Compile Data Set for Download or QSAR

Found 6 hits Enz. Inhib. hit(s) with Target = '4-hydroxyphenylpyruvate dioxygenase' AND taxid = 10116   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
4-hydroxyphenylpyruvate dioxygenase (Rattus norvegicus)	BDBM50264347 (CHEMBL4092919) Show SMILES CC1(C)CC(=O)C(C(=O)c2ccc(cc2Cl)[N+]([O-])=O)C(=O)C1 Show InChI InChI=1S/C15H14ClNO5/c1-15(2)6-11(18)13(12(19)7-15)14(20)9-4-3-8(17(21)22)5-10(9)16/h3-5,13H,6-7H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Siena Curated by ChEMBL					Assay Description Inhibition of Wistar rat liver cytosol HPPD using HPP as substrate assessed as reduction in O2 consumption				J Med Chem 60: 4101-4125 (2017) Article DOI: 10.1021/acs.jmedchem.6b01395 BindingDB Entry DOI: 10.7270/Q2FN18ND
					More data for this Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase (Rattus norvegicus)	BDBM50264337 (CHEBI:38321 | MESOTRIONE) Show SMILES CS(=O)(=O)c1ccc(C(=O)C2C(=O)CCCC2=O)c(c1)[N+]([O-])=O Show InChI InChI=1S/C14H13NO7S/c1-23(21,22)8-5-6-9(10(7-8)15(19)20)14(18)13-11(16)3-2-4-12(13)17/h5-7,13H,2-4H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Siena Curated by ChEMBL					Assay Description Inhibition of Wistar rat liver cytosol HPPD using HPP as substrate assessed as reduction in O2 consumption				J Med Chem 60: 4101-4125 (2017) Article DOI: 10.1021/acs.jmedchem.6b01395 BindingDB Entry DOI: 10.7270/Q2FN18ND
					More data for this Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase (Rattus norvegicus)	BDBM50088804 (1,3-Cyclohexanedione, 2-(2-nitro-4-(trifluoromethy...) Show SMILES [O-][N+](=O)c1cc(ccc1C(=O)C1C(=O)CCCC1=O)C(F)(F)F Show InChI InChI=1S/C14H10F3NO5/c15-14(16,17)7-4-5-8(9(6-7)18(22)23)13(21)12-10(19)2-1-3-11(12)20/h4-6,12H,1-3H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Siena Curated by ChEMBL					Assay Description Inhibition of Wistar rat liver HPPD using 4-Hydroxyphenylpyruvate as substrate assessed as reduction in oxygen consumption preincubated for 3 mins fo...				J Med Chem 60: 4101-4125 (2017) Article DOI: 10.1021/acs.jmedchem.6b01395 BindingDB Entry DOI: 10.7270/Q2FN18ND
					More data for this Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase (Rattus norvegicus)	BDBM50088804 (1,3-Cyclohexanedione, 2-(2-nitro-4-(trifluoromethy...) Show SMILES [O-][N+](=O)c1cc(ccc1C(=O)C1C(=O)CCCC1=O)C(F)(F)F Show InChI InChI=1S/C14H10F3NO5/c15-14(16,17)7-4-5-8(9(6-7)18(22)23)13(21)12-10(19)2-1-3-11(12)20/h4-6,12H,1-3H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Siena Curated by ChEMBL					Assay Description Inhibition of Wistar rat liver cytosol HPPD using HPP as substrate assessed as reduction in O2 consumption				J Med Chem 60: 4101-4125 (2017) Article DOI: 10.1021/acs.jmedchem.6b01395 BindingDB Entry DOI: 10.7270/Q2FN18ND
					More data for this Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase (Rattus norvegicus)	BDBM50279373 (6-chloro-N-(4-(4-(cyclopropyl(hydroxy)methylene)-1...) Show SMILES Fc1ccc(CN2C(CCCCNC(=O)c3ccc(Cl)nc3)C(=O)C(C(=O)C3CC3)C2=O)cc1 Show InChI InChI=1S/C25H25ClFN3O4/c26-20-11-8-17(13-29-20)24(33)28-12-2-1-3-19-23(32)21(22(31)16-6-7-16)25(34)30(19)14-15-4-9-18(27)10-5-15/h4-5,8-11,13,16,19,21H,1-3,6-7,12,14H2,(H,28,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bayer CropScience AG Curated by ChEMBL					Assay Description Inhibition of rat 4-hydroxyphenylpyruvate dioxygenase				Bioorg Med Chem 17: 4035-46 (2009) Article DOI: 10.1016/j.bmc.2009.03.027 BindingDB Entry DOI: 10.7270/Q2KK9BP8
					More data for this Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase (Rattus norvegicus)	BDBM50264349 (CHEMBL1498742) Show SMILES Cc1cc(on1)C1C(=O)C(C(=O)c2ccc(Cl)cc2)C(=O)CC1(C)C Show InChI InChI=1S/C19H18ClNO4/c1-10-8-14(25-21-10)16-18(24)15(13(22)9-19(16,2)3)17(23)11-4-6-12(20)7-5-11/h4-8,15-16H,9H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Siena Curated by ChEMBL					Assay Description Inhibition of Wistar rat liver cytosol HPPD using HPP as substrate assessed as reduction in O2 consumption				J Med Chem 60: 4101-4125 (2017) Article DOI: 10.1021/acs.jmedchem.6b01395 BindingDB Entry DOI: 10.7270/Q2FN18ND
					More data for this Ligand-Target Pair