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Compile Data Set for Download or QSAR

Found 137 hits Enz. Inhib. hit(s) with Target = 'Serine hydroxymethyltransferase, cytosolic'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM18796
PNG
((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)
Show SMILES Nc1nc2[nH]cc(CCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)c2c(=O)[nH]1 |r|
Show InChI InChI=1S/C20H21N5O6/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29)/t13-/m0/s1
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Article
PubMed
1.91E+4n/an/an/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant Serine hydroxymethyltransferase, cytosolic by spectrophotometry


Eur J Med Chem 46: 1616-21 (2011)


Article DOI: 10.1016/j.ejmech.2011.02.009
BindingDB Entry DOI: 10.7270/Q22V2H35
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM18796
PNG
((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)
Show SMILES Nc1nc2[nH]cc(CCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)c2c(=O)[nH]1 |r|
Show InChI InChI=1S/C20H21N5O6/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29)/t13-/m0/s1
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3.30E+4n/an/an/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Serine hydroxymethyltransferase, cytosolic measured by slope intercepts of mixed-type inhibition against compound con...


Eur J Med Chem 46: 1616-21 (2011)


Article DOI: 10.1016/j.ejmech.2011.02.009
BindingDB Entry DOI: 10.7270/Q22V2H35
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM18796
PNG
((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)
Show SMILES Nc1nc2[nH]cc(CCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)c2c(=O)[nH]1 |r|
Show InChI InChI=1S/C20H21N5O6/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29)/t13-/m0/s1
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1.86E+5n/an/an/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Mixed-type inhibition of human recombinant Serine hydroxymethyltransferase, cytosolic measured by Y-axes intercepts of mixed-type inhibition against ...


Eur J Med Chem 46: 1616-21 (2011)


Article DOI: 10.1016/j.ejmech.2011.02.009
BindingDB Entry DOI: 10.7270/Q22V2H35
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285658
PNG
(US10077273, Compound 4 | US10584132, Compound 4 | ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCC(O)=O |c:13|
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n/an/a 0.170n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10934305 (2021)


BindingDB Entry DOI: 10.7270/Q2KK9FXN
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285663
PNG
(US10077273, Compound 11 | US10584132, Compound 11 ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCC(N)=O |c:13|
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n/an/a 0.400n/an/an/an/a7.4n/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)


BindingDB Entry DOI: 10.7270/Q2DR2XHK
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285659
PNG
(US10077273, Compound 68 | US10584132, Compound 68 ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C#CCCC(O)=O)C#N |c:13|
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n/an/a 0.400n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10934305 (2021)


BindingDB Entry DOI: 10.7270/Q2KK9FXN
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285663
PNG
(US10077273, Compound 11 | US10584132, Compound 11 ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCC(N)=O |c:13|
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n/an/a 0.400n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent




US Patent US10584132 (2020)


BindingDB Entry DOI: 10.7270/Q2K939XZ
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285660
PNG
(US10077273, Compound 1 | US10584132, Compound 1 | ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCCO |c:13|
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n/an/a 0.650n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10934305 (2021)


BindingDB Entry DOI: 10.7270/Q2KK9FXN
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285660
PNG
(US10077273, Compound 1 | US10584132, Compound 1 | ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCCO |c:13|
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n/an/a 0.790n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10934305 (2021)


BindingDB Entry DOI: 10.7270/Q2KK9FXN
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285661
PNG
(US10077273, Compound 69 | US10584132, Compound 69 ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCC(=O)N[C@@H](CCC(O)=O)C(O)=O |r,c:13|
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n/an/a 0.800n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10934305 (2021)


BindingDB Entry DOI: 10.7270/Q2KK9FXN
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285662
PNG
(US10077273, Compound 70 | US10584132, Compound 70 ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCC(=O)N[C@H](CCC(O)=O)C(O)=O |r,c:13|
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n/an/a 1n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10934305 (2021)


BindingDB Entry DOI: 10.7270/Q2KK9FXN
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285663
PNG
(US10077273, Compound 11 | US10584132, Compound 11 ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCC(N)=O |c:13|
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n/an/a 1.40n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10934305 (2021)


BindingDB Entry DOI: 10.7270/Q2KK9FXN
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285664
PNG
(US10077273, Compound 71 | US10584132, Compound 71 ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C#CCCCO)C#N |c:13|
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n/an/a 1.70n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10934305 (2021)


BindingDB Entry DOI: 10.7270/Q2KK9FXN
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285659
PNG
(US10077273, Compound 68 | US10584132, Compound 68 ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C#CCCC(O)=O)C#N |c:13|
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n/an/a 1.70n/an/an/an/a7.4n/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)


BindingDB Entry DOI: 10.7270/Q2DR2XHK
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285659
PNG
(US10077273, Compound 68 | US10584132, Compound 68 ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C#CCCC(O)=O)C#N |c:13|
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n/an/a 1.70n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent




US Patent US10584132 (2020)


BindingDB Entry DOI: 10.7270/Q2K939XZ
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285666
PNG
(US10077273, Compound 2 | US10584132, Compound 2 | ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCO |c:13|
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n/an/a 2n/an/an/an/a7.4n/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)


BindingDB Entry DOI: 10.7270/Q2DR2XHK
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285666
PNG
(US10077273, Compound 2 | US10584132, Compound 2 | ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCO |c:13|
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n/an/a 2n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent




US Patent US10584132 (2020)


BindingDB Entry DOI: 10.7270/Q2K939XZ
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285665
PNG
(US10077273, Compound 72 | US10584132, Compound 72 ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCC(=O)NC(C)(C)C(O)=O |c:13|
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The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10934305 (2021)


BindingDB Entry DOI: 10.7270/Q2KK9FXN
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285664
PNG
(US10077273, Compound 71 | US10584132, Compound 71 ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C#CCCCO)C#N |c:13|
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The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)


BindingDB Entry DOI: 10.7270/Q2DR2XHK
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285664
PNG
(US10077273, Compound 71 | US10584132, Compound 71 ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C#CCCCO)C#N |c:13|
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The Trustees of Princeton University

US Patent




US Patent US10584132 (2020)


BindingDB Entry DOI: 10.7270/Q2K939XZ
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285665
PNG
(US10077273, Compound 72 | US10584132, Compound 72 ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCC(=O)NC(C)(C)C(O)=O |c:13|
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The Trustees of Princeton University

US Patent




US Patent US10584132 (2020)


BindingDB Entry DOI: 10.7270/Q2K939XZ
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285665
PNG
(US10077273, Compound 72 | US10584132, Compound 72 ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCC(=O)NC(C)(C)C(O)=O |c:13|
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n/an/a 4n/an/an/an/a7.4n/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)


BindingDB Entry DOI: 10.7270/Q2DR2XHK
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285666
PNG
(US10077273, Compound 2 | US10584132, Compound 2 | ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCO |c:13|
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n/an/a 4n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10934305 (2021)


BindingDB Entry DOI: 10.7270/Q2KK9FXN
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285688
PNG
(US10077273, Compound HK-X2 | US10934305, Compound ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(CO)cc(c1)-c1ccccc1 |c:13|
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n/an/a 5n/an/an/an/a7.4n/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)


BindingDB Entry DOI: 10.7270/Q2DR2XHK
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285686
PNG
(US10077273, Compound HK-16 | US10077273, Compound ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C(F)(F)F |c:13|
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n/an/a 5n/an/an/an/a7.4n/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)


BindingDB Entry DOI: 10.7270/Q2DR2XHK
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285686
PNG
(US10077273, Compound HK-16 | US10077273, Compound ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C(F)(F)F |c:13|
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The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)


BindingDB Entry DOI: 10.7270/Q2DR2XHK
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285667
PNG
(US10077273, Compound 73 | US10584132, Compound 73 ...)
Show SMILES COC(=O)CCC#Cc1cc(cc(c1)C1(C(C)C)c2c(C)n[nH]c2OC(N)=C1C#N)C(F)(F)F |c:28|
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The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10934305 (2021)


BindingDB Entry DOI: 10.7270/Q2KK9FXN
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285689
PNG
(US10077273, Compound HK-X3 | US10934305, Compound ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(CO)cc(c1)-c1cccc(CC(N)=O)c1 |c:13|
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The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10934305 (2021)


BindingDB Entry DOI: 10.7270/Q2KK9FXN
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285668
PNG
(US10077273, Compound 8 | US10584132, Compound 8 | ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCCN |c:13|
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The Trustees of Princeton University

US Patent




US Patent US10584132 (2020)


BindingDB Entry DOI: 10.7270/Q2K939XZ
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285668
PNG
(US10077273, Compound 8 | US10584132, Compound 8 | ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCCN |c:13|
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The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)


BindingDB Entry DOI: 10.7270/Q2DR2XHK
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285687
PNG
(US10077273, Compound HK-X1 | US10934305, Compound ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)N1CCCC1 |c:13|
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The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)


BindingDB Entry DOI: 10.7270/Q2DR2XHK
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285688
PNG
(US10077273, Compound HK-X2 | US10934305, Compound ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(CO)cc(c1)-c1ccccc1 |c:13|
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The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10934305 (2021)


BindingDB Entry DOI: 10.7270/Q2KK9FXN
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM485192
PNG
(US10934305, Compound HK-16 (PK-2))
Show SMILES CC(C)[C@@]1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C(F)(F)F |r,c:13|
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n/an/a 15n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10934305 (2021)


BindingDB Entry DOI: 10.7270/Q2KK9FXN
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285689
PNG
(US10077273, Compound HK-X3 | US10934305, Compound ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(CO)cc(c1)-c1cccc(CC(N)=O)c1 |c:13|
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The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)


BindingDB Entry DOI: 10.7270/Q2DR2XHK
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285669
PNG
(US10077273, Compound 74 | US10584132, Compound 74 ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(CO)cc(c1)C#CCCCO |c:13|
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The Trustees of Princeton University

US Patent




US Patent US10584132 (2020)


BindingDB Entry DOI: 10.7270/Q2K939XZ
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285669
PNG
(US10077273, Compound 74 | US10584132, Compound 74 ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(CO)cc(c1)C#CCCCO |c:13|
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n/an/a 17n/an/an/an/a7.4n/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)


BindingDB Entry DOI: 10.7270/Q2DR2XHK
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285669
PNG
(US10077273, Compound 74 | US10584132, Compound 74 ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(CO)cc(c1)C#CCCCO |c:13|
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n/an/a 19n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10934305 (2021)


BindingDB Entry DOI: 10.7270/Q2KK9FXN
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285685
PNG
(US10077273, Compound HK-15 | US10934305, Compound ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(Cl)cc(c1)C(F)(F)F |c:13|
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The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)


BindingDB Entry DOI: 10.7270/Q2DR2XHK
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285686
PNG
(US10077273, Compound HK-16 | US10077273, Compound ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C(F)(F)F |c:13|
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The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)


BindingDB Entry DOI: 10.7270/Q2DR2XHK
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285686
PNG
(US10077273, Compound HK-16 | US10077273, Compound ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C(F)(F)F |c:13|
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The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10934305 (2021)


BindingDB Entry DOI: 10.7270/Q2KK9FXN
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285685
PNG
(US10077273, Compound HK-15 | US10934305, Compound ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(Cl)cc(c1)C(F)(F)F |c:13|
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The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10934305 (2021)


BindingDB Entry DOI: 10.7270/Q2KK9FXN
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285690
PNG
(6-amino-4-(3-bromo-5-(trifluoromethyl)phenyl)-4-is...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(Br)cc(c1)C(F)(F)F |c:13|
PDB
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n/an/a 42n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10934305 (2021)


BindingDB Entry DOI: 10.7270/Q2KK9FXN
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285668
PNG
(US10077273, Compound 8 | US10584132, Compound 8 | ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCCN |c:13|
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The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10934305 (2021)


BindingDB Entry DOI: 10.7270/Q2KK9FXN
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285687
PNG
(US10077273, Compound HK-X1 | US10934305, Compound ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)N1CCCC1 |c:13|
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The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10934305 (2021)


BindingDB Entry DOI: 10.7270/Q2KK9FXN
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285684
PNG
(US10077273, Compound HK-14 | US10934305, Compound ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(Cl)cc(Cl)c1 |c:13|
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The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)


BindingDB Entry DOI: 10.7270/Q2DR2XHK
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285685
PNG
(US10077273, Compound HK-15 | US10934305, Compound ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(Cl)cc(c1)C(F)(F)F |c:13|
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The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10934305 (2021)


BindingDB Entry DOI: 10.7270/Q2KK9FXN
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285684
PNG
(US10077273, Compound HK-14 | US10934305, Compound ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(Cl)cc(Cl)c1 |c:13|
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The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10934305 (2021)


BindingDB Entry DOI: 10.7270/Q2KK9FXN
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285682
PNG
(US10077273, Compound HK-12 | US10934305, Compound ...)
Show SMILES Cc1n[nH]c2OC(N)=C(C#N)C(C3CCC3)(c12)c1cc(cc(c1)C(F)(F)F)C(F)(F)F |t:7|
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The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10934305 (2021)


BindingDB Entry DOI: 10.7270/Q2KK9FXN
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM285682
PNG
(US10077273, Compound HK-12 | US10934305, Compound ...)
Show SMILES Cc1n[nH]c2OC(N)=C(C#N)C(C3CCC3)(c12)c1cc(cc(c1)C(F)(F)F)C(F)(F)F |t:7|
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The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)


BindingDB Entry DOI: 10.7270/Q2DR2XHK
More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens (Human))
BDBM485179
PNG
(US10934305, Compound HK-5 | US10934305, Compound H...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cccc(c1)C(F)(F)F |c:13|
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The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10934305 (2021)


BindingDB Entry DOI: 10.7270/Q2KK9FXN
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Ligand-Target Pair
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