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Compile Data Set for Download or QSAR

Found 376 hits Enz. Inhib. hit(s) with Target = 'Ubiquitin carboxyl-terminal hydrolase 14'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590269
PNG
(US11560385, Compound 42B)
Show SMILES Cc1c(cc(CCCC2(C)COC2)n1-c1ccc(cc1)C#N)C(=O)CN1C2CCC1[C@@H](O)C2 |r,TLB:24:25:30.32:28.27,THB:31:30:28.27:25|
PDB
MMDB

KEGG

UniProtKB/SwissProt

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n/an/a<50n/an/an/an/an/an/a


TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590270
PNG
(US11560385, Compound 43B)
Show SMILES Cc1c(cc(CCC2COC2)n1-c1ccc(cc1)C#N)C(=O)CN1C2CCC1[C@@H](O)C2 |r,TLB:22:23:28.30:26.25,THB:29:28:26.25:23|
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UniProtKB/SwissProt

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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590271
PNG
(US11560385, Compound 44B)
Show SMILES Cc1c(cc(CC2CCOCC2)n1-c1ccc(cc1)C#N)C(=O)CN1C2CCC1[C@@H](O)C2 |r,TLB:23:24:29.31:27.26,THB:30:29:27.26:24|
PDB
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UniProtKB/SwissProt

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n/an/a<50n/an/an/an/an/an/a


TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590272
PNG
(US11560385, Compound 45B)
Show SMILES Cc1c(cc(C[C@H]2C[C@@H](C2)C#N)n1-c1ccc(cc1)C#N)C(=O)CN1C2CCC1[C@@H](O)C2 |r,wU:8.10,wD:6.5,29.33,TLB:23:24:29.31:27.26,THB:30:29:27.26:24,(-3.57,-.98,;-2.24,-.21,;-1.76,1.25,;-.22,1.25,;.25,-.21,;1.74,-.61,;2.83,.48,;4.37,.48,;4.37,2.02,;2.83,2.02,;5.46,3.1,;6.55,4.19,;-.99,-1.12,;-.99,-2.66,;-2.33,-3.43,;-2.33,-4.97,;-.99,-5.74,;.34,-4.97,;.34,-3.43,;-.99,-7.28,;-.99,-8.82,;-2.85,2.34,;-4.34,1.94,;-2.45,3.83,;-3.54,4.92,;-4.64,6,;-3.3,6.77,;-2.9,8.26,;-4.24,7.49,;-5.78,7.49,;-6.55,8.82,;-6.18,6,)|
PDB
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590274
PNG
(US11560385, Compound 47B)
Show SMILES Cc1c(cc(C#N)n1-c1ccc(cc1)C#N)C(=O)CN1C2CCC1[C@@H](O)C2 |r,TLB:18:19:24.26:22.21,THB:25:24:22.21:19|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590276
PNG
(US11560385, Compound 51B)
Show SMILES Cc1c(cc(CCCC2CC(C)(C)OC2=O)n1-c1ccc(cc1)C#N)C(=O)CN1C2CCC1[C@@H](O)C2 |r,TLB:27:28:33.35:31.30,THB:34:33:31.30:28|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590277
PNG
(US11560385, Compound 52B)
Show SMILES Cc1c(cc(\C=C\CC2CC(C)(C)OC2=O)n1-c1ccc(cc1)C#N)C(=O)CN1C2CCC1[C@@H](O)C2 |r,TLB:27:28:33.35:31.30,THB:34:33:31.30:28|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590278
PNG
(US11560385, Compound 53B)
Show SMILES C[C@H]1CC2CCC1N2CC(=O)c1cc(CC2COC2)n(c1C)-c1ccc(cc1)C#N |r,TLB:0:1:5.4:7,THB:8:7:1.2:5.4|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590279
PNG
(US11560385, Compound 54B)
Show SMILES Cc1c(cc(CC2COC2)n1-c1ccc(cc1)C#N)C(=O)CN1C2CCC1CC2 |TLB:21:22:28.27:24.25|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590280
PNG
(US11560385, Compound 55B)
Show SMILES Cc1c(cc(CCC2(C)COC2)n1-c1ccc(cc1)C#N)C(=O)CN1C2CCC1[C@@H](O)C2 |r,TLB:23:24:29.31:27.26,THB:30:29:27.26:24|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590299
PNG
(US11560385, Compound 80B)
Show SMILES Cc1cc(C(=O)CN2C3CC4CC(C3)CC2C4)c(C)n1-c1ccc(cc1)C#N |TLB:6:7:9:12.11.13,THB:11:12:7:9.10.16,11:10:7:12.14.13,6:7:12.14.13:9.10.16,14:12:9:7.15.16,14:15:9:12.11.13|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590711
PNG
(US11560385, Compound 153B)
Show SMILES Cc1c(cc(\C=C\CN2C(=O)c3ccccc3C2=O)n1-c1ccc(cc1)C#N)C(=O)CN1C2CCC1[C@@H](O)C2 |r,TLB:30:31:36.38:34.33,THB:37:36:34.33:31|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590713
PNG
(US11560385, Compound 156B)
Show SMILES Cc1c(cc(\C=C\CN)n1-c1ccc(cc1)C#N)C(=O)CN1C2CCC1[C@@H](O)C2 |r,TLB:20:21:26.28:24.23,THB:27:26:24.23:21|
PDB
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UniProtKB/SwissProt

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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590309
PNG
(US11560385, Compound 90B)
Show SMILES Cc1cc(C(=O)CN2C3CCC2[C@@H](O)C3)c(C)n1-c1ccc(C#N)c(F)c1 |r,TLB:6:7:12.14:10.9,THB:13:12:10.9:7|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590327
PNG
(US11560385, Compound 108B)
Show SMILES Cc1c(cc(C2CCC2)n1-c1ccc(cc1)C#N)C(=O)CN1C2CCC1[C@@H](O)C2 |r,TLB:20:21:26.28:24.23,THB:27:26:24.23:21|
PDB
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590680
PNG
(US11560385, Compound 120B)
Show SMILES Cc1c(F)c(C(=O)CN2C3CCC2[C@@H](O)C3)c(C)n1-c1ccc(C#N)c(F)c1 |r,TLB:7:8:13.15:11.10,THB:14:13:11.10:8|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590687
PNG
(US11560385, Compound 128B)
Show SMILES Cc1nc(Cc2c(Cl)c(C(=O)CN3C4CCC3[C@@H](O)C4)c(C)n2-c2ccc(cc2)C#N)cs1 |r,TLB:11:12:17.19:15.14,THB:18:17:15.14:12|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590691
PNG
(US11560385, Compound 132B)
Show SMILES Cc1c(cc(C2CC(F)C2)n1-c1ccc(cc1)C#N)C(=O)CN1C2CCC1[C@@H](O)C2 |r,wD:27.31,TLB:21:22:27.29:25.24,THB:28:27:25.24:22,(-2.97,-.98,;-1.63,-.21,;-1.16,1.25,;.38,1.25,;.86,-.21,;2.35,-.61,;3.12,-1.95,;4.45,-1.18,;5.94,-1.58,;3.68,.16,;-.39,-1.12,;-.39,-2.66,;-1.72,-3.43,;-1.72,-4.97,;-.39,-5.74,;.95,-4.97,;.95,-3.43,;-.39,-7.28,;-.39,-8.82,;-2.24,2.34,;-3.73,1.94,;-1.85,3.83,;-2.93,4.92,;-4.03,6,;-2.7,6.77,;-2.3,8.26,;-3.63,7.49,;-5.17,7.49,;-5.94,8.82,;-5.57,6,)|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590692
PNG
(US11560385, Compound 133B)
Show SMILES Cc1c(cc(CC2CCC2)n1-c1ccc(cc1)C#N)C(=O)CN1C2CCC1[C@@H](O)C2 |r,TLB:21:22:27.29:25.24,THB:28:27:25.24:22|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590693
PNG
(US11560385, Compound 134B)
Show SMILES Cc1c(cc(CC2CC(C)(C)C2)n1-c1ccc(cc1)C#N)C(=O)CN1C2CCC1[C@@H](O)C2 |r,TLB:23:24:29.31:27.26,THB:30:29:27.26:24|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590694
PNG
(US11560385, Compound 135B)
Show SMILES Cc1c(cc(CC2CC(F)(F)C2)n1-c1ccc(cc1)C#N)C(=O)CN1C2CCC1[C@@H](O)C2 |r,TLB:23:24:29.31:27.26,THB:30:29:27.26:24|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590695
PNG
(US11560385, Compound 136B)
Show SMILES C[C@H]1CC2CCC1N2CC(=O)c1cc(C#N)n(c1C)-c1ccc(cc1)C#N |r,TLB:0:1:5.4:7,THB:8:7:1.2:5.4|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590696
PNG
(US11560385, Compound 137B)
Show SMILES Cc1c(cc(C#N)n1-c1ccc(cc1)C#N)C(=O)CN1C2CCC1CC2 |TLB:18:19:25.24:21.22|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590191
PNG
(US11560385, Compound 1A)
Show SMILES Cc1c(C(=O)CN2C3CCC2CC3)c2ccc(CCS(C)(=O)=O)cc2n1-c1ccc(Cl)cc1 |THB:5:6:12.11:8.9|
PDB
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590192
PNG
(US11560385, Compound 2A)
Show SMILES Cc1c(C(=O)CN2C3CCC2CCC3)c2ccc(CCS(C)(=O)=O)cc2n1-c1ccc(Cl)cc1
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590194
PNG
(US11560385, Compound 4A)
Show SMILES Cc1c(C(=O)CN2C3CCC2CC(O)C3)c2ccc(CCS(C)(=O)=O)cc2n1-c1ccc(Cl)cc1 |THB:13:12:8.9:6|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590195
PNG
(US11560385, Compound 5A)
Show SMILES Cc1c(C(=O)CN2C3CCC2CC(O)C3)c2ccc(CCS(C)(=O)=O)cc2n1-c1ccc(Cl)cc1 |TLB:13:12:8.9:6|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590196
PNG
(US11560385, Compound 6A)
Show SMILES Cc1c(C(=O)CN2C3CCC2[C@@H](O)C3)c2ccc(CCS(C)(=O)=O)cc2n1-c1ccc(Cl)cc1 |r,THB:5:6:11.13:9.8,12:11:9.8:6|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590197
PNG
(US11560385, Compound 7A)
Show SMILES Cc1c(C(=O)CN2CCC(O)CC2)c2ccc(CCS(C)(=O)=O)cc2n1-c1ccc(Cl)cc1
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590198
PNG
(US11560385, Compound 8A)
Show SMILES Cc1c(C(=O)CN2C3CCC2CC3)c2ccc(CCC#N)cc2n1-c1ccc(Cl)cc1 |THB:5:6:12.11:8.9|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590200
PNG
(US11560385, Compound 10A | US11560385, Compound 15...)
Show SMILES Cc1c(C(=O)CN2C3CCC2[C@@H](O)C3)c2ccc(CCC#N)cc2n1-c1ccc(Cl)cc1 |r,THB:5:6:11.13:9.8,12:11:9.8:6|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590201
PNG
(US11560385, Compound 11A)
Show SMILES Cc1c(C(=O)CN2C3CCC2CC3)c2ccc(CC3COC3)cc2n1-c1ccc(Cl)cc1 |THB:5:6:12.11:8.9|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590203
PNG
(US11560385, Compound 13A)
Show SMILES Cc1c(C(=O)CN2C3CCC2[C@@H](O)C3)c2ccc(CC3COC3)cc2n1-c1ccc(Cl)cc1 |r,THB:5:6:11.13:9.8,12:11:9.8:6|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590200
PNG
(US11560385, Compound 10A | US11560385, Compound 15...)
Show SMILES Cc1c(C(=O)CN2C3CCC2[C@@H](O)C3)c2ccc(CCC#N)cc2n1-c1ccc(Cl)cc1 |r,THB:5:6:11.13:9.8,12:11:9.8:6|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590206
PNG
(US11560385, Compound 16A)
Show SMILES Cc1c(C(=O)CN2C3CCC2CC3)c2ccc(CCS(=O)(=O)C3CC3)cc2n1-c1ccc(Cl)cc1
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590207
PNG
(US11560385, Compound 17A)
Show SMILES Cc1c(C(=O)CN2C3CCC2CC3)c2ccc(CCCC#N)cc2n1-c1ccc(Cl)cc1 |THB:5:6:12.11:8.9|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590208
PNG
(US11560385, Compound 18A)
Show SMILES Cc1c(C(=O)CN2C3CCC2[C@@H](O)C3)c2ccc(CCCC#N)cc2n1-c1ccc(Cl)cc1 |r,THB:5:6:11.13:9.8,12:11:9.8:6|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590209
PNG
(US11560385, Compound 19A)
Show SMILES Cc1c(C(=O)CN2C3CCC2[C@@H](CO)C3)c2ccc(CCCC#N)cc2n1-c1ccc(Cl)cc1 |r,THB:12:11:9.8:6,5:6:11.14:9.8|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590213
PNG
(US11560385, Compound 23A | US11560385, Compound 24...)
Show SMILES Cc1c(C(=O)CN2C3CCC2CC(O)C3)c2ccc(CCS(=O)(=O)C3CC3)cc2n1-c1ccc(Cl)cc1 |THB:13:12:8.9:6|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590218
PNG
(US11560385, Compound 28A)
Show SMILES CN1CCN=C1CCc1ccc2c(C(=O)CN3C4CCC3CC(O)C4)c(C)n(-c3ccc(Cl)cc3)c2c1 |c:4,THB:23:22:18.19:16|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590219
PNG
(US11560385, Compound 29A)
Show SMILES CN1CCN=C1CCc1ccc2c(C(=O)CN3C4CCC3CC(O)C4)c(C)n(-c3ccc(Cl)cc3)c2c1 |c:4,TLB:23:22:18.19:16|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590223
PNG
(US11560385, Compound 33A)
Show SMILES Cc1c(C(=O)CN2C3CCC2CCC3)c2ccc(CCC#N)cc2n1-c1ccc(Cl)cc1
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590226
PNG
(US11560385, Compound 2B)
Show SMILES Cc1c(cc(CCCC2CCOCC2)n1-c1ccc(cc1)C#N)C(=O)CN1C2CCC1[C@@H](O)C2 |r,TLB:25:26:31.33:29.28,THB:32:31:29.28:26|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590227
PNG
(US11560385, Compound 3B)
Show SMILES Cc1c(cc(C#CCCC#N)n1-c1ccc(cc1)C#N)C(=O)CN1C2CCC1CC2 |TLB:22:23:29.28:25.26|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590228
PNG
(US11560385, Compound 4B)
Show SMILES Cc1c(cc(C[C@H]2C[C@H](C2)C#N)n1-c1ccc(cc1)C#N)C(=O)CN1C2CCC1[C@@H](O)C2 |r,wU:6.5,8.10,wD:29.33,TLB:23:24:29.31:27.26,THB:30:29:27.26:24,(-3.57,-.98,;-2.24,-.21,;-1.76,1.25,;-.22,1.25,;.25,-.21,;1.74,-.61,;2.83,.48,;2.83,2.02,;4.37,2.02,;4.37,.48,;5.46,3.1,;6.55,4.19,;-.99,-1.12,;-.99,-2.66,;-2.33,-3.43,;-2.33,-4.97,;-.99,-5.74,;.34,-4.97,;.34,-3.43,;-.99,-7.28,;-.99,-8.82,;-2.85,2.34,;-4.34,1.94,;-2.45,3.83,;-3.54,4.92,;-4.64,6,;-3.3,6.77,;-2.9,8.26,;-4.24,7.49,;-5.78,7.49,;-6.55,8.82,;-6.18,6,)|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590230
PNG
(US11560385, Compound 6B)
Show SMILES Cc1nccn1C\C=C\c1cc(C(=O)CN2C3CCC2[C@@H](O)C3)c(C)n1-c1ccc(cc1)C#N |r,TLB:14:15:20.22:18.17,THB:21:20:18.17:15|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590231
PNG
(US11560385, Compound 7B)
Show SMILES Cc1c(cc(CCCCS(C)(=O)=O)n1-c1ccc(cc1)C#N)C(=O)CN1[C@@H]2CC[C@@H]1CC(O)C2 |r,TLB:24:25:27.28:30.33.31,THB:32:31:27.28:25|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590232
PNG
(US11560385, Compound 8B)
Show SMILES Cc1c(cc(CCCCS(C)(=O)=O)n1-c1ccc(cc1)C#N)C(=O)CN1C2CCC1[C@@H](O)C2 |r,TLB:24:25:30.32:28.27,THB:31:30:28.27:25|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590233
PNG
(US11560385, Compound 9B)
Show SMILES Cc1c(cc(CCC2CCOCC2)n1-c1ccc(cc1)C#N)C(=O)CN1C2CCC1[C@@H](O)C2 |r,TLB:24:25:30.32:28.27,THB:31:30:28.27:25|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 14


(Homo sapiens (Human))
BDBM590234
PNG
(US11560385, Compound 10B)
Show SMILES Cc1c(cc(C#CCCC#N)n1-c1ccc(cc1)C#N)C(=O)CN1C2CCC1[C@@H](O)C2 |r,TLB:22:23:28.30:26.25,THB:29:28:26.25:23|
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TBA

Assay Description
Usp14 Inhibition Assay was described in B. H. Lee et al. Nature 2010, 467 (9), 179.


Citation and Details

BindingDB Entry DOI: 10.7270/Q2445RDM
More data for this
Ligand-Target Pair
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