BindingDB PrimarySearch

Found 7 hits Enz. Inhib. hit(s) with Target = 'UDP-glucuronosyltransferase 1A10'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
UDP-glucuronosyltransferase 1A10 (Homo sapiens (Human))	BDBM13066 (2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid...) Show SMILES OC(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	2.80E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of British Columbia Curated by ChEMBL					Assay Description Inhibition of 4-methylumbelliferone glucuronidation by human recombinant UGT1A10				Pharmacol Ther 106: 97-132 (2005) Article DOI: 10.1016/j.pharmthera.2004.10.013 BindingDB Entry DOI: 10.7270/Q2959HZ9
The University of British Columbia Curated by ChEMBL					More data for this Ligand-Target Pair
UDP-glucuronosyltransferase 1A10 (Homo sapiens (Human))	BDBM50088511 (CHEBI:87620 \| Epiestriol \| Epioestriol) Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	9.81E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Helsinki Curated by ChEMBL					Assay Description Inhibition of recombinant human C-terminal His-tagged UGT1A10 after 15 to 60 mins by Michaelis-Menten equation analysis in presence of UDPGA				Drug Metab Dispos 41: 582-91 (2013) Article DOI: 10.1124/dmd.112.049072 BindingDB Entry DOI: 10.7270/Q2959K9M
University of Helsinki Curated by ChEMBL					More data for this Ligand-Target Pair
UDP-glucuronosyltransferase 1A10 (Homo sapiens (Human))	BDBM50088502 (CHEBI:5970 \| CHEMBL3527329) Show SMILES Oc1ccc(cc1)-c1coc2cc3OCOc3c(O)c2c1=O Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	1.21E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Max Rubner-Institute Curated by ChEMBL					Assay Description Substrate inhibition of human recombinant UGT1A10 assessed as IRI-O-4'-monoglucuronide formation incubated for 5 mins prior to UDPGA addition measure...				Drug Metab Dispos 39: 610-6 (2011) Article DOI: 10.1124/dmd.110.033076 BindingDB Entry DOI: 10.7270/Q20V8FHC
Max Rubner-Institute Curated by ChEMBL					More data for this Ligand-Target Pair
UDP-glucuronosyltransferase 1A10 (Homo sapiens (Human))	BDBM50242284 (CHEMBL487805 \| scutellarin) Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	2.08E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Drug metabolism assessed as human recombinant UGT1A10-mediated formation of scutellarein-6,7-diglucuronide after 25 mins by HPLC/UV analysis				Drug Metab Dispos 40: 2009-20 (2012) Article DOI: 10.1124/dmd.112.047183 BindingDB Entry DOI: 10.7270/Q2V40WXM
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
UDP-glucuronosyltransferase 1A10 (Homo sapiens (Human))	BDBM50206509 (4-Dipropylsulfamoyl-benzoic acid \| 4-Dipropylsulfa...) Show SMILES CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(O)=O Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	2.31E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of British Columbia Curated by ChEMBL					Assay Description Inhibition of 4-methylumbelliferone glucuronidation by human recombinant UGT1A10				Pharmacol Ther 106: 97-132 (2005) Article DOI: 10.1016/j.pharmthera.2004.10.013 BindingDB Entry DOI: 10.7270/Q2959HZ9
The University of British Columbia Curated by ChEMBL					More data for this Ligand-Target Pair
UDP-glucuronosyltransferase 1A10 (Homo sapiens (Human))	BDBM50358252 (CHEMBL1922235) Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	2.35E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant UGT1A10 after 10 mins in presence of UDPGA				Drug Metab Dispos 40: 276-82 (2012) Article DOI: 10.1124/dmd.111.042614 BindingDB Entry DOI: 10.7270/Q2G162JK
Astellas Pharma Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
UDP-glucuronosyltransferase 1A10 (Homo sapiens (Human))	BDBM50088505 (CHEMBL3542370) Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	2.42E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Drug metabolism assessed as human recombinant UGT1A10-mediated formation of scutellarein-6,7-diglucuronide after 25 mins by HPLC/UV analysis				Drug Metab Dispos 40: 2009-20 (2012) Article DOI: 10.1124/dmd.112.047183 BindingDB Entry DOI: 10.7270/Q2V40WXM
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair