Found 36 hits Enz. Inhib. hit(s) with Target = 'Protein ADM2' AND taxid = 9606 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Protein ADM2
(Homo sapiens (Human)) | BDBM50570409
(CHEMBL4857810)Show SMILES CNCc1ccccc1CN(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)C(=O)C(C)(C)C | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.631 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Antagonist activity at human AM2 expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins fol... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02191
BindingDB Entry DOI: 10.7270/Q2474FM7 |
More data for this
Ligand-Target Pair | |
Protein ADM2
(Homo sapiens (Human)) | BDBM50570410
(CHEMBL4851152)Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1ccccc1CNC1CC1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Antagonist activity at human AM2 expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins fol... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02191
BindingDB Entry DOI: 10.7270/Q2474FM7 |
More data for this
Ligand-Target Pair | |
Protein ADM2
(Homo sapiens (Human)) | BDBM50570411
(CHEMBL4877585)Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1ccccc1CN1CCC1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Antagonist activity at human AM2 expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins fol... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02191
BindingDB Entry DOI: 10.7270/Q2474FM7 |
More data for this
Ligand-Target Pair | |
Protein ADM2
(Homo sapiens (Human)) | BDBM50570413
(CHEMBL4850259)Show SMILES CC(N)c1ccccc1CN(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)C(=O)C(C)(C)C | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Antagonist activity at human AM2 expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins fol... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02191
BindingDB Entry DOI: 10.7270/Q2474FM7 |
More data for this
Ligand-Target Pair | |
Protein ADM2
(Homo sapiens (Human)) | BDBM50570396
(CHEMBL4871934)Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1ccccc1N | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Antagonist activity at human AM2 expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins fol... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02191
BindingDB Entry DOI: 10.7270/Q2474FM7 |
More data for this
Ligand-Target Pair | |
Protein ADM2
(Homo sapiens (Human)) | BDBM50570397
(CHEMBL4852669)Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1ccccc1CN | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Antagonist activity at human AM2 expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins fol... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02191
BindingDB Entry DOI: 10.7270/Q2474FM7 |
More data for this
Ligand-Target Pair | |
Protein ADM2
(Homo sapiens (Human)) | BDBM50246690
(Ac-WVTHRLAGLLSRSGGVVRKNFVPTDVGPFAF-NH2 | CHEMBL503...)Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r,wU:184.188,213.219,228.235,50.51,92.94,117.119,131.133,78.80,36.43,151.153,185.191,199.203,17.21,wD:12.12,170.173,180.185,54.67,72.76,103.105,46.47,4.4,124.126,142.144,86.88,159.161,191.195,25.32,217.222,233.239,(-1.99,-10.08,;-2,-8.53,;-.67,-7.76,;-3.34,-7.77,;-3.35,-6.23,;-4.7,-5.49,;-6.03,-6.26,;-6.03,-7.8,;-7.37,-5.5,;-8.7,-6.27,;-10.01,-5.47,;-10.02,-3.93,;-11.35,-6.25,;-11.34,-7.78,;-12.7,-5.52,;-14.04,-6.29,;-14.02,-7.82,;-15.37,-5.52,;-15.37,-3.98,;-14.05,-3.21,;-14.05,-1.67,;-12.71,-3.97,;-16.7,-6.3,;-18.03,-5.53,;-18.03,-3.99,;-19.36,-6.31,;-19.36,-7.85,;-18.02,-8.62,;-18.01,-10.15,;-16.69,-10.95,;-16.65,-12.49,;-18.01,-13.29,;-15.34,-13.27,;-20.71,-5.56,;-22.04,-6.33,;-22.03,-7.87,;-23.38,-5.56,;-23.38,-4.02,;-22.06,-3.24,;-20.66,-3.86,;-19.63,-2.72,;-20.4,-1.39,;-21.91,-1.71,;-24.71,-6.35,;-26.03,-5.55,;-26.05,-4.01,;-27.38,-6.33,;-28.73,-5.59,;-30.06,-6.36,;-30.07,-7.9,;-31.41,-5.6,;-32.72,-6.38,;-34.07,-5.62,;-34.08,-4.08,;-35.38,-6.39,;-35.38,-7.93,;-36.7,-8.71,;-38.12,-8.09,;-39.12,-9.24,;-38.34,-10.57,;-38.8,-12.02,;-37.77,-13.15,;-36.27,-12.82,;-35.82,-11.35,;-36.86,-10.23,;-36.73,-5.63,;-36.74,-4.1,;-35.41,-3.32,;-38.07,-3.34,;-31.42,-4.06,;-30.09,-3.28,;-32.75,-3.3,;-27.36,-7.87,;-28.7,-8.65,;-26.07,-8.66,;-2.01,-5.45,;-2.02,-3.91,;-.7,-6.25,;.63,-5.47,;.63,-3.92,;1.96,-3.15,;1.95,-1.6,;3.29,-3.91,;1.98,-6.23,;1.98,-7.77,;3.31,-5.46,;4.66,-6.2,;4.67,-7.74,;5.99,-8.52,;5.99,-5.42,;5.98,-3.89,;7.31,-6.21,;8.64,-5.44,;8.63,-3.9,;9.96,-3.12,;9.95,-1.58,;11.29,-.81,;11.29,.73,;9.95,1.48,;12.62,1.5,;9.98,-6.21,;9.98,-7.74,;11.3,-5.43,;12.66,-6.16,;12.67,-7.7,;13.96,-8.48,;13.99,-5.38,;13.98,-3.84,;15.31,-6.18,;16.64,-5.4,;17.98,-6.16,;17.99,-7.7,;19.31,-5.39,;20.66,-6.13,;21.99,-5.35,;21.99,-3.81,;23.31,-6.14,;24.64,-5.36,;24.63,-3.83,;25.97,-3.05,;23.29,-3.06,;25.98,-6.13,;25.98,-7.68,;27.31,-5.36,;28.67,-6.1,;28.68,-7.63,;30.01,-8.4,;27.35,-8.41,;30,-5.32,;29.99,-3.78,;31.32,-6.11,;32.65,-5.33,;32.64,-3.79,;33.97,-3.02,;33.96,-1.48,;35.29,-.7,;35.28,.84,;36.6,1.61,;33.94,1.6,;33.98,-6.1,;33.99,-7.64,;35.32,-5.33,;36.67,-6.07,;36.67,-7.61,;38.01,-8.37,;38.02,-9.91,;39.36,-10.66,;39.37,-12.2,;38,-5.29,;38,-3.75,;39.32,-6.08,;40.65,-5.3,;40.64,-3.76,;41.96,-2.98,;43.29,-3.77,;41.96,-1.44,;41.98,-6.06,;41.99,-7.6,;43.32,-5.29,;44.66,-6.04,;44.66,-7.58,;46,-8.35,;47.35,-7.58,;48.67,-8.34,;48.67,-9.87,;47.34,-10.63,;46,-9.87,;46,-5.27,;46,-3.73,;47.33,-6.04,;48.67,-5.27,;50,-6.04,;50,-7.58,;51.34,-5.27,;48.67,-3.73,;47.33,-2.96,;50.04,-3.03,;51.41,-3.72,;52.49,-2.63,;51.81,-1.25,;50.28,-1.5,;49.19,-.41,;47.7,-.81,;49.59,1.08,;48.5,2.17,;47.01,1.77,;46.61,.28,;45.91,2.85,;48.9,3.66,;50.38,4.06,;47.8,4.73,;48.12,6.24,;49.59,6.72,;49.9,8.24,;48.74,9.25,;51.37,8.71,;46.97,7.26,;45.51,6.78,;47.29,8.77,;46.14,9.8,;44.68,9.33,;43.53,10.35,;44.36,7.81,;46.46,11.31,;47.92,11.78,;45.31,12.33,;45.62,13.84,;44.48,14.88,;43.01,14.39,;44.72,16.23,;43.66,17.34,;44.4,18.68,;45.91,18.4,;46.12,16.86,;47.47,16.15,;47.51,14.6,;48.79,16.95,;50.14,16.21,;50.19,14.68,;51.53,13.94,;52.84,14.73,;54.2,14.01,;54.24,12.47,;52.93,11.66,;51.58,12.4,;51.45,17.02,;51.41,18.56,;52.81,16.29,;54.12,17.09,;54.07,18.63,;55.47,16.36,;55.52,14.81,;56.78,17.16,;58.13,16.42,;58.17,14.88,;59.53,14.15,;60.84,14.96,;62.19,14.22,;62.23,12.69,;60.92,11.88,;59.58,12.62,;59.45,17.23,;60.8,16.49,;59.4,18.78,)| Show InChI InChI=1S/C159H246N46O39/c1-79(2)60-104(182-119(213)74-175-131(219)87(17)179-138(226)105(61-80(3)4)188-136(224)100(49-35-55-170-157(163)164)184-142(230)110(67-96-71-169-78-178-96)193-155(243)129(90(20)209)203-153(241)126(85(13)14)199-145(233)109(181-91(21)210)66-95-70-173-98-47-32-31-46-97(95)98)140(228)189-106(62-81(5)6)141(229)196-114(77-207)147(235)185-101(50-36-56-171-158(165)166)137(225)195-113(76-206)133(221)176-72-118(212)174-73-120(214)197-124(83(9)10)152(240)200-125(84(11)12)151(239)186-102(51-37-57-172-159(167)168)134(222)183-99(48-33-34-54-160)135(223)191-111(68-117(161)211)143(231)190-108(65-94-44-29-24-30-45-94)144(232)201-127(86(15)16)156(244)205-59-39-53-116(205)149(237)202-128(89(19)208)154(242)194-112(69-122(216)217)146(234)198-123(82(7)8)150(238)177-75-121(215)204-58-38-52-115(204)148(236)192-107(64-93-42-27-23-28-43-93)139(227)180-88(18)132(220)187-103(130(162)218)63-92-40-25-22-26-41-92/h22-32,40-47,70-71,78-90,99-116,123-129,173,206-209H,33-39,48-69,72-77,160H2,1-21H3,(H2,161,211)(H2,162,218)(H,169,178)(H,174,212)(H,175,219)(H,176,221)(H,177,238)(H,179,226)(H,180,227)(H,181,210)(H,182,213)(H,183,222)(H,184,230)(H,185,235)(H,186,239)(H,187,220)(H,188,224)(H,189,228)(H,190,231)(H,191,223)(H,192,236)(H,193,243)(H,194,242)(H,195,225)(H,196,229)(H,197,214)(H,198,234)(H,199,233)(H,200,240)(H,201,232)(H,202,237)(H,203,241)(H,216,217)(H4,163,164,170)(H4,165,166,171)(H4,167,168,172)/t87-,88-,89+,90+,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,123-,124-,125-,126-,127-,128-,129-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human adrenomedullin 2 receptor expressed in CHO cells assessed as effect on cAMP accumulation |
J Med Chem 51: 7889-97 (2008)
Article DOI: 10.1021/jm8009298
BindingDB Entry DOI: 10.7270/Q2P26Z0C |
More data for this
Ligand-Target Pair | |
Protein ADM2
(Homo sapiens (Human)) | BDBM50570401
(CHEMBL4879142)Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1ccccc1CCN | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Antagonist activity at human AM2 expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins fol... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02191
BindingDB Entry DOI: 10.7270/Q2474FM7 |
More data for this
Ligand-Target Pair | |
Protein ADM2
(Homo sapiens (Human)) | BDBM50570400
(CHEMBL4876643)Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1ccccc1C(N)=O | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 79 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Antagonist activity at human AM2 expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins fol... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02191
BindingDB Entry DOI: 10.7270/Q2474FM7 |
More data for this
Ligand-Target Pair | |
Protein ADM2
(Homo sapiens (Human)) | BDBM50570402
(CHEMBL4856402)Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1cccc2CCNCc12 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Antagonist activity at human AM2 expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins fol... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02191
BindingDB Entry DOI: 10.7270/Q2474FM7 |
More data for this
Ligand-Target Pair | |
Protein ADM2
(Homo sapiens (Human)) | BDBM50570408
(CHEMBL4873687)Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1ccccc1CNC(N)=N | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Antagonist activity at human AM2 expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins fol... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02191
BindingDB Entry DOI: 10.7270/Q2474FM7 |
More data for this
Ligand-Target Pair | |
Protein ADM2
(Homo sapiens (Human)) | BDBM50246693
(Ac-WVTH[Cit]LAGLLS[Cit]SGGVVRKNFVPTDVGPFAF-NH2 | C...)Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| Show InChI InChI=1S/C159H244N44O41/c1-79(2)60-104(180-119(211)74-173-131(217)87(17)177-138(224)105(61-80(3)4)186-136(222)100(50-36-56-169-158(165)243)182-142(228)110(67-96-71-167-78-176-96)191-155(241)129(90(20)207)201-153(239)126(85(13)14)197-145(231)109(179-91(21)208)66-95-70-171-98-47-32-31-46-97(95)98)140(226)187-106(62-81(5)6)141(227)194-114(77-205)147(233)183-101(51-37-57-170-159(166)244)137(223)193-113(76-204)133(219)174-72-118(210)172-73-120(212)195-124(83(9)10)152(238)198-125(84(11)12)151(237)184-102(49-35-55-168-157(163)164)134(220)181-99(48-33-34-54-160)135(221)189-111(68-117(161)209)143(229)188-108(65-94-44-29-24-30-45-94)144(230)199-127(86(15)16)156(242)203-59-39-53-116(203)149(235)200-128(89(19)206)154(240)192-112(69-122(214)215)146(232)196-123(82(7)8)150(236)175-75-121(213)202-58-38-52-115(202)148(234)190-107(64-93-42-27-23-28-43-93)139(225)178-88(18)132(218)185-103(130(162)216)63-92-40-25-22-26-41-92/h22-32,40-47,70-71,78-90,99-116,123-129,171,204-207H,33-39,48-69,72-77,160H2,1-21H3,(H2,161,209)(H2,162,216)(H,167,176)(H,172,210)(H,173,217)(H,174,219)(H,175,236)(H,177,224)(H,178,225)(H,179,208)(H,180,211)(H,181,220)(H,182,228)(H,183,233)(H,184,237)(H,185,218)(H,186,222)(H,187,226)(H,188,229)(H,189,221)(H,190,234)(H,191,241)(H,192,240)(H,193,223)(H,194,227)(H,195,212)(H,196,232)(H,197,231)(H,198,238)(H,199,230)(H,200,235)(H,201,239)(H,214,215)(H4,163,164,168)(H3,165,169,243)(H3,166,170,244)/t87-,88-,89+,90+,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,123-,124-,125-,126-,127-,128-,129-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 108 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human adrenomedullin 2 receptor expressed in CHO cells assessed as effect on cAMP accumulation |
J Med Chem 51: 7889-97 (2008)
Article DOI: 10.1021/jm8009298
BindingDB Entry DOI: 10.7270/Q2P26Z0C |
More data for this
Ligand-Target Pair | |
Protein ADM2
(Homo sapiens (Human)) | BDBM50570398
(CHEMBL4861626)Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1ccccc1CO | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 126 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Antagonist activity at human AM2 expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins fol... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02191
BindingDB Entry DOI: 10.7270/Q2474FM7 |
More data for this
Ligand-Target Pair | |
Protein ADM2
(Homo sapiens (Human)) | BDBM50570404
(CHEMBL4850583)Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1ccccc1Cn1ccnc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 126 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Antagonist activity at human AM2 expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins fol... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02191
BindingDB Entry DOI: 10.7270/Q2474FM7 |
More data for this
Ligand-Target Pair | |
Protein ADM2
(Homo sapiens (Human)) | BDBM50570388
(CHEMBL4858139)Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1ccccc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Antagonist activity at human AM2 expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins fol... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02191
BindingDB Entry DOI: 10.7270/Q2474FM7 |
More data for this
Ligand-Target Pair | |
Protein ADM2
(Homo sapiens (Human)) | BDBM50000743
(CHEMBL525571 | [Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Se...)Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| Show InChI InChI=1S/C139H230N44O38/c1-66(2)48-86(161-102(193)60-155-113(197)74(17)159-120(204)87(49-67(3)4)168-118(202)83(40-31-45-152-138(147)148)163-123(207)90(53-80-57-151-65-158-80)173-136(220)111(77(20)188)182-131(215)105(145)69(7)8)121(205)169-88(50-68(5)6)122(206)176-96(64-186)129(213)165-84(41-32-46-153-139(149)150)119(203)175-94(62-184)115(199)156-58-101(192)154-59-104(195)177-107(71(11)12)134(218)179-108(72(13)14)133(217)166-82(39-28-30-44-141)117(201)171-91(54-98(142)189)125(209)172-92(55-99(143)190)124(208)170-89(52-79-36-25-22-26-37-79)126(210)180-109(73(15)16)137(221)183-47-33-42-97(183)130(214)181-110(76(19)187)135(219)174-93(56-100(144)191)127(211)178-106(70(9)10)132(216)157-61-103(194)162-95(63-185)128(212)164-81(38-27-29-43-140)116(200)160-75(18)114(198)167-85(112(146)196)51-78-34-23-21-24-35-78/h21-26,34-37,57,65-77,81-97,105-111,184-188H,27-33,38-56,58-64,140-141,145H2,1-20H3,(H2,142,189)(H2,143,190)(H2,144,191)(H2,146,196)(H,151,158)(H,154,192)(H,155,197)(H,156,199)(H,157,216)(H,159,204)(H,160,200)(H,161,193)(H,162,194)(H,163,207)(H,164,212)(H,165,213)(H,166,217)(H,167,198)(H,168,202)(H,169,205)(H,170,208)(H,171,201)(H,172,209)(H,173,220)(H,174,219)(H,175,203)(H,176,206)(H,177,195)(H,178,211)(H,179,218)(H,180,210)(H,181,214)(H,182,215)(H4,147,148,152)(H4,149,150,153)/t74-,75-,76+,77+,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,105-,106-,107-,108-,109-,110-,111-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 266 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human adrenomedullin 2 receptor expressed in CHO cells assessed as effect on cAMP accumulation |
J Med Chem 51: 7889-97 (2008)
Article DOI: 10.1021/jm8009298
BindingDB Entry DOI: 10.7270/Q2P26Z0C |
More data for this
Ligand-Target Pair | |
Protein ADM2
(Homo sapiens (Human)) | BDBM50570394
(CHEMBL4866548)Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1ccccc1C1CCNC1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Antagonist activity at human AM2 expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins fol... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02191
BindingDB Entry DOI: 10.7270/Q2474FM7 |
More data for this
Ligand-Target Pair | |
Protein ADM2
(Homo sapiens (Human)) | BDBM50570395
(CHEMBL4866915)Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1cccc2[nH]ncc12 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Antagonist activity at human AM2 expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins fol... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02191
BindingDB Entry DOI: 10.7270/Q2474FM7 |
More data for this
Ligand-Target Pair | |
Protein ADM2
(Homo sapiens (Human)) | BDBM50246697
(Ac-WVTH[Cit]LAGLLS[Cit]SGGVV[hArg]KNFVPTDVGPFAF-NH...)Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| Show InChI InChI=1S/C160H246N44O41/c1-80(2)61-105(181-120(212)75-174-132(218)88(17)178-139(225)106(62-81(3)4)187-137(223)102(51-37-57-170-159(166)244)183-143(229)111(68-97-72-168-79-177-97)192-156(242)130(91(20)208)202-154(240)127(86(13)14)198-146(232)110(180-92(21)209)67-96-71-172-99-48-32-31-47-98(96)99)141(227)188-107(63-82(5)6)142(228)195-115(78-206)148(234)184-103(52-38-58-171-160(167)245)138(224)194-114(77-205)134(220)175-73-119(211)173-74-121(213)196-125(84(9)10)153(239)199-126(85(11)12)152(238)185-101(50-34-36-56-169-158(164)165)135(221)182-100(49-33-35-55-161)136(222)190-112(69-118(162)210)144(230)189-109(66-95-45-29-24-30-46-95)145(231)200-128(87(15)16)157(243)204-60-40-54-117(204)150(236)201-129(90(19)207)155(241)193-113(70-123(215)216)147(233)197-124(83(7)8)151(237)176-76-122(214)203-59-39-53-116(203)149(235)191-108(65-94-43-27-23-28-44-94)140(226)179-89(18)133(219)186-104(131(163)217)64-93-41-25-22-26-42-93/h22-32,41-48,71-72,79-91,100-117,124-130,172,205-208H,33-40,49-70,73-78,161H2,1-21H3,(H2,162,210)(H2,163,217)(H,168,177)(H,173,211)(H,174,218)(H,175,220)(H,176,237)(H,178,225)(H,179,226)(H,180,209)(H,181,212)(H,182,221)(H,183,229)(H,184,234)(H,185,238)(H,186,219)(H,187,223)(H,188,227)(H,189,230)(H,190,222)(H,191,235)(H,192,242)(H,193,241)(H,194,224)(H,195,228)(H,196,213)(H,197,233)(H,198,232)(H,199,239)(H,200,231)(H,201,236)(H,202,240)(H,215,216)(H4,164,165,169)(H3,166,170,244)(H3,167,171,245)/t88-,89-,90+,91+,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,124-,125-,126-,127-,128-,129-,130-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 318 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human adrenomedullin 2 receptor expressed in CHO cells assessed as effect on cAMP accumulation |
J Med Chem 51: 7889-97 (2008)
Article DOI: 10.1021/jm8009298
BindingDB Entry DOI: 10.7270/Q2P26Z0C |
More data for this
Ligand-Target Pair | |
Protein ADM2
(Homo sapiens (Human)) | BDBM50246708
(Ac-WVTH[Cit]LAGLLS[Cit]SGGVV[hArg]KNFVPTDVGP[1-Nal...)Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N1CCC[C@@H]1C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| Show InChI InChI=1S/C164H248N44O41/c1-82(2)63-109(185-124(216)77-178-136(222)90(17)182-143(229)110(64-83(3)4)191-141(227)106(53-37-59-174-163(170)248)187-147(233)115(70-100-74-172-81-181-100)196-160(246)134(93(20)212)206-158(244)131(88(13)14)202-150(236)113(184-94(21)213)69-99-73-176-103-50-31-30-49-102(99)103)145(231)192-111(65-84(5)6)146(232)199-119(80-210)152(238)188-107(54-38-60-175-164(171)249)142(228)198-118(79-209)138(224)179-75-123(215)177-76-125(217)200-129(86(9)10)157(243)203-130(87(11)12)156(242)189-105(52-33-35-58-173-162(168)169)139(225)186-104(51-32-34-57-165)140(226)194-116(71-122(166)214)148(234)193-112(67-96-43-26-23-27-44-96)149(235)204-132(89(15)16)161(247)208-62-40-56-121(208)154(240)205-133(92(19)211)159(245)197-117(72-127(219)220)151(237)201-128(85(7)8)155(241)180-78-126(218)207-61-39-55-120(207)153(239)195-114(68-98-47-36-46-97-45-28-29-48-101(97)98)144(230)183-91(18)137(223)190-108(135(167)221)66-95-41-24-22-25-42-95/h22-31,36,41-50,73-74,81-93,104-121,128-134,176,209-212H,32-35,37-40,51-72,75-80,165H2,1-21H3,(H2,166,214)(H2,167,221)(H,172,181)(H,177,215)(H,178,222)(H,179,224)(H,180,241)(H,182,229)(H,183,230)(H,184,213)(H,185,216)(H,186,225)(H,187,233)(H,188,238)(H,189,242)(H,190,223)(H,191,227)(H,192,231)(H,193,234)(H,194,226)(H,195,239)(H,196,246)(H,197,245)(H,198,228)(H,199,232)(H,200,217)(H,201,237)(H,202,236)(H,203,243)(H,204,235)(H,205,240)(H,206,244)(H,219,220)(H4,168,169,173)(H3,170,174,248)(H3,171,175,249)/t90-,91-,92+,93+,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120+,121-,128-,129-,130-,131-,132-,133-,134-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 375 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human adrenomedullin 2 receptor expressed in CHO cells assessed as effect on cAMP accumulation |
J Med Chem 51: 7889-97 (2008)
Article DOI: 10.1021/jm8009298
BindingDB Entry DOI: 10.7270/Q2P26Z0C |
More data for this
Ligand-Target Pair | |
Protein ADM2
(Homo sapiens (Human)) | BDBM50246709
(Ac-WVTH[Cit]LAGLLS[Cit]SGGVV[hArg]KNFVPTDVGP[2-Nal...)Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N1CCC[C@@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| Show InChI InChI=1S/C164H248N44O41/c1-82(2)62-109(185-124(216)77-178-136(222)90(17)182-143(229)110(63-83(3)4)191-141(227)106(50-36-58-174-163(170)248)187-147(233)115(70-101-74-172-81-181-101)196-160(246)134(93(20)212)206-158(244)131(88(13)14)202-150(236)114(184-94(21)213)69-100-73-176-103-47-31-30-46-102(100)103)145(231)192-111(64-84(5)6)146(232)199-119(80-210)152(238)188-107(51-37-59-175-164(171)249)142(228)198-118(79-209)138(224)179-75-123(215)177-76-125(217)200-129(86(9)10)157(243)203-130(87(11)12)156(242)189-105(49-33-35-57-173-162(168)169)139(225)186-104(48-32-34-56-165)140(226)194-116(71-122(166)214)148(234)193-112(67-96-42-26-23-27-43-96)149(235)204-132(89(15)16)161(247)208-61-39-53-121(208)154(240)205-133(92(19)211)159(245)197-117(72-127(219)220)151(237)201-128(85(7)8)155(241)180-78-126(218)207-60-38-52-120(207)153(239)195-113(68-97-54-55-98-44-28-29-45-99(98)65-97)144(230)183-91(18)137(223)190-108(135(167)221)66-95-40-24-22-25-41-95/h22-31,40-47,54-55,65,73-74,81-93,104-121,128-134,176,209-212H,32-39,48-53,56-64,66-72,75-80,165H2,1-21H3,(H2,166,214)(H2,167,221)(H,172,181)(H,177,215)(H,178,222)(H,179,224)(H,180,241)(H,182,229)(H,183,230)(H,184,213)(H,185,216)(H,186,225)(H,187,233)(H,188,238)(H,189,242)(H,190,223)(H,191,227)(H,192,231)(H,193,234)(H,194,226)(H,195,239)(H,196,246)(H,197,245)(H,198,228)(H,199,232)(H,200,217)(H,201,237)(H,202,236)(H,203,243)(H,204,235)(H,205,240)(H,206,244)(H,219,220)(H4,168,169,173)(H3,170,174,248)(H3,171,175,249)/t90-,91-,92+,93+,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120+,121-,128-,129-,130-,131-,132-,133-,134-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 418 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human adrenomedullin 2 receptor expressed in CHO cells assessed as effect on cAMP accumulation |
J Med Chem 51: 7889-97 (2008)
Article DOI: 10.1021/jm8009298
BindingDB Entry DOI: 10.7270/Q2P26Z0C |
More data for this
Ligand-Target Pair | |
Protein ADM2
(Homo sapiens (Human)) | BDBM50025073
(CHEMBL2372187)Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N1C2CCCCC2C[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| Show InChI InChI=1S/C164H252N44O41/c1-82(2)62-108(185-124(216)77-178-136(222)90(17)182-143(229)109(63-83(3)4)191-141(227)105(53-39-59-174-163(170)248)187-147(233)114(70-100-74-172-81-181-100)196-160(246)134(93(20)212)206-158(244)131(88(13)14)202-150(236)113(184-94(21)213)68-99-73-176-102-50-33-32-49-101(99)102)145(231)192-110(64-84(5)6)146(232)199-118(80-210)152(238)188-106(54-40-60-175-164(171)249)142(228)198-117(79-209)138(224)179-75-123(215)177-76-125(217)200-129(86(9)10)157(243)203-130(87(11)12)156(242)189-104(52-36-38-58-173-162(168)169)139(225)186-103(51-35-37-57-165)140(226)194-115(71-122(166)214)148(234)193-112(67-97-46-29-24-30-47-97)149(235)204-132(89(15)16)161(247)207-61-41-56-120(207)153(239)205-133(92(19)211)159(245)197-116(72-127(219)220)151(237)201-128(85(7)8)155(241)180-78-126(218)208-119-55-34-31-48-98(119)69-121(208)154(240)195-111(66-96-44-27-23-28-45-96)144(230)183-91(18)137(223)190-107(135(167)221)65-95-42-25-22-26-43-95/h22-30,32-33,42-47,49-50,73-74,81-93,98,103-121,128-134,176,209-212H,31,34-41,48,51-72,75-80,165H2,1-21H3,(H2,166,214)(H2,167,221)(H,172,181)(H,177,215)(H,178,222)(H,179,224)(H,180,241)(H,182,229)(H,183,230)(H,184,213)(H,185,216)(H,186,225)(H,187,233)(H,188,238)(H,189,242)(H,190,223)(H,191,227)(H,192,231)(H,193,234)(H,194,226)(H,195,240)(H,196,246)(H,197,245)(H,198,228)(H,199,232)(H,200,217)(H,201,237)(H,202,236)(H,203,243)(H,204,235)(H,205,239)(H,206,244)(H,219,220)(H4,168,169,173)(H3,170,174,248)(H3,171,175,249)/t90-,91-,92+,93+,98?,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119?,120-,121-,128-,129-,130-,131-,132-,133-,134-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 496 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human adrenomedullin 2 receptor expressed in CHO cells assessed as effect on cAMP accumulation |
J Med Chem 51: 7889-97 (2008)
Article DOI: 10.1021/jm8009298
BindingDB Entry DOI: 10.7270/Q2P26Z0C |
More data for this
Ligand-Target Pair | |
Protein ADM2
(Homo sapiens (Human)) | BDBM50570406
(CHEMBL4862324)Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1ccccc1C#N | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 501 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Antagonist activity at human AM2 expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins fol... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02191
BindingDB Entry DOI: 10.7270/Q2474FM7 |
More data for this
Ligand-Target Pair | |
Protein ADM2
(Homo sapiens (Human)) | BDBM50570412
(CHEMBL4853766)Show SMILES CC(N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)C(=O)C(C)(C)C)c1ccccc1CN | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 794 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Antagonist activity at human AM2 expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins fol... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02191
BindingDB Entry DOI: 10.7270/Q2474FM7 |
More data for this
Ligand-Target Pair | |
Protein ADM2
(Homo sapiens (Human)) | BDBM50570393
(CHEMBL4878394)Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1nccs1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Antagonist activity at human AM2 expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins fol... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02191
BindingDB Entry DOI: 10.7270/Q2474FM7 |
More data for this
Ligand-Target Pair | |
Protein ADM2
(Homo sapiens (Human)) | BDBM50570405
(CHEMBL4874859)Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1ccccc1-c1cccnc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Antagonist activity at human AM2 expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins fol... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02191
BindingDB Entry DOI: 10.7270/Q2474FM7 |
More data for this
Ligand-Target Pair | |
Protein ADM2
(Homo sapiens (Human)) | BDBM50570390
(CHEMBL4851106)Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1ccccn1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Antagonist activity at human AM2 expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins fol... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02191
BindingDB Entry DOI: 10.7270/Q2474FM7 |
More data for this
Ligand-Target Pair | |
Protein ADM2
(Homo sapiens (Human)) | BDBM50570403
(CHEMBL4874651)Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1ccccc1CN1CCOCC1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.26E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Antagonist activity at human AM2 expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins fol... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02191
BindingDB Entry DOI: 10.7270/Q2474FM7 |
More data for this
Ligand-Target Pair | |
Protein ADM2
(Homo sapiens (Human)) | BDBM50570386
(CHEMBL4864804)Show SMILES CN1C(=O)NC(=O)C11Cc2ccc(NC(=O)CN(Cc3ccccc3)C(=O)C(C)(C)C)cc2C1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.26E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Antagonist activity at human AM2 expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins fol... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02191
BindingDB Entry DOI: 10.7270/Q2474FM7 |
More data for this
Ligand-Target Pair | |
Protein ADM2
(Homo sapiens (Human)) | BDBM50570407
(CHEMBL4865654)Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1ncccc1CN | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Antagonist activity at human AM2 expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins fol... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02191
BindingDB Entry DOI: 10.7270/Q2474FM7 |
More data for this
Ligand-Target Pair | |
Protein ADM2
(Homo sapiens (Human)) | BDBM50025076
(CHEMBL2372194)Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](C(C)C)C(=O)N1C2CCCCC2CC1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N1C2CCCCC2C[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(N)=O |r| Show InChI InChI=1S/C176H262N44O41/c1-88(2)65-119(197-136(228)83-190-148(234)96(17)194-155(241)120(66-89(3)4)203-153(239)116(53-39-63-186-175(182)260)199-159(245)125(76-111-80-184-87-193-111)208-172(258)146(99(20)224)218-170(256)143(94(13)14)214-162(248)124(196-100(21)225)73-110-79-188-113-50-32-31-49-112(110)113)157(243)204-121(67-90(5)6)158(244)211-129(86-222)164(250)200-117(54-40-64-187-176(183)261)154(240)210-128(85-221)150(236)191-81-135(227)189-82-137(229)212-141(92(9)10)169(255)215-142(93(11)12)168(254)201-115(52-36-38-62-185-174(180)181)151(237)198-114(51-35-37-61-177)152(238)206-126(77-134(178)226)160(246)205-123(72-103-58-60-105-44-26-28-46-107(105)69-103)161(247)216-144(95(15)16)173(259)220-131-56-34-30-48-109(131)75-133(220)166(252)217-145(98(19)223)171(257)209-127(78-139(231)232)163(249)213-140(91(7)8)167(253)192-84-138(230)219-130-55-33-29-47-108(130)74-132(219)165(251)207-122(70-101-41-23-22-24-42-101)156(242)195-97(18)149(235)202-118(147(179)233)71-102-57-59-104-43-25-27-45-106(104)68-102/h22-28,31-32,41-46,49-50,57-60,68-69,79-80,87-99,108-109,114-133,140-146,188,221-224H,29-30,33-40,47-48,51-56,61-67,70-78,81-86,177H2,1-21H3,(H2,178,226)(H2,179,233)(H,184,193)(H,189,227)(H,190,234)(H,191,236)(H,192,253)(H,194,241)(H,195,242)(H,196,225)(H,197,228)(H,198,237)(H,199,245)(H,200,250)(H,201,254)(H,202,235)(H,203,239)(H,204,243)(H,205,246)(H,206,238)(H,207,251)(H,208,258)(H,209,257)(H,210,240)(H,211,244)(H,212,229)(H,213,249)(H,214,248)(H,215,255)(H,216,247)(H,217,252)(H,218,256)(H,231,232)(H4,180,181,185)(H3,182,186,260)(H3,183,187,261)/t96-,97-,98+,99+,108?,109?,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130?,131?,132-,133?,140-,141-,142-,143-,144-,145-,146-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human adrenomedullin 2 receptor expressed in CHO cells assessed as effect on cAMP accumulation |
J Med Chem 51: 7889-97 (2008)
Article DOI: 10.1021/jm8009298
BindingDB Entry DOI: 10.7270/Q2P26Z0C |
More data for this
Ligand-Target Pair | |
Protein ADM2
(Homo sapiens (Human)) | BDBM50570399
(CHEMBL4846989)Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1cccc(CN)c1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Antagonist activity at human AM2 expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins fol... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02191
BindingDB Entry DOI: 10.7270/Q2474FM7 |
More data for this
Ligand-Target Pair | |
Protein ADM2
(Homo sapiens (Human)) | BDBM50570392
(CHEMBL4870543)Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1ccnn1-c1ccccc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.94E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Antagonist activity at human AM2 expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins fol... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02191
BindingDB Entry DOI: 10.7270/Q2474FM7 |
More data for this
Ligand-Target Pair | |
Protein ADM2
(Homo sapiens (Human)) | BDBM50570391
(CHEMBL4876213)Show SMILES CN1CCCC(CN(CC(=O)Nc2ccc3CC4(Cc3c2)C(=O)Nc2ncccc42)C(=O)C(C)(C)C)C1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Antagonist activity at human AM2 expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins fol... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02191
BindingDB Entry DOI: 10.7270/Q2474FM7 |
More data for this
Ligand-Target Pair | |
Protein ADM2
(Homo sapiens (Human)) | BDBM50570389
(CHEMBL4867733)Show SMILES CC(C)(C)C(=O)N(CC(=O)N1CCC(CC1)N1Cc2ccccc2NC1=O)Cc1ccccc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Antagonist activity at human AM2 expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins fol... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02191
BindingDB Entry DOI: 10.7270/Q2474FM7 |
More data for this
Ligand-Target Pair | |
Protein ADM2
(Homo sapiens (Human)) | BDBM50570387
(CHEMBL4853613)Show SMILES CC(C)(C)C(=O)N(CC(=O)N1CCC(CC1)n1c2cccnc2[nH]c1=O)Cc1ccccc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Antagonist activity at human AM2 expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins fol... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02191
BindingDB Entry DOI: 10.7270/Q2474FM7 |
More data for this
Ligand-Target Pair | |
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