Compile Data Set for Download or QSAR

Found 22 hits Enz. Inhib. hit(s) with Target = 'Retinoic acid receptor RXR-alpha [225-462]/Thyroid hormone receptor beta [148-410]'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Retinoic acid receptor RXR-alpha [225-462]/Thyroid hormone receptor beta [148-410] (Homo sapiens (Human))	BDBM50012902 (CHEMBL3261318 | USRE46024, 1) Show SMILES CC(C)c1cc(Oc2c(C)cc(CC(O)=O)cc2C)n[nH]c1=O Show InChI InChI=1S/C17H20N2O4/c1-9(2)13-8-14(18-19-17(13)22)23-16-10(3)5-12(6-11(16)4)7-15(20)21/h5-6,8-9H,7H2,1-4H3,(H,19,22)(H,20,21)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	n/a	n/a	7.75E+3	n/a	n/a	7.0	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Thirty microliters of H6-TRβ (50 nM) in 50 mM Hepes, pH 7.0, 1 mM DTT, 0.05% NP40 and 0.2 mg/ml BSA (Binding Buffer) was mixed with an equal vol...				US Patent USRE46024 (2016) BindingDB Entry DOI: 10.7270/Q24X56PH
					More data for this Ligand-Target Pair
Retinoic acid receptor RXR-alpha [225-462]/Thyroid hormone receptor beta [148-410] (Homo sapiens (Human))	BDBM50012908 (CHEMBL3261334 | USRE46024, 22) Show SMILES CC(C)c1cc(Cc2c(Cl)cc(cc2Cl)-n2nc(C#N)c(=O)[nH]c2=O)nn(C)c1=O Show InChI InChI=1S/C19H16Cl2N6O3/c1-9(2)12-4-10(24-26(3)18(12)29)5-13-14(20)6-11(7-15(13)21)27-19(30)23-17(28)16(8-22)25-27/h4,6-7,9H,5H2,1-3H3,(H,23,28,30)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	n/a	n/a	136	n/a	n/a	7.0	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Thirty microliters of H6-TRβ (50 nM) in 50 mM Hepes, pH 7.0, 1 mM DTT, 0.05% NP40 and 0.2 mg/ml BSA (Binding Buffer) was mixed with an equal vol...				US Patent USRE46024 (2016) BindingDB Entry DOI: 10.7270/Q24X56PH
					More data for this Ligand-Target Pair
Retinoic acid receptor RXR-alpha [225-462]/Thyroid hormone receptor beta [148-410] (Homo sapiens (Human))	BDBM50012901 (CHEMBL3261320 | USRE46024, 4) Show SMILES CC(C)c1cc(Oc2c(Cl)cc(CC(O)=O)cc2Cl)n[nH]c1=O Show InChI InChI=1S/C15H14Cl2N2O4/c1-7(2)9-6-12(18-19-15(9)22)23-14-10(16)3-8(4-11(14)17)5-13(20)21/h3-4,6-7H,5H2,1-2H3,(H,19,22)(H,20,21)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	2.33E+3	n/a	n/a	7.0	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Thirty microliters of H6-TRβ (50 nM) in 50 mM Hepes, pH 7.0, 1 mM DTT, 0.05% NP40 and 0.2 mg/ml BSA (Binding Buffer) was mixed with an equal vol...				US Patent USRE46024 (2016) BindingDB Entry DOI: 10.7270/Q24X56PH
					More data for this Ligand-Target Pair
Retinoic acid receptor RXR-alpha [225-462]/Thyroid hormone receptor beta [148-410] (Homo sapiens (Human))	BDBM50012916 (CHEMBL3261322 | USRE46024, 5) Show SMILES CC(C)c1cc(Oc2c(Br)cc(CCC(O)=O)cc2Br)n[nH]c1=O Show InChI InChI=1S/C16H16Br2N2O4/c1-8(2)10-7-13(19-20-16(10)23)24-15-11(17)5-9(6-12(15)18)3-4-14(21)22/h5-8H,3-4H2,1-2H3,(H,20,23)(H,21,22)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	n/a	n/a	699	n/a	n/a	7.0	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Thirty microliters of H6-TRβ (50 nM) in 50 mM Hepes, pH 7.0, 1 mM DTT, 0.05% NP40 and 0.2 mg/ml BSA (Binding Buffer) was mixed with an equal vol...				US Patent USRE46024 (2016) BindingDB Entry DOI: 10.7270/Q24X56PH
					More data for this Ligand-Target Pair
Retinoic acid receptor RXR-alpha [225-462]/Thyroid hormone receptor beta [148-410] (Homo sapiens (Human))	BDBM50012918 (CHEMBL3261324 | USRE46024, 6) Show SMILES CC(C)c1cc(Oc2c(Cl)cc(NCC(O)=O)cc2Cl)n[nH]c1=O Show InChI InChI=1S/C15H15Cl2N3O4/c1-7(2)9-5-12(19-20-15(9)23)24-14-10(16)3-8(4-11(14)17)18-6-13(21)22/h3-5,7,18H,6H2,1-2H3,(H,20,23)(H,21,22)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	n/a	n/a	666	n/a	n/a	7.0	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Thirty microliters of H6-TRβ (50 nM) in 50 mM Hepes, pH 7.0, 1 mM DTT, 0.05% NP40 and 0.2 mg/ml BSA (Binding Buffer) was mixed with an equal vol...				US Patent USRE46024 (2016) BindingDB Entry DOI: 10.7270/Q24X56PH
					More data for this Ligand-Target Pair
Retinoic acid receptor RXR-alpha [225-462]/Thyroid hormone receptor beta [148-410] (Homo sapiens (Human))	BDBM50012905 (CHEMBL3261331 | USRE46024, 8) Show SMILES CC(C)c1cc(Oc2c(Cl)cc(cc2Cl)-n2nc(C#N)c(=O)[nH]c2=O)n[nH]c1=O Show InChI InChI=1S/C17H12Cl2N6O4/c1-7(2)9-5-13(22-23-15(9)26)29-14-10(18)3-8(4-11(14)19)25-17(28)21-16(27)12(6-20)24-25/h3-5,7H,1-2H3,(H,23,26)(H,21,27,28)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	192	n/a	n/a	7.0	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Thirty microliters of H6-TRβ (50 nM) in 50 mM Hepes, pH 7.0, 1 mM DTT, 0.05% NP40 and 0.2 mg/ml BSA (Binding Buffer) was mixed with an equal vol...				US Patent USRE46024 (2016) BindingDB Entry DOI: 10.7270/Q24X56PH
					More data for this Ligand-Target Pair
Retinoic acid receptor RXR-alpha [225-462]/Thyroid hormone receptor beta [148-410] (Homo sapiens (Human))	BDBM50012915 (CHEMBL3261335 | USRE46024, 9) Show SMILES CC(C)c1cc(Oc2c(Cl)cc(cc2Cl)-n2ncc(=O)[nH]c2=O)n[nH]c1=O Show InChI InChI=1S/C16H13Cl2N5O4/c1-7(2)9-5-13(21-22-15(9)25)27-14-10(17)3-8(4-11(14)18)23-16(26)20-12(24)6-19-23/h3-7H,1-2H3,(H,22,25)(H,20,24,26)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	115	n/a	n/a	7.0	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Thirty microliters of H6-TRβ (50 nM) in 50 mM Hepes, pH 7.0, 1 mM DTT, 0.05% NP40 and 0.2 mg/ml BSA (Binding Buffer) was mixed with an equal vol...				US Patent USRE46024 (2016) BindingDB Entry DOI: 10.7270/Q24X56PH
					More data for this Ligand-Target Pair
Retinoic acid receptor RXR-alpha [225-462]/Thyroid hormone receptor beta [148-410] (Homo sapiens (Human))	BDBM237173 (USRE46024, 11) Show SMILES CC(C)n1cc(Oc2c(Br)cc(CC(O)=O)cc2Br)ccc1=O Show InChI InChI=1S/C16H15Br2NO4/c1-9(2)19-8-11(3-4-14(19)20)23-16-12(17)5-10(6-13(16)18)7-15(21)22/h3-6,8-9H,7H2,1-2H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.20E+3	n/a	n/a	7.0	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Thirty microliters of H6-TRβ (50 nM) in 50 mM Hepes, pH 7.0, 1 mM DTT, 0.05% NP40 and 0.2 mg/ml BSA (Binding Buffer) was mixed with an equal vol...				US Patent USRE46024 (2016) BindingDB Entry DOI: 10.7270/Q24X56PH
					More data for this Ligand-Target Pair
Retinoic acid receptor RXR-alpha [225-462]/Thyroid hormone receptor beta [148-410] (Homo sapiens (Human))	BDBM50012911 (CHEMBL3261332 | USRE46024, 12) Show SMILES CC(C)c1cc(Cc2c(Cl)cc(cc2Cl)-n2nc(C#N)c(=O)[nH]c2=O)n[nH]c1=O Show InChI InChI=1S/C18H14Cl2N6O3/c1-8(2)11-3-9(23-24-16(11)27)4-12-13(19)5-10(6-14(12)20)26-18(29)22-17(28)15(7-21)25-26/h3,5-6,8H,4H2,1-2H3,(H,24,27)(H,22,28,29)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	n/a	n/a	133	n/a	n/a	7.0	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Thirty microliters of H6-TRβ (50 nM) in 50 mM Hepes, pH 7.0, 1 mM DTT, 0.05% NP40 and 0.2 mg/ml BSA (Binding Buffer) was mixed with an equal vol...				US Patent USRE46024 (2016) BindingDB Entry DOI: 10.7270/Q24X56PH
					More data for this Ligand-Target Pair
Retinoic acid receptor RXR-alpha [225-462]/Thyroid hormone receptor beta [148-410] (Homo sapiens (Human))	BDBM50012907 (CHEMBL3261336 | USRE46024, 13) Show SMILES CC(C)c1cc(Cc2c(Cl)cc(cc2Cl)-n2ncc(=O)[nH]c2=O)n[nH]c1=O Show InChI InChI=1S/C17H15Cl2N5O3/c1-8(2)11-3-9(22-23-16(11)26)4-12-13(18)5-10(6-14(12)19)24-17(27)21-15(25)7-20-24/h3,5-8H,4H2,1-2H3,(H,23,26)(H,21,25,27)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	92	n/a	n/a	7.0	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Thirty microliters of H6-TRβ (50 nM) in 50 mM Hepes, pH 7.0, 1 mM DTT, 0.05% NP40 and 0.2 mg/ml BSA (Binding Buffer) was mixed with an equal vol...				US Patent USRE46024 (2016) BindingDB Entry DOI: 10.7270/Q24X56PH
					More data for this Ligand-Target Pair
Retinoic acid receptor RXR-alpha [225-462]/Thyroid hormone receptor beta [148-410] (Homo sapiens (Human))	BDBM50012917 (CHEMBL3261327 | USRE46024, 15) Show SMILES CC(C)c1cc(Cc2c(Br)cc(CC(O)=O)cc2Br)n[nH]c1=O Show InChI InChI=1S/C16H16Br2N2O3/c1-8(2)11-6-10(19-20-16(11)23)7-12-13(17)3-9(4-14(12)18)5-15(21)22/h3-4,6,8H,5,7H2,1-2H3,(H,20,23)(H,21,22)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	n/a	n/a	601	n/a	n/a	7.0	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Thirty microliters of H6-TRβ (50 nM) in 50 mM Hepes, pH 7.0, 1 mM DTT, 0.05% NP40 and 0.2 mg/ml BSA (Binding Buffer) was mixed with an equal vol...				US Patent USRE46024 (2016) BindingDB Entry DOI: 10.7270/Q24X56PH
					More data for this Ligand-Target Pair
Retinoic acid receptor RXR-alpha [225-462]/Thyroid hormone receptor beta [148-410] (Homo sapiens (Human))	BDBM50012913 (CHEMBL3261333 | USRE46024, 16) Show SMILES CC(C)c1cc(Oc2c(Cl)cc(cc2Cl)-n2nc(C#N)c(=O)[nH]c2=O)nn(C)c1=O Show InChI InChI=1S/C18H14Cl2N6O4/c1-8(2)10-6-14(24-25(3)17(10)28)30-15-11(19)4-9(5-12(15)20)26-18(29)22-16(27)13(7-21)23-26/h4-6,8H,1-3H3,(H,22,27,29)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	n/a	n/a	66	n/a	n/a	7.0	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Thirty microliters of H6-TRβ (50 nM) in 50 mM Hepes, pH 7.0, 1 mM DTT, 0.05% NP40 and 0.2 mg/ml BSA (Binding Buffer) was mixed with an equal vol...				US Patent USRE46024 (2016) BindingDB Entry DOI: 10.7270/Q24X56PH
					More data for this Ligand-Target Pair
Retinoic acid receptor RXR-alpha [225-462]/Thyroid hormone receptor beta [148-410] (Homo sapiens (Human))	BDBM50012903 (CHEMBL3261328 | USRE46024, 17) Show SMILES CC(C)c1cc(Sc2c(Cl)cc(CC(O)=O)cc2Cl)n[nH]c1=O Show InChI InChI=1S/C15H14Cl2N2O3S/c1-7(2)9-6-12(18-19-15(9)22)23-14-10(16)3-8(4-11(14)17)5-13(20)21/h3-4,6-7H,5H2,1-2H3,(H,19,22)(H,20,21)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	n/a	n/a	2.04E+3	n/a	n/a	7.0	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Thirty microliters of H6-TRβ (50 nM) in 50 mM Hepes, pH 7.0, 1 mM DTT, 0.05% NP40 and 0.2 mg/ml BSA (Binding Buffer) was mixed with an equal vol...				US Patent USRE46024 (2016) BindingDB Entry DOI: 10.7270/Q24X56PH
					More data for this Ligand-Target Pair
Retinoic acid receptor RXR-alpha [225-462]/Thyroid hormone receptor beta [148-410] (Homo sapiens (Human))	BDBM50012817 (CHEMBL3261330 | USRE46024, 19) Show SMILES CC(C)c1cc(n[nH]c1=O)S(=O)(=O)c1c(Cl)cc(CC(O)=O)cc1Cl Show InChI InChI=1S/C15H14Cl2N2O5S/c1-7(2)9-6-12(18-19-15(9)22)25(23,24)14-10(16)3-8(4-11(14)17)5-13(20)21/h3-4,6-7H,5H2,1-2H3,(H,19,22)(H,20,21)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	6.98E+3	n/a	n/a	7.0	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Thirty microliters of H6-TRβ (50 nM) in 50 mM Hepes, pH 7.0, 1 mM DTT, 0.05% NP40 and 0.2 mg/ml BSA (Binding Buffer) was mixed with an equal vol...				US Patent USRE46024 (2016) BindingDB Entry DOI: 10.7270/Q24X56PH
					More data for this Ligand-Target Pair
Retinoic acid receptor RXR-alpha [225-462]/Thyroid hormone receptor beta [148-410] (Homo sapiens (Human))	BDBM237175 (USRE46024, 20) Show SMILES CC(C)c1cc(n[nH]c1=O)S(=O)(=O)c1c(Cl)cc(cc1Cl)-n1nc(C#N)c(=O)[nH]c1=O Show InChI InChI=1S/C17H12Cl2N6O5S/c1-7(2)9-5-13(22-23-15(9)26)31(29,30)14-10(18)3-8(4-11(14)19)25-17(28)21-16(27)12(6-20)24-25/h3-5,7H,1-2H3,(H,23,26)(H,21,27,28)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	7.04E+3	n/a	n/a	7.0	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Thirty microliters of H6-TRβ (50 nM) in 50 mM Hepes, pH 7.0, 1 mM DTT, 0.05% NP40 and 0.2 mg/ml BSA (Binding Buffer) was mixed with an equal vol...				US Patent USRE46024 (2016) BindingDB Entry DOI: 10.7270/Q24X56PH
					More data for this Ligand-Target Pair
Retinoic acid receptor RXR-alpha [225-462]/Thyroid hormone receptor beta [148-410] (Homo sapiens (Human))	BDBM237176 (USRE46024, 21) Show SMILES CC(C)c1cc(n[nH]c1=O)S(=O)(=O)c1c(Cl)cc(cc1Cl)-n1ncc(=O)[nH]c1=O Show InChI InChI=1S/C16H13Cl2N5O5S/c1-7(2)9-5-13(21-22-15(9)25)29(27,28)14-10(17)3-8(4-11(14)18)23-16(26)20-12(24)6-19-23/h3-7H,1-2H3,(H,22,25)(H,20,24,26)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.21E+3	n/a	n/a	7.0	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Thirty microliters of H6-TRβ (50 nM) in 50 mM Hepes, pH 7.0, 1 mM DTT, 0.05% NP40 and 0.2 mg/ml BSA (Binding Buffer) was mixed with an equal vol...				US Patent USRE46024 (2016) BindingDB Entry DOI: 10.7270/Q24X56PH
					More data for this Ligand-Target Pair
Retinoic acid receptor RXR-alpha [225-462]/Thyroid hormone receptor beta [148-410] (Homo sapiens (Human))	BDBM50012912 (CHEMBL3261321 | USRE46024, 3) Show SMILES CC(C)c1cc(Oc2c(Br)cc(CC(O)=O)cc2Br)n[nH]c1=O Show InChI InChI=1S/C15H14Br2N2O4/c1-7(2)9-6-12(18-19-15(9)22)23-14-10(16)3-8(4-11(14)17)5-13(20)21/h3-4,6-7H,5H2,1-2H3,(H,19,22)(H,20,21)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	519	n/a	n/a	7.0	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Thirty microliters of H6-TRβ (50 nM) in 50 mM Hepes, pH 7.0, 1 mM DTT, 0.05% NP40 and 0.2 mg/ml BSA (Binding Buffer) was mixed with an equal vol...				US Patent USRE46024 (2016) BindingDB Entry DOI: 10.7270/Q24X56PH
					More data for this Ligand-Target Pair
Retinoic acid receptor RXR-alpha [225-462]/Thyroid hormone receptor beta [148-410] (Homo sapiens (Human))	BDBM60964 (USRE46024, 7) Show SMILES CC(C)C1=CC(Oc2c(Cl)cc(NC(=O)C(O)=O)cc2Cl)=NNC1 |c:21,t:3| Show InChI InChI=1S/C15H15Cl2N3O4/c1-7(2)8-3-12(20-18-6-8)24-13-10(16)4-9(5-11(13)17)19-14(21)15(22)23/h3-5,7,18H,6H2,1-2H3,(H,19,21)(H,22,23)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	117	n/a	n/a	7.0	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Thirty microliters of H6-TRβ (50 nM) in 50 mM Hepes, pH 7.0, 1 mM DTT, 0.05% NP40 and 0.2 mg/ml BSA (Binding Buffer) was mixed with an equal vol...				US Patent USRE46024 (2016) BindingDB Entry DOI: 10.7270/Q24X56PH
					More data for this Ligand-Target Pair
Retinoic acid receptor RXR-alpha [225-462]/Thyroid hormone receptor beta [148-410] (Homo sapiens (Human))	BDBM50012906 (CHEMBL3261323 | USRE46024, 10) Show SMILES CC(C)c1cc(Oc2c(Cl)cc(CC(O)=O)cc2Cl)nn(C)c1=O Show InChI InChI=1S/C16H16Cl2N2O4/c1-8(2)10-7-13(19-20(3)16(10)23)24-15-11(17)4-9(5-12(15)18)6-14(21)22/h4-5,7-8H,6H2,1-3H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	n/a	n/a	767	n/a	n/a	7.0	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Thirty microliters of H6-TRβ (50 nM) in 50 mM Hepes, pH 7.0, 1 mM DTT, 0.05% NP40 and 0.2 mg/ml BSA (Binding Buffer) was mixed with an equal vol...				US Patent USRE46024 (2016) BindingDB Entry DOI: 10.7270/Q24X56PH
					More data for this Ligand-Target Pair
Retinoic acid receptor RXR-alpha [225-462]/Thyroid hormone receptor beta [148-410] (Homo sapiens (Human))	BDBM50012910 (CHEMBL3261326 | USRE46024, 14) Show SMILES CC(C)c1cc(Cc2c(Cl)cc(CC(O)=O)cc2Cl)n[nH]c1=O Show InChI InChI=1S/C16H16Cl2N2O3/c1-8(2)11-6-10(19-20-16(11)23)7-12-13(17)3-9(4-14(12)18)5-15(21)22/h3-4,6,8H,5,7H2,1-2H3,(H,20,23)(H,21,22)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	n/a	n/a	2.99E+3	n/a	n/a	7.0	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Thirty microliters of H6-TRβ (50 nM) in 50 mM Hepes, pH 7.0, 1 mM DTT, 0.05% NP40 and 0.2 mg/ml BSA (Binding Buffer) was mixed with an equal vol...				US Patent USRE46024 (2016) BindingDB Entry DOI: 10.7270/Q24X56PH
					More data for this Ligand-Target Pair
Retinoic acid receptor RXR-alpha [225-462]/Thyroid hormone receptor beta [148-410] (Homo sapiens (Human))	BDBM237174 (USRE46024, 18) Show SMILES CC(C)c1cc(n[nH]c1=O)S(=O)c1c(Cl)cc(CC(O)=O)cc1Cl Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	9.18E+3	n/a	n/a	7.0	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Thirty microliters of H6-TRβ (50 nM) in 50 mM Hepes, pH 7.0, 1 mM DTT, 0.05% NP40 and 0.2 mg/ml BSA (Binding Buffer) was mixed with an equal vol...				US Patent USRE46024 (2016) BindingDB Entry DOI: 10.7270/Q24X56PH
					More data for this Ligand-Target Pair
Retinoic acid receptor RXR-alpha [225-462]/Thyroid hormone receptor beta [148-410] (Homo sapiens (Human))	BDBM50012859 (CHEMBL3261319 | USRE46024, 2) Show SMILES CC(C)c1cc(Oc2c(C)cc(CC(O)=O)cc2Cl)n[nH]c1=O Show InChI InChI=1S/C16H17ClN2O4/c1-8(2)11-7-13(18-19-16(11)22)23-15-9(3)4-10(5-12(15)17)6-14(20)21/h4-5,7-8H,6H2,1-3H3,(H,19,22)(H,20,21)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	n/a	n/a	7.31E+3	n/a	n/a	7.0	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Thirty microliters of H6-TRβ (50 nM) in 50 mM Hepes, pH 7.0, 1 mM DTT, 0.05% NP40 and 0.2 mg/ml BSA (Binding Buffer) was mixed with an equal vol...				US Patent USRE46024 (2016) BindingDB Entry DOI: 10.7270/Q24X56PH
					More data for this Ligand-Target Pair