Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
POU domain, class 2, transcription factor 1 (Homo sapiens (Human)) | BDBM50228403 ((R)-8-(3-aminopiperidin-1-yl)-7-(but-2-ynyl)-3-met...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 4.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Nippon Boehringer Ingelheim Co., Ltd. Curated by ChEMBL | Assay Description Inhibition of OCT1 (unknown origin) expressed in HEK293 cells assessed as reduction of [14C]metformin substrate uptake at 100 uM by liquid scintillat... | Drug Metab Dispos 41: 149-58 (2012) Article DOI: 10.1124/dmd.112.048470 BindingDB Entry DOI: 10.7270/Q2QC0574 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
POU domain, class 2, transcription factor 1 (Homo sapiens (Human)) | BDBM50228403 ((R)-8-(3-aminopiperidin-1-yl)-7-(but-2-ynyl)-3-met...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 4.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Nippon Boehringer Ingelheim Co., Ltd. Curated by ChEMBL | Assay Description Inhibition of OCT1 (unknown origin) expressed in HEK293 cells assessed as reduction of [ethyl 1-14C]TEA substrate uptake at 100 uM by liquid scintill... | Drug Metab Dispos 41: 149-58 (2012) Article DOI: 10.1124/dmd.112.048470 BindingDB Entry DOI: 10.7270/Q2QC0574 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
POU domain, class 2, transcription factor 1 (Homo sapiens (Human)) | BDBM50576849 (CHEMBL4876008) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of OCT1 (unknown origin) expressed in HEK293 cells | Citation and Details Article DOI: 10.1016/j.ejmech.2020.112373 BindingDB Entry DOI: 10.7270/Q2XP78Q8 | |||||||||||
More data for this Ligand-Target Pair |