Found 288 hits Enz. Inhib. hit(s) with Target = 'Solute carrier family 22 member 2' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Solute carrier family 22 member 2
(RAT) | BDBM50420215
(CHEMBL339858)Show SMILES CC(C)N1\C(=C/c2cc[n+](C(C)C)c3ccccc23)C=Cc2ccccc12 |c:21| Show InChI InChI=1S/C25H27N2/c1-18(2)26-16-15-21(23-10-6-8-12-25(23)26)17-22-14-13-20-9-5-7-11-24(20)27(22)19(3)4/h5-19H,1-4H3/q+1 | UniProtKB/SwissProt
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| 5.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Heidelberg
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of Dopamine uptake in OCT2-expressing HEK293 cells |
J Biol Chem 273: 30915-20 (1998)
BindingDB Entry DOI: 10.7270/Q2V40WGS |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(RAT) | BDBM50420215
(CHEMBL339858)Show SMILES CC(C)N1\C(=C/c2cc[n+](C(C)C)c3ccccc23)C=Cc2ccccc12 |c:21| Show InChI InChI=1S/C25H27N2/c1-18(2)26-16-15-21(23-10-6-8-12-25(23)26)17-22-14-13-20-9-5-7-11-24(20)27(22)19(3)4/h5-19H,1-4H3/q+1 | UniProtKB/SwissProt
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| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Heidelberg
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of Adrenaline uptake in OCT2-expressing HEK293 cells |
J Biol Chem 273: 30915-20 (1998)
BindingDB Entry DOI: 10.7270/Q2V40WGS |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(RAT) | BDBM50420215
(CHEMBL339858)Show SMILES CC(C)N1\C(=C/c2cc[n+](C(C)C)c3ccccc23)C=Cc2ccccc12 |c:21| Show InChI InChI=1S/C25H27N2/c1-18(2)26-16-15-21(23-10-6-8-12-25(23)26)17-22-14-13-20-9-5-7-11-24(20)27(22)19(3)4/h5-19H,1-4H3/q+1 | UniProtKB/SwissProt
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| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Heidelberg
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of Noradrenaline uptake in OCT2-expressing HEK293 cells |
J Biol Chem 273: 30915-20 (1998)
BindingDB Entry DOI: 10.7270/Q2V40WGS |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(RAT) | BDBM50420215
(CHEMBL339858)Show SMILES CC(C)N1\C(=C/c2cc[n+](C(C)C)c3ccccc23)C=Cc2ccccc12 |c:21| Show InChI InChI=1S/C25H27N2/c1-18(2)26-16-15-21(23-10-6-8-12-25(23)26)17-22-14-13-20-9-5-7-11-24(20)27(22)19(3)4/h5-19H,1-4H3/q+1 | UniProtKB/SwissProt
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| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Heidelberg
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of Serotonin uptake in OCT2-expressing HEK293 cells |
J Biol Chem 273: 30915-20 (1998)
BindingDB Entry DOI: 10.7270/Q2V40WGS |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(Homo sapiens (Human)) | BDBM39687
((2E)-1-ethyl-2-[(1-ethyl-2-quinolin-1-iumyl)methyl...)Show SMILES CCN1\C(=C\c2ccc3ccccc3[n+]2CC)C=Cc2ccccc12 |c:19| Show InChI InChI=1S/C23H23N2/c1-3-24-20(15-13-18-9-5-7-11-22(18)24)17-21-16-14-19-10-6-8-12-23(19)25(21)4-2/h5-17H,3-4H2,1-2H3/q+1 | Reactome pathway
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| 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Anatomisches Institut der Bayerischen Julius-Maximilians-Universit£t
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake in Xenopus laevis oocytes |
DNA Cell Biol 16: 871-81 (1997)
Article DOI: 10.1089/dna.1997.16.871
BindingDB Entry DOI: 10.7270/Q2R2148R |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(Homo sapiens (Human)) | BDBM50420192
(CHEMBL2074851)Show SMILES CC[n+]1c(CC2C=C(C)N=C(N2C)c2ccccc2)ccc2ccccc12 |c:9,t:6| Show InChI InChI=1S/C24H26N3/c1-4-27-21(15-14-19-10-8-9-13-23(19)27)17-22-16-18(2)25-24(26(22)3)20-11-6-5-7-12-20/h5-16,22H,4,17H2,1-3H3/q+1 | Reactome pathway
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| 210 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Anatomisches Institut der Bayerischen Julius-Maximilians-Universit£t
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake in Xenopus laevis oocytes |
DNA Cell Biol 16: 871-81 (1997)
Article DOI: 10.1089/dna.1997.16.871
BindingDB Entry DOI: 10.7270/Q2R2148R |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(RAT) | BDBM50170653
((11beta)-11,21-dihydroxypregn-4-ene-3,20-dione | 1...)Show SMILES C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO |r,t:9| Show InChI InChI=1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1 | UniProtKB/SwissProt
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| 390 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Heidelberg
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of Dopamine uptake in OCT2-expressing HEK293 cells |
J Biol Chem 273: 30915-20 (1998)
BindingDB Entry DOI: 10.7270/Q2V40WGS |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(RAT) | BDBM50170653
((11beta)-11,21-dihydroxypregn-4-ene-3,20-dione | 1...)Show SMILES C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO |r,t:9| Show InChI InChI=1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1 | UniProtKB/SwissProt
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| 420 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Heidelberg
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of Adrenaline uptake in OCT2-expressing HEK293 cells |
J Biol Chem 273: 30915-20 (1998)
BindingDB Entry DOI: 10.7270/Q2V40WGS |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(RAT) | BDBM50170653
((11beta)-11,21-dihydroxypregn-4-ene-3,20-dione | 1...)Show SMILES C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO |r,t:9| Show InChI InChI=1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1 | UniProtKB/SwissProt
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| 460 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Heidelberg
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of Noradrenaline uptake in OCT2-expressing HEK293 cells |
J Biol Chem 273: 30915-20 (1998)
BindingDB Entry DOI: 10.7270/Q2V40WGS |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(RAT) | BDBM50170653
((11beta)-11,21-dihydroxypregn-4-ene-3,20-dione | 1...)Show SMILES C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO |r,t:9| Show InChI InChI=1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1 | UniProtKB/SwissProt
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| 605 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Heidelberg
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of Serotonin uptake in OCT2-expressing HEK293 cells |
J Biol Chem 273: 30915-20 (1998)
BindingDB Entry DOI: 10.7270/Q2V40WGS |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(RAT) | BDBM50420192
(CHEMBL2074851)Show SMILES CC[n+]1c(CC2C=C(C)N=C(N2C)c2ccccc2)ccc2ccccc12 |c:9,t:6| Show InChI InChI=1S/C24H26N3/c1-4-27-21(15-14-19-10-8-9-13-23(19)27)17-22-16-18(2)25-24(26(22)3)20-11-6-5-7-12-20/h5-16,22H,4,17H2,1-3H3/q+1 | UniProtKB/SwissProt
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| 861 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas M. D. Anderson Cancer Center
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (apical to cell) in OCT2-expressing NIH3T3 cells |
Toxicol Sci 47: 181-6 (1999)
BindingDB Entry DOI: 10.7270/Q2F1910T |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 20
(Mus musculus) | BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)Show InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15) | KEGG
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| 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description
Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr |
J Biol Chem 282: 23841-53 (2007)
Article DOI: 10.1074/jbc.M703467200
BindingDB Entry DOI: 10.7270/Q2W95B35 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(Homo sapiens (Human)) | BDBM50420181
(CHEMBL2074704)Show InChI InChI=1S/C20H44N/c1-5-9-13-17-21(18-14-10-6-2,19-15-11-7-3)20-16-12-8-4/h5-20H2,1-4H3/q+1 | Reactome pathway
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| 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Anatomisches Institut der Bayerischen Julius-Maximilians-Universit£t
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake in Xenopus laevis oocytes |
DNA Cell Biol 16: 871-81 (1997)
Article DOI: 10.1089/dna.1997.16.871
BindingDB Entry DOI: 10.7270/Q2R2148R |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(RAT) | BDBM81945
(CAS_39484 | CHEMBL105891 | CHEMBL108926 | CHEMBL27...)Show InChI InChI=1S/C12H12N/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11/h2-10H,1H3/q+1 | UniProtKB/SwissProt
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| 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (basolateral to cell) in OCT2-expressing MDCK cells |
J Pharmacol Exp Ther 287: 800-5 (1998)
BindingDB Entry DOI: 10.7270/Q2D79CQ4 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(Homo sapiens (Human)) | BDBM81945
(CAS_39484 | CHEMBL105891 | CHEMBL108926 | CHEMBL27...)Show InChI InChI=1S/C12H12N/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11/h2-10H,1H3/q+1 | Reactome pathway
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| 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Anatomisches Institut der Bayerischen Julius-Maximilians-Universit£t
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake in Xenopus laevis oocytes |
DNA Cell Biol 16: 871-81 (1997)
Article DOI: 10.1089/dna.1997.16.871
BindingDB Entry DOI: 10.7270/Q2R2148R |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(RAT) | BDBM86278
(MCL-202)Show SMILES CN1CCc2c(Cl)c(O)c(O)cc2[C@@H](C1)c1cccc(C)c1 |r| Show InChI InChI=1S/C18H20ClNO2/c1-11-4-3-5-12(8-11)15-10-20(2)7-6-13-14(15)9-16(21)18(22)17(13)19/h3-5,8-9,15,21-22H,6-7,10H2,1-2H3/t15-/m0/s1 | UniProtKB/SwissProt
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| 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard University
Curated by PDSP Ki Database
| |
Eur J Pharmacol 474: 137-40 (2003)
Article DOI: 10.1016/s0014-2999(03)02008-9
BindingDB Entry DOI: 10.7270/Q2DN43MQ |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(Homo sapiens (Human)) | BDBM50367247
(QUININE | Quinamm | Quinsan | cid_3034034)Show SMILES COc1ccc2nccc([C@@H](O)[C@@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1 |THB:20:19:12.13:16.15,10:12:19.18:16.15| Show InChI InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19-,20+/m0/s1 | Reactome pathway
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| 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Anatomisches Institut der Bayerischen Julius-Maximilians-Universit£t
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake in Xenopus laevis oocytes |
DNA Cell Biol 16: 871-81 (1997)
Article DOI: 10.1089/dna.1997.16.871
BindingDB Entry DOI: 10.7270/Q2R2148R |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 20
(Mus musculus) | BDBM50206441
(2-(2,4,5,7-tetrabromo-3-hydroxy-6-oxo-6H-xanthen-9...)Show SMILES OC(=O)c1ccccc1-c1c2cc(Br)c(O)c(Br)c2oc2c(Br)c(=O)c(Br)cc12 |(32.53,-16.69,;33.02,-15.23,;32,-14.07,;34.53,-14.92,;34.52,-13.38,;35.85,-12.6,;37.19,-13.36,;37.2,-14.9,;35.87,-15.67,;35.87,-17.21,;37.21,-17.96,;38.54,-17.19,;39.88,-17.94,;41.21,-17.16,;39.89,-19.5,;41.23,-20.26,;38.56,-20.28,;38.57,-21.82,;37.22,-19.51,;35.88,-20.29,;34.55,-19.52,;33.22,-20.3,;33.22,-21.84,;31.88,-19.53,;30.55,-20.3,;31.88,-17.98,;30.56,-17.2,;33.22,-17.24,;34.55,-17.98,)| Show InChI InChI=1S/C20H8Br4O5/c21-11-5-9-13(7-3-1-2-4-8(7)20(27)28)10-6-12(22)17(26)15(24)19(10)29-18(9)14(23)16(11)25/h1-6,25H,(H,27,28) | KEGG
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| 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description
Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr |
J Biol Chem 282: 23841-53 (2007)
Article DOI: 10.1074/jbc.M703467200
BindingDB Entry DOI: 10.7270/Q2W95B35 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(RAT) | BDBM16173
(3,5-diamino-6-chloro-N-(diaminomethylene)pyrazinam...)Show InChI InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15) | UniProtKB/SwissProt
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| 4.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake in OCT2-expressing MDCK cells |
Pharm Res 18: 1528-34 (2001)
BindingDB Entry DOI: 10.7270/Q28G8N0T |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(Homo sapiens (Human)) | BDBM50420216
(MEPIPERPHENIDOL BROMIDE)Show InChI InChI=1S/C19H32NO/c1-16(2)19(17-10-6-4-7-11-17)18(21)12-15-20(3)13-8-5-9-14-20/h4,6-7,10-11,16,18-19,21H,5,8-9,12-15H2,1-3H3/q+1 | Reactome pathway
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| 4.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Anatomisches Institut der Bayerischen Julius-Maximilians-Universit£t
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake in Xenopus laevis oocytes |
DNA Cell Biol 16: 871-81 (1997)
Article DOI: 10.1089/dna.1997.16.871
BindingDB Entry DOI: 10.7270/Q2R2148R |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(RAT) | BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)Show InChI InChI=1S/C13H15N3/c1-2-4-12-11(3-1)5-6-13(15-12)16-9-7-14-8-10-16/h1-6,14H,7-10H2 | UniProtKB/SwissProt
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| 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University
Curated by PDSP Ki Database
| |
Eur J Pharmacol 168: 387-92 (1989)
Article DOI: 10.1016/0014-2999(89)90802-9
BindingDB Entry DOI: 10.7270/Q23R0RC5 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 20
(Mus musculus) | BDBM50269966
(2-ethylhexanoate | CHEMBL1762647)Show InChI InChI=1S/C8H16O2/c1-3-5-6-7(4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)/p-1 | KEGG
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| 6.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description
Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr |
J Biol Chem 282: 23841-53 (2007)
Article DOI: 10.1074/jbc.M703467200
BindingDB Entry DOI: 10.7270/Q2W95B35 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 20
(Mus musculus) | BDBM50412192
(CHEMBL1162486)Show InChI InChI=1S/C8H16O2/c1-3-5-6-7(4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)/t7-/m0/s1 | KEGG
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| 6.61E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description
Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr |
J Biol Chem 282: 23841-53 (2007)
Article DOI: 10.1074/jbc.M703467200
BindingDB Entry DOI: 10.7270/Q2W95B35 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 20
(Mus musculus) | BDBM50412193
(CHEMBL1162487)Show InChI InChI=1S/C8H16O2/c1-3-5-6-7(4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)/t7-/m1/s1 | KEGG
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| 6.61E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description
Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr |
J Biol Chem 282: 23841-53 (2007)
Article DOI: 10.1074/jbc.M703467200
BindingDB Entry DOI: 10.7270/Q2W95B35 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 20
(Mus musculus) | BDBM50240408
(1-hexanecarboxylate | CH3-[CH2]5-COO(-) | enanthat...)Show InChI InChI=1S/C7H14O2/c1-2-3-4-5-6-7(8)9/h2-6H2,1H3,(H,8,9)/p-1 | KEGG
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| 8.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description
Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr |
J Biol Chem 282: 23841-53 (2007)
Article DOI: 10.1074/jbc.M703467200
BindingDB Entry DOI: 10.7270/Q2W95B35 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 20
(Mus musculus) | BDBM50206509
(4-Dipropylsulfamoyl-benzoic acid | 4-Dipropylsulfa...)Show InChI InChI=1S/C13H19NO4S/c1-3-9-14(10-4-2)19(17,18)12-7-5-11(6-8-12)13(15)16/h5-8H,3-4,9-10H2,1-2H3,(H,15,16) | KEGG
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| 8.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description
Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr |
J Biol Chem 282: 23841-53 (2007)
Article DOI: 10.1074/jbc.M703467200
BindingDB Entry DOI: 10.7270/Q2W95B35 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 20
(Mus musculus) | BDBM16433
(CHEMBL14184 | Caproic acid | Hexanoic acid | n-Cap...)Show InChI InChI=1S/C6H12O2/c1-2-3-4-5-6(7)8/h2-5H2,1H3,(H,7,8) | KEGG
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| 9.12E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description
Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr |
J Biol Chem 282: 23841-53 (2007)
Article DOI: 10.1074/jbc.M703467200
BindingDB Entry DOI: 10.7270/Q2W95B35 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(RAT) | BDBM50403559
(Brumetadina | CIMETIDINE)Show InChI InChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14) | UniProtKB/SwissProt
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| 9.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (basolateral to cell) in OCT2-expressing MDCK cells |
J Pharmacol Exp Ther 287: 800-5 (1998)
BindingDB Entry DOI: 10.7270/Q2D79CQ4 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(RAT) | BDBM86694
(N'-(3-Chloro-4-morpholinophenyl)-N-hydroxyform...)Show InChI InChI=1S/C11H14ClN3O2/c12-10-7-9(13-8-14-16)1-2-11(10)15-3-5-17-6-4-15/h1-2,7-8,16H,3-6H2,(H,13,14) | UniProtKB/SwissProt
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 314: 77-85 (2005)
Article DOI: 10.1124/jpet.105.083964
BindingDB Entry DOI: 10.7270/Q2MW2FQQ |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(RAT) | BDBM50416487
(CHEMBL1236196 | TETRABUTYLAMMONIUM)Show InChI InChI=1S/C16H36N/c1-5-9-13-17(14-10-6-2,15-11-7-3)16-12-8-4/h5-16H2,1-4H3/q+1 | UniProtKB/SwissProt
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| 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Anatomy of the Bayerische Julius-Maximilians-Universit£t
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (electrogenicity) in Xenopus laevis oocytes |
Am J Physiol Renal Physiol 281: 454-68 (2001)
Article DOI: 10.1152/ajprenal.2001.281.3.F454
BindingDB Entry DOI: 10.7270/Q2BR8TF3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 20
(Mus musculus) | BDBM36181
(SODIUM BENZOATE | benzoate | benzoic acid | benzoi...)Show InChI InChI=1S/C7H6O2/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H,8,9)/p-1 | KEGG
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| 1.38E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description
Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr |
J Biol Chem 282: 23841-53 (2007)
Article DOI: 10.1074/jbc.M703467200
BindingDB Entry DOI: 10.7270/Q2W95B35 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(Homo sapiens (Human)) | BDBM35229
(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)Show InChI InChI=1S/C18H22N2/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20/h2-5,7-10,19H,6,11-14H2,1H3 | Reactome pathway
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| 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Anatomisches Institut der Bayerischen Julius-Maximilians-Universit£t
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake in Xenopus laevis oocytes |
DNA Cell Biol 16: 871-81 (1997)
Article DOI: 10.1089/dna.1997.16.871
BindingDB Entry DOI: 10.7270/Q2R2148R |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 20
(Mus musculus) | BDBM35847
((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 | KEGG
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| 1.82E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description
Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr |
J Biol Chem 282: 23841-53 (2007)
Article DOI: 10.1074/jbc.M703467200
BindingDB Entry DOI: 10.7270/Q2W95B35 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(RAT) | BDBM50017681
((1S,2R,4S,5R)-2-[(S)-Hydroxy-(6-methoxy-quinolin-4...)Show SMILES COc1ccc2nccc([C@H](O)C3CC4CCN3CC4C=C)c2c1 |TLB:10:12:18.19:16.15,20:19:12.13:16.15| Show InChI InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13?,14?,19?,20-/m0/s1 | UniProtKB/SwissProt
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| 1.91E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (basolateral to cell) in OCT2-expressing MDCK cells |
J Pharmacol Exp Ther 287: 800-5 (1998)
BindingDB Entry DOI: 10.7270/Q2D79CQ4 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 20
(Mus musculus) | BDBM50269985
(2-oxo-3-phenylpropanoate | 3-(4-hydroxyphenyl)pyru...)Show InChI InChI=1S/C9H8O3/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,11,12)/p-1 | KEGG
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| 2.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description
Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr |
J Biol Chem 282: 23841-53 (2007)
Article DOI: 10.1074/jbc.M703467200
BindingDB Entry DOI: 10.7270/Q2W95B35 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(RAT) | BDBM50028893
(4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutana...)Show InChI InChI=1S/C21H29N3O/c1-16(2)24(17(3)4)15-13-21(20(22)25,18-10-6-5-7-11-18)19-12-8-9-14-23-19/h5-12,14,16-17H,13,15H2,1-4H3,(H2,22,25) | UniProtKB/SwissProt
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| 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake in OCT2-expressing MDCK cells |
Pharm Res 18: 1528-34 (2001)
BindingDB Entry DOI: 10.7270/Q28G8N0T |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 20
(Mus musculus) | BDBM50269962
(3-methyl-n-butyrate | 3-methylbutanoate | 3-methyl...)Show InChI InChI=1S/C5H10O2/c1-4(2)3-5(6)7/h4H,3H2,1-2H3,(H,6,7)/p-1 | KEGG
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| 3.23E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description
Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr |
J Biol Chem 282: 23841-53 (2007)
Article DOI: 10.1074/jbc.M703467200
BindingDB Entry DOI: 10.7270/Q2W95B35 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(RAT) | BDBM39344
(4-amino-N-[2-(diethylamino)ethyl]benzamide;hydroch...)Show InChI InChI=1S/C13H21N3O/c1-3-16(4-2)10-9-15-13(17)11-5-7-12(14)8-6-11/h5-8H,3-4,9-10,14H2,1-2H3,(H,15,17) | UniProtKB/SwissProt
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| 3.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake in OCT2-expressing MDCK cells |
Pharm Res 18: 1528-34 (2001)
BindingDB Entry DOI: 10.7270/Q28G8N0T |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 20
(Mus musculus) | BDBM50240453
((+/-)-2-methylbutanoate | 2-methylbutanoate | 2-me...)Show InChI InChI=1S/C5H10O2/c1-3-4(2)5(6)7/h4H,3H2,1-2H3,(H,6,7)/p-1 | KEGG
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| 4.07E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description
Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr |
J Biol Chem 282: 23841-53 (2007)
Article DOI: 10.1074/jbc.M703467200
BindingDB Entry DOI: 10.7270/Q2W95B35 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 20
(Mus musculus) | BDBM50412188
(CHEMBL1162483)Show InChI InChI=1S/C5H10O2/c1-3-4(2)5(6)7/h4H,3H2,1-2H3,(H,6,7)/t4-/m1/s1 | KEGG
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| 4.07E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description
Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr |
J Biol Chem 282: 23841-53 (2007)
Article DOI: 10.1074/jbc.M703467200
BindingDB Entry DOI: 10.7270/Q2W95B35 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 20
(Mus musculus) | BDBM50412189
(CHEMBL1162482)Show InChI InChI=1S/C5H10O2/c1-3-4(2)5(6)7/h4H,3H2,1-2H3,(H,6,7)/t4-/m0/s1 | KEGG
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| 4.07E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description
Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr |
J Biol Chem 282: 23841-53 (2007)
Article DOI: 10.1074/jbc.M703467200
BindingDB Entry DOI: 10.7270/Q2W95B35 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 20
(Mus musculus) | BDBM26193
(2-Hydroxybenzoate, I | 2-hydroxybenzoic acid | CHE...)Show InChI InChI=1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10) | KEGG
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| 4.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description
Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr |
J Biol Chem 282: 23841-53 (2007)
Article DOI: 10.1074/jbc.M703467200
BindingDB Entry DOI: 10.7270/Q2W95B35 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 20
(Mus musculus) | BDBM50269998
((S)-2-((R)-5-chloro-8-hydroxy-3-methyl-1-oxoisochr...)Show SMILES C[C@@H]1Cc2c(Cl)cc(C(=O)N[C@@H](Cc3ccccc3)C([O-])=O)c(O)c2C(=O)O1 |r| Show InChI InChI=1S/C20H18ClNO6/c1-10-7-12-14(21)9-13(17(23)16(12)20(27)28-10)18(24)22-15(19(25)26)8-11-5-3-2-4-6-11/h2-6,9-10,15,23H,7-8H2,1H3,(H,22,24)(H,25,26)/p-1/t10-,15+/m1/s1 | KEGG
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| 4.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description
Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr |
J Biol Chem 282: 23841-53 (2007)
Article DOI: 10.1074/jbc.M703467200
BindingDB Entry DOI: 10.7270/Q2W95B35 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(Homo sapiens (Human)) | BDBM39344
(4-amino-N-[2-(diethylamino)ethyl]benzamide;hydroch...)Show InChI InChI=1S/C13H21N3O/c1-3-16(4-2)10-9-15-13(17)11-5-7-12(14)8-6-11/h5-8H,3-4,9-10,14H2,1-2H3,(H,15,17) | Reactome pathway
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| 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Anatomisches Institut der Bayerischen Julius-Maximilians-Universit£t
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake in Xenopus laevis oocytes |
DNA Cell Biol 16: 871-81 (1997)
Article DOI: 10.1089/dna.1997.16.871
BindingDB Entry DOI: 10.7270/Q2R2148R |
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Ligand-Target Pair | |
Solute carrier family 22 member 2
(RAT) | BDBM82070
(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1 | UniProtKB/SwissProt
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| 5.05E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (basolateral to cell) in OCT2-expressing MDCK cells |
J Pharmacol Exp Ther 287: 800-5 (1998)
BindingDB Entry DOI: 10.7270/Q2D79CQ4 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(RAT) | BDBM50149890
(CHEMBL9324 | tetraethylammonium)Show InChI InChI=1S/C8H20N/c1-5-9(6-2,7-3)8-4/h5-8H2,1-4H3/q+1 | UniProtKB/SwissProt
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| 5.22E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (apical to cell) in OCT2-expressing MDCK cells |
J Pharmacol Exp Ther 287: 800-5 (1998)
BindingDB Entry DOI: 10.7270/Q2D79CQ4 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(RAT) | BDBM50367247
(QUININE | Quinamm | Quinsan | cid_3034034)Show SMILES COc1ccc2nccc([C@@H](O)[C@@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1 |THB:20:19:12.13:16.15,10:12:19.18:16.15| Show InChI InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19-,20+/m0/s1 | UniProtKB/SwissProt
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| 5.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Anatomy of the Bayerische Julius-Maximilians-Universit£t
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake in Xenopus laevis oocytes |
Am J Physiol Renal Physiol 281: 454-68 (2001)
Article DOI: 10.1152/ajprenal.2001.281.3.F454
BindingDB Entry DOI: 10.7270/Q2BR8TF3 |
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Ligand-Target Pair | |
Solute carrier family 22 member 2
(Homo sapiens (Human)) | BDBM22889
((Cimetidine) N-Methyl-N''''-[2-(5-methyl-1H-imidaz...)Show InChI InChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14) | Reactome pathway
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| 5.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake in OCT2 expressing oocytes |
Eur J Pharmacol 503: 25-30 (2004)
Article DOI: 10.1016/j.ejphar.2004.09.032
BindingDB Entry DOI: 10.7270/Q2TD9ZDK |
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Ligand-Target Pair | |
Solute carrier family 22 member 20
(Mus musculus) | BDBM50366524
(ESTRONE | ESTROPIPATE | Estrone 3-sulfate | Estron...)Show SMILES C[C@]12CC[C@H]3[C@@H](CCc4cc(OS(O)(=O)=O)ccc34)[C@@H]1CCC2=O Show InChI InChI=1S/C18H22O5S/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22)/t14-,15-,16+,18+/m1/s1 | KEGG
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| 5.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description
Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr |
J Biol Chem 282: 23841-53 (2007)
Article DOI: 10.1074/jbc.M703467200
BindingDB Entry DOI: 10.7270/Q2W95B35 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 20
(Mus musculus) | BDBM50269993
((4-hydroxyphenyl)pyruvate | 3-(4-Hydroxyphenyl)pyr...)Show InChI InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 | KEGG
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| 6.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description
Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr |
J Biol Chem 282: 23841-53 (2007)
Article DOI: 10.1074/jbc.M703467200
BindingDB Entry DOI: 10.7270/Q2W95B35 |
More data for this
Ligand-Target Pair | |
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