Found 344 hits Enz. Inhib. hit(s) with Target = 'Lysosomal alpha-glucosidase' AND taxid = 10116 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Lysosomal alpha-glucosidase
(Rattus norvegicus) | CHEMBL5276586
| PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
UniChem
| | 0.510 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | CHEMBL5269400
| PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
UniChem
| | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | CHEMBL5268739
| PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
UniChem
| | 0.690 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | CHEMBL5282029
| PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
UniChem
| | 0.770 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | CHEMBL5283777
| PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
UniChem
| | 0.840 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50333455
((2S,3S,4S,5S)-2-butyl-5-(hydroxymethyl)pyrrolidine...)Show InChI InChI=1S/C9H19NO3/c1-2-3-4-6-8(12)9(13)7(5-11)10-6/h6-13H,2-5H2,1H3/t6-,7-,8-,9-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 85 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toyama
Curated by ChEMBL
| Assay Description
Competitive inhibition of rat intestinal maltase by Lineweaver-Burk plot analysis |
J Med Chem 55: 10347-62 (2012)
Article DOI: 10.1021/jm301304e
BindingDB Entry DOI: 10.7270/Q2K35VTX |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50242818
(1-Oxo-1lambda-4-thia-cyclotridecan-3,4,5,6,8,10,11...)Show InChI InChI=1S/C12H24O9S/c13-5-1-6(14)10(18)8(16)3-22(21)4-9(17)12(20)11(19)7(15)2-5/h5-20H,1-4H2 | PDB
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| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fuji-Sangyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of rat intestinal maltase |
J Nat Prod 71: 981-4 (2008)
Article DOI: 10.1021/np070604h
BindingDB Entry DOI: 10.7270/Q2XS5W9M |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50242271
((2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)...)Show SMILES OCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO |r| Show InChI InChI=1S/C8H17NO5/c10-2-1-9-3-6(12)8(14)7(13)5(9)4-11/h5-8,10-14H,1-4H2/t5-,6+,7-,8-/m1/s1 | PDB
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| PDB
Article
PubMed
| 460 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toyama
Curated by ChEMBL
| Assay Description
Competitive inhibition of rat intestinal maltase by Lineweaver-Burk plot analysis |
J Med Chem 55: 10347-62 (2012)
Article DOI: 10.1021/jm301304e
BindingDB Entry DOI: 10.7270/Q2K35VTX |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50316179
((1S,2R,3R,4S)-1-{(1S)-2-[(2R,3S,4S)-3,4-dihydroxy-...)Show SMILES OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](OS([O-])(=O)=O)[C@H](O)C[S+]1C[C@@H](O)[C@H](O)[C@H]1CO |r| Show InChI InChI=1S/C12H24O12S2/c13-1-5(15)10(19)11(20)12(24-26(21,22)23)7(17)4-25-3-6(16)9(18)8(25)2-14/h5-20H,1-4H2/t5-,6+,7+,8+,9-,10+,11+,12+,25?/m0/s1 | PDB
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| 540 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fuji-Sangyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of rat intestinal maltase |
J Nat Prod 71: 981-4 (2008)
Article DOI: 10.1021/np070604h
BindingDB Entry DOI: 10.7270/Q2XS5W9M |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50330955
((1S,2S)-3-[(2R,3S,4S)-3,4-dihydroxy-2-(hydroxymeth...)Show SMILES OC[C@H](OS([O-])(=O)=O)[C@H](O)C[S@@+]1C[C@@H](O)[C@H](O)[C@H]1CO |r| Show InChI InChI=1S/C9H18O9S2/c10-1-7(18-20(15,16)17)5(12)3-19-4-6(13)9(14)8(19)2-11/h5-14H,1-4H2/t5-,6-,7+,8-,9+,19-/m1/s1 | PDB
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| 970 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fuji-Sangyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of rat intestinal maltase |
J Nat Prod 71: 981-4 (2008)
Article DOI: 10.1021/np070604h
BindingDB Entry DOI: 10.7270/Q2XS5W9M |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50333465
((2R,3R,4R,5R,6R)-5-((2R,3R,4R,5S,6R)-5-((2R,3R,4S,...)Show SMILES C[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@H](O[C@@H]3[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O |r,t:37| Show InChI InChI=1S/C25H43NO18/c1-6-11(26-8-2-7(3-27)12(30)15(33)13(8)31)14(32)19(37)24(40-6)43-22-10(5-29)42-25(20(38)17(22)35)44-21-9(4-28)41-23(39)18(36)16(21)34/h2,6,8-39H,3-5H2,1H3/t6-,8+,9-,10-,11-,12-,13+,14+,15+,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-/m1/s1 | PDB
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| 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Competitive inhibition of rat alpha-glucosidase assessed as production of chromogenic p-Nitrphenol measured after 3 mins by HPLC and Michaelis-Menton... |
Bioorg Med Chem Lett 21: 2441-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.062
BindingDB Entry DOI: 10.7270/Q2Z60PCK |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50438500
(CHEMBL2414822)Show SMILES CC(=O)Oc1ccc(\C=C\C(=O)NC[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1OC(C)=O |r| Show InChI InChI=1S/C20H25NO10/c1-10(23)29-13-5-3-12(7-14(13)30-11(2)24)4-6-17(25)21-8-15-18(26)20(28)19(27)16(9-22)31-15/h3-7,15-16,18-20,22,26-28H,8-9H2,1-2H3,(H,21,25)/b6-4+/t15-,16+,18-,19+,20+/m0/s1 | PDB
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PubMed
| 4.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Xi'an Jiaotong University
Curated by ChEMBL
| Assay Description
Competitive inhibition of rat intestinal maltase using maltose as substrate by Lineweaver-Burk plot analysis |
Bioorg Med Chem 21: 5442-50 (2013)
Article DOI: 10.1016/j.bmc.2013.06.002
BindingDB Entry DOI: 10.7270/Q2HD7X24 |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50439692
(CHEMBL2418233)Show SMILES O[C@@H]1C[C@@H](OC(=O)\C=C\c2ccc(O)c(O)c2)[C@H](O)[C@H](O)[C@H]1O |r| Show InChI InChI=1S/C15H18O8/c16-8-3-1-7(5-9(8)17)2-4-12(19)23-11-6-10(18)13(20)15(22)14(11)21/h1-5,10-11,13-18,20-22H,6H2/b4-2+/t10-,11-,13+,14+,15-/m1/s1 | PDB
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PubMed
| 2.38E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Chulalongkorn University
Curated by ChEMBL
| Assay Description
Competitive inhibition of rat intestine maltase using maltose as substrate by Lineweaver-Burk plot analysis |
Eur J Med Chem 66: 296-304 (2013)
Article DOI: 10.1016/j.ejmech.2013.05.047
BindingDB Entry DOI: 10.7270/Q2X63PCD |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50439692
(CHEMBL2418233)Show SMILES O[C@@H]1C[C@@H](OC(=O)\C=C\c2ccc(O)c(O)c2)[C@H](O)[C@H](O)[C@H]1O |r| Show InChI InChI=1S/C15H18O8/c16-8-3-1-7(5-9(8)17)2-4-12(19)23-11-6-10(18)13(20)15(22)14(11)21/h1-5,10-11,13-18,20-22H,6H2/b4-2+/t10-,11-,13+,14+,15-/m1/s1 | PDB
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| 6.45E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Chulalongkorn University
Curated by ChEMBL
| Assay Description
Non-competitive inhibition of rat intestine maltase using maltose as substrate by Lineweaver-Burk plot analysis |
Eur J Med Chem 66: 296-304 (2013)
Article DOI: 10.1016/j.ejmech.2013.05.047
BindingDB Entry DOI: 10.7270/Q2X63PCD |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50208826
((+)-Pinoresinol | 4-[(1S,3aR,4S,6aR)-4-(4-hydroxy-...)Show SMILES COc1cc(ccc1O)[C@@H]1OC[C@@H]2[C@H]1CO[C@H]2c1ccc(O)c(OC)c1 |r| Show InChI InChI=1S/C20H22O6/c1-23-17-7-11(3-5-15(17)21)19-13-9-26-20(14(13)10-25-19)12-4-6-16(22)18(8-12)24-2/h3-8,13-14,19-22H,9-10H2,1-2H3/t13-,14-,19+,20+/m1/s1 | PDB
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| 2.88E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Chulalongkorn University
Curated by ChEMBL
| Assay Description
Competitive inhibition of rat intestinal maltase using maltose as substrate assessed as dissociation of enzyme-inhibitor complex at 0.1 to 1 mg/ml by... |
Bioorg Med Chem Lett 22: 5215-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.06.068
BindingDB Entry DOI: 10.7270/Q28G8MR8 |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50123930
(CHEMBL3621759)Show SMILES O[C@@H](CCCCCCCC(=O)c1c(O)cc(O)cc1O)c1ccccc1 |r| Show InChI InChI=1S/C21H26O5/c22-16-13-19(25)21(20(26)14-16)18(24)12-8-3-1-2-7-11-17(23)15-9-5-4-6-10-15/h4-6,9-10,13-14,17,22-23,25-26H,1-3,7-8,11-12H2/t17-/m0/s1 | PDB
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| 4.80E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Chulalongkorn University
Curated by ChEMBL
| Assay Description
Non-competitive inhibition of rat intestinal Maltase using maltose as substrate assessed as glucose release after 10 mins by Lineweaver-Burk plot ana... |
Bioorg Med Chem Lett 25: 4529-33 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.069
BindingDB Entry DOI: 10.7270/Q2WD42C3 |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50123929
(CHEMBL3621760)Show SMILES O[C@@H](CCCCCCCC(=O)c1c(O)cc(O)c(C(CCc2ccccc2)c2ccc(O)cc2O)c1O)c1ccccc1 |r| Show InChI InChI=1S/C36H40O7/c37-26-19-21-27(31(40)22-26)28(20-18-24-12-6-4-7-13-24)34-32(41)23-33(42)35(36(34)43)30(39)17-11-3-1-2-10-16-29(38)25-14-8-5-9-15-25/h4-9,12-15,19,21-23,28-29,37-38,40-43H,1-3,10-11,16-18,20H2/t28?,29-/m0/s1 | PDB
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| 5.30E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Chulalongkorn University
Curated by ChEMBL
| Assay Description
Non-competitive inhibition of rat intestinal Maltase using maltose as substrate assessed as glucose release after 10 mins by Lineweaver-Burk plot ana... |
Bioorg Med Chem Lett 25: 4529-33 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.069
BindingDB Entry DOI: 10.7270/Q2WD42C3 |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50208826
((+)-Pinoresinol | 4-[(1S,3aR,4S,6aR)-4-(4-hydroxy-...)Show SMILES COc1cc(ccc1O)[C@@H]1OC[C@@H]2[C@H]1CO[C@H]2c1ccc(O)c(OC)c1 |r| Show InChI InChI=1S/C20H22O6/c1-23-17-7-11(3-5-15(17)21)19-13-9-26-20(14(13)10-25-19)12-4-6-16(22)18(8-12)24-2/h3-8,13-14,19-22H,9-10H2,1-2H3/t13-,14-,19+,20+/m1/s1 | PDB
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| 1.34E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Chulalongkorn University
Curated by ChEMBL
| Assay Description
Non-competitive inhibition of rat intestinal maltase using maltose as substrate assessed as dissociation of enzyme-substrate-inhibitor complex at 0.1... |
Bioorg Med Chem Lett 22: 5215-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.06.068
BindingDB Entry DOI: 10.7270/Q28G8MR8 |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50123930
(CHEMBL3621759)Show SMILES O[C@@H](CCCCCCCC(=O)c1c(O)cc(O)cc1O)c1ccccc1 |r| Show InChI InChI=1S/C21H26O5/c22-16-13-19(25)21(20(26)14-16)18(24)12-8-3-1-2-7-11-17(23)15-9-5-4-6-10-15/h4-6,9-10,13-14,17,22-23,25-26H,1-3,7-8,11-12H2/t17-/m0/s1 | PDB
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| 1.64E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Chulalongkorn University
Curated by ChEMBL
| Assay Description
Competitive inhibition of rat intestinal Maltase using maltose as substrate assessed as glucose release after 10 mins by Lineweaver-Burk plot analysi... |
Bioorg Med Chem Lett 25: 4529-33 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.069
BindingDB Entry DOI: 10.7270/Q2WD42C3 |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50123929
(CHEMBL3621760)Show SMILES O[C@@H](CCCCCCCC(=O)c1c(O)cc(O)c(C(CCc2ccccc2)c2ccc(O)cc2O)c1O)c1ccccc1 |r| Show InChI InChI=1S/C36H40O7/c37-26-19-21-27(31(40)22-26)28(20-18-24-12-6-4-7-13-24)34-32(41)23-33(42)35(36(34)43)30(39)17-11-3-1-2-10-16-29(38)25-14-8-5-9-15-25/h4-9,12-15,19,21-23,28-29,37-38,40-43H,1-3,10-11,16-18,20H2/t28?,29-/m0/s1 | PDB
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| 1.96E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Chulalongkorn University
Curated by ChEMBL
| Assay Description
Competitive inhibition of rat intestinal Maltase using maltose as substrate assessed as glucose release after 10 mins by Lineweaver-Burk plot analysi... |
Bioorg Med Chem Lett 25: 4529-33 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.069
BindingDB Entry DOI: 10.7270/Q2WD42C3 |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50065252
(2,6-Bis-hydroxymethyl-1-methyl-piperidine-3,4,5-tr...)Show SMILES CN1[C@H](CO)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1CO |r| Show InChI InChI=1S/C8H17NO5/c1-9-4(2-10)6(12)8(14)7(13)5(9)3-11/h4-8,10-14H,2-3H2,1H3/t4-,5-,6-,7+,8+/m1/s1 | PDB
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| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description
Inhibitory activity measured against alpha-glucosidase of rat intestinal sucrase by colorimetric assay using the D-glucose oxidase-peroxidase method |
J Med Chem 41: 2565-71 (1998)
Article DOI: 10.1021/jm970836l
BindingDB Entry DOI: 10.7270/Q25D8SHK |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50259956
(2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol | CHE...)Show SMILES OC[C@H]1N[C@H](CO)[C@H](O)[C@@H](O)[C@@H]1O |r| Show InChI InChI=1S/C7H15NO5/c9-1-3-5(11)7(13)6(12)4(2-10)8-3/h3-13H,1-2H2/t3-,4-,5-,6+,7+/m1/s1 | PDB
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| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description
Inhibition of rat intestinal brush border membrane maltase |
Bioorg Med Chem 16: 7330-6 (2008)
Article DOI: 10.1016/j.bmc.2008.06.026
BindingDB Entry DOI: 10.7270/Q27D2W2B |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50263044
(CHEMBL476960 | Voglibose)Show SMILES OCC(CO)N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O |r| Show InChI InChI=1S/C10H21NO7/c12-2-5(3-13)11-6-1-10(18,4-14)9(17)8(16)7(6)15/h5-9,11-18H,1-4H2/t6-,7-,8+,9-,10-/m0/s1 | PDB
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Hokuriku University
Curated by ChEMBL
| Assay Description
Inhibition of rat intestinal brush border membrane maltase |
Bioorg Med Chem 16: 7330-6 (2008)
Article DOI: 10.1016/j.bmc.2008.06.026
BindingDB Entry DOI: 10.7270/Q27D2W2B |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50048087
(CHEMBL3311516)Show SMILES COc1ccc(CCCC[C@@H]2N[C@@H](CO)[C@H](O)[C@H]2O)cc1 |r| Show InChI InChI=1S/C16H25NO4/c1-21-12-8-6-11(7-9-12)4-2-3-5-13-15(19)16(20)14(10-18)17-13/h6-9,13-20H,2-5,10H2,1H3/t13-,14-,15-,16-/m0/s1 | PDB
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| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Tohoku Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of Wistar rat intestinal maltase assessed as inhibition of D-glucose release after 30 mins by spectrophotometry |
Bioorg Med Chem Lett 24: 3298-301 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.001
BindingDB Entry DOI: 10.7270/Q2T43VRS |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50263044
(CHEMBL476960 | Voglibose)Show SMILES OCC(CO)N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O |r| Show InChI InChI=1S/C10H21NO7/c12-2-5(3-13)11-6-1-10(18,4-14)9(17)8(16)7(6)15/h5-9,11-18H,1-4H2/t6-,7-,8+,9-,10-/m0/s1 | PDB
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Tohoku Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of Wistar rat intestinal maltase assessed as inhibition of D-glucose release after 30 mins by spectrophotometry |
Bioorg Med Chem Lett 24: 3298-301 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.001
BindingDB Entry DOI: 10.7270/Q2T43VRS |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50263044
(CHEMBL476960 | Voglibose)Show SMILES OCC(CO)N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O |r| Show InChI InChI=1S/C10H21NO7/c12-2-5(3-13)11-6-1-10(18,4-14)9(17)8(16)7(6)15/h5-9,11-18H,1-4H2/t6-,7-,8+,9-,10-/m0/s1 | PDB
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| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toyama
Curated by ChEMBL
| Assay Description
Inhibition of rat intestinal maltase using moltose as substrate |
J Med Chem 55: 10347-62 (2012)
Article DOI: 10.1021/jm301304e
BindingDB Entry DOI: 10.7270/Q2K35VTX |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50333455
((2S,3S,4S,5S)-2-butyl-5-(hydroxymethyl)pyrrolidine...)Show InChI InChI=1S/C9H19NO3/c1-2-3-4-6-8(12)9(13)7(5-11)10-6/h6-13H,2-5H2,1H3/t6-,7-,8-,9-/m0/s1 | PDB
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University of Toyama
Curated by ChEMBL
| Assay Description
Inhibition of rat intestinal maltase using moltose as substrate |
J Med Chem 55: 10347-62 (2012)
Article DOI: 10.1021/jm301304e
BindingDB Entry DOI: 10.7270/Q2K35VTX |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50333455
((2S,3S,4S,5S)-2-butyl-5-(hydroxymethyl)pyrrolidine...)Show InChI InChI=1S/C9H19NO3/c1-2-3-4-6-8(12)9(13)7(5-11)10-6/h6-13H,2-5H2,1H3/t6-,7-,8-,9-/m0/s1 | PDB
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Tohoku Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of Wistar rat intestinal maltase assessed as inhibition of D-glucose release after 30 mins by spectrophotometry |
Bioorg Med Chem Lett 24: 3298-301 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.001
BindingDB Entry DOI: 10.7270/Q2T43VRS |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
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| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description
Inhibition of rat intestinal brush border membrane maltase |
Bioorg Med Chem 16: 7330-6 (2008)
Article DOI: 10.1016/j.bmc.2008.06.026
BindingDB Entry DOI: 10.7270/Q27D2W2B |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50333465
((2R,3R,4R,5R,6R)-5-((2R,3R,4R,5S,6R)-5-((2R,3R,4S,...)Show SMILES C[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@H](O[C@@H]3[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O |r,t:37| Show InChI InChI=1S/C25H43NO18/c1-6-11(26-8-2-7(3-27)12(30)15(33)13(8)31)14(32)19(37)24(40-6)43-22-10(5-29)42-25(20(38)17(22)35)44-21-9(4-28)41-23(39)18(36)16(21)34/h2,6,8-39H,3-5H2,1H3/t6-,8+,9-,10-,11-,12-,13+,14+,15+,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-/m1/s1 | PDB
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Tohoku Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of Wistar rat small intestine maltase after 30 mins |
Bioorg Med Chem Lett 21: 738-41 (2011)
Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50259956
(2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol | CHE...)Show SMILES OC[C@H]1N[C@H](CO)[C@H](O)[C@@H](O)[C@@H]1O |r| Show InChI InChI=1S/C7H15NO5/c9-1-3-5(11)7(13)6(12)4(2-10)8-3/h3-13H,1-2H2/t3-,4-,5-,6+,7+/m1/s1 | PDB
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| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description
Inhibitory activity measured against alpha-glucosidase of rat intestinal sucrase by colorimetric assay using the D-glucose oxidase-peroxidase method |
J Med Chem 41: 2565-71 (1998)
Article DOI: 10.1021/jm970836l
BindingDB Entry DOI: 10.7270/Q25D8SHK |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50048088
(CHEMBL3311517)Show SMILES OC[C@@H]1N[C@@H](CCCCc2ccc(O)cc2)[C@H](O)[C@H]1O |r| Show InChI InChI=1S/C15H23NO4/c17-9-13-15(20)14(19)12(16-13)4-2-1-3-10-5-7-11(18)8-6-10/h5-8,12-20H,1-4,9H2/t12-,13-,14-,15-/m0/s1 | PDB
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| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Tohoku Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of Wistar rat intestinal maltase assessed as inhibition of D-glucose release after 30 mins by spectrophotometry |
Bioorg Med Chem Lett 24: 3298-301 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.001
BindingDB Entry DOI: 10.7270/Q2T43VRS |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50263044
(CHEMBL476960 | Voglibose)Show SMILES OCC(CO)N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O |r| Show InChI InChI=1S/C10H21NO7/c12-2-5(3-13)11-6-1-10(18,4-14)9(17)8(16)7(6)15/h5-9,11-18H,1-4H2/t6-,7-,8+,9-,10-/m0/s1 | PDB
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| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Tohoku Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of Wistar rat small intestine maltase after 30 mins |
Bioorg Med Chem Lett 21: 738-41 (2011)
Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50333465
((2R,3R,4R,5R,6R)-5-((2R,3R,4R,5S,6R)-5-((2R,3R,4S,...)Show SMILES C[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@H](O[C@@H]3[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O |r,t:37| Show InChI InChI=1S/C25H43NO18/c1-6-11(26-8-2-7(3-27)12(30)15(33)13(8)31)14(32)19(37)24(40-6)43-22-10(5-29)42-25(20(38)17(22)35)44-21-9(4-28)41-23(39)18(36)16(21)34/h2,6,8-39H,3-5H2,1H3/t6-,8+,9-,10-,11-,12-,13+,14+,15+,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-/m1/s1 | PDB
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| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toyama
Curated by ChEMBL
| Assay Description
Inhibition of rat intestinal maltase using moltose as substrate |
J Med Chem 55: 10347-62 (2012)
Article DOI: 10.1021/jm301304e
BindingDB Entry DOI: 10.7270/Q2K35VTX |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50048089
(CHEMBL3311518)Show SMILES OC[C@@H]1N[C@@H](CCCCc2ccc(F)cc2)[C@H](O)[C@H]1O |r| Show InChI InChI=1S/C15H22FNO3/c16-11-7-5-10(6-8-11)3-1-2-4-12-14(19)15(20)13(9-18)17-12/h5-8,12-15,17-20H,1-4,9H2/t12-,13-,14-,15-/m0/s1 | PDB
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| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Tohoku Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of Wistar rat intestinal maltase assessed as inhibition of D-glucose release after 30 mins by spectrophotometry |
Bioorg Med Chem Lett 24: 3298-301 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.001
BindingDB Entry DOI: 10.7270/Q2T43VRS |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50333465
((2R,3R,4R,5R,6R)-5-((2R,3R,4R,5S,6R)-5-((2R,3R,4S,...)Show SMILES C[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@H](O[C@@H]3[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O |r,t:37| Show InChI InChI=1S/C25H43NO18/c1-6-11(26-8-2-7(3-27)12(30)15(33)13(8)31)14(32)19(37)24(40-6)43-22-10(5-29)42-25(20(38)17(22)35)44-21-9(4-28)41-23(39)18(36)16(21)34/h2,6,8-39H,3-5H2,1H3/t6-,8+,9-,10-,11-,12-,13+,14+,15+,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-/m1/s1 | PDB
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| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Tohoku Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of Wistar rat intestinal maltase assessed as inhibition of D-glucose release after 30 mins by spectrophotometry |
Bioorg Med Chem Lett 24: 3298-301 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.001
BindingDB Entry DOI: 10.7270/Q2T43VRS |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50596693
(CHEMBL5189075) | PDB
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TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114230
BindingDB Entry DOI: 10.7270/Q24F1VSC |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50399654
(CHEMBL2177691)Show SMILES CC(C)CCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r| Show InChI InChI=1S/C11H23NO3/c1-7(2)4-3-5-8-10(14)11(15)9(6-13)12-8/h7-15H,3-6H2,1-2H3/t8-,9-,10-,11-/m0/s1 | PDB
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| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toyama
Curated by ChEMBL
| Assay Description
Inhibition of rat intestinal maltase using moltose as substrate |
J Med Chem 55: 10347-62 (2012)
Article DOI: 10.1021/jm301304e
BindingDB Entry DOI: 10.7270/Q2K35VTX |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | CHEMBL5276586
| PDB
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TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50263044
(CHEMBL476960 | Voglibose)Show SMILES OCC(CO)N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O |r| Show InChI InChI=1S/C10H21NO7/c12-2-5(3-13)11-6-1-10(18,4-14)9(17)8(16)7(6)15/h5-9,11-18H,1-4H2/t6-,7-,8+,9-,10-/m0/s1 | PDB
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| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Kinki University
Curated by ChEMBL
| Assay Description
Inhibition of rat small intestinal maltase after 30 mins |
Bioorg Med Chem 19: 2252-62 (2011)
Article DOI: 10.1016/j.bmc.2011.02.028
BindingDB Entry DOI: 10.7270/Q2GH9J8R |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50333455
((2S,3S,4S,5S)-2-butyl-5-(hydroxymethyl)pyrrolidine...)Show InChI InChI=1S/C9H19NO3/c1-2-3-4-6-8(12)9(13)7(5-11)10-6/h6-13H,2-5H2,1H3/t6-,7-,8-,9-/m0/s1 | PDB
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| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Tohoku Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of Wistar rat small intestine maltase after 30 mins |
Bioorg Med Chem Lett 21: 738-41 (2011)
Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50596691
(CHEMBL5198563) | PDB
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TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114230
BindingDB Entry DOI: 10.7270/Q24F1VSC |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50399655
(CHEMBL2177690)Show SMILES OC[C@@H]1N[C@@H](CCCCc2ccccc2)[C@H](O)[C@H]1O |r| Show InChI InChI=1S/C15H23NO3/c17-10-13-15(19)14(18)12(16-13)9-5-4-8-11-6-2-1-3-7-11/h1-3,6-7,12-19H,4-5,8-10H2/t12-,13-,14-,15-/m0/s1 | PDB
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| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Tohoku Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of Wistar rat intestinal maltase assessed as inhibition of D-glucose release after 30 mins by spectrophotometry |
Bioorg Med Chem Lett 24: 3298-301 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.001
BindingDB Entry DOI: 10.7270/Q2T43VRS |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50399655
(CHEMBL2177690)Show SMILES OC[C@@H]1N[C@@H](CCCCc2ccccc2)[C@H](O)[C@H]1O |r| Show InChI InChI=1S/C15H23NO3/c17-10-13-15(19)14(18)12(16-13)9-5-4-8-11-6-2-1-3-7-11/h1-3,6-7,12-19H,4-5,8-10H2/t12-,13-,14-,15-/m0/s1 | PDB
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PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toyama
Curated by ChEMBL
| Assay Description
Inhibition of rat intestinal maltase using moltose as substrate |
J Med Chem 55: 10347-62 (2012)
Article DOI: 10.1021/jm301304e
BindingDB Entry DOI: 10.7270/Q2K35VTX |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50242818
(1-Oxo-1lambda-4-thia-cyclotridecan-3,4,5,6,8,10,11...)Show InChI InChI=1S/C12H24O9S/c13-5-1-6(14)10(18)8(16)3-22(21)4-9(17)12(20)11(19)7(15)2-5/h5-20H,1-4H2 | PDB
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| n/a | n/a | 227 | n/a | n/a | n/a | n/a | n/a | n/a |
Fuji-Sangyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of rat intestinal maltase |
J Nat Prod 71: 981-4 (2008)
Article DOI: 10.1021/np070604h
BindingDB Entry DOI: 10.7270/Q2XS5W9M |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | CHEMBL5269400
| PDB
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UniProtKB/SwissProt
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| | n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50259956
(2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol | CHE...)Show SMILES OC[C@H]1N[C@H](CO)[C@H](O)[C@@H](O)[C@@H]1O |r| Show InChI InChI=1S/C7H15NO5/c9-1-3-5(11)7(13)6(12)4(2-10)8-3/h3-13H,1-2H2/t3-,4-,5-,6+,7+/m1/s1 | PDB
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| n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description
Inhibitory activity measured against alpha-glucosidase of rat liver lysosomal by colorimetric assay using the D-glucose oxidase-peroxidase method |
J Med Chem 41: 2565-71 (1998)
Article DOI: 10.1021/jm970836l
BindingDB Entry DOI: 10.7270/Q25D8SHK |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50048086
(CHEMBL3311515)Show SMILES Cc1ccc(CCCC[C@@H]2N[C@@H](CO)[C@H](O)[C@H]2O)cc1 |r| Show InChI InChI=1S/C16H25NO3/c1-11-6-8-12(9-7-11)4-2-3-5-13-15(19)16(20)14(10-18)17-13/h6-9,13-20H,2-5,10H2,1H3/t13-,14-,15-,16-/m0/s1 | PDB
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| n/a | n/a | 280 | n/a | n/a | n/a | n/a | n/a | n/a |
Tohoku Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of Wistar rat intestinal maltase assessed as inhibition of D-glucose release after 30 mins by spectrophotometry |
Bioorg Med Chem Lett 24: 3298-301 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.001
BindingDB Entry DOI: 10.7270/Q2T43VRS |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50333459
((2S,3S,4S,5S)-2-(hydroxymethyl)-5-octylpyrrolidine...)Show SMILES CCCCCCCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r| Show InChI InChI=1S/C13H27NO3/c1-2-3-4-5-6-7-8-10-12(16)13(17)11(9-15)14-10/h10-17H,2-9H2,1H3/t10-,11-,12-,13-/m0/s1 | PDB
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| n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
Tohoku Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of Wistar rat small intestine maltase after 30 mins |
Bioorg Med Chem Lett 21: 738-41 (2011)
Article DOI: 10.1016/j.bmcl.2010.11.112
BindingDB Entry DOI: 10.7270/Q2D21XVS |
More data for this
Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM50333459
((2S,3S,4S,5S)-2-(hydroxymethyl)-5-octylpyrrolidine...)Show SMILES CCCCCCCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O |r| Show InChI InChI=1S/C13H27NO3/c1-2-3-4-5-6-7-8-10-12(16)13(17)11(9-15)14-10/h10-17H,2-9H2,1H3/t10-,11-,12-,13-/m0/s1 | PDB
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| n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toyama
Curated by ChEMBL
| Assay Description
Inhibition of rat intestinal maltase using moltose as substrate |
J Med Chem 55: 10347-62 (2012)
Article DOI: 10.1021/jm301304e
BindingDB Entry DOI: 10.7270/Q2K35VTX |
More data for this
Ligand-Target Pair | |
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