Compile Data Set for Download or QSAR

Found 9 hits Enz. Inhib. hit(s) with Target = 'UDP-glucuronosyltransferase 1A9'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
UDP-glucuronosyltransferase 1A9 (Homo sapiens (Human))	BDBM13066 (2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid...) Show SMILES OC(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl Show InChI InChI=1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of British Columbia Curated by ChEMBL					Assay Description Inhibition of 4-methylumbelliferone glucuronidation by human recombinant UGT1A9				Pharmacol Ther 106: 97-132 (2005) Article DOI: 10.1016/j.pharmthera.2004.10.013 BindingDB Entry DOI: 10.7270/Q2959HZ9
					More data for this Ligand-Target Pair
UDP-glucuronosyltransferase 1A9 (Homo sapiens (Human))	BDBM21398 (4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...) Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	3.44E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kanazawa University Curated by ChEMBL					Assay Description Drug metabolism assessed as recombinant human UGT1A9 assessed as O-glucuronidation measured as inhibition constant at 10 to 400 uM incubated for 60 m...				Drug Metab Dispos 40: 240-8 (2012) Article DOI: 10.1124/dmd.111.042150 BindingDB Entry DOI: 10.7270/Q2KS6T8M
					More data for this Ligand-Target Pair
UDP-glucuronosyltransferase 1A9 (Homo sapiens (Human))	BDBM50088502 (CHEBI:5970 | CHEMBL3527329) Show SMILES Oc1ccc(cc1)-c1coc2cc3OCOc3c(O)c2c1=O Show InChI InChI=1S/C16H10O6/c17-9-3-1-8(2-4-9)10-6-20-11-5-12-16(22-7-21-12)15(19)13(11)14(10)18/h1-6,17,19H,7H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	5.34E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Max Rubner-Institute Curated by ChEMBL					Assay Description Substrate inhibition of human recombinant UGT1A9 assessed as IRI-O-5-monoglucuronide formation incubated for 5 mins prior to UDPGA addition measured ...				Drug Metab Dispos 39: 610-6 (2011) Article DOI: 10.1124/dmd.110.033076 BindingDB Entry DOI: 10.7270/Q20V8FHC
					More data for this Ligand-Target Pair
UDP-glucuronosyltransferase 1A9 (Homo sapiens (Human))	BDBM50008347 (5-(2-(diethylamino)ethylamino)-8-hydroxy-6H-imidaz...) Show SMILES CCN(CC)CCNc1ccc2ncn3c2c1c(=O)c1cc(O)ccc31 Show InChI InChI=1S/C20H22N4O2/c1-3-23(4-2)10-9-21-15-6-7-16-19-18(15)20(26)14-11-13(25)5-8-17(14)24(19)12-22-16/h5-8,11-12,21,25H,3-4,9-10H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	9.58E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gdansk University of Technology Curated by ChEMBL					Assay Description Inhibition of human recombinant UGT1A9 activity expressed in baculovirus-infected Sf9 cells				Drug Metab Dispos 40: 1736-43 (2012) Article DOI: 10.1124/dmd.112.045401 BindingDB Entry DOI: 10.7270/Q25H7J0M
					More data for this Ligand-Target Pair
UDP-glucuronosyltransferase 1A9 (Homo sapiens (Human))	BDBM50088499 (CHEMBL329092) Show SMILES CN(C)CCCNc1ccc2nnn3c2c1c(=O)c1cc(O)ccc31 Show InChI InChI=1S/C18H19N5O2/c1-22(2)9-3-8-19-13-5-6-14-17-16(13)18(25)12-10-11(24)4-7-15(12)23(17)21-20-14/h4-7,10,19,24H,3,8-9H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.65E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gdansk University of Technology Curated by ChEMBL					Assay Description Inhibition of human recombinant UGT1A9 activity expressed in baculovirus-infected Sf9 cells				Drug Metab Dispos 40: 1736-43 (2012) Article DOI: 10.1124/dmd.112.045401 BindingDB Entry DOI: 10.7270/Q25H7J0M
					More data for this Ligand-Target Pair
UDP-glucuronosyltransferase 1A9 (Homo sapiens (Human))	BDBM50206509 (4-Dipropylsulfamoyl-benzoic acid | 4-Dipropylsulfa...) Show SMILES CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(O)=O Show InChI InChI=1S/C13H19NO4S/c1-3-9-14(10-4-2)19(17,18)12-7-5-11(6-8-12)13(15)16/h5-8H,3-4,9-10H2,1-2H3,(H,15,16)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	2.45E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of British Columbia Curated by ChEMBL					Assay Description Inhibition of 4-methylumbelliferone glucuronidation by human recombinant UGT1A9				Pharmacol Ther 106: 97-132 (2005) Article DOI: 10.1016/j.pharmthera.2004.10.013 BindingDB Entry DOI: 10.7270/Q2959HZ9
					More data for this Ligand-Target Pair
UDP-glucuronosyltransferase 1A9 (Homo sapiens (Human))	BDBM50511112 (CHEMBL4567446) Show SMILES COc1cc(cc(n1)-c1ccc(cc1)C(O)=O)C(=O)N1CCC2(CC1)Cc1cnn(C(C)C)c1C(=O)C2 Show InChI InChI=1S/C28H30N4O5/c1-17(2)32-25-21(16-29-32)14-28(15-23(25)33)8-10-31(11-9-28)26(34)20-12-22(30-24(13-20)37-3)18-4-6-19(7-5-18)27(35)36/h4-7,12-13,16-17H,8-11,14-15H2,1-3H3,(H,35,36)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of UGT1A9 in human liver microsomes incubated for 30 mins in presence of UDPGA by LC-MS/MS analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00640 BindingDB Entry DOI: 10.7270/Q2RR22VT
					More data for this Ligand-Target Pair
UDP-glucuronosyltransferase 1A9 (Homo sapiens (Human))	BDBM50508419 (CHEMBL4471264) Show SMILES Cl.O=C1c2ccccc2C(=O)c2c(cccc12)-c1cnn(c1)C1CCNCC1 Show InChI InChI=1S/C22H19N3O2/c26-21-17-4-1-2-5-18(17)22(27)20-16(6-3-7-19(20)21)14-12-24-25(13-14)15-8-10-23-11-9-15/h1-7,12-13,15,23H,8-11H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Gwangju Institute of Science and Technology Curated by ChEMBL					Assay Description Inhibition of UGT1A9 in human liver microsomes assessed as reduction in mycophenolic acid glucuronidation by tandem mass spectrometry analysis				J Med Chem 62: 575-588 (2019) Article DOI: 10.1021/acs.jmedchem.8b01168 BindingDB Entry DOI: 10.7270/Q2QZ2F8H
					More data for this Ligand-Target Pair
UDP-glucuronosyltransferase 1A9 (Homo sapiens (Human))	BDBM50103451 (CHEMBL3398252) Show SMILES O\C(=C/C(=O)c1cc(Cc2cc(F)cc(F)c2)cn(Cc2ccccc2F)c1=O)C(=O)N1CCN(CC1)c1ccc(cc1)-n1cccc1 Show InChI InChI=1S/C37H31F3N4O4/c38-28-18-25(19-29(39)21-28)17-26-20-32(36(47)44(23-26)24-27-5-1-2-6-33(27)40)34(45)22-35(46)37(48)43-15-13-42(14-16-43)31-9-7-30(8-10-31)41-11-3-4-12-41/h1-12,18-23,46H,13-17,24H2/b35-22-	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Georgia Curated by ChEMBL					Assay Description Inhibition of of UGT1A9 in pooled mixed-gender human liver microsomes using 4-methylumbelliferone substrate by HPLC method				Bioorg Med Chem Lett 25: 1269-73 (2015) Article DOI: 10.1016/j.bmcl.2015.01.050 BindingDB Entry DOI: 10.7270/Q2KW5HTQ
					More data for this Ligand-Target Pair