Found 186 hits Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 5-phosphate 4-kinase type-2 beta' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | CHEMBL5271804
| PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
UniChem
| | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50527927
(CHEMBL4436648)Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1cncc(\C=C2/SC(=N)NC2=O)c1 Show InChI InChI=1S/C16H14N4O3S2/c1-25(22,23)20-13-4-2-11(3-5-13)12-6-10(8-18-9-12)7-14-15(21)19-16(17)24-14/h2-9,20H,1H3,(H2,17,19,21)/b14-7- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
PDB
UniChem
| Article
PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged recombinant PI5P4Kbeta (unknown origin) incubated for 1 hr in presence of DPPS and PI5P by ADP-Glo assay |
J Med Chem 63: 4880-4895 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00227
BindingDB Entry DOI: 10.7270/Q2SB4964 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50527943
(CHEMBL4447308)Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1cncc(\C=C2/SC(=O)NC2=O)c1 Show InChI InChI=1S/C16H13N3O4S2/c1-25(22,23)19-13-4-2-11(3-5-13)12-6-10(8-17-9-12)7-14-15(20)18-16(21)24-14/h2-9,19H,1H3,(H,18,20,21)/b14-7- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged recombinant PI5P4Kbeta (unknown origin) incubated for 1 hr in presence of DPPS and PI5P by ADP-Glo assay |
J Med Chem 63: 4880-4895 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00227
BindingDB Entry DOI: 10.7270/Q2SB4964 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50511409
(Imanixil)Show SMILES CC1(C)CN(C(=O)N1)c1ncc(C(=O)Nc2cccc(c2)C(F)(F)F)c(N)n1 Show InChI InChI=1S/C17H17F3N6O2/c1-16(2)8-26(15(28)25-16)14-22-7-11(12(21)24-14)13(27)23-10-5-3-4-9(6-10)17(18,19)20/h3-7H,8H2,1-2H3,(H,23,27)(H,25,28)(H2,21,22,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| | n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50527938
(CHEMBL4454033)Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1cc(\C=C2/SC(=N)NC2=O)cnc1N Show InChI InChI=1S/C16H15N5O3S2/c1-26(23,24)21-11-4-2-10(3-5-11)12-6-9(8-19-14(12)17)7-13-15(22)20-16(18)25-13/h2-8,21H,1H3,(H2,17,19)(H2,18,20,22)/b13-7- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged recombinant PI5P4Kbeta (unknown origin) incubated for 1 hr in presence of DPPS and PI5P by ADP-Glo assay |
J Med Chem 63: 4880-4895 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00227
BindingDB Entry DOI: 10.7270/Q2SB4964 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50511409
(Imanixil)Show SMILES CC1(C)CN(C(=O)N1)c1ncc(C(=O)Nc2cccc(c2)C(F)(F)F)c(N)n1 Show InChI InChI=1S/C17H17F3N6O2/c1-16(2)8-26(15(28)25-16)14-22-7-11(12(21)24-14)13(27)23-10-5-3-4-9(6-10)17(18,19)20/h3-7H,8H2,1-2H3,(H,23,27)(H,25,28)(H2,21,22,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute
Curated by ChEMBL
| Assay Description
Inhibition of PI5P4Kbeta (unknown origin) incubated for 15 mins in presence of ATP by ADP-Glo assay |
ACS Med Chem Lett 11: 346-352 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00402
BindingDB Entry DOI: 10.7270/Q2TM7FDP |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50527931
(CHEMBL4519752)Show SMILES CNS(=O)(=O)c1ccc(cc1)-c1cncc(\C=C2/SC(=N)NC2=O)c1 Show InChI InChI=1S/C16H14N4O3S2/c1-18-25(22,23)13-4-2-11(3-5-13)12-6-10(8-19-9-12)7-14-15(21)20-16(17)24-14/h2-9,18H,1H3,(H2,17,20,21)/b14-7- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged recombinant PI5P4Kbeta (unknown origin) incubated for 1 hr in presence of DPPS and PI5P by ADP-Glo assay |
J Med Chem 63: 4880-4895 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00227
BindingDB Entry DOI: 10.7270/Q2SB4964 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50511422
(CHEMBL4446338)Show SMILES CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2cc(ncn2)-c2c[nH]c3ccccc23)c1 Show InChI InChI=1S/C31H29N7O2/c1-38(2)16-6-11-30(39)36-22-14-12-21(13-15-22)31(40)37-24-8-5-7-23(17-24)35-29-18-28(33-20-34-29)26-19-32-27-10-4-3-9-25(26)27/h3-15,17-20,32H,16H2,1-2H3,(H,36,39)(H,37,40)(H,33,34,35)/b11-6+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
PDB
UniChem
| Article
PubMed
| n/a | n/a | 5.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute
Curated by ChEMBL
| Assay Description
Inhibition of PI5P4Kbeta (unknown origin) incubated for 15 mins in presence of ATP by ADP-Glo assay |
ACS Med Chem Lett 11: 346-352 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00402
BindingDB Entry DOI: 10.7270/Q2TM7FDP |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50511415
(CHEMBL4461694)Show SMILES CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2cc(Nc3ccc(C)cc3)ncn2)c1 Show InChI InChI=1S/C30H31N7O2/c1-21-9-13-23(14-10-21)33-27-19-28(32-20-31-27)34-25-6-4-7-26(18-25)36-30(39)22-11-15-24(16-12-22)35-29(38)8-5-17-37(2)3/h4-16,18-20H,17H2,1-3H3,(H,35,38)(H,36,39)(H2,31,32,33,34)/b8-5+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute
Curated by ChEMBL
| Assay Description
Inhibition of PI5P4Kbeta (unknown origin) incubated for 15 mins in presence of ATP by ADP-Glo assay |
ACS Med Chem Lett 11: 346-352 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00402
BindingDB Entry DOI: 10.7270/Q2TM7FDP |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50511414
(CHEMBL4472811)Show SMILES CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2cc(Nc3ccc(cc3)-c3ccccc3)ncn2)c1 Show InChI InChI=1S/C35H33N7O2/c1-42(2)21-7-12-34(43)40-29-19-15-27(16-20-29)35(44)41-31-11-6-10-30(22-31)39-33-23-32(36-24-37-33)38-28-17-13-26(14-18-28)25-8-4-3-5-9-25/h3-20,22-24H,21H2,1-2H3,(H,40,43)(H,41,44)(H2,36,37,38,39)/b12-7+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute
Curated by ChEMBL
| Assay Description
Inhibition of PI5P4Kbeta (unknown origin) incubated for 15 mins in presence of ATP by ADP-Glo assay |
ACS Med Chem Lett 11: 346-352 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00402
BindingDB Entry DOI: 10.7270/Q2TM7FDP |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50527925
(CHEMBL4577337)Show SMILES CNC(=O)Nc1ccc(cc1)-c1cncc(\C=C2/SC(=N)NC2=O)c1 Show InChI InChI=1S/C17H15N5O2S/c1-19-17(24)21-13-4-2-11(3-5-13)12-6-10(8-20-9-12)7-14-15(23)22-16(18)25-14/h2-9H,1H3,(H2,18,22,23)(H2,19,21,24)/b14-7- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged recombinant PI5P4Kbeta (unknown origin) incubated for 1 hr in presence of DPPS and PI5P by ADP-Glo assay |
J Med Chem 63: 4880-4895 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00227
BindingDB Entry DOI: 10.7270/Q2SB4964 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50511418
(CHEMBL4533123)Show SMILES CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1cccc(Nc2cc(ncn2)-c2cnc3[nH]ccc3c2)c1 Show InChI InChI=1S/C30H28N8O2/c1-38(2)13-5-10-28(39)36-23-7-3-6-21(15-23)30(40)37-25-9-4-8-24(16-25)35-27-17-26(33-19-34-27)22-14-20-11-12-31-29(20)32-18-22/h3-12,14-19H,13H2,1-2H3,(H,31,32)(H,36,39)(H,37,40)(H,33,34,35)/b10-5+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute
Curated by ChEMBL
| Assay Description
Inhibition of PI5P4Kbeta (unknown origin) incubated for 15 mins in presence of ATP by ADP-Glo assay |
ACS Med Chem Lett 11: 346-352 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00402
BindingDB Entry DOI: 10.7270/Q2TM7FDP |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50527929
(CHEMBL4455633)Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1cncc(c1)-c1cccc2[nH]ccc12 Show InChI InChI=1S/C20H17N3O2S/c1-26(24,25)23-17-7-5-14(6-8-17)15-11-16(13-21-12-15)18-3-2-4-20-19(18)9-10-22-20/h2-13,22-23H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged recombinant PI5P4Kbeta (unknown origin) incubated for 1 hr in presence of DPPS and PI5P by ADP-Glo assay |
J Med Chem 63: 4880-4895 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00227
BindingDB Entry DOI: 10.7270/Q2SB4964 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50511421
(CHEMBL4439287)Show SMILES CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncnc3n(ccc23)-c2ccc(C)cc2)c1 Show InChI InChI=1S/C32H31N7O2/c1-22-9-15-27(16-10-22)39-19-17-28-30(33-21-34-31(28)39)36-25-6-4-7-26(20-25)37-32(41)23-11-13-24(14-12-23)35-29(40)8-5-18-38(2)3/h4-17,19-21H,18H2,1-3H3,(H,35,40)(H,37,41)(H,33,34,36)/b8-5+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute
Curated by ChEMBL
| Assay Description
Inhibition of PI5P4Kbeta (unknown origin) incubated for 15 mins in presence of ATP by ADP-Glo assay |
ACS Med Chem Lett 11: 346-352 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00402
BindingDB Entry DOI: 10.7270/Q2TM7FDP |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50511420
(CHEMBL4449493)Show SMILES CN(C)C\C=C\C(=O)NC1CCN(CC1)C(=O)Cc1cccc(Nc2cc(ncn2)-c2cnc3[nH]ccc3c2)c1 Show InChI InChI=1S/C30H34N8O2/c1-37(2)12-4-7-28(39)36-24-9-13-38(14-10-24)29(40)16-21-5-3-6-25(15-21)35-27-18-26(33-20-34-27)23-17-22-8-11-31-30(22)32-19-23/h3-8,11,15,17-20,24H,9-10,12-14,16H2,1-2H3,(H,31,32)(H,36,39)(H,33,34,35)/b7-4+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.01E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute
Curated by ChEMBL
| Assay Description
Inhibition of PI5P4Kbeta (unknown origin) incubated for 15 mins in presence of ATP by ADP-Glo assay |
ACS Med Chem Lett 11: 346-352 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00402
BindingDB Entry DOI: 10.7270/Q2TM7FDP |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50511413
(CHEMBL4571099)Show SMILES CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2cc(ncn2)-c2cnc3[nH]ccc3c2)c1 Show InChI InChI=1S/C30H28N8O2/c1-38(2)14-4-7-28(39)36-23-10-8-20(9-11-23)30(40)37-25-6-3-5-24(16-25)35-27-17-26(33-19-34-27)22-15-21-12-13-31-29(21)32-18-22/h3-13,15-19H,14H2,1-2H3,(H,31,32)(H,36,39)(H,37,40)(H,33,34,35)/b7-4+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.09E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute
Curated by ChEMBL
| Assay Description
Inhibition of PI5P4Kbeta (unknown origin) incubated for 15 mins in presence of ATP by ADP-Glo assay |
ACS Med Chem Lett 11: 346-352 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00402
BindingDB Entry DOI: 10.7270/Q2TM7FDP |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50527946
(CHEMBL4467678)Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1cncc(c1)-c1cccc2NC(=O)Cc12 Show InChI InChI=1S/C20H17N3O3S/c1-27(25,26)23-16-7-5-13(6-8-16)14-9-15(12-21-11-14)17-3-2-4-19-18(17)10-20(24)22-19/h2-9,11-12,23H,10H2,1H3,(H,22,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged recombinant PI5P4Kbeta (unknown origin) incubated for 1 hr in presence of DPPS and PI5P by ADP-Glo assay |
J Med Chem 63: 4880-4895 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00227
BindingDB Entry DOI: 10.7270/Q2SB4964 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50511423
(CHEMBL4454740)Show SMILES CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2cc(ncn2)-c2ccc3nn(C)cc3c2)c1 Show InChI InChI=1S/C31H30N8O2/c1-38(2)15-5-8-30(40)35-24-12-9-21(10-13-24)31(41)36-26-7-4-6-25(17-26)34-29-18-28(32-20-33-29)22-11-14-27-23(16-22)19-39(3)37-27/h4-14,16-20H,15H2,1-3H3,(H,35,40)(H,36,41)(H,32,33,34)/b8-5+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.58E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute
Curated by ChEMBL
| Assay Description
Inhibition of PI5P4Kbeta (unknown origin) incubated for 15 mins in presence of ATP by ADP-Glo assay |
ACS Med Chem Lett 11: 346-352 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00402
BindingDB Entry DOI: 10.7270/Q2TM7FDP |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50511424
(CHEMBL4518868)Show SMILES CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1ccc(C)c(Nc2cc(ncn2)-c2cnc3[nH]ccc3c2)c1 Show InChI InChI=1S/C31H30N8O2/c1-20-6-9-25(37-31(41)21-7-10-24(11-8-21)36-29(40)5-4-14-39(2)3)16-26(20)38-28-17-27(34-19-35-28)23-15-22-12-13-32-30(22)33-18-23/h4-13,15-19H,14H2,1-3H3,(H,32,33)(H,36,40)(H,37,41)(H,34,35,38)/b5-4+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.05E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute
Curated by ChEMBL
| Assay Description
Inhibition of PI5P4Kbeta (unknown origin) incubated for 15 mins in presence of ATP by ADP-Glo assay |
ACS Med Chem Lett 11: 346-352 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00402
BindingDB Entry DOI: 10.7270/Q2TM7FDP |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50527932
(CHEMBL4456203)Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1cncc(c1)-c1ccc2[nH]ccc2c1 Show InChI InChI=1S/C20H17N3O2S/c1-26(24,25)23-19-5-2-14(3-6-19)17-11-18(13-21-12-17)15-4-7-20-16(10-15)8-9-22-20/h2-13,22-23H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged recombinant PI5P4Kbeta (unknown origin) incubated for 1 hr in presence of DPPS and PI5P by ADP-Glo assay |
J Med Chem 63: 4880-4895 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00227
BindingDB Entry DOI: 10.7270/Q2SB4964 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50527929
(CHEMBL4455633)Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1cncc(c1)-c1cccc2[nH]ccc12 Show InChI InChI=1S/C20H17N3O2S/c1-26(24,25)23-17-7-5-14(6-8-17)15-11-16(13-21-12-15)18-3-2-4-20-19(18)9-10-22-20/h2-13,22-23H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of PI5P4Kbeta (unknown origin) by fluorescence polarization assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01819
BindingDB Entry DOI: 10.7270/Q2SQ9493 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50511416
(CHEMBL4537067)Show SMILES CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2cc(Nc3cccc(c3)-c3ccccc3)ncn2)c1 Show InChI InChI=1S/C35H33N7O2/c1-42(2)20-8-15-34(43)40-28-18-16-26(17-19-28)35(44)41-31-14-7-13-30(22-31)39-33-23-32(36-24-37-33)38-29-12-6-11-27(21-29)25-9-4-3-5-10-25/h3-19,21-24H,20H2,1-2H3,(H,40,43)(H,41,44)(H2,36,37,38,39)/b15-8+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.45E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute
Curated by ChEMBL
| Assay Description
Inhibition of PI5P4Kbeta (unknown origin) incubated for 15 mins in presence of ATP by ADP-Glo assay |
ACS Med Chem Lett 11: 346-352 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00402
BindingDB Entry DOI: 10.7270/Q2TM7FDP |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50527939
(CHEMBL4436057)Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1cnc(N)c(\C=C2/SC(=N)NC2=O)c1 Show InChI InChI=1S/C16H15N5O3S2/c1-26(23,24)21-12-4-2-9(3-5-12)11-6-10(14(17)19-8-11)7-13-15(22)20-16(18)25-13/h2-8,21H,1H3,(H2,17,19)(H2,18,20,22)/b13-7- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged recombinant PI5P4Kbeta (unknown origin) incubated for 1 hr in presence of DPPS and PI5P by ADP-Glo assay |
J Med Chem 63: 4880-4895 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00227
BindingDB Entry DOI: 10.7270/Q2SB4964 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50527934
(CHEMBL4573568)Show SMILES CC(=O)Nc1cccc(Oc2cncc(c2)-c2ccc(NS(C)(=O)=O)cc2)c1 Show InChI InChI=1S/C20H19N3O4S/c1-14(24)22-18-4-3-5-19(11-18)27-20-10-16(12-21-13-20)15-6-8-17(9-7-15)23-28(2,25)26/h3-13,23H,1-2H3,(H,22,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged recombinant PI5P4Kbeta (unknown origin) incubated for 1 hr in presence of DPPS and PI5P by ADP-Glo assay |
J Med Chem 63: 4880-4895 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00227
BindingDB Entry DOI: 10.7270/Q2SB4964 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50584982
(CHEMBL1479741) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <2.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of PI5P4Kbeta (unknown origin) by ADP-Glo assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01819
BindingDB Entry DOI: 10.7270/Q2SQ9493 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50584983
(CHEMBL5083347)Show SMILES FC(F)(F)c1ccccc1-c1nc(NCC2CCCCC2)c2ccccc2n1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <2.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of PI5P4Kbeta (unknown origin) by ADP-Glo assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01819
BindingDB Entry DOI: 10.7270/Q2SQ9493 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50497353
(CHEMBL3356099)Show SMILES FC(F)(F)c1ccccc1-c1nc(NCc2ccccc2)c2ccccc2n1 Show InChI InChI=1S/C22H16F3N3/c23-22(24,25)18-12-6-4-10-16(18)21-27-19-13-7-5-11-17(19)20(28-21)26-14-15-8-2-1-3-9-15/h1-13H,14H2,(H,26,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <2.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of PI5P4Kbeta (unknown origin) by ADP-Glo assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01819
BindingDB Entry DOI: 10.7270/Q2SQ9493 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50584984
(CHEMBL5079093)Show SMILES FC(F)(F)c1ccccc1-c1nc(NCc2ccccn2)c2ccccc2n1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <2.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of PI5P4Kbeta (unknown origin) by ADP-Glo assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01819
BindingDB Entry DOI: 10.7270/Q2SQ9493 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50584985
(CHEMBL5083265) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <2.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of PI5P4Kbeta (unknown origin) by ADP-Glo assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01819
BindingDB Entry DOI: 10.7270/Q2SQ9493 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50584986
(CHEMBL5069855)Show SMILES CC(C)c1ccccc1-c1nc(NC(C)c2ccccn2)c2ccccc2n1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <2.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of PI5P4Kbeta (unknown origin) by ADP-Glo assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01819
BindingDB Entry DOI: 10.7270/Q2SQ9493 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50584987
(CHEMBL5076920) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <2.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of PI5P4Kbeta (unknown origin) by ADP-Glo assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01819
BindingDB Entry DOI: 10.7270/Q2SQ9493 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50584988
(CHEMBL5090399) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <2.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of PI5P4Kbeta (unknown origin) by ADP-Glo assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01819
BindingDB Entry DOI: 10.7270/Q2SQ9493 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50033288
((2-Phenyl-quinazolin-4-yl)-thiophen-2-ylmethyl-ami...)Show InChI InChI=1S/C19H15N3S/c1-2-7-14(8-3-1)18-21-17-11-5-4-10-16(17)19(22-18)20-13-15-9-6-12-23-15/h1-12H,13H2,(H,20,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
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| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | <2.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of PI5P4Kbeta (unknown origin) by ADP-Glo assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01819
BindingDB Entry DOI: 10.7270/Q2SQ9493 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50584990
(CHEMBL5077419) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <2.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of PI5P4Kbeta (unknown origin) by ADP-Glo assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01819
BindingDB Entry DOI: 10.7270/Q2SQ9493 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50584991
(CHEMBL5077987)Show SMILES FC(F)(F)c1ccccc1-c1nc(NCc2ccccn2)c2cccnc2n1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <2.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of PI5P4Kbeta (unknown origin) by ADP-Glo assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01819
BindingDB Entry DOI: 10.7270/Q2SQ9493 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50584992
(CHEMBL5085734) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
PDB
UniChem
| Article
PubMed
| n/a | n/a | <2.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of PI5P4Kbeta (unknown origin) by ADP-Glo assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01819
BindingDB Entry DOI: 10.7270/Q2SQ9493 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50584993
(CHEMBL5092753) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <2.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of PI5P4Kbeta (unknown origin) by ADP-Glo assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01819
BindingDB Entry DOI: 10.7270/Q2SQ9493 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50584989
(CHEMBL5084764) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <2.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of PI5P4Kbeta (unknown origin) by ADP-Glo assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01819
BindingDB Entry DOI: 10.7270/Q2SQ9493 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50497347
(CHEMBL1529478)Show InChI InChI=1S/C20H14F3N3S/c21-20(22,23)16-9-3-1-7-14(16)19-25-17-10-4-2-8-15(17)18(26-19)24-12-13-6-5-11-27-13/h1-11H,12H2,(H,24,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <2.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of PI5P4Kbeta (unknown origin) by ADP-Glo assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01819
BindingDB Entry DOI: 10.7270/Q2SQ9493 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50584981
(CHEMBL1394113) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <2.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of PI5P4Kbeta (unknown origin) by ADP-Glo assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01819
BindingDB Entry DOI: 10.7270/Q2SQ9493 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50527941
(CHEMBL4475338)Show SMILES FC(F)(F)c1ccc(cc1)-c1cncc(\C=C2/SC(=N)NC2=O)c1 Show InChI InChI=1S/C16H10F3N3OS/c17-16(18,19)12-3-1-10(2-4-12)11-5-9(7-21-8-11)6-13-14(23)22-15(20)24-13/h1-8H,(H2,20,22,23)/b13-6- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged recombinant PI5P4Kbeta (unknown origin) incubated for 1 hr in presence of DPPS and PI5P by ADP-Glo assay |
J Med Chem 63: 4880-4895 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00227
BindingDB Entry DOI: 10.7270/Q2SB4964 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50527936
(CHEMBL4559878)Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1cncc(\C=C2/CC(=O)NC2=O)c1 Show InChI InChI=1S/C17H15N3O4S/c1-25(23,24)20-15-4-2-12(3-5-15)14-7-11(9-18-10-14)6-13-8-16(21)19-17(13)22/h2-7,9-10,20H,8H2,1H3,(H,19,21,22)/b13-6+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged recombinant PI5P4Kbeta (unknown origin) incubated for 1 hr in presence of DPPS and PI5P by ADP-Glo assay |
J Med Chem 63: 4880-4895 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00227
BindingDB Entry DOI: 10.7270/Q2SB4964 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50527940
(CHEMBL4441998)Show InChI InChI=1S/C15H10FN3OS/c16-12-3-1-10(2-4-12)11-5-9(7-18-8-11)6-13-14(20)19-15(17)21-13/h1-8H,(H2,17,19,20)/b13-6- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged recombinant PI5P4Kbeta (unknown origin) incubated for 1 hr in presence of DPPS and PI5P by ADP-Glo assay |
J Med Chem 63: 4880-4895 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00227
BindingDB Entry DOI: 10.7270/Q2SB4964 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50527948
(CHEMBL4440465)Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1cncc(c1)-c1ccc2cc[nH]c2c1 Show InChI InChI=1S/C20H17N3O2S/c1-26(24,25)23-19-6-4-14(5-7-19)17-10-18(13-21-12-17)16-3-2-15-8-9-22-20(15)11-16/h2-13,22-23H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged recombinant PI5P4Kbeta (unknown origin) incubated for 1 hr in presence of DPPS and PI5P by ADP-Glo assay |
J Med Chem 63: 4880-4895 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00227
BindingDB Entry DOI: 10.7270/Q2SB4964 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50511412
(CHEMBL4550598)Show SMILES CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)NCc1cccc(Nc2cc(ncn2)-c2c[nH]c3ccccc23)c1 Show InChI InChI=1S/C32H31N7O2/c1-39(2)16-6-11-31(40)38-24-14-12-23(13-15-24)32(41)34-19-22-7-5-8-25(17-22)37-30-18-29(35-21-36-30)27-20-33-28-10-4-3-9-26(27)28/h3-15,17-18,20-21,33H,16,19H2,1-2H3,(H,34,41)(H,38,40)(H,35,36,37)/b11-6+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.98E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute
Curated by ChEMBL
| Assay Description
Inhibition of PI5P4Kbeta (unknown origin) incubated for 15 mins in presence of ATP by ADP-Glo assay |
ACS Med Chem Lett 11: 346-352 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00402
BindingDB Entry DOI: 10.7270/Q2TM7FDP |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50511411
(CHEMBL4563077)Show SMILES CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2cc(ncn2)-c2cccc(c2)-c2ccccc2)c1 Show InChI InChI=1S/C35H32N6O2/c1-41(2)20-8-15-34(42)39-29-18-16-26(17-19-29)35(43)40-31-14-7-13-30(22-31)38-33-23-32(36-24-37-33)28-12-6-11-27(21-28)25-9-4-3-5-10-25/h3-19,21-24H,20H2,1-2H3,(H,39,42)(H,40,43)(H,36,37,38)/b15-8+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.04E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute
Curated by ChEMBL
| Assay Description
Inhibition of PI5P4Kbeta (unknown origin) incubated for 15 mins in presence of ATP by ADP-Glo assay |
ACS Med Chem Lett 11: 346-352 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00402
BindingDB Entry DOI: 10.7270/Q2TM7FDP |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50511419
(CHEMBL4517979)Show SMILES CN(C)C\C=C\C(=O)NC1CCC(CC1)C(=O)Nc1cccc(Nc2cc(ncn2)-c2cnc3[nH]ccc3c2)c1 |(4.78,-11.85,;6.12,-11.08,;6.12,-9.54,;7.45,-11.85,;8.78,-11.08,;10.12,-11.85,;11.45,-11.08,;11.45,-9.54,;12.78,-11.85,;14.11,-11.08,;15.44,-11.85,;16.78,-11.08,;16.78,-9.54,;15.44,-8.77,;14.11,-9.54,;18.11,-8.77,;18.11,-7.23,;19.44,-9.54,;20.77,-8.77,;20.77,-7.23,;22.11,-6.46,;23.44,-7.24,;23.44,-8.76,;24.78,-9.53,;26.11,-8.76,;27.45,-9.54,;28.78,-8.76,;28.78,-7.23,;27.44,-6.46,;26.11,-7.22,;30.11,-9.53,;30.11,-11.08,;31.44,-11.84,;32.77,-11.07,;34.24,-11.54,;35.14,-10.3,;34.24,-9.05,;32.77,-9.53,;31.44,-8.76,;22.12,-9.54,)| Show InChI InChI=1S/C30H34N8O2/c1-38(2)14-4-7-28(39)36-23-10-8-20(9-11-23)30(40)37-25-6-3-5-24(16-25)35-27-17-26(33-19-34-27)22-15-21-12-13-31-29(21)32-18-22/h3-7,12-13,15-20,23H,8-11,14H2,1-2H3,(H,31,32)(H,36,39)(H,37,40)(H,33,34,35)/b7-4+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.18E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute
Curated by ChEMBL
| Assay Description
Inhibition of PI5P4Kbeta (unknown origin) incubated for 15 mins in presence of ATP by ADP-Glo assay |
ACS Med Chem Lett 11: 346-352 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00402
BindingDB Entry DOI: 10.7270/Q2TM7FDP |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50511417
(CHEMBL4464636)Show SMILES CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cc(Nc2cc(ncn2)-c2c[nH]c3ccccc23)ccc1C Show InChI InChI=1S/C32H31N7O2/c1-21-10-13-24(36-30-18-29(34-20-35-30)26-19-33-27-8-5-4-7-25(26)27)17-28(21)38-32(41)22-11-14-23(15-12-22)37-31(40)9-6-16-39(2)3/h4-15,17-20,33H,16H2,1-3H3,(H,37,40)(H,38,41)(H,34,35,36)/b9-6+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.36E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute
Curated by ChEMBL
| Assay Description
Inhibition of PI5P4Kbeta (unknown origin) incubated for 15 mins in presence of ATP by ADP-Glo assay |
ACS Med Chem Lett 11: 346-352 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00402
BindingDB Entry DOI: 10.7270/Q2TM7FDP |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50511425
(CHEMBL4572941)Show SMILES CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1ccc(Nc2cc(ncn2)-c2cnc3[nH]ccc3c2)cc1 Show InChI InChI=1S/C30H28N8O2/c1-38(2)15-3-4-28(39)36-24-7-5-20(6-8-24)30(40)37-25-11-9-23(10-12-25)35-27-17-26(33-19-34-27)22-16-21-13-14-31-29(21)32-18-22/h3-14,16-19H,15H2,1-2H3,(H,31,32)(H,36,39)(H,37,40)(H,33,34,35)/b4-3+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.56E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute
Curated by ChEMBL
| Assay Description
Inhibition of PI5P4Kbeta (unknown origin) incubated for 15 mins in presence of ATP by ADP-Glo assay |
ACS Med Chem Lett 11: 346-352 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00402
BindingDB Entry DOI: 10.7270/Q2TM7FDP |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Homo sapiens (Human)) | BDBM50527935
(CHEMBL4567681)Show SMILES CC(=O)Nc1cccc(c1)-c1cncc(c1)-c1ccc(NS(C)(=O)=O)cc1 Show InChI InChI=1S/C20H19N3O3S/c1-14(24)22-20-5-3-4-16(11-20)18-10-17(12-21-13-18)15-6-8-19(9-7-15)23-27(2,25)26/h3-13,23H,1-2H3,(H,22,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged recombinant PI5P4Kbeta (unknown origin) incubated for 1 hr in presence of DPPS and PI5P by ADP-Glo assay |
J Med Chem 63: 4880-4895 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00227
BindingDB Entry DOI: 10.7270/Q2SB4964 |
More data for this
Ligand-Target Pair | |
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