Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase WNK1 [198-401]'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase WNK1 [198-401] (Homo sapiens (Human))	BDBM49829 ((2-fluorophenyl)(5-(2-(methylamino)thiazol-4-yl)in...) Show SMILES CNc1nc(cs1)-c1ccc2N(CCc2c1)C(=O)c1ccccc1F Show InChI InChI=1S/C19H16FN3OS/c1-21-19-22-16(11-25-19)12-6-7-17-13(10-12)8-9-23(17)18(24)14-4-2-3-5-15(14)20/h2-7,10-11H,8-9H2,1H3,(H,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research, Inc.					Assay Description For hit validation, eight compound replicates were made from the original stock dilution plates. The Cybi-WellTM dispenser was used to prepare 1.5 &#...				ACS Chem Biol 11: 3338-3346 (2016) Article DOI: 10.1021/acschembio.6b00511 BindingDB Entry DOI: 10.7270/Q2FB51SQ
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase WNK1 [198-401] (Homo sapiens (Human))	BDBM49829 ((2-fluorophenyl)(5-(2-(methylamino)thiazol-4-yl)in...) Show SMILES CNc1nc(cs1)-c1ccc2N(CCc2c1)C(=O)c1ccccc1F Show InChI InChI=1S/C19H16FN3OS/c1-21-19-22-16(11-25-19)12-6-7-17-13(10-12)8-9-23(17)18(24)14-4-2-3-5-15(14)20/h2-7,10-11H,8-9H2,1H3,(H,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research, Inc.					Assay Description For hit validation, eight compound replicates were made from the original stock dilution plates. The Cybi-WellTM dispenser was used to prepare 1.5 &#...				ACS Chem Biol 11: 3338-3346 (2016) Article DOI: 10.1021/acschembio.6b00511 BindingDB Entry DOI: 10.7270/Q2FB51SQ
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase WNK1 [198-401] (Homo sapiens (Human))	BDBM207990 ((2-((4-Chlorobenzyl)oxy)phenyl)(5-(2-(methylamino)...) Show SMILES CNc1nc(cs1)-c1ccc2N(CCc2c1)C(=O)c1ccccc1OCc1ccc(Cl)cc1 Show InChI InChI=1S/C26H22ClN3O2S/c1-28-26-29-22(16-33-26)18-8-11-23-19(14-18)12-13-30(23)25(31)21-4-2-3-5-24(21)32-15-17-6-9-20(27)10-7-17/h2-11,14,16H,12-13,15H2,1H3,(H,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research, Inc.					Assay Description For hit validation, eight compound replicates were made from the original stock dilution plates. The Cybi-WellTM dispenser was used to prepare 1.5 &#...				ACS Chem Biol 11: 3338-3346 (2016) Article DOI: 10.1021/acschembio.6b00511 BindingDB Entry DOI: 10.7270/Q2FB51SQ
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase WNK1 [198-401] (Homo sapiens (Human))	BDBM207990 ((2-((4-Chlorobenzyl)oxy)phenyl)(5-(2-(methylamino)...) Show SMILES CNc1nc(cs1)-c1ccc2N(CCc2c1)C(=O)c1ccccc1OCc1ccc(Cl)cc1 Show InChI InChI=1S/C26H22ClN3O2S/c1-28-26-29-22(16-33-26)18-8-11-23-19(14-18)12-13-30(23)25(31)21-4-2-3-5-24(21)32-15-17-6-9-20(27)10-7-17/h2-11,14,16H,12-13,15H2,1H3,(H,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	>8.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research, Inc.					Assay Description For hit validation, eight compound replicates were made from the original stock dilution plates. The Cybi-WellTM dispenser was used to prepare 1.5 &#...				ACS Chem Biol 11: 3338-3346 (2016) Article DOI: 10.1021/acschembio.6b00511 BindingDB Entry DOI: 10.7270/Q2FB51SQ
					More data for this Ligand-Target Pair