20)21)7-5(17)6(18)10(26-7)16-3-15-4-8(12)13-2-14-9(4)16/h2-3,5-7,10-11,17-18H,1H3,(H,22,23)(H,24,25)(H2,12,13,14)(H2,19,20,21)/t5-,6+,7-,10+,11?/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 4.10E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory constant against rat kidney Methionine adenosyltransferase II, activity expressed as Ki |
J Med Chem 29: 318-22 (1986)
BindingDB Entry DOI: 10.7270/Q2DF6RSH |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Rattus norvegicus) | BDBM50025158
(2-Amino-3-methyl-4-methylsulfanyl-butyric acid | C...)Show InChI InChI=1S/C6H13NO2S/c1-4(3-10-2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9) | PDB MMDB
KEGG
UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Competitive inhibitory activity against Methionine adenosyltransferase II |
J Med Chem 29: 1743-8 (1986)
BindingDB Entry DOI: 10.7270/Q24748V9 |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Rattus norvegicus) | BDBM50367306
(CHEMBL608929)Show SMILES NC(CCSc1nc2c(N)ncnc2n1C1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O)C(O)=O |r| Show InChI InChI=1S/C14H23N6O15P3S/c15-5(13(23)24)1-2-39-14-19-7-10(16)17-4-18-11(7)20(14)12-9(22)8(21)6(33-12)3-32-37(28,29)35-38(30,31)34-36(25,26)27/h4-6,8-9,12,21-22H,1-3,15H2,(H,23,24)(H,28,29)(H,30,31)(H2,16,17,18)(H2,25,26,27)/t5?,6-,8-,9-,12?/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 5.20E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory constant against rat kidney Methionine adenosyltransferase II |
J Med Chem 29: 318-22 (1986)
BindingDB Entry DOI: 10.7270/Q2DF6RSH |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Rattus norvegicus) | BDBM50367304
(CHEMBL610404)Show SMILES CCCCNc1ncnc2n(cnc12)C1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C14H24N5O13P3/c1-2-3-4-15-12-9-13(17-6-16-12)19(7-18-9)14-11(21)10(20)8(30-14)5-29-34(25,26)32-35(27,28)31-33(22,23)24/h6-8,10-11,14,20-21H,2-5H2,1H3,(H,25,26)(H,27,28)(H,15,16,17)(H2,22,23,24)/t8-,10-,11-,14?/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
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| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 5.30E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory constant against rat kidney Methionine adenosyltransferase II |
J Med Chem 29: 318-22 (1986)
BindingDB Entry DOI: 10.7270/Q2DF6RSH |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Rattus norvegicus) | BDBM50118232
(2-MeSATP | ATP, 2-meS | CHEMBL336208)Show SMILES CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O)c2n1 Show InChI InChI=1S/C11H18N5O13P3S/c1-33-11-14-8(12)5-9(15-11)16(3-13-5)10-7(18)6(17)4(27-10)2-26-31(22,23)29-32(24,25)28-30(19,20)21/h3-4,6-7,10,17-18H,2H2,1H3,(H,22,23)(H,24,25)(H2,12,14,15)(H2,19,20,21)/t4-,6-,7-,10-/m1/s1 | PDB MMDB
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| 6.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory constant against rat kidney Methionine adenosyltransferase II |
J Med Chem 29: 318-22 (1986)
BindingDB Entry DOI: 10.7270/Q2DF6RSH |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Rattus norvegicus) | BDBM50025157
(2-Amino-2-methyl-4-methylsulfanyl-pentanoic acid |...)Show InChI InChI=1S/C7H15NO2S/c1-5(11-3)4-7(2,8)6(9)10/h5H,4,8H2,1-3H3,(H,9,10)/t5-,7-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
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| 1.50E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Competitive inhibitory activity against M-2 Methionine adenosyltransferase II |
J Med Chem 29: 1743-8 (1986)
BindingDB Entry DOI: 10.7270/Q24748V9 |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Rattus norvegicus) | BDBM50025156
(2-Amino-4-methylsulfanyl-pentanoic acid | CHEMBL45...)Show InChI InChI=1S/C6H13NO2S/c1-4(10-2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4?,5-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 2.40E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Competitive inhibitory activity against Methionine adenosyltransferase II |
J Med Chem 29: 1743-8 (1986)
BindingDB Entry DOI: 10.7270/Q24748V9 |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Human) | BDBM50576014
(CHEMBL4521249)Show SMILES O=c1c(-c2ccc3ncccc3c2)c(Nc2cc[nH]n2)[nH]c2c(c(nn12)-c1ccccc1)C1=CCCCC1 |t:38| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human MAT2A expressed in baculovirus infected Sf9 cells assessed as S-adenosyl methionine production using L-methionine as ... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01895 BindingDB Entry DOI: 10.7270/Q20R9T7P |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Human) | BDBM50576017
(CHEMBL4552959)Show SMILES CCOC(=O)c1nnc(Nc2[nH]c3c(c(nn3c(=O)c2-c2ccc3ncccc3c2)-c2ccccc2)-c2ccccc2)o1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human MAT2A expressed in baculovirus infected Sf9 cells assessed as S-adenosyl methionine production using L-methionine as ... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01895 BindingDB Entry DOI: 10.7270/Q20R9T7P |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Human) | BDBM50598619
(CHEMBL5199008)Show SMILES CCOc1ncc2cc(C3=CC4N=C(CCN5CCC(O)C5)N(C)C4C=C3)c(=O)n(-c3ccc(OC(F)F)cc3)c2n1 |c:27,t:9,12| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00395 BindingDB Entry DOI: 10.7270/Q28G8QRH |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Human) | BDBM50576013
(CHEMBL4558617)Show SMILES COc1ccc(cc1)-c1c(Nc2cc[nH]n2)[nH]c2c(c(nn2c1=O)-c1ccccc1)C1=CCCCC1 |t:35| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human MAT2A expressed in baculovirus infected Sf9 cells assessed as S-adenosyl methionine production using L-methionine as ... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01895 BindingDB Entry DOI: 10.7270/Q20R9T7P |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Human) | BDBM50576015
(CHEMBL4582312)Show SMILES O=c1c(-c2ccc3ncccc3c2)c(Nc2cc[nH]n2)[nH]c2c(c(nn12)-c1ccccc1)-c1ccccc1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human MAT2A expressed in baculovirus infected Sf9 cells assessed as S-adenosyl methionine production using L-methionine as ... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01895 BindingDB Entry DOI: 10.7270/Q20R9T7P |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Human) | BDBM50576011
(CHEMBL4514699)Show SMILES Oc1ccc(cc1)-c1c(Nc2cc[nH]n2)[nH]c2c(c(nn2c1=O)-c1ccccc1)-c1ccccc1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human MAT2A expressed in baculovirus infected Sf9 cells assessed as S-adenosyl methionine production using L-methionine as ... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01895 BindingDB Entry DOI: 10.7270/Q20R9T7P |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
S-adenosylmethionine synthase isoform type-2
(Human) | BDBM50576019
(CHEMBL4568226)Show SMILES COc1ccc(cc1)-c1c(Nc2ccccn2)[nH]c2c(c(nn2c1=O)-c1ccccc1)-c1ccccc1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human MAT2A expressed in baculovirus infected Sf9 cells assessed as S-adenosyl methionine production using L-methionine as ... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01895 BindingDB Entry DOI: 10.7270/Q20R9T7P |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Human) | BDBM50575996
(CHEMBL4870597)Show SMILES Cc1[nH]c2c(N3CCCCC3)c(nn2c(=O)c1-c1ccc2OCOc2c1)-c1ccccc1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human MAT2A expressed in baculovirus infected Sf9 cells assessed as S-adenosyl methionine production using L-methionine as ... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01895 BindingDB Entry DOI: 10.7270/Q20R9T7P |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Human) | BDBM50575978
(CHEMBL4860456) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00395 BindingDB Entry DOI: 10.7270/Q28G8QRH |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Human) | BDBM50576018
(CHEMBL4585665)Show SMILES COc1ccc(cc1)-c1c(Nc2ccon2)[nH]c2c(c(nn2c1=O)-c1ccccc1)C1=CCCCC1 |t:35| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human MAT2A expressed in baculovirus infected Sf9 cells assessed as S-adenosyl methionine production using L-methionine as ... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01895 BindingDB Entry DOI: 10.7270/Q20R9T7P |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Human) | BDBM50604362
(CHEMBL5185760)Show SMILES CCNc1ccc2cn(-c3ccc4nn(C)cc4c3)c(=O)c(-c3ccc(Cl)cc3)c2n1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01595 BindingDB Entry DOI: 10.7270/Q28K7F57 |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Human) | BDBM50604357
(CHEMBL5177250)Show SMILES Cn1cc2cc(ccc2n1)-n1cc2ccc(NCC(F)(F)F)nc2c(-c2ccc(Cl)cc2)c1=O | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01595 BindingDB Entry DOI: 10.7270/Q28K7F57 |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Human) | BDBM50576016
(CHEMBL4584451)Show SMILES CCOC(=O)n1ccc(Nc2[nH]c3c(c(nn3c(=O)c2-c2ccc(OC)cc2)-c2ccccc2)-c2ccccc2)n1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human MAT2A expressed in baculovirus infected Sf9 cells assessed as S-adenosyl methionine production using L-methionine as ... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01895 BindingDB Entry DOI: 10.7270/Q20R9T7P |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Human) | BDBM50604360
(CHEMBL5187048)Show SMILES Cn1cc2cc(ccc2n1)-n1cc2ccc(OCC(F)F)nc2c(-c2ccc(Cl)cc2)c1=O | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01595 BindingDB Entry DOI: 10.7270/Q28K7F57 |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Human) | BDBM50576012
(CHEMBL4559088)Show SMILES COc1ccc(cc1)-c1c(Nc2cc[nH]n2)[nH]c2c(c(nn2c1=O)-c1ccccc1)-c1ccccc1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human MAT2A expressed in baculovirus infected Sf9 cells assessed as S-adenosyl methionine production using L-methionine as ... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01895 BindingDB Entry DOI: 10.7270/Q20R9T7P |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Human) | BDBM50581712
(CHEMBL5078281) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00067 BindingDB Entry DOI: 10.7270/Q2RR234T |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Human) | BDBM637532
((3-amino-6-((1rs,2RS,3SR)-2,3- dimethylcyclopropyl...)Show SMILES COc1ccccc1C(=O)n1nc(N)c2ccc(nc12)[C@@H]1[C@@H](C)[C@H]1C |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Human) | BDBM50604356
(CHEMBL5178902)Show SMILES Cn1cc2cc(ccc2n1)-n1cc2cnc(NCC(F)(F)F)nc2c(-c2ccc(Cl)cc2)c1=O | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01595 BindingDB Entry DOI: 10.7270/Q28K7F57 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
S-adenosylmethionine synthase isoform type-2
(Human) | BDBM50576021
(CHEMBL4573938)Show SMILES COc1ccc(cc1)-c1c(Nc2ccccn2)[nH]c2c(c(nn2c1=O)-c1ccccc1)C1=CCCCC1 |t:36| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human MAT2A expressed in baculovirus infected Sf9 cells assessed as S-adenosyl methionine production using L-methionine as ... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01895 BindingDB Entry DOI: 10.7270/Q20R9T7P |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
S-adenosylmethionine synthase isoform type-2
(Human) | BDBM50581709
(CHEMBL5075691) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00067 BindingDB Entry DOI: 10.7270/Q2RR234T |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
S-adenosylmethionine synthase isoform type-2
(Human) | BDBM637523
(US20230382911, Example 35 | [3-amino-6-(2,5-dihydr...)Show SMILES COc1ccccc1C(=O)n1nc(N)c2ccc(nc12)C1=CCOC1 |t:23| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-2
(Human) | BDBM637564
((3-amino-6-cyclopropyl-1H- pyrazolo[3,4-b]pyridin-...) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |