Compile Data Set for Download or QSAR

Found 241 hits Enz. Inhib. hit(s) with Target = 'Non-receptor tyrosine-protein kinase TNK1'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM2579 ((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...) Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	0.584	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Inhibition of human TNK1 using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assay				Eur J Med Chem 161: 456-467 (2019) Article DOI: 10.1016/j.ejmech.2018.10.052 BindingDB Entry DOI: 10.7270/Q2W380MT
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419721 (US10464919, Example 59) Show SMILES [O-][N+](=O)c1ccc(N2CCN(Cc3ccc4c5NCCCc5c(=O)[nH]c4c3)CC2)c(F)c1 Show InChI InChI=1S/C23H24FN5O3/c24-19-13-16(29(31)32)4-6-21(19)28-10-8-27(9-11-28)14-15-3-5-17-20(12-15)26-23(30)18-2-1-7-25-22(17)18/h3-6,12-13,25H,1-2,7-11,14H2,(H,26,30)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.37	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM2579 ((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...) Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human TNK1 using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assay				Citation and Details Article DOI: 10.1016/j.bmc.2018.02.022 BindingDB Entry DOI: 10.7270/Q2DJ5KB8
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419794 (US10464919, Example 132) Show SMILES O=c1[nH]c2cc(CN3CCN(CC3)c3ccc(nn3)C#N)ccc2c2NCCCc12 Show InChI InChI=1S/C22H23N7O/c23-13-16-4-6-20(27-26-16)29-10-8-28(9-11-29)14-15-3-5-17-19(12-15)25-22(30)18-2-1-7-24-21(17)18/h3-6,12,24H,1-2,7-11,14H2,(H,25,30)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.77	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419844 (US10464919, Example 182) Show SMILES Fc1cc(CN2CCN(CC2)c2ccc(nn2)C#N)cc2[nH]c(=O)c3CCCNc3c12 Show InChI InChI=1S/C22H22FN7O/c23-17-10-14(11-18-20(17)21-16(22(31)26-18)2-1-5-25-21)13-29-6-8-30(9-7-29)19-4-3-15(12-24)27-28-19/h3-4,10-11,25H,1-2,5-9,13H2,(H,26,31)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.33	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419799 (US10464919, Example 137) Show SMILES COc1cc(ncc1C#N)N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1 Show InChI InChI=1S/C24H26N6O2/c1-32-21-12-22(27-14-17(21)13-25)30-9-7-29(8-10-30)15-16-4-5-18-20(11-16)28-24(31)19-3-2-6-26-23(18)19/h4-5,11-12,14,26H,2-3,6-10,15H2,1H3,(H,28,31)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.36	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419755 (US10464919, Example 93) Show SMILES Clc1ccc(nn1)N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1 Show InChI InChI=1S/C21H23ClN6O/c22-18-5-6-19(26-25-18)28-10-8-27(9-11-28)13-14-3-4-15-17(12-14)24-21(29)16-2-1-7-23-20(15)16/h3-6,12,23H,1-2,7-11,13H2,(H,24,29)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.59	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419785 (US10464919, Example 123) Show SMILES O=c1[nH]c2cc(CN3CCN(CC3)c3ccc(nc3)C#N)ccc2c2NCCCc12 Show InChI InChI=1S/C23H24N6O/c24-13-17-4-5-18(14-26-17)29-10-8-28(9-11-29)15-16-3-6-19-21(12-16)27-23(30)20-2-1-7-25-22(19)20/h3-6,12,14,25H,1-2,7-11,15H2,(H,27,30)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.92	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419797 (US10464919, Example 135) Show SMILES Clc1cc(ncc1C#N)N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1 Show InChI InChI=1S/C23H23ClN6O/c24-19-11-21(27-13-16(19)12-25)30-8-6-29(7-9-30)14-15-3-4-17-20(10-15)28-23(31)18-2-1-5-26-22(17)18/h3-4,10-11,13,26H,1-2,5-9,14H2,(H,28,31)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.04	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419796 (US10464919, Example 134) Show SMILES Clc1cc(N2CCN(Cc3ccc4c5NCCCc5c(=O)[nH]c4c3)CC2)c(cn1)C#N Show InChI InChI=1S/C23H23ClN6O/c24-21-11-20(16(12-25)13-27-21)30-8-6-29(7-9-30)14-15-3-4-17-19(10-15)28-23(31)18-2-1-5-26-22(17)18/h3-4,10-11,13,26H,1-2,5-9,14H2,(H,28,31)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.15	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419804 (US10464919, Example 142) Show SMILES O=c1[nH]c2cc(CN3CCN(CC3)c3ncc(s3)C#N)ccc2c2NCCCc12 Show InChI InChI=1S/C21H22N6OS/c22-11-15-12-24-21(29-15)27-8-6-26(7-9-27)13-14-3-4-16-18(10-14)25-20(28)17-2-1-5-23-19(16)17/h3-4,10,12,23H,1-2,5-9,13H2,(H,25,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.42	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419718 (US10464919, Example 56) Show SMILES CC(=O)c1cc(ccc1N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1)C#N Show InChI InChI=1S/C26H27N5O2/c1-17(32)22-13-18(15-27)5-7-24(22)31-11-9-30(10-12-31)16-19-4-6-20-23(14-19)29-26(33)21-3-2-8-28-25(20)21/h4-7,13-14,28H,2-3,8-12,16H2,1H3,(H,29,33)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.96	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419781 (US10464919, Example 119) Show SMILES [O-][N+](=O)c1ccc(cc1F)N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1 Show InChI InChI=1S/C23H24FN5O3/c24-19-13-16(4-6-21(19)29(31)32)28-10-8-27(9-11-28)14-15-3-5-17-20(12-15)26-23(30)18-2-1-7-25-22(17)18/h3-6,12-13,25H,1-2,7-11,14H2,(H,26,30)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419751 (US10464919, Example 89) Show SMILES O=c1[nH]c2cc(CN3CCN(CC3)c3ccc(cn3)C#N)ccc2c2NCCCc12 Show InChI InChI=1S/C23H24N6O/c24-13-17-4-6-21(26-14-17)29-10-8-28(9-11-29)15-16-3-5-18-20(12-16)27-23(30)19-2-1-7-25-22(18)19/h3-6,12,14,25H,1-2,7-11,15H2,(H,27,30)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	5.07	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419791 (US10464919, Example 129) Show SMILES O=c1[nH]c2cc(CN3CCN(CC3)c3cnc(cn3)C#N)ccc2c2NCCCc12 Show InChI InChI=1S/C22H23N7O/c23-11-16-12-26-20(13-25-16)29-8-6-28(7-9-29)14-15-3-4-17-19(10-15)27-22(30)18-2-1-5-24-21(17)18/h3-4,10,12-13,24H,1-2,5-9,14H2,(H,27,30)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.56	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419761 (US10464919, Example 99) Show SMILES CCOC(=O)c1csc(n1)N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1 Show InChI InChI=1S/C23H27N5O3S/c1-2-31-22(30)19-14-32-23(26-19)28-10-8-27(9-11-28)13-15-5-6-16-18(12-15)25-21(29)17-4-3-7-24-20(16)17/h5-6,12,14,24H,2-4,7-11,13H2,1H3,(H,25,29)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.59	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419731 (US10464919, Example 69) Show SMILES Fc1cc(ccc1N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1)C(=O)NC1CC1 Show InChI InChI=1S/C27H30FN5O2/c28-22-15-18(26(34)30-19-5-6-19)4-8-24(22)33-12-10-32(11-13-33)16-17-3-7-20-23(14-17)31-27(35)21-2-1-9-29-25(20)21/h3-4,7-8,14-15,19,29H,1-2,5-6,9-13,16H2,(H,30,34)(H,31,35)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.77	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419803 (US10464919, Example 141) Show SMILES CCOC(=O)c1cnc(s1)N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1 Show InChI InChI=1S/C23H27N5O3S/c1-2-31-22(30)19-13-25-23(32-19)28-10-8-27(9-11-28)14-15-5-6-16-18(12-15)26-21(29)17-4-3-7-24-20(16)17/h5-6,12-13,24H,2-4,7-11,14H2,1H3,(H,26,29)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.82	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419807 (US10464919, Example 145) Show SMILES O=c1[nH]c2cc(CN3CCN(CC3)c3nc(ns3)C#N)ccc2c2NCCCc12 Show InChI InChI=1S/C20H21N7OS/c21-11-17-24-20(29-25-17)27-8-6-26(7-9-27)12-13-3-4-14-16(10-13)23-19(28)15-2-1-5-22-18(14)15/h3-4,10,22H,1-2,5-9,12H2,(H,23,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.29	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419758 (US10464919, Example 96) Show SMILES CCNC(=O)c1ccc(nc1)N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1 Show InChI InChI=1S/C25H30N6O2/c1-2-26-24(32)18-6-8-22(28-15-18)31-12-10-30(11-13-31)16-17-5-7-19-21(14-17)29-25(33)20-4-3-9-27-23(19)20/h5-8,14-15,27H,2-4,9-13,16H2,1H3,(H,26,32)(H,29,33)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.77	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419784 (US10464919, Example 122) Show SMILES CS(=O)(=O)c1ccc(nc1)N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1 Show InChI InChI=1S/C23H27N5O3S/c1-32(30,31)17-5-7-21(25-14-17)28-11-9-27(10-12-28)15-16-4-6-18-20(13-16)26-23(29)19-3-2-8-24-22(18)19/h4-7,13-14,24H,2-3,8-12,15H2,1H3,(H,26,29)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.28	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419842 (US10464919, Example 180) Show SMILES Fc1cc(CN2CCN(CC2)c2ccc(nc2)C#N)cc2[nH]c(=O)c3CCCNc3c12 Show InChI InChI=1S/C23H23FN6O/c24-19-10-15(11-20-21(19)22-18(23(31)28-20)2-1-5-26-22)14-29-6-8-30(9-7-29)17-4-3-16(12-25)27-13-17/h3-4,10-11,13,26H,1-2,5-9,14H2,(H,28,31)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.05	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419746 (US10464919, Example 84) Show SMILES CCNC(=O)c1cc(F)c(N2CCN(Cc3ccc4c5NCCCc5c(=O)[nH]c4c3)CC2)c(F)c1 Show InChI InChI=1S/C26H29F2N5O2/c1-2-29-25(34)17-13-20(27)24(21(28)14-17)33-10-8-32(9-11-33)15-16-5-6-18-22(12-16)31-26(35)19-4-3-7-30-23(18)19/h5-6,12-14,30H,2-4,7-11,15H2,1H3,(H,29,34)(H,31,35)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.46	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419759 (US10464919, Example 97) Show SMILES O=C(NC1CC1)c1ccc(nc1)N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1 Show InChI InChI=1S/C26H30N6O2/c33-25(29-19-5-6-19)18-4-8-23(28-15-18)32-12-10-31(11-13-32)16-17-3-7-20-22(14-17)30-26(34)21-2-1-9-27-24(20)21/h3-4,7-8,14-15,19,27H,1-2,5-6,9-13,16H2,(H,29,33)(H,30,34)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.81	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419832 (US10464919, Example 170) Show SMILES Fc1cc(CN2CCN(CC2)c2ccc(cn2)C#N)cc2[nH]c(=O)c3CCCNc3c12 Show InChI InChI=1S/C23H23FN6O/c24-18-10-16(11-19-21(18)22-17(23(31)28-19)2-1-5-26-22)14-29-6-8-30(9-7-29)20-4-3-15(12-25)13-27-20/h3-4,10-11,13,26H,1-2,5-9,14H2,(H,28,31)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.65	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419793 (US10464919, Example 131) Show SMILES COc1ccc(nn1)N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1 Show InChI InChI=1S/C22H26N6O2/c1-30-20-7-6-19(25-26-20)28-11-9-27(10-12-28)14-15-4-5-16-18(13-15)24-22(29)17-3-2-8-23-21(16)17/h4-7,13,23H,2-3,8-12,14H2,1H3,(H,24,29)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.89	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419782 (US10464919, Example 120) Show SMILES Clc1ccc(nc1)N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1 Show InChI InChI=1S/C22H24ClN5O/c23-16-4-6-20(25-13-16)28-10-8-27(9-11-28)14-15-3-5-17-19(12-15)26-22(29)18-2-1-7-24-21(17)18/h3-6,12-13,24H,1-2,7-11,14H2,(H,26,29)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.2	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419786 (US10464919, Example 124) Show SMILES O=c1[nH]c2cc(CN3CCN(CC3)c3cc(ccn3)C#N)ccc2c2NCCCc12 Show InChI InChI=1S/C23H24N6O/c24-14-16-5-7-25-21(13-16)29-10-8-28(9-11-29)15-17-3-4-18-20(12-17)27-23(30)19-2-1-6-26-22(18)19/h3-5,7,12-13,26H,1-2,6,8-11,15H2,(H,27,30)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.4	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419787 (US10464919, Example 125) Show SMILES O=c1[nH]c2cc(CN3CCN(CC3)c3ncccc3C#N)ccc2c2NCCCc12 Show InChI InChI=1S/C23H24N6O/c24-14-17-3-1-8-26-22(17)29-11-9-28(10-12-29)15-16-5-6-18-20(13-16)27-23(30)19-4-2-7-25-21(18)19/h1,3,5-6,8,13,25H,2,4,7,9-12,15H2,(H,27,30)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.4	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419801 (US10464919, Example 139) Show SMILES O=c1[nH]c2cc(CN3CCN(CC3)c3nc(cs3)C#N)ccc2c2NCCCc12 Show InChI InChI=1S/C21H22N6OS/c22-11-15-13-29-21(24-15)27-8-6-26(7-9-27)12-14-3-4-16-18(10-14)25-20(28)17-2-1-5-23-19(16)17/h3-4,10,13,23H,1-2,5-9,12H2,(H,25,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.6	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419775 (US10464919, Example 113) Show SMILES C[C@H]1CN(CCN1Cc1ccc2c3NCCCc3c(=O)[nH]c2c1)c1ccc(C#N)c(F)c1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.7	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419822 (US10464919, Example 160) Show SMILES Clc1ccc(nn1)N1CC2CCC(C1)N2Cc1ccc2c3NCCCc3c(=O)[nH]c2c1 Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.7	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419740 (US10464919, Example 78) Show SMILES Fc1cc(ccc1C(=O)NC1CC1)N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1 Show InChI InChI=1S/C27H30FN5O2/c28-23-15-19(6-8-20(23)26(34)30-18-4-5-18)33-12-10-32(11-13-33)16-17-3-7-21-24(14-17)31-27(35)22-2-1-9-29-25(21)22/h3,6-8,14-15,18,29H,1-2,4-5,9-13,16H2,(H,30,34)(H,31,35)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419738 (US10464919, Example 76) Show SMILES CNC(=O)c1ccc(cc1F)N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1 Show InChI InChI=1S/C25H28FN5O2/c1-27-24(32)18-7-5-17(14-21(18)26)31-11-9-30(10-12-31)15-16-4-6-19-22(13-16)29-25(33)20-3-2-8-28-23(19)20/h4-7,13-14,28H,2-3,8-12,15H2,1H3,(H,27,32)(H,29,33)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11.3	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419769 (US10464919, Example 107) Show SMILES CC1CN(CCN1Cc1ccc2c3NCCCc3c(=O)[nH]c2c1)c1ccc(cc1F)C#N |w:1.0| Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11.4	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419757 (US10464919, Example 95) Show SMILES CNC(=O)c1ccc(nc1)N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1 Show InChI InChI=1S/C24H28N6O2/c1-25-23(31)17-5-7-21(27-14-17)30-11-9-29(10-12-30)15-16-4-6-18-20(13-16)28-24(32)19-3-2-8-26-22(18)19/h4-7,13-14,26H,2-3,8-12,15H2,1H3,(H,25,31)(H,28,32)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11.4	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419737 (US10464919, Example 75) Show SMILES Brc1cc(ccc1N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1)C(=O)NC1CC1 Show InChI InChI=1S/C27H30BrN5O2/c28-22-15-18(26(34)30-19-5-6-19)4-8-24(22)33-12-10-32(11-13-33)16-17-3-7-20-23(14-17)31-27(35)21-2-1-9-29-25(20)21/h3-4,7-8,14-15,19,29H,1-2,5-6,9-13,16H2,(H,30,34)(H,31,35)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11.4	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419843 (US10464919, Example 181) Show SMILES Fc1cc(CN2CCN(CC2)c2ccc(Cl)nn2)cc2[nH]c(=O)c3CCCNc3c12 Show InChI InChI=1S/C21H22ClFN6O/c22-17-3-4-18(27-26-17)29-8-6-28(7-9-29)12-13-10-15(23)19-16(11-13)25-21(30)14-2-1-5-24-20(14)19/h3-4,10-11,24H,1-2,5-9,12H2,(H,25,30)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11.6	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419747 (US10464919, Example 85) Show SMILES Fc1cc(cc(F)c1N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1)C(=O)NC1CC1 Show InChI InChI=1S/C27H29F2N5O2/c28-21-13-17(26(35)31-18-4-5-18)14-22(29)25(21)34-10-8-33(9-11-34)15-16-3-6-19-23(12-16)32-27(36)20-2-1-7-30-24(19)20/h3,6,12-14,18,30H,1-2,4-5,7-11,15H2,(H,31,35)(H,32,36)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11.8	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419722 (US10464919, Example 60) Show SMILES Fc1cc(ccc1C#N)N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1 Show InChI InChI=1S/C24H24FN5O/c25-21-13-18(5-4-17(21)14-26)30-10-8-29(9-11-30)15-16-3-6-19-22(12-16)28-24(31)20-2-1-7-27-23(19)20/h3-6,12-13,27H,1-2,7-11,15H2,(H,28,31)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.1	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419732 (US10464919, Example 70) Show SMILES CNC(=O)c1ccc(N2CCN(Cc3ccc4c5NCCCc5c(=O)[nH]c4c3)CC2)c(Cl)c1 Show InChI InChI=1S/C25H28ClN5O2/c1-27-24(32)17-5-7-22(20(26)14-17)31-11-9-30(10-12-31)15-16-4-6-18-21(13-16)29-25(33)19-3-2-8-28-23(18)19/h4-7,13-14,28H,2-3,8-12,15H2,1H3,(H,27,32)(H,29,33)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.4	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419765 (US10464919, Example 103) Show SMILES Fc1cc(ccc1C#N)N1C[C@@H]2C[C@H]1CN2Cc1ccc2c3NCCCc3c(=O)[nH]c2c1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419774 (US10464919, Example 112) Show SMILES C[C@@H]1CN(CCN1Cc1ccc2c3NCCCc3c(=O)[nH]c2c1)c1ccc(C#N)c(F)c1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.6	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419754 (US10464919, Example 92) Show SMILES O=c1[nH]c2cc(CN3CCN(CC3)c3cnccn3)ccc2c2NCCCc12 Show InChI InChI=1S/C21H24N6O/c28-21-17-2-1-5-24-20(17)16-4-3-15(12-18(16)25-21)14-26-8-10-27(11-9-26)19-13-22-6-7-23-19/h3-4,6-7,12-13,24H,1-2,5,8-11,14H2,(H,25,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.9	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419728 (US10464919, Example 66) Show SMILES CNC(=O)c1ccc(N2CCN(Cc3ccc4c5NCCCc5c(=O)[nH]c4c3)CC2)c(F)c1 Show InChI InChI=1S/C25H28FN5O2/c1-27-24(32)17-5-7-22(20(26)14-17)31-11-9-30(10-12-31)15-16-4-6-18-21(13-16)29-25(33)19-3-2-8-28-23(18)19/h4-7,13-14,28H,2-3,8-12,15H2,1H3,(H,27,32)(H,29,33)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13.2	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419723 (US10464919, Example 61) Show SMILES Clc1cc(ccc1C#N)N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1 Show InChI InChI=1S/C24H24ClN5O/c25-21-13-18(5-4-17(21)14-26)30-10-8-29(9-11-30)15-16-3-6-19-22(12-16)28-24(31)20-2-1-7-27-23(19)20/h3-6,12-13,27H,1-2,7-11,15H2,(H,28,31)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13.7	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419727 (US10464919, Example 65) Show SMILES Cc1cc(ccc1N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1)C(=O)NC1CC1 Show InChI InChI=1S/C28H33N5O2/c1-18-15-20(27(34)30-21-6-7-21)5-9-25(18)33-13-11-32(12-14-33)17-19-4-8-22-24(16-19)31-28(35)23-3-2-10-29-26(22)23/h4-5,8-9,15-16,21,29H,2-3,6-7,10-14,17H2,1H3,(H,30,34)(H,31,35)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13.9	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419729 (US10464919, Example 67) Show SMILES CCNC(=O)c1ccc(N2CCN(Cc3ccc4c5NCCCc5c(=O)[nH]c4c3)CC2)c(F)c1 Show InChI InChI=1S/C26H30FN5O2/c1-2-28-25(33)18-6-8-23(21(27)15-18)32-12-10-31(11-13-32)16-17-5-7-19-22(14-17)30-26(34)20-4-3-9-29-24(19)20/h5-8,14-15,29H,2-4,9-13,16H2,1H3,(H,28,33)(H,30,34)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419733 (US10464919, Example 71) Show SMILES CCNC(=O)c1ccc(N2CCN(Cc3ccc4c5NCCCc5c(=O)[nH]c4c3)CC2)c(Cl)c1 Show InChI InChI=1S/C26H30ClN5O2/c1-2-28-25(33)18-6-8-23(21(27)15-18)32-12-10-31(11-13-32)16-17-5-7-19-22(14-17)30-26(34)20-4-3-9-29-24(19)20/h5-8,14-15,29H,2-4,9-13,16H2,1H3,(H,28,33)(H,30,34)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14.2	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419795 (US10464919, Example 133) Show SMILES Clc1cc(cnc1N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1)C#N Show InChI InChI=1S/C23H23ClN6O/c24-19-10-16(12-25)13-27-22(19)30-8-6-29(7-9-30)14-15-3-4-17-20(11-15)28-23(31)18-2-1-5-26-21(17)18/h3-4,10-11,13,26H,1-2,5-9,14H2,(H,28,31)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14.2	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair

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