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Compile Data Set for Download or QSAR

Found 822 hits Enz. Inhib. hit(s) with Target = 'Polymerase basic protein 2'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552303
PNG
(US11312727, Compound 123A)
Show SMILES Oc1c2C(=O)N3CN([C@H](c4ccccc4C4CC4)c4cccc(Cl)c4OC\C=C\C3)n2ccc1=O |r,t:30|
PDB

UniProtKB/SwissProt

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n/an/a 0.400n/an/an/an/an/an/a


TBA

Assay Description
EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552356
PNG
((17a*R,*E)-24,25-difluoro-12-hydroxy-2,6,9,17a-tet...)
Show SMILES Oc1c2C(=O)N3CN([C@@H]4c5ccccc5SCc5c(F)c(F)cc(OC\C=C/C3)c45)n2ccc1=O |r,c:27|
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UniProtKB/SwissProt

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n/an/a 1n/an/an/an/an/an/a


TBA

Assay Description
EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552337
PNG
(US11312727, Compound 136A)
Show SMILES Oc1c2C(=O)N3CN([C@H](c4ccccc4C4CC4)c4ccc(F)c(F)c4OC\C=C/C3)n2ccc1=O |r,c:31|
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n/an/a 1n/an/an/an/an/an/a


TBA

Assay Description
EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552377
PNG
(US11312727, Compound 152BA)
Show SMILES Oc1c2C(=O)N3CN([C@H](c4ccccc4)c4ccc(F)c(F)c4OC\C=C\[C@@H]3C3CC3)n2ccc1=O |r,t:27|
PDB

UniProtKB/SwissProt

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n/an/a 1.20n/an/an/an/an/an/a


TBA

Assay Description
EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552440
PNG
(US11312727, Compound 175A)
Show SMILES Oc1c2C(=O)N3CN([C@H](c4ccccc4CF)c4ccc(F)c(F)c4OC\C=C/C3)n2ccc1=O |r,c:29|
PDB

UniProtKB/SwissProt

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n/an/a 1.90n/an/an/an/an/an/a


TBA

Assay Description
EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552297
PNG
((18*R,*Z)-4-fluoro-12-hydroxy-18-(2-(methylthio)ph...)
Show SMILES CSc1ccccc1[C@H]1N2CN(C\C=C/COc3c(F)cccc13)C(=O)c1c(O)c(=O)ccn21 |r,c:14|
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n/an/a 2n/an/an/an/an/an/a


TBA

Assay Description
EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552278
PNG
((17a′*R,*E)-24′,25′-difluoro-12&...)
Show SMILES Oc1c2C(=O)N3CN([C@@H]4c5ccccc5SCc5c(F)c(F)cc(OC\C=C\C33CC3)c45)n2ccc1=O |r,t:27|
PDB

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TBA

Assay Description
EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552406
PNG
((9*R,17a*R,*E)-24,25-difluoro-12-hydroxy-9-methyl-...)
Show SMILES C[C@H]1\C=C/COc2cc(F)c(F)c3CSc4ccccc4C(N4CN1C(=O)c1c(O)c(=O)ccn41)c23 |r,c:2|
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n/an/a 2n/an/an/an/an/an/a


TBA

Assay Description
EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552314
PNG
((13*S,21a*R,Z)-13-ethyl-24,25-difluoro-16-hydroxy-...)
Show SMILES CC[C@@H]1\C=C/COc2cc(F)c(F)c3CSc4ccccc4[C@@H](N4CN1C(=O)c1c(O)c(=O)ccn41)c23 |r,c:3|
PDB

UniProtKB/SwissProt

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n/an/a 2.40n/an/an/an/an/an/a


TBA

Assay Description
EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552388
PNG
(US11312727, Compound 155A)
Show SMILES Cc1ccccc1[C@H]1N2CN(C\C=C/COc3c(F)c(F)ccc13)C(=O)c1c(O)c(=O)ccn21 |r,c:13|
PDB

UniProtKB/SwissProt

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n/an/a 2.80n/an/an/an/an/an/a


TBA

Assay Description
EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552350
PNG
(US11312727, Compound 140B)
Show SMILES Oc1c2C(=O)N3CN([C@@H]4c5ccccc5SCc5c(F)c(F)cc(OC\C=C\C3)c45)n2ccc1=O |r,t:27|
PDB

UniProtKB/SwissProt

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n/an/a 3n/an/an/an/an/an/a


TBA

Assay Description
EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552344
PNG
(US11312727, Compound 138D)
Show SMILES C[C@H]1\C=C\COc2cccc3CSc4ccccc4[C@@H](N4CN1C(=O)c1c(O)c(=O)ccn41)c23 |r,t:2|
PDB

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n/an/a 3n/an/an/an/an/an/a


TBA

Assay Description
EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552336
PNG
(US11312727, Compound 108D)
Show SMILES Oc1c2C(=O)N3CN([C@@H]4c5ccccc5SCc5c(F)c(F)cc(OC\C=C/C33CC3)c45)n2ccc1=O |r,c:27|
PDB

UniProtKB/SwissProt

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n/an/a 3n/an/an/an/an/an/a


TBA

Assay Description
EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552147
PNG
(US11312727, Compound 46B)
Show SMILES Oc1c2C(=O)N3CN([C@@H]4c5ccccc5SCc5cccc(OC\C=C/C3)c45)n2ccc1=O |r,c:25|
PDB

UniProtKB/SwissProt

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n/an/a 3n/an/an/an/an/an/a


TBA

Assay Description
EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552255
PNG
(US11312727, Compound 100AA)
Show SMILES C[C@H]1C\C=C\COc2c(F)cccc2[C@H](N2CN1C(=O)c1c(O)c(=O)ccn21)c1ccccc1 |r,t:3|
PDB

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n/an/a 3n/an/an/an/an/an/a


TBA

Assay Description
EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552412
PNG
(US11312727, Compound 165A)
Show SMILES Oc1c2C(=O)N3CN([C@H](c4ccccc4C(F)F)c4ccc(F)c(F)c4OC\C=C/C3)n2ccc1=O |r,c:30|
PDB

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n/an/a 3n/an/an/an/an/an/a


TBA

Assay Description
EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552313
PNG
(US11312727, Compound 126BA)
Show SMILES CC[C@H]1\C=C\COc2cc(F)c(F)c3CSc4ccccc4[C@@H](N4CN1C(=O)c1c(O)c(=O)ccn41)c23 |r,t:3|
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n/an/a 3.40n/an/an/an/an/an/a


TBA

Assay Description
EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552439
PNG
((18′*R,*E)-3′,4′-difluoro-12R...)
Show SMILES Cc1ccccc1[C@@H]1N2CN(C(=O)c3c(O)c(=O)ccn23)C2(CCC2)\C=C\COc2c(F)c(F)ccc12 |r,t:29|
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n/an/a 3.80n/an/an/an/an/an/a


TBA

Assay Description
EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552291
PNG
(US11312727, Compound 116A)
Show SMILES Oc1c2C(=O)N3CN([C@@H](c4ccccc4)c4ccc(F)c(F)c4OC\C=C/CC3)n2ccc1=O |r,c:27|
PDB

UniProtKB/SwissProt

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TBA

Assay Description
EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552341
PNG
(US11312727, Compound 138AA)
Show SMILES C[C@H]1\C=C/COc2cccc3CSc4ccccc4[C@@H](N4CN1C(=O)c1c(O)c(=O)ccn41)c23 |r,c:2|
PDB

UniProtKB/SwissProt

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n/an/a 4n/an/an/an/an/an/a


TBA

Assay Description
EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552287
PNG
(US11312727, Compound 114A)
Show SMILES Oc1c2C(=O)N3CN([C@H](c4ccccc4)c4cccc(F)c4OCCCC3)n2ccc1=O |r|
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TBA

Assay Description
EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552381
PNG
(US11312727, Compound 153BB)
Show SMILES COC[C@H]1\C=C\COc2c(F)c(F)ccc2[C@H](N2CN1C(=O)c1c(O)c(=O)ccn21)c1ccccc1 |r,t:4|
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Assay Description
EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552261
PNG
(US11312727, Compound 102A)
Show SMILES Oc1c2C(=O)N3CN([C@H](c4ccccc4)c4ccc(F)c(F)c4OC\C=C\C33CC3)n2ccc1=O |r,t:27|
PDB

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TBA

Assay Description
EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552292
PNG
(US11312727, Compound 117A)
Show SMILES COc1ccccc1[C@H]1N2CN(C\C=C/COc3c(F)cccc13)C(=O)c1c(O)c(=O)ccn21 |r,c:14|
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Assay Description
EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552385
PNG
(US11312727, Compound 154BB)
Show SMILES CC[C@H]1\C=C\COc2c(F)cccc2[C@@H](N2CN1C(=O)c1c(O)c(=O)ccn21)c1ccccn1 |r,t:3|
PDB

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n/an/a 4.20n/an/an/an/an/an/a


TBA

Assay Description
EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552404
PNG
(US11312727, Compound 162B)
Show SMILES C[C@H]1\C=C\COc2cc(F)c(F)c3CSc4ccccc4[C@@H](N4CN1C(=O)c1c(O)c(=O)ccn41)c23 |r,t:2|
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n/an/a 4.30n/an/an/an/an/an/a


TBA

Assay Description
EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552369
PNG
(US11312727, Compound 148AA)
Show SMILES C[C@@H]1\C=C\COc2c(F)c(F)ccc2[C@H](N2CN1C(=O)c1c(O)c(=O)ccn21)c1ccccc1 |r,t:2|
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n/an/a 4.60n/an/an/an/an/an/a


TBA

Assay Description
EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552378
PNG
(US11312727, Compound 152BB)
Show SMILES Oc1c2C(=O)N3CN([C@H](c4ccccc4)c4ccc(F)c(F)c4OC\C=C\[C@H]3C3CC3)n2ccc1=O |r,t:27|
PDB

UniProtKB/SwissProt

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n/an/a 4.80n/an/an/an/an/an/a


TBA

Assay Description
EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552259
PNG
(US11312727, Compound 101AA)
Show SMILES CC[C@H]1\C=C\COc2c(F)c(F)ccc2[C@H](N2CN1C(=O)c1c(O)c(=O)ccn21)c1ccccc1 |r,t:3|
PDB

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TBA

Assay Description
EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552444
PNG
((3*R,17a′*R,*E)-24′,25′-difluoro...)
Show SMILES Oc1c2C(=O)N3CN([C@@H]4c5ccccc5SCc5c(F)c(F)cc(OC\C=C\[C@]33CCOC3)c45)n2ccc1=O |r,t:27|
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EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552421
PNG
((21a′*R,*E)-24′,25′-difluoro-16&...)
Show SMILES Oc1c2C(=O)N3CN([C@@H]4c5ncccc5SCc5c(F)c(F)cc(OC\C=C\C33CCC3)c45)n2ccc1=O |r,t:27|
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EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552446
PNG
(US11312727, Compound 177AB)
Show SMILES COC[C@@H]1\C=C\COc2cc(F)c(F)c3CSc4ccccc4[C@H](N4CN1C(=O)c1c(O)c(=O)ccn41)c23 |r,t:4|
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EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552416
PNG
(US11312727, Compound 167AA)
Show SMILES CC[C@H]1\C=C\COc2c(F)c(F)ccc2[C@H](N2CN1C(=O)c1c(O)c(=O)ccn21)c1ccccc1C |r,t:3|
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EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552423
PNG
(US11312727, Compound 169BB)
Show SMILES CC(C)[C@@H]1\C=C\COc2cc(F)c(F)c3CSc4ccccc4[C@H](N4CN1C(=O)c1c(O)c(=O)ccn41)c23 |r,t:4|
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EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552316
PNG
((1a*S,11b*S,20a*S)-22,23-difluoro-17-hydroxy-1a,2,...)
Show SMILES Oc1c2C(=O)N3CN([C@@H]4c5ccccc5SCc5c(F)c(F)cc(OC[C@H]6C[C@@H]6C3)c45)n2ccc1=O |r|
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EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552324
PNG
(US11312727, Compound 131AB)
Show SMILES Oc1c2C(=O)N3CN([C@H]4c5ccccc5SCc5cccc(OC[C@H]6CC6CC3)c45)n2ccc1=O |r|
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EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552418
PNG
(US11312727, Compound 167AB)
Show SMILES CC[C@@H]1\C=C\COc2c(F)c(F)ccc2[C@H](N2CN1C(=O)c1c(O)c(=O)ccn21)c1ccccc1C |r,t:3|
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EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552276
PNG
((17a′*R,*E)-12′-hydroxy-2′,17a&#...)
Show SMILES Oc1c2C(=O)N3CN([C@@H]4c5ccccc5SCc5cccc(OC\C=C\C33CC3)c45)n2ccc1=O |r,t:25|
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EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552267
PNG
(US11312727, Compound 101AB)
Show SMILES CC[C@@H]1\C=C\COc2c(F)c(F)ccc2[C@H](N2CN1C(=O)c1c(O)c(=O)ccn21)c1ccccc1 |r,t:3|
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EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552230
PNG
((23b*R, Z)-16,17-difluoro-6-hydroxy-10,13,18,23b-t...)
Show SMILES Oc1c2C(=O)N3CN([C@@H]4c5ccccc5SCc5c(F)c(F)cc(OC\C=C\CC3)c45)n2ccc1=O |r,t:27|
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EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552225
PNG
(US11312727, Compound 88B)
Show SMILES Oc1c2C(=O)N3CN([C@@H]4c5ccccc5SCc5c(F)c(F)cc(OC\C=C/CC3)c45)n2ccc1=O |r,c:27|
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EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552353
PNG
(US11312727, Compound 141AB)
Show SMILES C[C@H]1\C=C\COc2c(F)cccc2[C@H](N2CN1C(=O)c1c(O)c(=O)ccn21)c1ccccc1 |r,t:2|
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EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552164
PNG
((*Z)-4-hydroxy-15-phenyl-8,15-dihydro-7H-6,16-meth...)
Show SMILES Oc1c2C(=O)N3CN([C@@H](c4ccccc4)c4ccccc4\C=C/CCC3)n2ccc1=O |r,c:23|
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EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552195
PNG
((18*R,Z)-3,4-difluoro-12-hydroxy-18-phenyl-6,9-dih...)
Show SMILES Oc1c2C(=O)N3CN([C@@H](c4ccccc4)c4ccc(F)c(F)c4OC\C=C/C3)n2ccc1=O |r,c:27|
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EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552370
PNG
(US11312727, Compound 148BB)
Show SMILES C[C@H]1\C=C\COc2c(F)c(F)ccc2[C@@H](N2CN1C(=O)c1c(O)c(=O)ccn21)c1ccccc1 |r,t:2|
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EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552365
PNG
(US11312727, Compound 146A)
Show SMILES Oc1c2C(=O)N3CN([C@H](c4ccccc4)c4ccc(F)c(F)c4OC\C=C\C33CCC3)n2ccc1=O |r,t:27|
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EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552443
PNG
(US11312727, Compound 176BA)
Show SMILES Oc1c2C(=O)N3CN([C@@H]4c5ccccc5SCc5c(F)c(F)cc(OC\C=C\[C@@]33CCOC3)c45)n2ccc1=O |r,t:27|
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EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552427
PNG
(US11312727, Compound 170BB)
Show SMILES CC[C@@H]1\C=C\COc2c(F)c(Cl)ccc2[C@H](N2CN1C(=O)c1c(O)c(=O)ccn21)c1ccccc1 |r,t:3|
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EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552437
PNG
((9*S,18*S,*E)-4-chloro-9-ethyl-3-fluoro-12-hydroxy...)
Show SMILES CC[C@H]1\C=C\COc2c(Cl)c(F)ccc2[C@H](N2CN1C(=O)c1c(O)c(=O)ccn21)c1ccccc1 |r,t:3|
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EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
Polymerase basic protein 2


(Influenza A virus (strain A/WS/1933 H1N1))
BDBM552363
PNG
(US11312727, Compound 145A)
Show SMILES Oc1c2C(=O)N3CN([C@H](c4ccccc4)c4cccc(F)c4OC\C=C\C33CCC3)n2ccc1=O |r,t:26|
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EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2P272BG
More data for this
Ligand-Target Pair
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