Compile Data Set for Download or QSAR

Found 1065 hits Enz. Inhib. hit(s) with Target = 'Solute carrier family 22 member 12'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Solute carrier family 22 member 12 (Homo sapiens (Human))	BDBM50538736 (CHEMBL4640580) Show SMILES Oc1c(Br)cc(cc1Br)C(=O)N1CCOc2ccncc12 Show InChI InChI=1S/C14H10Br2N2O3/c15-9-5-8(6-10(16)13(9)19)14(20)18-3-4-21-12-1-2-17-7-11(12)18/h1-2,5-7,19H,3-4H2	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	57	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
West China Hospital of Sichuan University Curated by ChEMBL					Assay Description Inhibition of human URAT1				Eur J Med Chem 166: 186-196 (2019) Article DOI: 10.1016/j.ejmech.2019.01.043 BindingDB Entry DOI: 10.7270/Q20C50BS
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Solute carrier family 22 member 12 (Homo sapiens (Human))	BDBM26658 (2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-1-benzopy...) Show SMILES Oc1ccc(c(O)c1)-c1oc2cc(O)cc(O)c2c(=O)c1O Show InChI InChI=1S/C15H10O7/c16-6-1-2-8(9(18)3-6)15-14(21)13(20)12-10(19)4-7(17)5-11(12)22-15/h1-5,16-19,21H	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	5.74E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Chinese University of Hong Kong Curated by ChEMBL					Assay Description Inhibition of human URAT1-mediated urate uptake in HEK293 cells by competitive inhibition assay				Drug Metab Dispos 35: 981-6 (2007) Article DOI: 10.1124/dmd.106.012187 BindingDB Entry DOI: 10.7270/Q2KK9CPP
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Solute carrier family 22 member 12 (Homo sapiens (Human))	BDBM165905 (US9067922, 247) Show SMILES OCc1ccc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)cc1Cl Show InChI InChI=1S/C19H13ClFN3O4S/c20-17-8-15(3-1-12(17)11-25)28-18-5-4-16(7-13(18)9-22)29(26,27)24-19-6-2-14(21)10-23-19/h1-8,10,25H,11H2,(H,23,24)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.4	n/a
Pfizer Limited US Patent					Assay Description Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...				US Patent US9067922 (2015) BindingDB Entry DOI: 10.7270/Q2VQ31F0
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Solute carrier family 22 member 12 (Homo sapiens (Human))	BDBM50239134 (CHEMBL4087516) Show SMILES FC(F)(F)S(=O)(=O)Nc1ccncc1-c1ccc(cc1)C#N Show InChI InChI=1S/C13H8F3N3O2S/c14-13(15,16)22(20,21)19-12-5-6-18-8-11(12)10-3-1-9(7-17)2-4-10/h1-6,8H,(H,18,19)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human URAT1 expressed in HEK293T cells assessed as reduction in [14C]uric acid uptake measured after 5 mins by liquid scintillation cou...				Bioorg Med Chem Lett 27: 1919-1922 (2017) Article DOI: 10.1016/j.bmcl.2017.03.041 BindingDB Entry DOI: 10.7270/Q2NK3H6D
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Homo sapiens (Human))	BDBM165898 (US9067922, 239) Show SMILES OCc1ncc(Oc2ccc(c(F)c2)S(=O)(=O)Nc2ccc(F)cn2)cc1Cl Show InChI InChI=1S/C17H12ClF2N3O4S/c18-13-5-12(8-21-15(13)9-24)27-11-2-3-16(14(20)6-11)28(25,26)23-17-4-1-10(19)7-22-17/h1-8,24H,9H2,(H,22,23)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.4	n/a
Pfizer Limited US Patent					Assay Description Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...				US Patent US9067922 (2015) BindingDB Entry DOI: 10.7270/Q2VQ31F0
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Solute carrier family 22 member 12 (Homo sapiens (Human))	BDBM165900 (US9067922, 241) Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3cc(Cl)c(C#N)c(Cl)c3)c(c2)C#N)nc1 Show InChI InChI=1S/C19H9Cl2FN4O3S/c20-16-6-13(7-17(21)15(16)9-24)29-18-3-2-14(5-11(18)8-23)30(27,28)26-19-4-1-12(22)10-25-19/h1-7,10H,(H,25,26)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.4	n/a
Pfizer Limited US Patent					Assay Description Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...				US Patent US9067922 (2015) BindingDB Entry DOI: 10.7270/Q2VQ31F0
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Homo sapiens (Human))	CHEMBL5271398 Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL UniChem		n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
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Solute carrier family 22 member 12 (Homo sapiens (Human))	BDBM50546900 (CHEMBL4756866) Show SMILES Brc1nnc(SCC(=O)NS(=O)(=O)c2ccc(Br)cc2)n1-c1ccc(C2CC2)c2ccccc12 |(37.92,-23.83,;39.38,-23.35,;39.87,-21.89,;41.4,-21.88,;41.88,-23.35,;43.41,-23.34,;44.18,-22,;45.72,-22,;46.49,-23.33,;46.48,-20.66,;48.02,-20.65,;49.34,-21.42,;48.02,-22.18,;48.78,-19.33,;50.32,-19.33,;51.08,-18,;50.31,-16.67,;51.06,-15.34,;48.77,-16.68,;48.02,-18.01,;40.63,-24.25,;40.64,-25.79,;39.31,-26.56,;39.31,-28.1,;40.64,-28.88,;40.65,-30.42,;39.9,-31.75,;41.44,-31.74,;41.99,-28.1,;43.32,-28.86,;44.66,-28.09,;44.65,-26.54,;43.31,-25.78,;41.98,-26.55,)| Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
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Solute carrier family 22 member 12 (Homo sapiens (Human))	BDBM165745 (US9067922, 235 | US9067922, 79) Show SMILES Cc1cc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)cc(C)c1C#N Show InChI InChI=1S/C21H15FN4O3S/c1-13-7-17(8-14(2)19(13)11-24)29-20-5-4-18(9-15(20)10-23)30(27,28)26-21-6-3-16(22)12-25-21/h3-9,12H,1-2H3,(H,25,26)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.4	n/a
Pfizer Limited US Patent					Assay Description Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...				US Patent US9067922 (2015) BindingDB Entry DOI: 10.7270/Q2VQ31F0
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Solute carrier family 22 member 12 (Homo sapiens (Human))	CHEMBL5277301 Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL UniChem		n/a	n/a	7.30	n/a	n/a	n/a	n/a	n/a	n/a
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Solute carrier family 22 member 12 (Homo sapiens (Human))	CHEMBL5284974 Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL UniChem		n/a	n/a	7.60	n/a	n/a	n/a	n/a	n/a	n/a
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Solute carrier family 22 member 12 (Homo sapiens (Human))	CHEMBL5287151 Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL UniChem		n/a	n/a	7.70	n/a	n/a	n/a	n/a	n/a	n/a
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Solute carrier family 22 member 12 (Homo sapiens (Human))	CHEMBL5289202 Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL UniChem		n/a	n/a	7.90	n/a	n/a	n/a	n/a	n/a	n/a
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Solute carrier family 22 member 12 (Homo sapiens (Human))	BDBM165896 (US9067922, 237) Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3cc(F)c(C#N)c(Cl)c3)c(c2)C#N)nc1 Show InChI InChI=1S/C19H9ClF2N4O3S/c20-16-6-13(7-17(22)15(16)9-24)29-18-3-2-14(5-11(18)8-23)30(27,28)26-19-4-1-12(21)10-25-19/h1-7,10H,(H,25,26)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	7.4	n/a
Pfizer Limited US Patent					Assay Description Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...				US Patent US9067922 (2015) BindingDB Entry DOI: 10.7270/Q2VQ31F0
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Solute carrier family 22 member 12 (Homo sapiens (Human))	BDBM290450 (2{[4-(4-Cyanonaphthalen)isoquinolin-6-yl]thio}-2-m...) Show SMILES CC(C)(Sc1ccc2cncc(-c3ccc(C#N)c4ccccc34)c2c1)C(O)=O Show InChI InChI=1S/C24H18N2O2S/c1-24(2,23(27)28)29-17-9-7-16-13-26-14-22(21(16)11-17)20-10-8-15(12-25)18-5-3-4-6-19(18)20/h3-11,13-14H,1-2H3,(H,27,28)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI YINGLI PHARMACEUTICAL CO., LTD. US Patent					Assay Description Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...				US Patent US10100016 (2018) BindingDB Entry DOI: 10.7270/Q2TH8PQZ
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Homo sapiens (Human))	CHEMBL5269373 Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL UniChem		n/a	n/a	9.30	n/a	n/a	n/a	n/a	n/a	n/a
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Solute carrier family 22 member 12 (Homo sapiens (Human))	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES OC(=O)CSc1nnc(Br)n1-c1ccc(C2CC2)c2ccccc12 |(-2.97,1.02,;-1.83,-.01,;-2.15,-1.52,;-.36,.46,;-.04,1.97,;1.42,2.45,;1.9,3.91,;3.44,3.91,;3.91,2.45,;5.38,1.97,;2.67,1.54,;2.67,,;1.33,-.77,;1.33,-2.31,;2.67,-3.08,;2.67,-4.62,;3.44,-5.95,;1.9,-5.95,;4,-2.31,;5.33,-3.08,;6.67,-2.31,;6.67,-.77,;5.33,,;4,-.77,)| Show InChI InChI=1S/C25H32N4O3/c1-18-13-14-19(2)21(16-18)29(17-24(31)27-20-8-3-4-9-20)25(32)12-7-11-23(30)28-22-10-5-6-15-26-22/h5-6,10,13-16,20H,3-4,7-9,11-12,17H2,1-2H3,(H,27,31)(H,26,28,30)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars		n/a	n/a	9.40	n/a	n/a	n/a	n/a	n/a	n/a
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Solute carrier family 22 member 12 (Homo sapiens (Human))	CHEMBL5278085 Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL UniChem		n/a	n/a	9.70	n/a	n/a	n/a	n/a	n/a	n/a
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Solute carrier family 22 member 12 (Homo sapiens (Human))	CHEMBL5279672 Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL UniChem		n/a	n/a	9.70	n/a	n/a	n/a	n/a	n/a	n/a
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Solute carrier family 22 member 12 (Homo sapiens (Human))	CHEMBL5289441 Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL UniChem		n/a	n/a	9.80	n/a	n/a	n/a	n/a	n/a	n/a
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Solute carrier family 22 member 12 (Homo sapiens (Human))	CHEMBL5273217 Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL UniChem		n/a	n/a	9.80	n/a	n/a	n/a	n/a	n/a	n/a
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Solute carrier family 22 member 12 (Homo sapiens (Human))	CHEMBL5277066 Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL UniChem		n/a	n/a	9.90	n/a	n/a	n/a	n/a	n/a	n/a
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Solute carrier family 22 member 12 (Homo sapiens (Human))	BDBM152041 (US8987473, 122) Show SMILES Cc1nn(Cc2c(Cl)cccc2Cl)c2cc(CCC(O)=O)ccc12 Show InChI InChI=1S/C18H16Cl2N2O2/c1-11-13-7-5-12(6-8-18(23)24)9-17(13)22(21-11)10-14-15(19)3-2-4-16(14)20/h2-5,7,9H,6,8,10H2,1H3,(H,23,24)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Sato Pharmaceutical Co., Ltd. US Patent					Assay Description It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...				US Patent US8987473 (2015) BindingDB Entry DOI: 10.7270/Q23F4NCB
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Solute carrier family 22 member 12 (Homo sapiens (Human))	BDBM152051 (US8987473, 137) Show SMILES Cc1nn(Cc2c(Cl)cccc2Cl)c2cc(Cc3n[nH]c(=S)o3)ccc12 Show InChI InChI=1S/C18H14Cl2N4OS/c1-10-12-6-5-11(8-17-21-22-18(26)25-17)7-16(12)24(23-10)9-13-14(19)3-2-4-15(13)20/h2-7H,8-9H2,1H3,(H,22,26)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Sato Pharmaceutical Co., Ltd. US Patent					Assay Description It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...				US Patent US8987473 (2015) BindingDB Entry DOI: 10.7270/Q23F4NCB
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Homo sapiens (Human))	BDBM50239146 (CHEMBL4088988) Show SMILES FC(F)(F)S(=O)(=O)Nc1ccncc1-c1ccc(C#N)c2ccccc12 Show InChI InChI=1S/C17H10F3N3O2S/c18-17(19,20)26(24,25)23-16-7-8-22-10-15(16)14-6-5-11(9-21)12-3-1-2-4-13(12)14/h1-8,10H,(H,22,23)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human URAT1 expressed in HEK293T cells assessed as reduction in [14C]uric acid uptake measured after 5 mins by liquid scintillation cou...				Bioorg Med Chem Lett 27: 1919-1922 (2017) Article DOI: 10.1016/j.bmcl.2017.03.041 BindingDB Entry DOI: 10.7270/Q2NK3H6D
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Homo sapiens (Human))	CHEMBL5290258 Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
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Solute carrier family 22 member 12 (Homo sapiens (Human))	CHEMBL5268478 Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
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Solute carrier family 22 member 12 (Homo sapiens (Human))	BDBM290480 (US10100016, Compound 45B) Show SMILES C[C@@H](CC(O)=O)c1cc2cncc(-c3ccc(C#N)c4ccccc34)c2s1 |r| Show InChI InChI=1S/C22H16N2O2S/c1-13(8-21(25)26)20-9-15-11-24-12-19(22(15)27-20)18-7-6-14(10-23)16-4-2-3-5-17(16)18/h2-7,9,11-13H,8H2,1H3,(H,25,26)/t13-/m0/s1	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI YINGLI PHARMACEUTICAL CO., LTD. US Patent					Assay Description Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...				US Patent US10100016 (2018) BindingDB Entry DOI: 10.7270/Q2TH8PQZ
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Solute carrier family 22 member 12 (Homo sapiens (Human))	BDBM290470 (US10100016, Compound 43A) Show SMILES C[C@H](CC(O)=O)c1cc2c(cncc2s1)-c1ccc(C#N)c2ccccc12 |r| Show InChI InChI=1S/C22H16N2O2S/c1-13(8-22(25)26)20-9-18-19(11-24-12-21(18)27-20)17-7-6-14(10-23)15-4-2-3-5-16(15)17/h2-7,9,11-13H,8H2,1H3,(H,25,26)/t13-/m1/s1	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI YINGLI PHARMACEUTICAL CO., LTD. US Patent					Assay Description Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...				US Patent US10100016 (2018) BindingDB Entry DOI: 10.7270/Q2TH8PQZ
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Homo sapiens (Human))	CHEMBL5291373 Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
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Solute carrier family 22 member 12 (Homo sapiens (Human))	CHEMBL5267010 Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
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Solute carrier family 22 member 12 (Homo sapiens (Human))	CHEMBL5282615 Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
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Solute carrier family 22 member 12 (Homo sapiens (Human))	CHEMBL5267727 Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
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Solute carrier family 22 member 12 (Homo sapiens (Human))	CHEMBL5285786 Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Solute carrier family 22 member 12 (Homo sapiens (Human))	BDBM290481 (3-[4-(4-Cyanonaphthalen-1-yl)isoquinolin-6-yl]-2,2...) Show SMILES CC(C)(Cc1ccc2cncc(-c3ccc(C#N)c4ccccc34)c2c1)C(O)=O Show InChI InChI=1S/C25H20N2O2/c1-25(2,24(28)29)12-16-7-8-18-14-27-15-23(22(18)11-16)21-10-9-17(13-26)19-5-3-4-6-20(19)21/h3-11,14-15H,12H2,1-2H3,(H,28,29)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI YINGLI PHARMACEUTICAL CO., LTD. US Patent					Assay Description Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...				US Patent US10100016 (2018) BindingDB Entry DOI: 10.7270/Q2TH8PQZ
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Solute carrier family 22 member 12 (Homo sapiens (Human))	BDBM290489 (3-[4-(4-Cyanophenyl)thieno[2,3-c]pyridin-2-yl]-2,2...) Show SMILES CC(C)(Cc1cc2c(cncc2s1)-c1ccc(cc1)C#N)C(O)=O Show InChI InChI=1S/C19H16N2O2S/c1-19(2,18(22)23)8-14-7-15-16(10-21-11-17(15)24-14)13-5-3-12(9-20)4-6-13/h3-7,10-11H,8H2,1-2H3,(H,22,23)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI YINGLI PHARMACEUTICAL CO., LTD. US Patent					Assay Description Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...				US Patent US10100016 (2018) BindingDB Entry DOI: 10.7270/Q2TH8PQZ
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Homo sapiens (Human))	BDBM318948 (2-Methyl-2-[[7-(4-nitrophenyl)benzo[d]isothiazol-6...) Show SMILES CC(C)(Sc1ccc2cnsc2c1-c1ccc(cc1)[N+]([O-])=O)C(O)=O Show InChI InChI=1S/C17H14N2O4S2/c1-17(2,16(20)21)24-13-8-5-11-9-18-25-15(11)14(13)10-3-6-12(7-4-10)19(22)23/h3-9H,1-2H3,(H,20,21)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Nippon Chemiphar Co., Ltd.; J-Pharma Co., Ltd.; DeThree Res. Lab. Inc. US Patent					Assay Description URAT1 stably expressed HEK293 cells (HEK-URAT1) or HEK293 cells transfected with empty vector (HEK-mock) were cultured in DMEM culture medium supplem...				US Patent US10173990 (2019) BindingDB Entry DOI: 10.7270/Q2RR21BP
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Homo sapiens (Human))	BDBM165893 (US9067922, 232) Show SMILES Clc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(C#N)c(Cl)c3)c(c2)C#N)nc1 Show InChI InChI=1S/C19H10Cl2N4O3S/c20-14-2-6-19(24-11-14)25-29(26,27)16-4-5-18(13(7-16)10-23)28-15-3-1-12(9-22)17(21)8-15/h1-8,11H,(H,24,25)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	7.4	n/a
Pfizer Limited US Patent					Assay Description Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...				US Patent US9067922 (2015) BindingDB Entry DOI: 10.7270/Q2VQ31F0
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Homo sapiens (Human))	CHEMBL5266247 Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL UniChem		n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Homo sapiens (Human))	CHEMBL5282586 Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL UniChem		n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Homo sapiens (Human))	CHEMBL5268476 Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL UniChem		n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Homo sapiens (Human))	CHEMBL5290341 Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL UniChem		n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Homo sapiens (Human))	CHEMBL5285533 Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL UniChem		n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Homo sapiens (Human))	BDBM165745 (US9067922, 235 | US9067922, 79) Show SMILES Cc1cc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)cc(C)c1C#N Show InChI InChI=1S/C21H15FN4O3S/c1-13-7-17(8-14(2)19(13)11-24)29-20-5-4-18(9-15(20)10-23)30(27,28)26-21-6-3-16(22)12-25-21/h3-9,12H,1-2H3,(H,25,26)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	7.4	n/a
Pfizer Limited US Patent					Assay Description Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...				US Patent US9067922 (2015) BindingDB Entry DOI: 10.7270/Q2VQ31F0
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Homo sapiens (Human))	CHEMBL5272958 Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL UniChem		n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Homo sapiens (Human))	BDBM165667 (US9067922, 1) Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(C#N)c(Cl)c3)c(c2)C#N)nc1 Show InChI InChI=1S/C19H10ClFN4O3S/c20-17-8-15(3-1-12(17)9-22)28-18-5-4-16(7-13(18)10-23)29(26,27)25-19-6-2-14(21)11-24-19/h1-8,11H,(H,24,25)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	7.4	n/a
Pfizer Limited US Patent					Assay Description Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...				US Patent US9067922 (2015) BindingDB Entry DOI: 10.7270/Q2VQ31F0
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Homo sapiens (Human))	BDBM152048 (US8987473, 134) Show SMILES Cc1nn(Cc2c(Cl)cccc2Cl)c2cc(Cc3nnn[nH]3)ccc12 Show InChI InChI=1S/C17H14Cl2N6/c1-10-12-6-5-11(8-17-20-23-24-21-17)7-16(12)25(22-10)9-13-14(18)3-2-4-15(13)19/h2-7H,8-9H2,1H3,(H,20,21,23,24)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Sato Pharmaceutical Co., Ltd. US Patent					Assay Description It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...				US Patent US8987473 (2015) BindingDB Entry DOI: 10.7270/Q23F4NCB
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Homo sapiens (Human))	BDBM377700 (US10266496, Example 27) Show SMILES OC(=O)c1ccc(cc1O)-c1cc(cc2oc(Cl)cc12)C#N Show InChI InChI=1S/C16H8ClNO4/c17-15-6-12-11(3-8(7-18)4-14(12)22-15)9-1-2-10(16(20)21)13(19)5-9/h1-6,19H,(H,20,21)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Curacyte Chemistry GmbH					Assay Description a. Construction of a Cell Line Stably Expressing hURAT1hURAT1 plasmid was transfected into HEK293T cell, and a cell line stably expressing hURAT1 was...				J Med Chem 49: 4116-26 (2006) BindingDB Entry DOI: 10.7270/Q2ST7S5F
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Homo sapiens (Human))	CHEMBL5278304 Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL UniChem		n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Homo sapiens (Human))	BDBM152017 (US8987473, 82) Show SMILES Cc1cn(Cc2c(Cl)cccc2Cl)c2cc(CC(O)=O)ccc12 Show InChI InChI=1S/C18H15Cl2NO2/c1-11-9-21(10-14-15(19)3-2-4-16(14)20)17-7-12(8-18(22)23)5-6-13(11)17/h2-7,9H,8,10H2,1H3,(H,22,23)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Sato Pharmaceutical Co., Ltd. US Patent					Assay Description It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...				US Patent US8987473 (2015) BindingDB Entry DOI: 10.7270/Q23F4NCB
					More data for this Ligand-Target Pair

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