BindingDB PrimarySearch

Found 17 hits Enz. Inhib. hit(s) with Target = 'Tubulin polymerization-promoting protein'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Tubulin polymerization-promoting protein (Homo sapiens (Human))	BDBM59225 (Boronic acid, cis-6 \| Boronic acid, trans-6) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
University of Virginia					Assay Description IC50 values for inhibition of cell growth using MCF-7 cell line were obtained by measuring the amount of total cell protein with the sulforhodamine B...				Chem Biol 12: 1007-14 (2005) Article DOI: 10.1016/j.chembiol.2005.06.016 BindingDB Entry DOI: 10.7270/Q2DN43HC
University of Virginia					More data for this Ligand-Target Pair
Tubulin polymerization-promoting protein (Homo sapiens (Human))	BDBM50005480 ((-)-combretastatin \| (Z)-3'-hydroxy-3,4,4',5-tetra...) Show SMILES COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1O Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
University of Virginia					Assay Description IC50 values for inhibition of cell growth using MCF-7 cell line were obtained by measuring the amount of total cell protein with the sulforhodamine B...				Chem Biol 12: 1007-14 (2005) Article DOI: 10.1016/j.chembiol.2005.06.016 BindingDB Entry DOI: 10.7270/Q2DN43HC
University of Virginia					More data for this Ligand-Target Pair
Tubulin polymerization-promoting protein (Homo sapiens (Human))	BDBM59225 (Boronic acid, cis-6 \| Boronic acid, trans-6) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	470	n/a	n/a	n/a	n/a	n/a	n/a
University of Virginia					Assay Description IC50 values for inhibition of cell growth using MCF-7 cell line were obtained by measuring the amount of total cell protein with the sulforhodamine B...				Chem Biol 12: 1007-14 (2005) Article DOI: 10.1016/j.chembiol.2005.06.016 BindingDB Entry DOI: 10.7270/Q2DN43HC
University of Virginia					More data for this Ligand-Target Pair
Tubulin polymerization-promoting protein (Homo sapiens (Human))	BDBM59225 (Boronic acid, cis-6 \| Boronic acid, trans-6) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Virginia					Assay Description Tubulin polymerization was followed turbidimetrically at 350nm in Beckman model DU-7400 and DU-7500 spectrophotometers equipped with electric tempera...				Chem Biol 12: 1007-14 (2005) Article DOI: 10.1016/j.chembiol.2005.06.016 BindingDB Entry DOI: 10.7270/Q2DN43HC
University of Virginia					More data for this Ligand-Target Pair
Tubulin polymerization-promoting protein (Homo sapiens (Human))	BDBM50005480 ((-)-combretastatin \| (Z)-3'-hydroxy-3,4,4',5-tetra...) Show SMILES COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1O Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Virginia					Assay Description Tubulin polymerization was followed turbidimetrically at 350nm in Beckman model DU-7400 and DU-7500 spectrophotometers equipped with electric tempera...				Chem Biol 12: 1007-14 (2005) Article DOI: 10.1016/j.chembiol.2005.06.016 BindingDB Entry DOI: 10.7270/Q2DN43HC
University of Virginia					More data for this Ligand-Target Pair
Tubulin polymerization-promoting protein (Homo sapiens (Human))	BDBM59225 (Boronic acid, cis-6 \| Boronic acid, trans-6) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Virginia					Assay Description Tubulin polymerization was followed turbidimetrically at 350nm in Beckman model DU-7400 and DU-7500 spectrophotometers equipped with electric tempera...				Chem Biol 12: 1007-14 (2005) Article DOI: 10.1016/j.chembiol.2005.06.016 BindingDB Entry DOI: 10.7270/Q2DN43HC
University of Virginia					More data for this Ligand-Target Pair
Tubulin polymerization-promoting protein (Bos taurus)	BDBM50099939 (2',3',4'-Trimethoxy-biphenyl-2-carbonitrile \| CHEM...) Show SMILES COc1ccc(c(OC)c1OC)-c1ccccc1C#N Show InChI	MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a
Rohm and Haas Company Curated by ChEMBL					Assay Description Inhibition of Bos taurus (bovine) brain tubulin polymerization				Bioorg Med Chem Lett 11: 1393-6 (2001) BindingDB Entry DOI: 10.7270/Q20V8C18
Rohm and Haas Company Curated by ChEMBL					More data for this Ligand-Target Pair
Tubulin polymerization-promoting protein (Bos taurus)	BDBM50099940 (2,3,4,4'-Tetramethoxy-2'-nitro-biphenyl \| CHEMBL31...) Show SMILES Show InChI	MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	6.25E+3	n/a	n/a	n/a	n/a
Rohm and Haas Company Curated by ChEMBL					Assay Description Inhibition of Bos taurus (bovine) brain tubulin polymerization				Bioorg Med Chem Lett 11: 1393-6 (2001) BindingDB Entry DOI: 10.7270/Q20V8C18
Rohm and Haas Company Curated by ChEMBL					More data for this Ligand-Target Pair
Tubulin polymerization-promoting protein (Bos taurus)	BDBM50099941 (4,2',3',4'-Tetramethoxy-biphenyl-2-carbonitrile \| ...) Show SMILES COc1ccc(c(c1)C#N)-c1ccc(OC)c(OC)c1OC Show InChI	MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	6.25E+3	n/a	n/a	n/a	n/a
Rohm and Haas Company Curated by ChEMBL					Assay Description Inhibition of Bos taurus (bovine) brain tubulin polymerization				Bioorg Med Chem Lett 11: 1393-6 (2001) BindingDB Entry DOI: 10.7270/Q20V8C18
Rohm and Haas Company Curated by ChEMBL					More data for this Ligand-Target Pair
Tubulin polymerization-promoting protein (Bos taurus)	BDBM50099943 (2,3,4,4'-Tetramethoxy-2'-methyl-biphenyl \| CHEMBL3...) Show SMILES COc1ccc(c(C)c1)-c1ccc(OC)c(OC)c1OC Show InChI	MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a
Rohm and Haas Company Curated by ChEMBL					Assay Description Inhibition of Bos taurus (bovine) brain tubulin polymerization				Bioorg Med Chem Lett 11: 1393-6 (2001) BindingDB Entry DOI: 10.7270/Q20V8C18
Rohm and Haas Company Curated by ChEMBL					More data for this Ligand-Target Pair
Tubulin polymerization-promoting protein (Bos taurus)	BDBM50099948 (2,3,4-Trimethoxy-2'-nitro-biphenyl \| CHEMBL32021) Show SMILES COc1ccc(c(OC)c1OC)-c1ccccc1[N+]([O-])=O Show InChI	MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Rohm and Haas Company Curated by ChEMBL					Assay Description Inhibition of Bos taurus (bovine) brain tubulin polymerization				Bioorg Med Chem Lett 11: 1393-6 (2001) BindingDB Entry DOI: 10.7270/Q20V8C18
Rohm and Haas Company Curated by ChEMBL					More data for this Ligand-Target Pair
Tubulin polymerization-promoting protein (Bos taurus)	BDBM50099942 (6-(2,3,4-Trimethoxy-phenyl)-cyclohex-3-enecarbonit...) Show SMILES COc1ccc(C2CC=CCC2C#N)c(OC)c1OC \|c:8\| Show InChI	MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Rohm and Haas Company Curated by ChEMBL					Assay Description Inhibition of Bos taurus (bovine) brain tubulin polymerization				Bioorg Med Chem Lett 11: 1393-6 (2001) BindingDB Entry DOI: 10.7270/Q20V8C18
Rohm and Haas Company Curated by ChEMBL					More data for this Ligand-Target Pair
Tubulin polymerization-promoting protein (Bos taurus)	BDBM50099946 (1,2,3-Trimethoxy-4-(6-nitro-cyclohex-3-enyl)-benze...) Show SMILES Show InChI	MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Rohm and Haas Company Curated by ChEMBL					Assay Description Inhibition of Bos taurus (bovine) brain tubulin polymerization				Bioorg Med Chem Lett 11: 1393-6 (2001) BindingDB Entry DOI: 10.7270/Q20V8C18
Rohm and Haas Company Curated by ChEMBL					More data for this Ligand-Target Pair
Tubulin polymerization-promoting protein (Bos taurus)	BDBM50099947 (2,3,4,4'-Tetramethoxy-biphenyl \| CHEMBL28250) Show SMILES COc1ccc(cc1)-c1ccc(OC)c(OC)c1OC Show InChI	MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	6.25E+3	n/a	n/a	n/a	n/a
Rohm and Haas Company Curated by ChEMBL					Assay Description Inhibition of Bos taurus (bovine) brain tubulin polymerization				Bioorg Med Chem Lett 11: 1393-6 (2001) BindingDB Entry DOI: 10.7270/Q20V8C18
Rohm and Haas Company Curated by ChEMBL					More data for this Ligand-Target Pair
Tubulin polymerization-promoting protein (Bos taurus)	BDBM50099938 (((1S,6R)-6-Nitro-cyclohex-3-enyl)-benzene \| CHEMBL...) Show SMILES Show InChI	MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Rohm and Haas Company Curated by ChEMBL					Assay Description Inhibition of Bos taurus (bovine) brain tubulin polymerization				Bioorg Med Chem Lett 11: 1393-6 (2001) BindingDB Entry DOI: 10.7270/Q20V8C18
Rohm and Haas Company Curated by ChEMBL					More data for this Ligand-Target Pair
Tubulin polymerization-promoting protein (Bos taurus)	BDBM50014846 ((S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-...) Show SMILES Show InChI	MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	750	n/a	n/a	n/a	n/a
Rohm and Haas Company Curated by ChEMBL					Assay Description Inhibition of Bos taurus (bovine) brain tubulin polymerization				Bioorg Med Chem Lett 11: 1393-6 (2001) BindingDB Entry DOI: 10.7270/Q20V8C18
Rohm and Haas Company Curated by ChEMBL					More data for this Ligand-Target Pair
Tubulin polymerization-promoting protein (Bos taurus)	BDBM50099944 (1-Methoxy-3-((1S,6R)-6-nitro-cyclohex-3-enyl)-benz...) Show SMILES Show InChI	MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Rohm and Haas Company Curated by ChEMBL					Assay Description Inhibition of Bos taurus (bovine) brain tubulin polymerization				Bioorg Med Chem Lett 11: 1393-6 (2001) BindingDB Entry DOI: 10.7270/Q20V8C18
Rohm and Haas Company Curated by ChEMBL					More data for this Ligand-Target Pair