Found 193 hits Enz. Inhib. hit(s) with Target = 'Parathyroid hormone/parathyroid hormone-related peptide receptor' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50002926
(CHEMBL244325)Show SMILES Cc1ccc2c(c1)N(c1ccc(NCCc3ncc[nH]3)cc1)C(=O)N(N=C2C1CCCCC1)C1CCc2ccccc2CC1 |c:28| Show InChI InChI=1S/C37H42N6O/c1-26-11-20-33-34(25-26)42(31-18-14-30(15-19-31)38-22-21-35-39-23-24-40-35)37(44)43(41-36(33)29-9-3-2-4-10-29)32-16-12-27-7-5-6-8-28(27)13-17-32/h5-8,11,14-15,18-20,23-25,29,32,38H,2-4,9-10,12-13,16-17,21-22H2,1H3,(H,39,40) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 0.910 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
James Black Foundation
Curated by ChEMBL
| Assay Description
Displacement of [125I]-[Nle,8,18 Tyr34]-hPTH(1-34) from human recombinant PTH1R expressed in HEK293 cells |
J Med Chem 50: 4789-92 (2007)
Checked by Author
Article DOI: 10.1021/jm0707626
BindingDB Entry DOI: 10.7270/Q2Z039C3 |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50002913
(CHEMBL389783)Show SMILES CN1N=C(C2CCCCC2)c2cc(NCc3ccccc3)c(C)cc2N(c2ccc(NCCc3ncc[nH]3)cc2)C1=O |t:2| Show InChI InChI=1S/C34H39N7O/c1-24-21-31-29(22-30(24)38-23-25-9-5-3-6-10-25)33(26-11-7-4-8-12-26)39-40(2)34(42)41(31)28-15-13-27(14-16-28)35-18-17-32-36-19-20-37-32/h3,5-6,9-10,13-16,19-22,26,35,38H,4,7-8,11-12,17-18,23H2,1-2H3,(H,36,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 1.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
James Black Foundation
Curated by ChEMBL
| Assay Description
Displacement of [125I]-[Nle,8,18 Tyr34]-hPTH(1-34) from human recombinant PTH1R expressed in HEK293 cells |
J Med Chem 50: 4789-92 (2007)
Checked by Author
Article DOI: 10.1021/jm0707626
BindingDB Entry DOI: 10.7270/Q2Z039C3 |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50002915
(CHEMBL389787)Show SMILES CN1N=C(C2CCCCC2)c2cc(OCc3ccccc3)c(C)cc2N(c2ccc(NCCc3ncc[nH]3)cc2)C1=O |t:2| Show InChI InChI=1S/C34H38N6O2/c1-24-21-30-29(22-31(24)42-23-25-9-5-3-6-10-25)33(26-11-7-4-8-12-26)38-39(2)34(41)40(30)28-15-13-27(14-16-28)35-18-17-32-36-19-20-37-32/h3,5-6,9-10,13-16,19-22,26,35H,4,7-8,11-12,17-18,23H2,1-2H3,(H,36,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
James Black Foundation
Curated by ChEMBL
| Assay Description
Displacement of [125I]-[Nle,8,18 Tyr34]-hPTH(1-34) from human recombinant PTH1R expressed in HEK293 cells |
J Med Chem 50: 4789-92 (2007)
Checked by Author
Article DOI: 10.1021/jm0707626
BindingDB Entry DOI: 10.7270/Q2Z039C3 |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50002923
(CHEMBL243698)Show SMILES CC(C)N1N=C(C2CCCCC2)c2ccc(C)cc2N(c2ccc(NCCc3ncc[nH]3)cc2)C1=O |t:4| Show InChI InChI=1S/C29H36N6O/c1-20(2)35-29(36)34(24-12-10-23(11-13-24)30-16-15-27-31-17-18-32-27)26-19-21(3)9-14-25(26)28(33-35)22-7-5-4-6-8-22/h9-14,17-20,22,30H,4-8,15-16H2,1-3H3,(H,31,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 3.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
James Black Foundation
Curated by ChEMBL
| Assay Description
Displacement of [125I]-[Nle,8,18 Tyr34]-hPTH(1-34) from human recombinant PTH1R expressed in HEK293 cells |
J Med Chem 50: 4789-92 (2007)
Checked by Author
Article DOI: 10.1021/jm0707626
BindingDB Entry DOI: 10.7270/Q2Z039C3 |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50002924
(CHEMBL242567)Show SMILES Cc1ccc2c(c1)N(c1ccc(NCCc3ncc[nH]3)cc1)C(=O)N(Cc1ccccc1)N=C2C1CCCCC1 |c:36| Show InChI InChI=1S/C33H36N6O/c1-24-12-17-29-30(22-24)39(28-15-13-27(14-16-28)34-19-18-31-35-20-21-36-31)33(40)38(23-25-8-4-2-5-9-25)37-32(29)26-10-6-3-7-11-26/h2,4-5,8-9,12-17,20-22,26,34H,3,6-7,10-11,18-19,23H2,1H3,(H,35,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
James Black Foundation
Curated by ChEMBL
| Assay Description
Displacement of [125I]-[Nle,8,18 Tyr34]-hPTH(1-34) from human recombinant PTH1R expressed in HEK293 cells |
J Med Chem 50: 4789-92 (2007)
Checked by Author
Article DOI: 10.1021/jm0707626
BindingDB Entry DOI: 10.7270/Q2Z039C3 |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50002914
(CHEMBL244956)Show SMILES Cc1ccc2c(c1)N(c1ccc(NCCc3ncc[nH]3)cc1)C(=O)N(N=C2C1CCCCC1)C1CCOCC1 |c:28| Show InChI InChI=1S/C31H38N6O2/c1-22-7-12-27-28(21-22)36(25-10-8-24(9-11-25)32-16-13-29-33-17-18-34-29)31(38)37(26-14-19-39-20-15-26)35-30(27)23-5-3-2-4-6-23/h7-12,17-18,21,23,26,32H,2-6,13-16,19-20H2,1H3,(H,33,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 6.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
James Black Foundation
Curated by ChEMBL
| Assay Description
Displacement of [125I]-[Nle,8,18 Tyr34]-hPTH(1-34) from human recombinant PTH1R expressed in HEK293 cells |
J Med Chem 50: 4789-92 (2007)
Checked by Author
Article DOI: 10.1021/jm0707626
BindingDB Entry DOI: 10.7270/Q2Z039C3 |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50002922
(CHEMBL224729)Show SMILES Cc1ccc2c(c1)N(c1ccc(NCCc3ncc[nH]3)cc1)C(=O)N(N=C2C1CCOCC1)C1CCc2ccccc2CC1 |c:28| Show InChI InChI=1S/C36H40N6O2/c1-25-6-15-32-33(24-25)41(30-13-9-29(10-14-30)37-19-16-34-38-20-21-39-34)36(43)42(40-35(32)28-17-22-44-23-18-28)31-11-7-26-4-2-3-5-27(26)8-12-31/h2-6,9-10,13-15,20-21,24,28,31,37H,7-8,11-12,16-19,22-23H2,1H3,(H,38,39) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 6.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
James Black Foundation
Curated by ChEMBL
| Assay Description
Displacement of [125I]-[Nle,8,18 Tyr34]-hPTH(1-34) from human recombinant PTH1R expressed in HEK293 cells |
J Med Chem 50: 4789-92 (2007)
Checked by Author
Article DOI: 10.1021/jm0707626
BindingDB Entry DOI: 10.7270/Q2Z039C3 |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50002925
(CHEMBL244074)Show SMILES CCCN1N=C(C2CCCCC2)c2ccc(C)cc2N(c2ccc(NCCc3ncc[nH]3)cc2)C1=O |t:4| Show InChI InChI=1S/C29H36N6O/c1-3-19-34-29(36)35(24-12-10-23(11-13-24)30-16-15-27-31-17-18-32-27)26-20-21(2)9-14-25(26)28(33-34)22-7-5-4-6-8-22/h9-14,17-18,20,22,30H,3-8,15-16,19H2,1-2H3,(H,31,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 6.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
James Black Foundation
Curated by ChEMBL
| Assay Description
Displacement of [125I]-[Nle,8,18 Tyr34]-hPTH(1-34) from human recombinant PTH1R expressed in HEK293 cells |
J Med Chem 50: 4789-92 (2007)
Checked by Author
Article DOI: 10.1021/jm0707626
BindingDB Entry DOI: 10.7270/Q2Z039C3 |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50002912
(CHEMBL388911)Show SMILES Cc1ccc2c(c1)N(c1ccc(NCCc3ncc[nH]3)cc1)C(=O)N(N=C2C1CCCCC1)C1COc2ccccc2OC1 |c:28| Show InChI InChI=1S/C35H38N6O3/c1-24-11-16-29-30(21-24)40(27-14-12-26(13-15-27)36-18-17-33-37-19-20-38-33)35(42)41(39-34(29)25-7-3-2-4-8-25)28-22-43-31-9-5-6-10-32(31)44-23-28/h5-6,9-16,19-21,25,28,36H,2-4,7-8,17-18,22-23H2,1H3,(H,37,38) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 8.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
James Black Foundation
Curated by ChEMBL
| Assay Description
Displacement of [125I]-[Nle,8,18 Tyr34]-hPTH(1-34) from human recombinant PTH1R expressed in HEK293 cells |
J Med Chem 50: 4789-92 (2007)
Checked by Author
Article DOI: 10.1021/jm0707626
BindingDB Entry DOI: 10.7270/Q2Z039C3 |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50411364
(CHEMBL242784)Show SMILES CN1N=C(C2CCCCC2)c2ccc(C)cc2N(c2ccc(NCCc3ncc[nH]3)cc2)C1=O |t:2| Show InChI InChI=1S/C27H32N6O/c1-19-8-13-23-24(18-19)33(27(34)32(2)31-26(23)20-6-4-3-5-7-20)22-11-9-21(10-12-22)28-15-14-25-29-16-17-30-25/h8-13,16-18,20,28H,3-7,14-15H2,1-2H3,(H,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
James Black Foundation
Curated by ChEMBL
| Assay Description
Displacement of [125I]-[Nle,8,18 Tyr34]-hPTH(1-34) from human recombinant PTH1R expressed in HEK293 cells |
J Med Chem 50: 4789-92 (2007)
Checked by Author
Article DOI: 10.1021/jm0707626
BindingDB Entry DOI: 10.7270/Q2Z039C3 |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50002929
(CHEMBL390628)Show SMILES CN1N=C(C2CCCCC2)c2ccc(C)cc2N(c2ccc(NCCCc3ncc[nH]3)cc2)C1=O |t:2| Show InChI InChI=1S/C28H34N6O/c1-20-10-15-24-25(19-20)34(28(35)33(2)32-27(24)21-7-4-3-5-8-21)23-13-11-22(12-14-23)29-16-6-9-26-30-17-18-31-26/h10-15,17-19,21,29H,3-9,16H2,1-2H3,(H,30,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
James Black Foundation
Curated by ChEMBL
| Assay Description
Displacement of [125I]-[Nle,8,18 Tyr34]-hPTH(1-34) from human recombinant PTH1R expressed in HEK293 cells |
J Med Chem 50: 4789-92 (2007)
Checked by Author
Article DOI: 10.1021/jm0707626
BindingDB Entry DOI: 10.7270/Q2Z039C3 |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50002910
(CHEMBL245110)Show SMILES CN1N=C(C2CCCCC2)c2ccc(C)cc2N(c2ccc(NCc3ncc[nH]3)cc2)C1=O |t:2| Show InChI InChI=1S/C26H30N6O/c1-18-8-13-22-23(16-18)32(26(33)31(2)30-25(22)19-6-4-3-5-7-19)21-11-9-20(10-12-21)29-17-24-27-14-15-28-24/h8-16,19,29H,3-7,17H2,1-2H3,(H,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 50 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
James Black Foundation
Curated by ChEMBL
| Assay Description
Displacement of [125I]-[Nle,8,18 Tyr34]-hPTH(1-34) from human recombinant PTH1R expressed in HEK293 cells |
J Med Chem 50: 4789-92 (2007)
Checked by Author
Article DOI: 10.1021/jm0707626
BindingDB Entry DOI: 10.7270/Q2Z039C3 |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50002927
(CHEMBL429099)Show SMILES Cc1ccc2c(c1)N(c1ccc(NC3=NCCN3)cc1)C(=O)N(Cc1ccccc1)N=C2C1CCCCC1 |c:34,t:14| Show InChI InChI=1S/C31H34N6O/c1-22-12-17-27-28(20-22)37(26-15-13-25(14-16-26)34-30-32-18-19-33-30)31(38)36(21-23-8-4-2-5-9-23)35-29(27)24-10-6-3-7-11-24/h2,4-5,8-9,12-17,20,24H,3,6-7,10-11,18-19,21H2,1H3,(H2,32,33,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 71 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
James Black Foundation
Curated by ChEMBL
| Assay Description
Displacement of [125I]-[Nle,8,18 Tyr34]-hPTH(1-34) from human recombinant PTH1R expressed in HEK293 cells |
J Med Chem 50: 4789-92 (2007)
Checked by Author
Article DOI: 10.1021/jm0707626
BindingDB Entry DOI: 10.7270/Q2Z039C3 |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50002911
(CHEMBL387793)Show SMILES COCCN1N=C(C2CCCCC2)c2ccc(C)cc2N(c2ccc(NCCc3ncc[nH]3)cc2)C1=O |t:5| Show InChI InChI=1S/C29H36N6O2/c1-21-8-13-25-26(20-21)35(24-11-9-23(10-12-24)30-15-14-27-31-16-17-32-27)29(36)34(18-19-37-2)33-28(25)22-6-4-3-5-7-22/h8-13,16-17,20,22,30H,3-7,14-15,18-19H2,1-2H3,(H,31,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 83 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
James Black Foundation
Curated by ChEMBL
| Assay Description
Displacement of [125I]-[Nle,8,18 Tyr34]-hPTH(1-34) from human recombinant PTH1R expressed in HEK293 cells |
J Med Chem 50: 4789-92 (2007)
Checked by Author
Article DOI: 10.1021/jm0707626
BindingDB Entry DOI: 10.7270/Q2Z039C3 |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50002906
(CHEMBL395054)Show SMILES CC(C)C(N)C(=O)Nc1ccc(cc1)N1c2cc(C)ccc2C(=NN(Cc2ccccc2)C1=O)C1CCCCC1 |c:24| Show InChI InChI=1S/C33H39N5O2/c1-22(2)30(34)32(39)35-26-15-17-27(18-16-26)38-29-20-23(3)14-19-28(29)31(25-12-8-5-9-13-25)36-37(33(38)40)21-24-10-6-4-7-11-24/h4,6-7,10-11,14-20,22,25,30H,5,8-9,12-13,21,34H2,1-3H3,(H,35,39) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 112 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
James Black Foundation
Curated by ChEMBL
| Assay Description
Displacement of [125I]-[Nle,8,18 Tyr34]-hPTH(1-34) from human recombinant PTH1R expressed in HEK293 cells |
J Med Chem 50: 4789-92 (2007)
Checked by Author
Article DOI: 10.1021/jm0707626
BindingDB Entry DOI: 10.7270/Q2Z039C3 |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50002907
(CHEMBL242778)Show SMILES Cc1ccc2c(c1)N(c1ccc(NC(N)=N)cc1)C(=O)N(Cc1ccccc1)N=C2C1CCCCC1 |c:31| Show InChI InChI=1S/C29H32N6O/c1-20-12-17-25-26(18-20)35(24-15-13-23(14-16-24)32-28(30)31)29(36)34(19-21-8-4-2-5-9-21)33-27(25)22-10-6-3-7-11-22/h2,4-5,8-9,12-18,22H,3,6-7,10-11,19H2,1H3,(H4,30,31,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 155 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
James Black Foundation
Curated by ChEMBL
| Assay Description
Displacement of [125I]-[Nle,8,18 Tyr34]-hPTH(1-34) from human recombinant PTH1R expressed in HEK293 cells |
J Med Chem 50: 4789-92 (2007)
Checked by Author
Article DOI: 10.1021/jm0707626
BindingDB Entry DOI: 10.7270/Q2Z039C3 |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50002917
(CHEMBL242590)Show SMILES O=C1N(Cc2ccccc2)N=C(C2CCCCC2)c2ccccc2N1c1ccc(NC2=NCCN2)cc1 |t:11,34| Show InChI InChI=1S/C30H32N6O/c37-30-35(21-22-9-3-1-4-10-22)34-28(23-11-5-2-6-12-23)26-13-7-8-14-27(26)36(30)25-17-15-24(16-18-25)33-29-31-19-20-32-29/h1,3-4,7-10,13-18,23H,2,5-6,11-12,19-21H2,(H2,31,32,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 288 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
James Black Foundation
Curated by ChEMBL
| Assay Description
Displacement of [125I]-[Nle,8,18 Tyr34]-hPTH(1-34) from human recombinant PTH1R expressed in HEK293 cells |
J Med Chem 50: 4789-92 (2007)
Checked by Author
Article DOI: 10.1021/jm0707626
BindingDB Entry DOI: 10.7270/Q2Z039C3 |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50002916
(CHEMBL387792)Show SMILES CC(C)C(N)C(=O)Nc1ccc(cc1)N1c2ccccc2C(=NN(Cc2ccccc2)C1=O)C1CCCCC1 |c:23| Show InChI InChI=1S/C32H37N5O2/c1-22(2)29(33)31(38)34-25-17-19-26(20-18-25)37-28-16-10-9-15-27(28)30(24-13-7-4-8-14-24)35-36(32(37)39)21-23-11-5-3-6-12-23/h3,5-6,9-12,15-20,22,24,29H,4,7-8,13-14,21,33H2,1-2H3,(H,34,38) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 380 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
James Black Foundation
Curated by ChEMBL
| Assay Description
Displacement of [125I]-[Nle,8,18 Tyr34]-hPTH(1-34) from human recombinant PTH1R expressed in HEK293 cells |
J Med Chem 50: 4789-92 (2007)
Checked by Author
Article DOI: 10.1021/jm0707626
BindingDB Entry DOI: 10.7270/Q2Z039C3 |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50002921
(CHEMBL244931)Show SMILES NC(=N)Nc1ccc(cc1)N1c2ccccc2C(CC2CCCCC2)=NN(Cc2ccccc2)C1=O |c:27| Show InChI InChI=1S/C29H32N6O/c30-28(31)32-23-15-17-24(18-16-23)35-27-14-8-7-13-25(27)26(19-21-9-3-1-4-10-21)33-34(29(35)36)20-22-11-5-2-6-12-22/h2,5-8,11-18,21H,1,3-4,9-10,19-20H2,(H4,30,31,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 562 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
James Black Foundation
Curated by ChEMBL
| Assay Description
Displacement of [125I]-[Nle,8,18 Tyr34]-hPTH(1-34) from human recombinant PTH1R expressed in HEK293 cells |
J Med Chem 50: 4789-92 (2007)
Checked by Author
Article DOI: 10.1021/jm0707626
BindingDB Entry DOI: 10.7270/Q2Z039C3 |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50002928
(CHEMBL244735)Show SMILES CN1N=C(C2CCOCC2)c2ccc(C)cc2N(c2ccc(NCCc3ncc[nH]3)cc2)C1=O |t:2| Show InChI InChI=1S/C26H30N6O2/c1-18-3-8-22-23(17-18)32(26(33)31(2)30-25(22)19-10-15-34-16-11-19)21-6-4-20(5-7-21)27-12-9-24-28-13-14-29-24/h3-8,13-14,17,19,27H,9-12,15-16H2,1-2H3,(H,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 617 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
James Black Foundation
Curated by ChEMBL
| Assay Description
Displacement of [125I]-[Nle,8,18 Tyr34]-hPTH(1-34) from human recombinant PTH1R expressed in HEK293 cells |
J Med Chem 50: 4789-92 (2007)
Checked by Author
Article DOI: 10.1021/jm0707626
BindingDB Entry DOI: 10.7270/Q2Z039C3 |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50002919
(CHEMBL242589)Show SMILES NCC(=O)Nc1ccc(cc1)N1c2ccccc2C(=NN(Cc2ccccc2)C1=O)C1CCCCC1 |c:20| Show InChI InChI=1S/C29H31N5O2/c30-19-27(35)31-23-15-17-24(18-16-23)34-26-14-8-7-13-25(26)28(22-11-5-2-6-12-22)32-33(29(34)36)20-21-9-3-1-4-10-21/h1,3-4,7-10,13-18,22H,2,5-6,11-12,19-20,30H2,(H,31,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 676 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
James Black Foundation
Curated by ChEMBL
| Assay Description
Displacement of [125I]-[Nle,8,18 Tyr34]-hPTH(1-34) from human recombinant PTH1R expressed in HEK293 cells |
J Med Chem 50: 4789-92 (2007)
Checked by Author
Article DOI: 10.1021/jm0707626
BindingDB Entry DOI: 10.7270/Q2Z039C3 |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50002908
(CHEMBL394513)Show SMILES NC(=N)Nc1ccc(cc1)N1c2ccccc2C(=NN(Cc2ccccc2)C1=O)C1CCCCC1 |c:19| Show InChI InChI=1S/C28H30N6O/c29-27(30)31-22-15-17-23(18-16-22)34-25-14-8-7-13-24(25)26(21-11-5-2-6-12-21)32-33(28(34)35)19-20-9-3-1-4-10-20/h1,3-4,7-10,13-18,21H,2,5-6,11-12,19H2,(H4,29,30,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 708 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
James Black Foundation
Curated by ChEMBL
| Assay Description
Displacement of [125I]-[Nle,8,18 Tyr34]-hPTH(1-34) from human recombinant PTH1R expressed in HEK293 cells |
J Med Chem 50: 4789-92 (2007)
Checked by Author
Article DOI: 10.1021/jm0707626
BindingDB Entry DOI: 10.7270/Q2Z039C3 |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50002931
(CHEMBL388909)Show SMILES NC(=N)Nc1ccc(Cc2ccc(cc2)N2c3ccccc3C(=NN(Cc3ccccc3)C2=O)C2CCCCC2)cc1 |c:24| Show InChI InChI=1S/C35H36N6O/c36-34(37)38-29-19-15-25(16-20-29)23-26-17-21-30(22-18-26)41-32-14-8-7-13-31(32)33(28-11-5-2-6-12-28)39-40(35(41)42)24-27-9-3-1-4-10-27/h1,3-4,7-10,13-22,28H,2,5-6,11-12,23-24H2,(H4,36,37,38) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 933 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
James Black Foundation
Curated by ChEMBL
| Assay Description
Displacement of [125I]-[Nle,8,18 Tyr34]-hPTH(1-34) from human recombinant PTH1R expressed in HEK293 cells |
J Med Chem 50: 4789-92 (2007)
Checked by Author
Article DOI: 10.1021/jm0707626
BindingDB Entry DOI: 10.7270/Q2Z039C3 |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50002933
(CHEMBL242391)Show SMILES NC(=N)Nc1cccc(c1)N1c2ccccc2C(=NN(Cc2ccccc2)C1=O)C1CCCCC1 |c:19| Show InChI InChI=1S/C28H30N6O/c29-27(30)31-22-14-9-15-23(18-22)34-25-17-8-7-16-24(25)26(21-12-5-2-6-13-21)32-33(28(34)35)19-20-10-3-1-4-11-20/h1,3-4,7-11,14-18,21H,2,5-6,12-13,19H2,(H4,29,30,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.82E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
James Black Foundation
Curated by ChEMBL
| Assay Description
Displacement of [125I]-[Nle,8,18 Tyr34]-hPTH(1-34) from human recombinant PTH1R expressed in HEK293 cells |
J Med Chem 50: 4789-92 (2007)
Checked by Author
Article DOI: 10.1021/jm0707626
BindingDB Entry DOI: 10.7270/Q2Z039C3 |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50002920
(CHEMBL244930)Show SMILES NC(=N)Nc1ccc(cc1)N1c2ccccc2C(=NN(Cc2ccccc2)C1=O)c1ccccc1 |c:19| Show InChI InChI=1S/C28H24N6O/c29-27(30)31-22-15-17-23(18-16-22)34-25-14-8-7-13-24(25)26(21-11-5-2-6-12-21)32-33(28(34)35)19-20-9-3-1-4-10-20/h1-18H,19H2,(H4,29,30,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.39E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
James Black Foundation
Curated by ChEMBL
| Assay Description
Displacement of [125I]-[Nle,8,18 Tyr34]-hPTH(1-34) from human recombinant PTH1R expressed in HEK293 cells |
J Med Chem 50: 4789-92 (2007)
Checked by Author
Article DOI: 10.1021/jm0707626
BindingDB Entry DOI: 10.7270/Q2Z039C3 |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50002934
(CHEMBL390813)Show SMILES CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC(=O)c1ccc(cc1)N1c2ccccc2C(=NN(Cc2ccccc2)C1=O)C1CCCCC1 |c:30| Show InChI InChI=1S/C28H27N3O3.C7H17NO5/c32-27(33)22-15-17-23(18-16-22)31-25-14-8-7-13-24(25)26(21-11-5-2-6-12-21)29-30(28(31)34)19-20-9-3-1-4-10-20;1-8-2-4(10)6(12)7(13)5(11)3-9/h1,3-4,7-10,13-18,21H,2,5-6,11-12,19H2,(H,32,33);4-13H,2-3H2,1H3/t;4-,5+,6+,7+/m.0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| <1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
James Black Foundation
Curated by ChEMBL
| Assay Description
Displacement of [125I]-[Nle,8,18 Tyr34]-hPTH(1-34) from human recombinant PTH1R expressed in HEK293 cells |
J Med Chem 50: 4789-92 (2007)
Checked by Author
Article DOI: 10.1021/jm0707626
BindingDB Entry DOI: 10.7270/Q2Z039C3 |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50318885
(CHEMBL525610 | teriparatide)Show SMILES [H][C@](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(O)=O |r| Show InChI InChI=1S/C181H291N55O51S2/c1-21-96(18)146(236-160(267)114(48-53-141(250)251)212-174(281)132(84-239)232-177(284)143(93(12)13)233-147(254)103(185)82-237)178(285)216-111(45-50-134(187)241)155(262)219-119(65-90(6)7)163(270)213-116(55-62-289-20)158(265)224-124(71-100-79-196-86-203-100)167(274)226-126(73-135(188)242)169(276)217-117(63-88(2)3)148(255)201-81-138(245)205-105(39-27-30-56-182)149(256)223-123(70-99-78-195-85-202-99)166(273)221-121(67-92(10)11)164(271)225-128(75-137(190)244)171(278)231-131(83-238)173(280)214-115(54-61-288-19)157(264)210-112(46-51-139(246)247)153(260)208-109(43-34-60-199-181(193)194)159(266)234-144(94(14)15)175(282)215-113(47-52-140(248)249)156(263)222-122(69-98-77-200-104-38-26-25-37-102(98)104)165(272)220-120(66-91(8)9)161(268)209-108(42-33-59-198-180(191)192)151(258)206-106(40-28-31-57-183)150(257)207-107(41-29-32-58-184)152(259)218-118(64-89(4)5)162(269)211-110(44-49-133(186)240)154(261)228-129(76-142(252)253)172(279)235-145(95(16)17)176(283)229-125(72-101-80-197-87-204-101)168(275)227-127(74-136(189)243)170(277)230-130(179(286)287)68-97-35-23-22-24-36-97/h22-26,35-38,77-80,85-96,103,105-132,143-146,200,237-239H,21,27-34,39-76,81-84,182-185H2,1-20H3,(H2,186,240)(H2,187,241)(H2,188,242)(H2,189,243)(H2,190,244)(H,195,202)(H,196,203)(H,197,204)(H,201,255)(H,205,245)(H,206,258)(H,207,257)(H,208,260)(H,209,268)(H,210,264)(H,211,269)(H,212,281)(H,213,270)(H,214,280)(H,215,282)(H,216,285)(H,217,276)(H,218,259)(H,219,262)(H,220,272)(H,221,273)(H,222,263)(H,223,256)(H,224,265)(H,225,271)(H,226,274)(H,227,275)(H,228,261)(H,229,283)(H,230,277)(H,231,278)(H,232,284)(H,233,254)(H,234,266)(H,235,279)(H,236,267)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,286,287)(H4,191,192,198)(H4,193,194,199)/t96-,103-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,143-,144-,145-,146-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Displacement of 125I-PTH (1 to 15 residues) from human PTHR1 expressed in African green monkey COS7 cell membranes at 300 uM after 90 mins by gamma c... |
J Med Chem 61: 5949-5962 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00182
BindingDB Entry DOI: 10.7270/Q2ZC85GG |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50269976
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Arg-Ala-Ly...)Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r,wU:81.81,25.25,62.61,8.12,97.97,wD:16.21,92.93,72.72,55.55,106.106,4.4,44.44,29.34,(16.82,-7.68,;15.49,-6.94,;15.46,-5.4,;14.12,-4.66,;14.1,-3.13,;12.8,-2.32,;11.44,-3.04,;11.45,-4.59,;10.17,-2.17,;10.17,-.63,;11.5,.14,;11.51,1.68,;12.83,-.63,;8.95,-3.07,;7.59,-2.35,;7.59,-.8,;6.31,-3.21,;6.31,-4.76,;7.65,-5.53,;7.65,-7.06,;6.32,-7.84,;8.98,-7.84,;5.11,-2.32,;3.74,-3.06,;3.75,-4.6,;2.46,-2.19,;1.25,-3.09,;-.11,-2.37,;-.1,-.82,;-1.38,-3.23,;-1.38,-4.77,;-.05,-5.55,;-.05,-7.08,;-1.38,-7.86,;1.29,-7.86,;-2.59,-2.34,;-3.95,-3.07,;-3.94,-4.61,;-5.22,-2.2,;-4.41,-.9,;-6.06,-3.48,;-6.53,-1.45,;-6.57,.09,;-5.22,.85,;-7.96,.78,;-7.96,2.28,;-9.35,2.94,;-10.59,2.02,;-9.36,4.47,;-7.82,4.49,;-10.89,4.45,;-9.38,6.01,;-9.3,.01,;-9.31,-1.52,;-10.63,.79,;2.46,-.65,;3.8,.13,;1.13,.13,;1.11,1.67,;15.29,-2.34,;15.3,-.79,;16.65,-3.07,;17.87,-2.18,;17.87,-.63,;19.2,.14,;20.67,-.35,;21.59,.88,;20.7,2.14,;19.22,1.68,;19.15,-3.04,;19.16,-4.59,;20.51,-2.32,;21.72,-3.21,;21.73,-4.75,;23.05,-5.53,;23.05,-7.06,;21.73,-7.83,;24.4,-7.83,;23,-2.34,;23.01,-.79,;24.37,-3.07,;25.59,-2.18,;25.59,-.64,;26.92,.14,;26.93,1.68,;28.25,2.44,;28.25,3.97,;29.58,4.74,;26.93,4.74,;26.86,-3.05,;26.87,-4.59,;28.22,-2.32,;29.43,-3.21,;29.43,-4.76,;30.71,-2.35,;30.72,-.8,;32.08,-3.08,;33.29,-2.19,;33.3,-.64,;34.63,.13,;34.63,1.67,;35.96,2.44,;35.96,3.98,;34.58,-3.05,;34.58,-4.6,;35.93,-2.31,;37.28,-3.05,;37.31,-4.58,;38.65,-5.32,;38.67,-6.85,;40.01,-7.59,;41.33,-6.8,;42.67,-7.53,;41.29,-5.26,;39.95,-4.53,;38.59,-2.26,;39.93,-2.99,;38.56,-.72,)| Show InChI InChI=1S/C76H127N23O19/c1-13-15-19-46(90-68(113)53(34-39(3)4)94-66(111)50(27-30-56(79)102)92-70(115)59(41(7)14-2)97-67(112)51(28-31-57(103)104)96-73(118)76(11,12)99-71(116)58(40(5)6)98-72(117)75(9,10)83)64(109)95-54(36-44-37-84-38-86-44)69(114)91-49(26-29-55(78)101)65(110)89-48(21-18-33-85-74(81)82)62(107)87-42(8)61(106)88-47(20-16-17-32-77)63(108)93-52(60(80)105)35-43-22-24-45(100)25-23-43/h22-25,37-42,46-54,58-59,100H,13-21,26-36,77,83H2,1-12H3,(H2,78,101)(H2,79,102)(H2,80,105)(H,84,86)(H,87,107)(H,88,106)(H,89,110)(H,90,113)(H,91,114)(H,92,115)(H,93,108)(H,94,111)(H,95,109)(H,96,118)(H,97,112)(H,98,117)(H,99,116)(H,103,104)(H4,81,82,85)/t41-,42-,46-,47-,48-,49-,50-,51-,52-,53-,54-,58-,59-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.87 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]DPC-AJ1951 from PTH/PTH-related peptide receptor (unknown origin) expressed in HKRK-B28 cells |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50269975
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Har-Ala-Ly...)Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r,wU:81.81,25.25,62.61,8.12,98.98,wD:16.21,93.94,72.72,55.55,107.107,4.4,44.44,29.34,(18.87,-52.12,;17.53,-51.38,;17.51,-49.85,;16.17,-49.1,;16.14,-47.57,;14.85,-46.76,;13.48,-47.48,;13.49,-49.03,;12.21,-46.62,;12.21,-45.07,;13.55,-44.3,;13.55,-42.76,;14.87,-45.07,;10.99,-47.51,;9.63,-46.79,;9.63,-45.24,;8.36,-47.66,;8.36,-49.2,;9.69,-49.97,;9.69,-51.5,;8.36,-52.28,;11.02,-52.28,;7.15,-46.77,;5.78,-47.5,;5.79,-49.05,;4.5,-46.63,;3.29,-47.53,;1.94,-46.81,;1.94,-45.26,;.66,-47.67,;.66,-49.22,;1.99,-49.99,;1.99,-51.52,;.67,-52.3,;3.33,-52.3,;-.55,-46.78,;-1.91,-47.51,;-1.9,-49.05,;-3.18,-46.64,;-2.37,-45.34,;-4.02,-47.92,;-4.49,-45.89,;-4.52,-44.35,;-3.18,-43.6,;-5.92,-43.66,;-5.92,-42.16,;-7.31,-41.5,;-8.55,-42.43,;-7.31,-39.97,;-5.78,-39.96,;-8.85,-39.99,;-7.34,-38.44,;-7.26,-44.43,;-7.27,-45.97,;-8.58,-43.65,;4.5,-45.09,;5.84,-44.32,;3.17,-44.32,;3.16,-42.77,;17.33,-46.78,;17.34,-45.23,;18.7,-47.51,;19.91,-46.62,;19.91,-45.08,;21.25,-44.3,;22.72,-44.8,;23.63,-43.56,;22.74,-42.3,;21.26,-42.76,;21.19,-47.49,;21.2,-49.03,;22.55,-46.76,;23.77,-47.65,;23.77,-49.19,;25.09,-49.97,;25.1,-51.5,;23.77,-52.27,;26.44,-52.27,;25.05,-46.78,;25.05,-45.24,;26.42,-47.51,;27.63,-46.62,;27.63,-45.08,;28.97,-44.31,;28.97,-42.77,;30.3,-42,;30.3,-40.47,;31.62,-39.7,;31.62,-38.17,;32.95,-40.47,;28.9,-47.49,;28.91,-49.04,;30.27,-46.77,;31.47,-47.66,;31.47,-49.2,;32.75,-46.79,;32.76,-45.24,;34.12,-47.52,;35.34,-46.63,;35.34,-45.09,;36.67,-44.31,;36.67,-42.77,;38,-42.01,;38,-40.47,;36.62,-47.5,;36.62,-49.04,;37.98,-46.76,;39.32,-47.49,;39.35,-49.03,;40.69,-49.76,;40.72,-51.29,;42.06,-52.03,;43.37,-51.24,;44.71,-51.97,;43.33,-49.7,;41.99,-48.97,;40.63,-46.7,;41.97,-47.43,;40.6,-45.17,)| Show InChI InChI=1S/C77H129N23O19/c1-13-15-20-47(91-69(114)54(35-40(3)4)95-67(112)51(28-31-57(80)103)93-71(116)60(42(7)14-2)98-68(113)52(29-32-58(104)105)97-74(119)77(11,12)100-72(117)59(41(5)6)99-73(118)76(9,10)84)65(110)96-55(37-45-38-85-39-87-45)70(115)92-50(27-30-56(79)102)66(111)90-48(22-17-19-34-86-75(82)83)63(108)88-43(8)62(107)89-49(21-16-18-33-78)64(109)94-53(61(81)106)36-44-23-25-46(101)26-24-44/h23-26,38-43,47-55,59-60,101H,13-22,27-37,78,84H2,1-12H3,(H2,79,102)(H2,80,103)(H2,81,106)(H,85,87)(H,88,108)(H,89,107)(H,90,111)(H,91,114)(H,92,115)(H,93,116)(H,94,109)(H,95,112)(H,96,110)(H,97,119)(H,98,113)(H,99,118)(H,100,117)(H,104,105)(H4,82,83,86)/t42-,43-,47-,48-,49-,50-,51-,52-,53-,54-,55-,59-,60-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]DPC-AJ1951 from PTH/PTH-related peptide receptor (unknown origin) expressed in HKRK-B28 cells |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50269978
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Arg-Ala-Fl...)Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=O)c1ccccc1-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r,wU:62.61,8.12,81.81,97.97,25.25,wD:55.55,44.44,4.4,29.34,92.93,72.72,130.134,16.21,(17.08,-55.29,;15.74,-54.54,;15.72,-53,;14.37,-52.25,;14.35,-50.72,;13.05,-49.9,;11.68,-50.63,;11.69,-52.18,;10.41,-49.76,;10.41,-48.21,;11.75,-47.44,;11.75,-45.89,;13.08,-48.22,;9.18,-50.66,;7.82,-49.93,;7.82,-48.38,;6.54,-50.81,;6.54,-52.35,;7.88,-53.13,;7.88,-54.66,;6.54,-55.44,;9.21,-55.44,;5.33,-49.91,;3.96,-50.65,;3.97,-52.2,;2.68,-49.78,;1.46,-50.68,;.1,-49.96,;.11,-48.4,;-1.17,-50.82,;-1.17,-52.37,;.16,-53.14,;.16,-54.68,;-1.17,-55.47,;1.5,-55.47,;-2.39,-49.93,;-3.75,-50.66,;-3.74,-52.21,;-5.02,-49.78,;-4.21,-48.48,;-5.88,-51.07,;-6.33,-49.03,;-6.37,-47.49,;-5.03,-46.73,;-7.78,-46.8,;-7.77,-45.29,;-9.18,-44.63,;-10.4,-45.56,;-9.17,-43.1,;-7.63,-43.08,;-10.7,-43.12,;-9.19,-41.56,;-9.11,-47.57,;-9.14,-49.11,;-10.44,-46.79,;2.68,-48.23,;4.02,-47.46,;1.34,-47.45,;1.33,-45.91,;15.54,-49.93,;15.55,-48.38,;16.91,-50.66,;18.13,-49.76,;18.13,-48.22,;19.47,-47.44,;20.94,-47.94,;21.86,-46.7,;20.97,-45.43,;19.48,-45.89,;19.42,-50.64,;19.42,-52.19,;20.78,-49.91,;22,-50.8,;22,-52.35,;23.33,-53.12,;23.33,-54.66,;22,-55.44,;24.68,-55.43,;23.28,-49.93,;23.29,-48.38,;24.65,-50.66,;25.87,-49.77,;25.87,-48.22,;27.21,-47.45,;27.21,-45.9,;28.54,-45.13,;28.54,-43.6,;29.87,-42.83,;27.21,-42.83,;27.15,-50.64,;27.15,-52.19,;28.51,-49.91,;29.72,-50.81,;29.73,-52.35,;31.01,-49.93,;31.01,-48.38,;32.36,-50.66,;33.68,-49.87,;33.68,-48.34,;32.34,-47.58,;32.33,-46.04,;31,-45.28,;30.97,-43.74,;32.28,-42.95,;33.63,-43.7,;32.25,-41.42,;30.72,-41.45,;29.92,-40.13,;30.67,-38.78,;32.2,-38.76,;32.99,-40.08,;34.52,-40.06,;35.27,-38.71,;34.48,-37.39,;35.23,-36.05,;36.77,-36.03,;37.52,-34.69,;37.56,-37.34,;36.82,-38.69,;37.62,-40.01,;36.85,-41.36,;37.65,-42.68,;36.89,-44.03,;37.67,-45.35,;35.35,-44.05,;34.56,-42.72,;35.31,-41.38,;35.02,-50.64,;35.03,-52.17,;36.35,-49.86,;37.68,-50.62,;37.69,-52.15,;39.03,-52.92,;39.02,-54.45,;40.36,-55.21,;41.69,-54.44,;43.02,-55.2,;41.67,-52.89,;40.34,-52.14,;39.01,-49.84,;40.34,-50.6,;39,-48.31,)| Show InChI InChI=1S/C96H137N23O23/c1-13-15-23-62(110-88(136)69(42-49(3)4)114-86(134)66(35-38-74(98)124)112-90(138)78(51(7)14-2)117-87(135)67(36-39-75(125)126)116-93(141)96(11,12)119-91(139)77(50(5)6)118-92(140)95(9,10)102)84(132)115-70(44-54-47-103-48-106-54)89(137)111-65(34-37-73(97)123)85(133)109-64(25-20-41-105-94(100)101)82(130)107-52(8)80(128)108-63(83(131)113-68(79(99)127)43-53-26-28-55(120)29-27-53)24-18-19-40-104-81(129)59-22-17-16-21-58(59)76-60-32-30-56(121)45-71(60)142-72-46-57(122)31-33-61(72)76/h16-17,21-22,26-33,45-52,62-70,77-78,120-121H,13-15,18-20,23-25,34-44,102H2,1-12H3,(H2,97,123)(H2,98,124)(H2,99,127)(H,103,106)(H,104,129)(H,107,130)(H,108,128)(H,109,133)(H,110,136)(H,111,137)(H,112,138)(H,113,131)(H,114,134)(H,115,132)(H,116,141)(H,117,135)(H,118,140)(H,119,139)(H,125,126)(H4,100,101,105)/t51-,52-,62-,63-,64-,65-,66-,67-,68-,69-,70-,77-,78-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]DPC-AJ1951 from PTH/PTH-related peptide receptor (unknown origin) expressed in HKRK-B28 cells |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50600479
(CHEMBL5171680)Show SMILES CC1(C)c2ncc(Cl)cc2-c2ccc(Cl)cc2N(c2ccc(cc2)N2CC(CN[C@H]3CC[C@H](CC3)C(O)=O)C2)C1=O |r,wU:29.31,32.38,(3.5,-4,;2.01,-3.61,;3.1,-2.52,;1.35,-5,;2.4,-6.12,;1.96,-7.6,;.46,-7.96,;.06,-9.45,;-.6,-6.84,;-.16,-5.35,;-1.38,-4.39,;-2.7,-5.16,;-4.04,-4.4,;-4.04,-2.85,;-5.37,-2.08,;-2.71,-2.08,;-1.38,-2.85,;-.18,-1.89,;-.58,-.4,;-2.06,0,;-2.46,1.48,;-1.37,2.57,;.11,2.18,;.52,.7,;-1.77,4.06,;-1,5.4,;-2.36,6.18,;-2.75,7.67,;-1.67,8.75,;-.18,8.36,;.91,9.45,;2.4,9.05,;2.8,7.56,;1.71,6.47,;.22,6.87,;4.28,7.16,;5.37,8.25,;4.68,5.67,;-3.13,4.84,;1.32,-2.21,;2.41,-1.13,)| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmc.2022.116763
BindingDB Entry DOI: 10.7270/Q2280CPH |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50600480
(CHEMBL5192194)Show SMILES CC1(C)c2ncc(Cl)cc2-c2ccc(Cl)cc2N(c2ccc(cc2)N2CC(CN[C@H]3CC[C@@H](CC3)C(O)=O)C2)C1=O |r,wU:32.38,wD:29.31,(3.5,-4,;2.01,-3.61,;3.1,-2.52,;1.35,-5,;2.4,-6.12,;1.96,-7.6,;.46,-7.96,;.06,-9.45,;-.6,-6.84,;-.16,-5.35,;-1.38,-4.39,;-2.7,-5.16,;-4.04,-4.4,;-4.04,-2.85,;-5.37,-2.08,;-2.71,-2.08,;-1.38,-2.85,;-.18,-1.89,;-.58,-.4,;-2.06,0,;-2.46,1.48,;-1.37,2.57,;.11,2.18,;.52,.7,;-1.77,4.06,;-1,5.4,;-2.36,6.18,;-2.75,7.67,;-1.67,8.75,;-.18,8.36,;.22,6.87,;1.71,6.47,;2.8,7.56,;2.4,9.05,;.91,9.45,;4.28,7.16,;5.37,8.25,;4.68,5.67,;-3.13,4.84,;1.32,-2.21,;2.41,-1.13,)| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmc.2022.116763
BindingDB Entry DOI: 10.7270/Q2280CPH |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50269976
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Arg-Ala-Ly...)Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r,wU:81.81,25.25,62.61,8.12,97.97,wD:16.21,92.93,72.72,55.55,106.106,4.4,44.44,29.34,(16.82,-7.68,;15.49,-6.94,;15.46,-5.4,;14.12,-4.66,;14.1,-3.13,;12.8,-2.32,;11.44,-3.04,;11.45,-4.59,;10.17,-2.17,;10.17,-.63,;11.5,.14,;11.51,1.68,;12.83,-.63,;8.95,-3.07,;7.59,-2.35,;7.59,-.8,;6.31,-3.21,;6.31,-4.76,;7.65,-5.53,;7.65,-7.06,;6.32,-7.84,;8.98,-7.84,;5.11,-2.32,;3.74,-3.06,;3.75,-4.6,;2.46,-2.19,;1.25,-3.09,;-.11,-2.37,;-.1,-.82,;-1.38,-3.23,;-1.38,-4.77,;-.05,-5.55,;-.05,-7.08,;-1.38,-7.86,;1.29,-7.86,;-2.59,-2.34,;-3.95,-3.07,;-3.94,-4.61,;-5.22,-2.2,;-4.41,-.9,;-6.06,-3.48,;-6.53,-1.45,;-6.57,.09,;-5.22,.85,;-7.96,.78,;-7.96,2.28,;-9.35,2.94,;-10.59,2.02,;-9.36,4.47,;-7.82,4.49,;-10.89,4.45,;-9.38,6.01,;-9.3,.01,;-9.31,-1.52,;-10.63,.79,;2.46,-.65,;3.8,.13,;1.13,.13,;1.11,1.67,;15.29,-2.34,;15.3,-.79,;16.65,-3.07,;17.87,-2.18,;17.87,-.63,;19.2,.14,;20.67,-.35,;21.59,.88,;20.7,2.14,;19.22,1.68,;19.15,-3.04,;19.16,-4.59,;20.51,-2.32,;21.72,-3.21,;21.73,-4.75,;23.05,-5.53,;23.05,-7.06,;21.73,-7.83,;24.4,-7.83,;23,-2.34,;23.01,-.79,;24.37,-3.07,;25.59,-2.18,;25.59,-.64,;26.92,.14,;26.93,1.68,;28.25,2.44,;28.25,3.97,;29.58,4.74,;26.93,4.74,;26.86,-3.05,;26.87,-4.59,;28.22,-2.32,;29.43,-3.21,;29.43,-4.76,;30.71,-2.35,;30.72,-.8,;32.08,-3.08,;33.29,-2.19,;33.3,-.64,;34.63,.13,;34.63,1.67,;35.96,2.44,;35.96,3.98,;34.58,-3.05,;34.58,-4.6,;35.93,-2.31,;37.28,-3.05,;37.31,-4.58,;38.65,-5.32,;38.67,-6.85,;40.01,-7.59,;41.33,-6.8,;42.67,-7.53,;41.29,-5.26,;39.95,-4.53,;38.59,-2.26,;39.93,-2.99,;38.56,-.72,)| Show InChI InChI=1S/C76H127N23O19/c1-13-15-19-46(90-68(113)53(34-39(3)4)94-66(111)50(27-30-56(79)102)92-70(115)59(41(7)14-2)97-67(112)51(28-31-57(103)104)96-73(118)76(11,12)99-71(116)58(40(5)6)98-72(117)75(9,10)83)64(109)95-54(36-44-37-84-38-86-44)69(114)91-49(26-29-55(78)101)65(110)89-48(21-18-33-85-74(81)82)62(107)87-42(8)61(106)88-47(20-16-17-32-77)63(108)93-52(60(80)105)35-43-22-24-45(100)25-23-43/h22-25,37-42,46-54,58-59,100H,13-21,26-36,77,83H2,1-12H3,(H2,78,101)(H2,79,102)(H2,80,105)(H,84,86)(H,87,107)(H,88,106)(H,89,110)(H,90,113)(H,91,114)(H,92,115)(H,93,108)(H,94,111)(H,95,109)(H,96,118)(H,97,112)(H,98,117)(H,99,116)(H,103,104)(H4,81,82,85)/t41-,42-,46-,47-,48-,49-,50-,51-,52-,53-,54-,58-,59-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 55.4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]DPC-AJ1951 from PTH/PTH-related peptide receptor (unknown origin) expressed in HKRK-B28 cells in presence of SW106 |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50600483
(CHEMBL5201424)Show SMILES CC1(C)c2ncc(Cl)cc2-c2ccc(Cl)cc2N(c2ccc(cc2)N2CC(F)(CN[C@H]3CC[C@@H](CC3)C(O)=O)C2)C1=O |r,wU:30.32,wD:33.39,(3.5,-3.32,;2.01,-2.92,;3.1,-1.83,;1.35,-4.31,;2.4,-5.43,;1.96,-6.91,;.46,-7.27,;.06,-8.76,;-.6,-6.15,;-.16,-4.66,;-1.38,-3.7,;-2.7,-4.47,;-4.04,-3.71,;-4.04,-2.16,;-5.37,-1.39,;-2.71,-1.39,;-1.38,-2.16,;-.18,-1.2,;-.58,.29,;-2.06,.69,;-2.46,2.17,;-1.37,3.26,;.11,2.87,;.52,1.38,;-1.77,4.75,;-1,6.08,;-2.36,6.87,;-3.69,7.64,;-1.96,8.36,;-.47,8.76,;.62,7.67,;2.11,8.07,;3.2,6.98,;2.8,5.49,;1.31,5.09,;.22,6.18,;3.89,4.4,;3.49,2.91,;5.37,4.8,;-3.13,5.53,;1.32,-1.53,;2.41,-.44,)| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmc.2022.116763
BindingDB Entry DOI: 10.7270/Q2280CPH |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50600486
(CHEMBL5201635)Show SMILES CC1(C)c2ncc(Cl)cc2-c2ccc(Cl)cc2N(c2ccc(cc2)N2CC(F)(CNC34CCC(CC3)(CC4)C(O)=O)C2)C1=O | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmc.2022.116763
BindingDB Entry DOI: 10.7270/Q2280CPH |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50600485
(CHEMBL5202067)Show SMILES C[C@@]1(CC[C@@H](CC1)NCC1(F)CN(C1)c1ccc(cc1)N1c2cc(Cl)ccc2-c2cc(Cl)cnc2C(C)(C)C1=O)C(O)=O |r,wU:4.7,wD:1.45,(4.63,5.09,;3.14,5.49,;3.54,6.98,;2.45,8.07,;.96,7.67,;.57,6.18,;1.65,5.09,;-.12,8.76,;-1.61,8.36,;-2.01,6.87,;-3.35,7.64,;-.66,6.08,;-1.43,4.75,;-2.78,5.53,;-1.03,3.26,;-2.12,2.17,;-1.72,.69,;-.23,.29,;.86,1.38,;.45,2.87,;.17,-1.2,;-1.03,-2.16,;-2.36,-1.39,;-3.69,-2.16,;-5.03,-1.39,;-3.69,-3.71,;-2.36,-4.47,;-1.03,-3.7,;.19,-4.66,;-.26,-6.15,;.81,-7.27,;.41,-8.76,;2.3,-6.91,;2.75,-5.43,;1.69,-4.31,;2.35,-2.92,;3.84,-3.32,;3.44,-1.83,;1.67,-1.53,;2.76,-.44,;3.54,4,;5.03,3.6,;2.45,2.91,)| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmc.2022.116763
BindingDB Entry DOI: 10.7270/Q2280CPH |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50522126
(CHEMBL4465123)Show SMILES CC1(C)N=C(C2CCCCC2)c2ccc(cc2N(c2ccc(NCCNC3CCOCC3)cc2)C1=O)C#N |t:3| Show InChI InChI=1S/C31H39N5O2/c1-31(2)30(37)36(26-11-9-24(10-12-26)33-16-17-34-25-14-18-38-19-15-25)28-20-22(21-32)8-13-27(28)29(35-31)23-6-4-3-5-7-23/h8-13,20,23,25,33-34H,3-7,14-19H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co, Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human PTHR1 expressed in CHOK1 cells co-expressing Gs/Gq assessed as reduction in human PTH (1 to 34 residues)-induced cAMP ac... |
Bioorg Med Chem Lett 29: 2613-2616 (2019)
Article DOI: 10.1016/j.bmcl.2019.07.052
BindingDB Entry DOI: 10.7270/Q2XW4P6F |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50542604
(CHEMBL4642072)Show SMILES CC1(C)c2ncc(Cl)cc2-c2ccc(cc2N(c2ccc(NCCNC3CCOCC3)cc2)C1=O)C#N Show InChI InChI=1S/C29H30ClN5O2/c1-29(2)27-25(16-20(30)18-34-27)24-8-3-19(17-31)15-26(24)35(28(29)36)23-6-4-21(5-7-23)32-11-12-33-22-9-13-37-14-10-22/h3-8,15-16,18,22,32-33H,9-14H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at PTHR1 (unknown origin) expressed in CHOK1 cells co-expressing Gs/Gq assessed as reduction in human PTH (1 to 34 residues)-indu... |
Bioorg Med Chem 28: (2020)
Article DOI: 10.1016/j.bmc.2020.115524
BindingDB Entry DOI: 10.7270/Q2H135J0 |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50522126
(CHEMBL4465123)Show SMILES CC1(C)N=C(C2CCCCC2)c2ccc(cc2N(c2ccc(NCCNC3CCOCC3)cc2)C1=O)C#N |t:3| Show InChI InChI=1S/C31H39N5O2/c1-31(2)30(37)36(26-11-9-24(10-12-26)33-16-17-34-25-14-18-38-19-15-25)28-20-22(21-32)8-13-27(28)29(35-31)23-6-4-3-5-7-23/h8-13,20,23,25,33-34H,3-7,14-19H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at PTHR1 (unknown origin) expressed in CHOK1 cells co-expressing Gs/Gq assessed as reduction in human PTH (1 to 34 residues)-indu... |
Bioorg Med Chem 28: (2020)
Article DOI: 10.1016/j.bmc.2020.115524
BindingDB Entry DOI: 10.7270/Q2H135J0 |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50269977
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Arg-Ala-Ly...)Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCNC(=O)c1ccccc1-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(N)=O |r,wU:62.61,8.12,97.97,81.81,25.25,118.119,wD:55.55,106.106,4.4,44.44,29.34,16.21,92.93,72.72,(16.67,-31.38,;15.33,-30.63,;15.31,-29.09,;13.97,-28.35,;13.94,-26.81,;12.64,-26,;11.27,-26.72,;11.28,-28.28,;10,-25.85,;10,-24.31,;11.34,-23.53,;11.34,-21.99,;12.67,-24.31,;8.78,-26.75,;7.41,-26.03,;7.42,-24.48,;6.13,-26.9,;6.14,-28.44,;7.47,-29.22,;7.47,-30.76,;6.14,-31.53,;8.8,-31.53,;4.92,-26,;3.55,-26.74,;3.56,-28.29,;2.27,-25.87,;1.05,-26.77,;-.3,-26.05,;-.3,-24.49,;-1.58,-26.92,;-1.58,-28.46,;-.25,-29.24,;-.25,-30.77,;-1.58,-31.56,;1.09,-31.56,;-2.8,-26.02,;-4.15,-26.75,;-4.15,-28.3,;-5.43,-25.88,;-4.62,-24.58,;-6.27,-27.16,;-6.75,-25.13,;-6.78,-23.59,;-5.43,-22.83,;-8.17,-22.89,;-8.18,-21.39,;-9.57,-20.73,;-10.82,-21.65,;-9.58,-19.19,;-8.04,-19.18,;-11.11,-19.21,;-9.6,-17.65,;-9.53,-23.66,;-9.53,-25.2,;-10.85,-22.88,;2.27,-24.33,;3.61,-23.55,;.93,-23.55,;.92,-22,;15.13,-26.02,;15.15,-24.47,;16.5,-26.75,;17.72,-25.86,;17.72,-24.31,;19.06,-23.53,;20.53,-24.03,;21.45,-22.79,;20.56,-21.53,;19.07,-21.99,;19.01,-26.73,;19.01,-28.28,;20.37,-26,;21.59,-26.89,;21.59,-28.44,;22.92,-29.21,;22.92,-30.75,;21.59,-31.53,;24.27,-31.53,;22.87,-26.02,;22.88,-24.47,;24.24,-26.75,;25.46,-25.86,;25.46,-24.31,;26.8,-23.54,;26.8,-21.99,;28.13,-21.23,;28.13,-19.69,;29.46,-18.92,;26.8,-18.92,;26.74,-26.73,;26.74,-28.28,;28.1,-26,;29.31,-26.9,;29.31,-28.44,;30.6,-26.03,;30.6,-24.48,;31.97,-26.76,;33.19,-25.87,;33.19,-24.32,;34.53,-23.54,;34.53,-22,;35.86,-21.23,;35.86,-19.69,;34.47,-26.74,;34.48,-28.29,;35.83,-26,;37.18,-26.73,;37.21,-28.27,;38.56,-29.01,;38.58,-30.54,;39.93,-31.28,;41.24,-30.49,;42.59,-31.23,;41.2,-28.95,;39.86,-28.21,;38.49,-25.94,;38.46,-24.4,;39.84,-26.67,;41.16,-25.89,;41.15,-24.36,;39.82,-23.6,;39.81,-22.06,;38.48,-21.3,;38.45,-19.76,;39.76,-18.97,;41.1,-19.72,;39.72,-17.44,;38.19,-17.47,;37.4,-16.15,;38.14,-14.8,;39.68,-14.78,;40.47,-16.1,;41.99,-16.08,;42.74,-14.73,;41.96,-13.41,;42.71,-12.07,;44.25,-12.05,;44.99,-10.71,;45.04,-13.36,;44.3,-14.71,;45.1,-16.03,;44.33,-17.38,;45.12,-18.7,;44.36,-20.05,;45.15,-21.37,;42.82,-20.07,;42.04,-18.74,;42.79,-17.4,;42.5,-26.65,;42.51,-28.19,;43.83,-25.88,)| Show InChI InChI=1S/C102H149N25O24/c1-13-15-25-67(118-93(144)73(46-53(3)4)121-91(142)71(38-41-79(105)132)120-96(147)83(55(7)14-2)125-92(143)72(39-42-80(133)134)124-99(150)102(11,12)127-97(148)82(54(5)6)126-98(149)101(9,10)109)88(139)123-75(48-58-51-110-52-113-58)95(146)119-70(37-40-78(104)131)90(141)117-69(28-22-45-112-100(107)108)87(138)114-56(8)85(136)116-68(27-18-20-43-103)89(140)122-74(47-57-29-31-59(128)32-30-57)94(145)115-66(84(106)135)26-19-21-44-111-86(137)63-24-17-16-23-62(63)81-64-35-33-60(129)49-76(64)151-77-50-61(130)34-36-65(77)81/h16-17,23-24,29-36,49-56,66-75,82-83,128-129H,13-15,18-22,25-28,37-48,103,109H2,1-12H3,(H2,104,131)(H2,105,132)(H2,106,135)(H,110,113)(H,111,137)(H,114,138)(H,115,145)(H,116,136)(H,117,141)(H,118,144)(H,119,146)(H,120,147)(H,121,142)(H,122,140)(H,123,139)(H,124,150)(H,125,143)(H,126,149)(H,127,148)(H,133,134)(H4,107,108,112)/t55-,56-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,82-,83-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 98.2 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]DPC-AJ1951 from PTH/PTH-related peptide receptor (unknown origin) expressed in HKRK-B28 cells |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50600475
(CHEMBL5190633)Show SMILES COC1(CNC2CCOCC2)CN(C1)c1ccc(cc1)N1c2cc(Cl)ccc2-c2cc(Cl)cnc2C(C)(C)C1=O | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmc.2022.116763
BindingDB Entry DOI: 10.7270/Q2280CPH |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50600477
(CHEMBL5191139)Show SMILES COC(=O)C1(CNC2CCOCC2)CN(C1)c1ccc(cc1)N1c2cc(Cl)ccc2-c2cc(Cl)cnc2C(C)(C)C1=O | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmc.2022.116763
BindingDB Entry DOI: 10.7270/Q2280CPH |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50600481
(CHEMBL5189957)Show SMILES COC1(CN[C@H]2CC[C@H](CC2)C(O)=O)CN(C1)c1ccc(cc1)N1c2cc(Cl)ccc2-c2cc(Cl)cnc2C(C)(C)C1=O |r,wD:5.4,8.11,(-4.93,7.56,;-3.44,7.96,;-2.36,6.87,;-1.96,8.36,;-.47,8.76,;.62,7.67,;.22,6.18,;1.31,5.09,;2.8,5.49,;3.2,6.98,;2.11,8.07,;3.89,4.4,;3.49,2.91,;5.37,4.8,;-1,6.08,;-1.77,4.75,;-3.13,5.53,;-1.37,3.26,;-2.46,2.17,;-2.06,.69,;-.58,.29,;.52,1.38,;.11,2.87,;-.18,-1.2,;-1.38,-2.16,;-2.71,-1.39,;-4.04,-2.16,;-5.37,-1.39,;-4.04,-3.71,;-2.7,-4.47,;-1.38,-3.7,;-.16,-4.66,;-.6,-6.15,;.46,-7.27,;.06,-8.76,;1.96,-6.91,;2.4,-5.43,;1.35,-4.31,;2.01,-2.92,;3.5,-3.32,;3.1,-1.83,;1.32,-1.53,;2.41,-.44,)| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmc.2022.116763
BindingDB Entry DOI: 10.7270/Q2280CPH |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50542598
(CHEMBL4647898)Show SMILES CC1(C)c2ncc(Cl)cc2-c2ccc(Cl)cc2N(c2ccc(NCCNC3CCOCC3)cc2)C1=O Show InChI InChI=1S/C28H30Cl2N4O2/c1-28(2)26-24(15-19(30)17-33-26)23-8-3-18(29)16-25(23)34(27(28)35)22-6-4-20(5-7-22)31-11-12-32-21-9-13-36-14-10-21/h3-8,15-17,21,31-32H,9-14H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at PTHR1 (unknown origin) expressed in CHOK1 cells co-expressing Gs/Gq assessed as reduction in human PTH (1 to 34 residues)-indu... |
Bioorg Med Chem 28: (2020)
Article DOI: 10.1016/j.bmc.2020.115524
BindingDB Entry DOI: 10.7270/Q2H135J0 |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50600484
(CHEMBL5171324)Show SMILES C[C@]1(CC[C@@H](CC1)NCC1(F)CN(C1)c1ccc(cc1)N1c2cc(Cl)ccc2-c2cc(Cl)cnc2C(C)(C)C1=O)C(O)=O |r,wU:4.7,1.45,(4.63,5.09,;3.14,5.49,;3.54,6.98,;2.45,8.07,;.96,7.67,;.57,6.18,;1.65,5.09,;-.12,8.76,;-1.61,8.36,;-2.01,6.87,;-3.35,7.64,;-.66,6.08,;-1.43,4.75,;-2.78,5.53,;-1.03,3.26,;-2.12,2.17,;-1.72,.69,;-.23,.29,;.86,1.38,;.45,2.87,;.17,-1.2,;-1.03,-2.16,;-2.36,-1.39,;-3.69,-2.16,;-5.03,-1.39,;-3.69,-3.71,;-2.36,-4.47,;-1.03,-3.7,;.19,-4.66,;-.26,-6.15,;.81,-7.27,;.41,-8.76,;2.3,-6.91,;2.75,-5.43,;1.69,-4.31,;2.35,-2.92,;3.84,-3.32,;3.44,-1.83,;1.67,-1.53,;2.76,-.44,;3.54,4,;5.03,3.6,;2.45,2.91,)| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmc.2022.116763
BindingDB Entry DOI: 10.7270/Q2280CPH |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50600482
(CHEMBL5199789)Show SMILES COC1(CN[C@H]2CC[C@@H](CC2)C(O)=O)CN(C1)c1ccc(cc1)N1c2cc(Cl)ccc2-c2cc(Cl)cnc2C(C)(C)C1=O |r,wU:5.4,wD:8.11,(-4.93,7.56,;-3.44,7.96,;-2.36,6.87,;-1.96,8.36,;-.47,8.76,;.62,7.67,;2.11,8.07,;3.2,6.98,;2.8,5.49,;1.31,5.09,;.22,6.18,;3.89,4.4,;3.49,2.91,;5.37,4.8,;-1,6.08,;-1.77,4.75,;-3.13,5.53,;-1.37,3.26,;-2.46,2.17,;-2.06,.69,;-.58,.29,;.52,1.38,;.11,2.87,;-.18,-1.2,;-1.38,-2.16,;-2.71,-1.39,;-4.04,-2.16,;-5.37,-1.39,;-4.04,-3.71,;-2.7,-4.47,;-1.38,-3.7,;-.16,-4.66,;-.6,-6.15,;.46,-7.27,;.06,-8.76,;1.96,-6.91,;2.4,-5.43,;1.35,-4.31,;2.01,-2.92,;3.5,-3.32,;3.1,-1.83,;1.32,-1.53,;2.41,-.44,)| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmc.2022.116763
BindingDB Entry DOI: 10.7270/Q2280CPH |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50522125
(CHEMBL4563935)Show SMILES CC1(C)N=C(C2CCCCC2)c2ccc(cc2N(c2ccc(NCCNC3CCN(CC3)S(C)(=O)=O)cc2)C1=O)C#N |t:3| Show InChI InChI=1S/C32H42N6O3S/c1-32(2)31(39)38(29-21-23(22-33)9-14-28(29)30(36-32)24-7-5-4-6-8-24)27-12-10-25(11-13-27)34-17-18-35-26-15-19-37(20-16-26)42(3,40)41/h9-14,21,24,26,34-35H,4-8,15-20H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co, Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human PTHR1 expressed in CHOK1 cells co-expressing Gs/Gq assessed as reduction in human PTH (1 to 34 residues)-induced cAMP ac... |
Bioorg Med Chem Lett 29: 2613-2616 (2019)
Article DOI: 10.1016/j.bmcl.2019.07.052
BindingDB Entry DOI: 10.7270/Q2XW4P6F |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50542602
(CHEMBL4633101)Show SMILES CC1(C)c2ncc(Cl)cc2-c2ccc(F)cc2N(c2ccc(NCCNC3CCOCC3)cc2)C1=O Show InChI InChI=1S/C28H30ClFN4O2/c1-28(2)26-24(15-18(29)17-33-26)23-8-3-19(30)16-25(23)34(27(28)35)22-6-4-20(5-7-22)31-11-12-32-21-9-13-36-14-10-21/h3-8,15-17,21,31-32H,9-14H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at PTHR1 (unknown origin) expressed in CHOK1 cells co-expressing Gs/Gq assessed as reduction in human PTH (1 to 34 residues)-indu... |
Bioorg Med Chem 28: (2020)
Article DOI: 10.1016/j.bmc.2020.115524
BindingDB Entry DOI: 10.7270/Q2H135J0 |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50542603
(CHEMBL4640934)Show SMILES COc1ccc-2c(c1)N(c1ccc(NCCNC3CCOCC3)cc1)C(=O)C(C)(C)c1ncc(Cl)cc-21 Show InChI InChI=1S/C29H33ClN4O3/c1-29(2)27-25(16-19(30)18-33-27)24-9-8-23(36-3)17-26(24)34(28(29)35)22-6-4-20(5-7-22)31-12-13-32-21-10-14-37-15-11-21/h4-9,16-18,21,31-32H,10-15H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at PTHR1 (unknown origin) expressed in CHOK1 cells co-expressing Gs/Gq assessed as reduction in human PTH (1 to 34 residues)-indu... |
Bioorg Med Chem 28: (2020)
Article DOI: 10.1016/j.bmc.2020.115524
BindingDB Entry DOI: 10.7270/Q2H135J0 |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50600473
(CHEMBL5183438)Show SMILES CC1(C)c2ncc(Cl)cc2-c2ccc(Cl)cc2N(c2ccc(cc2)N2CC(CNC3CCOCC3)C2)C1=O | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 280 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmc.2022.116763
BindingDB Entry DOI: 10.7270/Q2280CPH |
More data for this
Ligand-Target Pair | |
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