BindingDB PrimarySearch

Found 14 hits Enz. Inhib. hit(s) with Target = 'Ribonucleoside-diphosphate reductase subunit M2'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Ribonucleoside-diphosphate reductase subunit M2 (Homo sapiens (Human))	BDBM50198892 (3-AP \| 3-aminopyridine-2-carboxaldehyde thiosemica...) Show SMILES NC(=S)N\N=C\c1ncccc1N Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	185	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human RRM2 expressed in Escherichia coli BL21-codon plus(DE3) using [14C]-ADP as substrate after 3 mins by liquid scintillation countin...				J Med Chem 61: 666-680 (2018) Article DOI: 10.1021/acs.jmedchem.7b00530 BindingDB Entry DOI: 10.7270/Q2W098CB
Case Western Reserve University Curated by ChEMBL					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase subunit M2 (Homo sapiens (Human))	BDBM50051772 ((Z)-N'-(5-amino-6-formylpyridin-2-yl)carbamohydraz...) Show SMILES NC(=S)NNc1ccc(N)c(C=O)n1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	820	n/a	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description Inhibitory activity against CDP reductase.				J Med Chem 39: 2586-93 (1996) Article DOI: 10.1021/jm9600454 BindingDB Entry DOI: 10.7270/Q2KS6QN9
Yale University Curated by ChEMBL					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase subunit M2 (Homo sapiens (Human))	BDBM50051768 ((1Z,N'E)-N'-((3-(methylamino)pyridin-2-yl)methylen...) Show SMILES CNc1cccnc1C=NNC(N)=S \|w:8.8\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description Inhibitory activity against CDP reductase.				J Med Chem 39: 2586-93 (1996) Article DOI: 10.1021/jm9600454 BindingDB Entry DOI: 10.7270/Q2KS6QN9
Yale University Curated by ChEMBL					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase subunit M2 (Homo sapiens (Human))	BDBM50051776 ((1Z,N'E)-N'-((5-(ethylamino)pyridin-2-yl)methylene...) Show SMILES CCNc1ccc(C=NNC(N)=S)nc1 \|w:7.6\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description Inhibitory activity against CDP reductase.				J Med Chem 39: 2586-93 (1996) Article DOI: 10.1021/jm9600454 BindingDB Entry DOI: 10.7270/Q2KS6QN9
Yale University Curated by ChEMBL					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase subunit M2 (Homo sapiens (Human))	BDBM50051769 ((1Z,N'E)-N'-((5-(methylamino)pyridin-2-yl)methylen...) Show SMILES CNc1ccc(C=NNC(N)=S)nc1 \|w:6.5\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description Inhibitory activity against CDP reductase.				J Med Chem 39: 2586-93 (1996) Article DOI: 10.1021/jm9600454 BindingDB Entry DOI: 10.7270/Q2KS6QN9
Yale University Curated by ChEMBL					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase subunit M2 (Homo sapiens (Human))	BDBM50051775 ((1Z,N'E)-N'-((5-(allylamino)pyridin-2-yl)methylene...) Show SMILES NC(=S)NN=Cc1ccc(NCC=C)cn1 \|w:5.5\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description Inhibitory activity against CDP reductase.				J Med Chem 39: 2586-93 (1996) Article DOI: 10.1021/jm9600454 BindingDB Entry DOI: 10.7270/Q2KS6QN9
Yale University Curated by ChEMBL					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase subunit M2 (Homo sapiens (Human))	BDBM50051767 ((1Z,N'E)-N'-((5-(propylamino)pyridin-2-yl)methylen...) Show SMILES CCCNc1ccc(C=NNC(N)=S)nc1 \|w:8.7\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description Inhibitory activity against CDP reductase.				J Med Chem 39: 2586-93 (1996) Article DOI: 10.1021/jm9600454 BindingDB Entry DOI: 10.7270/Q2KS6QN9
Yale University Curated by ChEMBL					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase subunit M2 (Homo sapiens (Human))	BDBM50051774 ((1Z,N'E)-N'-((3-(allylamino)pyridin-2-yl)methylene...) Show SMILES NC(=S)NN=Cc1ncccc1NCC=C \|w:5.5\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description Inhibitory activity against CDP reductase.				J Med Chem 39: 2586-93 (1996) Article DOI: 10.1021/jm9600454 BindingDB Entry DOI: 10.7270/Q2KS6QN9
Yale University Curated by ChEMBL					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase subunit M2 (Homo sapiens (Human))	BDBM50051777 ((1Z,N'E)-N'-((5-(aminomethyl)pyridin-2-yl)methylen...) Show SMILES NCc1ccc(C=NNC(N)=S)nc1 \|w:6.5\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description Inhibitory activity against CDP reductase.				J Med Chem 39: 2586-93 (1996) Article DOI: 10.1021/jm9600454 BindingDB Entry DOI: 10.7270/Q2KS6QN9
Yale University Curated by ChEMBL					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase subunit M2 (Homo sapiens (Human))	BDBM50051766 ((1Z,N'E)-N'-((5-(butylamino)pyridin-2-yl)methylene...) Show SMILES CCCCNc1ccc(C=NNC(N)=S)nc1 \|w:9.8\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description Inhibitory activity against CDP reductase.				J Med Chem 39: 2586-93 (1996) Article DOI: 10.1021/jm9600454 BindingDB Entry DOI: 10.7270/Q2KS6QN9
Yale University Curated by ChEMBL					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase subunit M2 (Homo sapiens (Human))	BDBM50051773 ((Z)-N'-(3-amino-6-formylpyridin-2-yl)carbamohydraz...) Show SMILES NC(=S)NNc1nc(C=O)ccc1N Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description Inhibitory activity against CDP reductase.				J Med Chem 39: 2586-93 (1996) Article DOI: 10.1021/jm9600454 BindingDB Entry DOI: 10.7270/Q2KS6QN9
Yale University Curated by ChEMBL					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase subunit M2 (Homo sapiens (Human))	BDBM50051771 ((1Z,N'E)-N'-((3,5-diaminopyridin-2-yl)methylene)ca...) Show SMILES NC(=S)NN=Cc1ncc(N)cc1N \|w:4.3\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description Inhibitory activity against CDP reductase.				J Med Chem 39: 2586-93 (1996) Article DOI: 10.1021/jm9600454 BindingDB Entry DOI: 10.7270/Q2KS6QN9
Yale University Curated by ChEMBL					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase subunit M2 (Homo sapiens (Human))	BDBM50051770 ((1Z,N'E)-N'-((5-amino-4-(morpholinomethyl)pyridin-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description Inhibitory activity against CDP reductase.				J Med Chem 39: 2586-93 (1996) Article DOI: 10.1021/jm9600454 BindingDB Entry DOI: 10.7270/Q2KS6QN9
Yale University Curated by ChEMBL					More data for this Ligand-Target Pair
Ribonucleoside-diphosphate reductase subunit M2 (Homo sapiens (Human))	BDBM50247408 (CHEMBL4067105) Show SMILES Oc1ccccc1C(=O)N\N=C\c1c(O)ccc2ccccc12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.23E+5	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description Inhibition of human RRM2 expressed in Escherichia coli BL21-codon plus(DE3) using [14C]-ADP as substrate after 3 mins by liquid scintillation countin...				J Med Chem 61: 666-680 (2018) Article DOI: 10.1021/acs.jmedchem.7b00530 BindingDB Entry DOI: 10.7270/Q2W098CB
Case Western Reserve University Curated by ChEMBL					More data for this Ligand-Target Pair