Compile Data Set for Download or QSAR

Found 5 hits Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase Mdm2 [2-188]/Protein Mdm4 [2-185]'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 [2-188]/Protein Mdm4 [2-185] (Homo sapiens (Human))	BDBM238901 (US9403827, 3) Show SMILES COc1ccccc1-c1nc2NC(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C Show InChI InChI=1S/C29H28Cl2N4O2/c1-16(2)34-26-25(21-13-12-19(30)14-18(21)4)35(23-15-20(31)11-10-17(23)3)29(36)33-27(26)32-28(34)22-8-6-7-9-24(22)37-5/h6-16,25H,1-5H3,(H,33,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.45E+3	n/a	n/a	n/a	n/a	n/a	25
NOVARTIS AG US Patent					Assay Description Assay 1: This assay was used to evaluate compounds displaying inhibition of p53-MDM2 interaction and p53-MDM4 interaction at IC50s of 0.005 to 50 &mu...				US Patent US9403827 (2016) BindingDB Entry DOI: 10.7270/Q2Z31XKH
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 [2-188]/Protein Mdm4 [2-185] (Homo sapiens (Human))	BDBM238899 (US9403827, 1) Show SMILES COc1ccccc1-c1nc2NC(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1cccc(Cl)c1F Show InChI InChI=1S/C27H23Cl2FN4O2/c1-15(2)33-24-23(16-11-13-17(28)14-12-16)34(20-9-6-8-19(29)22(20)30)27(35)32-25(24)31-26(33)18-7-4-5-10-21(18)36-3/h4-15,23H,1-3H3,(H,32,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.51E+3	n/a	n/a	n/a	n/a	n/a	25
NOVARTIS AG US Patent					Assay Description Assay 1: This assay was used to evaluate compounds displaying inhibition of p53-MDM2 interaction and p53-MDM4 interaction at IC50s of 0.005 to 50 &mu...				US Patent US9403827 (2016) BindingDB Entry DOI: 10.7270/Q2Z31XKH
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 [2-188]/Protein Mdm4 [2-185] (Homo sapiens (Human))	BDBM238900 (US9403827, 2) Show SMILES COc1ccccc1-c1nc2NC(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1C)c1cccc(Cl)c1F Show InChI InChI=1S/C28H25Cl2FN4O2/c1-15(2)34-25-24(18-13-12-17(29)14-16(18)3)35(21-10-7-9-20(30)23(21)31)28(36)33-26(25)32-27(34)19-8-5-6-11-22(19)37-4/h5-15,24H,1-4H3,(H,33,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.13E+3	n/a	n/a	n/a	n/a	n/a	25
NOVARTIS AG US Patent					Assay Description Assay 1: This assay was used to evaluate compounds displaying inhibition of p53-MDM2 interaction and p53-MDM4 interaction at IC50s of 0.005 to 50 &mu...				US Patent US9403827 (2016) BindingDB Entry DOI: 10.7270/Q2Z31XKH
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 [2-188]/Protein Mdm4 [2-185] (Homo sapiens (Human))	BDBM238904 (US9403827, 6) Show SMILES COc1ccncc1-c1nc2NC(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1cccc(Cl)c1F Show InChI InChI=1S/C26H22Cl2FN5O2/c1-14(2)33-23-22(15-7-9-16(27)10-8-15)34(19-6-4-5-18(28)21(19)29)26(35)32-24(23)31-25(33)17-13-30-12-11-20(17)36-3/h4-14,22H,1-3H3,(H,32,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a	25
NOVARTIS AG US Patent					Assay Description Assay 1: This assay was used to evaluate compounds displaying inhibition of p53-MDM2 interaction and p53-MDM4 interaction at IC50s of 0.005 to 50 &mu...				US Patent US9403827 (2016) BindingDB Entry DOI: 10.7270/Q2Z31XKH
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 [2-188]/Protein Mdm4 [2-185] (Homo sapiens (Human))	BDBM238902 (US9403827, 4) Show SMILES COc1ccncc1-c1nc2NC(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C Show InChI InChI=1S/C28H27Cl2N5O2/c1-15(2)34-25-24(20-9-8-18(29)12-17(20)4)35(22-13-19(30)7-6-16(22)3)28(36)33-26(25)32-27(34)21-14-31-11-10-23(21)37-5/h6-15,24H,1-5H3,(H,33,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.67E+4	n/a	n/a	n/a	n/a	n/a	25
NOVARTIS AG US Patent					Assay Description Assay 1: This assay was used to evaluate compounds displaying inhibition of p53-MDM2 interaction and p53-MDM4 interaction at IC50s of 0.005 to 50 &mu...				US Patent US9403827 (2016) BindingDB Entry DOI: 10.7270/Q2Z31XKH
					More data for this Ligand-Target Pair