Found 4234 hits Enz. Inhib. hit(s) with Target = 'D(4) dopamine receptor' AND taxid = 9606 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50122050
(CHEMBL156599 | N-{2-[4-(2,3-Dichloro-phenyl)-piper...)Show SMILES COc1cccc(c1)C(=O)NCCN1CCN(CC1)c1cccc(Cl)c1Cl Show InChI InChI=1S/C20H23Cl2N3O2/c1-27-16-5-2-4-15(14-16)20(26)23-8-9-24-10-12-25(13-11-24)18-7-3-6-17(21)19(18)22/h2-7,14H,8-13H2,1H3,(H,23,26) | PDB
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| 0.0180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Bari
Curated by ChEMBL
| Assay Description
Binding affinity towards human Dopamine receptor D4 using [3H]spiroperidol as radioligand |
J Med Chem 45: 5727-35 (2002)
BindingDB Entry DOI: 10.7270/Q2TT4RQC |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50122028
(3-Methoxy-N-[2-(4-p-tolyl-piperazin-1-yl)-ethyl]-b...)Show InChI InChI=1S/C21H27N3O2/c1-17-6-8-19(9-7-17)24-14-12-23(13-15-24)11-10-22-21(25)18-4-3-5-20(16-18)26-2/h3-9,16H,10-15H2,1-2H3,(H,22,25) | PDB
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| 0.0250 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Bari
Curated by ChEMBL
| Assay Description
Binding affinity towards human Dopamine receptor D4 using [3H]spiroperidol as radioligand |
J Med Chem 45: 5727-35 (2002)
BindingDB Entry DOI: 10.7270/Q2TT4RQC |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50530438
(Mosapramine | Mosapramine hydrochloride)Show SMILES Clc1ccc2CCc3ccccc3N(CCCN3CCC4(CC3)N3CCCCC3NC4=O)c2c1 Show InChI InChI=1S/C28H35ClN4O/c29-23-12-11-22-10-9-21-6-1-2-7-24(21)32(25(22)20-23)16-5-15-31-18-13-28(14-19-31)27(34)30-26-8-3-4-17-33(26)28/h1-2,6-7,11-12,20,26H,3-5,8-10,13-19H2,(H,30,34) | PDB
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| 0.0300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Palack£ University
Curated by ChEMBL
| Assay Description
Agonist activity at dopamine D4 receptor (unknown origin) |
Eur J Med Chem 181: (2019)
Article DOI: 10.1016/j.ejmech.2019.111569
BindingDB Entry DOI: 10.7270/Q2H41VXG |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50005120
(CHEMBL274491 | N-((2S,3S)-1-Benzyl-2-methyl-pyrrol...)Show SMILES CNc1cc(OC)c(cc1Cl)C(=O)N[C@H]1CCN(Cc2ccccc2)[C@H]1C Show InChI InChI=1S/C21H26ClN3O2/c1-14-18(9-10-25(14)13-15-7-5-4-6-8-15)24-21(26)16-11-17(22)19(23-2)12-20(16)27-3/h4-8,11-12,14,18,23H,9-10,13H2,1-3H3,(H,24,26)/t14-,18-/m0/s1 | PDB
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Washington University
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 268: 495-502 (1994)
BindingDB Entry DOI: 10.7270/Q2S75DWP |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50530438
(Mosapramine | Mosapramine hydrochloride)Show SMILES Clc1ccc2CCc3ccccc3N(CCCN3CCC4(CC3)N3CCCCC3NC4=O)c2c1 Show InChI InChI=1S/C28H35ClN4O/c29-23-12-11-22-10-9-21-6-1-2-7-24(21)32(25(22)20-23)16-5-15-31-18-13-28(14-19-31)27(34)30-26-8-3-4-17-33(26)28/h1-2,6-7,11-12,20,26H,3-5,8-10,13-19H2,(H,30,34) | PDB
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| 0.0300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Palack£ University
Curated by ChEMBL
| Assay Description
Agonist activity at dopamine D4 receptor (unknown origin) |
Eur J Med Chem 181: (2019)
Article DOI: 10.1016/j.ejmech.2019.111569
BindingDB Entry DOI: 10.7270/Q2H41VXG |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50005120
(CHEMBL274491 | N-((2S,3S)-1-Benzyl-2-methyl-pyrrol...)Show SMILES CNc1cc(OC)c(cc1Cl)C(=O)N[C@H]1CCN(Cc2ccccc2)[C@H]1C Show InChI InChI=1S/C21H26ClN3O2/c1-14-18(9-10-25(14)13-15-7-5-4-6-8-15)24-21(26)16-11-17(22)19(23-2)12-20(16)27-3/h4-8,11-12,14,18,23H,9-10,13H2,1-3H3,(H,24,26)/t14-,18-/m0/s1 | PDB
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| 0.0300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 268: 495-502 (1994)
BindingDB Entry DOI: 10.7270/Q2S75DWP |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50068366
(CHEMBL93403 | N-{2-[4-(4-Chloro-phenyl)-piperazin-...)Show InChI InChI=1S/C20H24ClN3O2/c1-26-19-4-2-3-16(15-19)20(25)22-9-10-23-11-13-24(14-12-23)18-7-5-17(21)6-8-18/h2-8,15H,9-14H2,1H3,(H,22,25) | PDB
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| 0.0400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Bari
Curated by ChEMBL
| Assay Description
Binding affinity towards human Dopamine receptor D4 using [3H]spiroperidol as radioligand |
J Med Chem 45: 5727-35 (2002)
BindingDB Entry DOI: 10.7270/Q2TT4RQC |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50068366
(CHEMBL93403 | N-{2-[4-(4-Chloro-phenyl)-piperazin-...)Show InChI InChI=1S/C20H24ClN3O2/c1-26-19-4-2-3-16(15-19)20(25)22-9-10-23-11-13-24(14-12-23)18-7-5-17(21)6-8-18/h2-8,15H,9-14H2,1H3,(H,22,25) | PDB
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| 0.0400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universitá di Bari
Curated by ChEMBL
| Assay Description
In vitro binding affinity at human Dopamine receptor D4.4 by [3H]-YM-09151-2 displacement. |
J Med Chem 43: 270-7 (2000)
BindingDB Entry DOI: 10.7270/Q2610ZH4 |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50122026
(CHEMBL157322 | N-{2-[4-(2-Chloro-phenyl)-piperazin...)Show InChI InChI=1S/C20H24ClN3O2/c1-26-17-6-4-5-16(15-17)20(25)22-9-10-23-11-13-24(14-12-23)19-8-3-2-7-18(19)21/h2-8,15H,9-14H2,1H3,(H,22,25) | PDB
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| 0.0400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Bari
Curated by ChEMBL
| Assay Description
Binding affinity towards human Dopamine receptor D4 using [3H]spiroperidol as radioligand |
J Med Chem 45: 5727-35 (2002)
BindingDB Entry DOI: 10.7270/Q2TT4RQC |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM81492
(BENPERIDOL | CAS_2062-84-2 | NSC_16363)Show SMILES Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c2ccccc2[nH]c1=O Show InChI InChI=1S/C22H24FN3O2/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-10,18H,3,6,11-15H2,(H,24,28) | PDB
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| 0.0660 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto
Curated by PDSP Ki Database
| |
Mol Psychiatry 3: 123-34 (1998)
Article DOI: 10.1038/sj.mp.4000336
BindingDB Entry DOI: 10.7270/Q2G15ZCQ |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50183266
(Anquil | Benperidol | Benquil | MCN-JR-4584 | R-45...)Show SMILES Oc1nc2ccccc2n1C1CCN(CCCC(=O)c2ccc(F)cc2)CC1 Show InChI InChI=1S/C22H24FN3O2/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-10,18H,3,6,11-15H2,(H,24,28) | PDB
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| 0.0660 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Florida A&M University
Curated by ChEMBL
| Assay Description
Binding affinity to human dopamine D4 receptor by radioligand displacement assay |
Bioorg Med Chem 24: 3671-9 (2016)
Article DOI: 10.1016/j.bmc.2016.06.011
BindingDB Entry DOI: 10.7270/Q2W66NPV |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM21397
(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)Show SMILES Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)N(CNC2=O)c1ccccc1 Show InChI InChI=1S/C23H26FN3O2/c24-19-10-8-18(9-11-19)21(28)7-4-14-26-15-12-23(13-16-26)22(29)25-17-27(23)20-5-2-1-3-6-20/h1-3,5-6,8-11H,4,7,12-17H2,(H,25,29) | PDB
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| 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto
Curated by PDSP Ki Database
| |
Nature 350: 610-4 (1991)
Article DOI: 10.1038/350610a0
BindingDB Entry DOI: 10.7270/Q24T6GVD |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM85223
(CAS_115368 | NSC_115368 | Perospirone)Show SMILES O=C1C2CCCCC2C(=O)N1CCCCN1CCN(CC1)c1nsc2ccccc12 Show InChI InChI=1S/C23H30N4O2S/c28-22-17-7-1-2-8-18(17)23(29)27(22)12-6-5-11-25-13-15-26(16-14-25)21-19-9-3-4-10-20(19)30-24-21/h3-4,9-10,17-18H,1-2,5-8,11-16H2 | PDB
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| 0.0900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto
Curated by PDSP Ki Database
| |
Mol Psychiatry 3: 123-34 (1998)
Article DOI: 10.1038/sj.mp.4000336
BindingDB Entry DOI: 10.7270/Q2G15ZCQ |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM21397
(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)Show SMILES Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)N(CNC2=O)c1ccccc1 Show InChI InChI=1S/C23H26FN3O2/c24-19-10-8-18(9-11-19)21(28)7-4-14-26-15-12-23(13-16-26)22(29)25-17-27(23)20-5-2-1-3-6-20/h1-3,5-6,8-11H,4,7,12-17H2,(H,25,29) | PDB
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| 0.0900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto
Curated by PDSP Ki Database
| |
Eur J Pharmacol 291: 59-66 (1995)
Article DOI: 10.1016/0922-4106(95)90125-6
BindingDB Entry DOI: 10.7270/Q2TT4PHV |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50005120
(CHEMBL274491 | N-((2S,3S)-1-Benzyl-2-methyl-pyrrol...)Show SMILES CNc1cc(OC)c(cc1Cl)C(=O)N[C@H]1CCN(Cc2ccccc2)[C@H]1C Show InChI InChI=1S/C21H26ClN3O2/c1-14-18(9-10-25(14)13-15-7-5-4-6-8-15)24-21(26)16-11-17(22)19(23-2)12-20(16)27-3/h4-8,11-12,14,18,23H,9-10,13H2,1-3H3,(H,24,26)/t14-,18-/m0/s1 | PDB
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| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto
Curated by PDSP Ki Database
| |
Eur J Pharmacol 291: 59-66 (1995)
Article DOI: 10.1016/0922-4106(95)90125-6
BindingDB Entry DOI: 10.7270/Q2TT4PHV |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50122032
(3-Methoxy-N-[2-(4-naphthalen-1-yl-piperazin-1-yl)-...)Show SMILES COc1cccc(c1)C(=O)NCCN1CCN(CC1)c1cccc2ccccc12 Show InChI InChI=1S/C24H27N3O2/c1-29-21-9-4-8-20(18-21)24(28)25-12-13-26-14-16-27(17-15-26)23-11-5-7-19-6-2-3-10-22(19)23/h2-11,18H,12-17H2,1H3,(H,25,28) | PDB
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Universit£ degli Studi di Bari
Curated by ChEMBL
| Assay Description
Binding affinity towards human Dopamine receptor D4 using [3H]spiroperidol as radioligand |
J Med Chem 45: 5727-35 (2002)
BindingDB Entry DOI: 10.7270/Q2TT4RQC |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM84637
(CAS_85760-74-3 | CHEMBL240773 | NSC_54562 | QUINPI...)Show InChI InChI=1S/C13H21N3/c1-2-5-16-6-3-4-10-7-12-11(8-13(10)16)9-14-15-12/h9-10,13H,2-8H2,1H3,(H,14,15)/t10-,13-/m1/s1 | PDB
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| 0.230 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 268: 495-502 (1994)
BindingDB Entry DOI: 10.7270/Q2S75DWP |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50189854
(6-bromo-2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl...)Show InChI InChI=1S/C19H21BrN4O/c1-25-18-5-3-2-4-17(18)23-10-8-22(9-11-23)13-16-14-24-12-15(20)6-7-19(24)21-16/h2-7,12,14H,8-11,13H2,1H3 | PDB
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| 0.25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoire de Chimie Th�rapeutique
Curated by ChEMBL
| Assay Description
Displacement of [3H]spiperone from human dopamine receptor D4.4 in CHO cell membrane |
J Med Chem 49: 3938-47 (2006)
Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5 |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50505700
(CHEMBL4442460)Show SMILES COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccccc2)CC1 Show InChI InChI=1S/C28H35N5O2/c1-35-27-16-9-8-15-26(27)32-21-19-31(20-22-32)18-10-17-29-28(34)30-33(25-13-6-3-7-14-25)23-24-11-4-2-5-12-24/h2-9,11-16H,10,17-23H2,1H3,(H2,29,30,34) | PDB
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Friedrich-Alexander-Universit£t Erlangen-N£rnberg
Curated by ChEMBL
| Assay Description
Displacement of [3H] Spiperone from human D4.4 receptor expressed in CHO cells by competitive radioligand binding assay |
J Med Chem 62: 9658-9679 (2019)
Article DOI: 10.1021/acs.jmedchem.9b01085
BindingDB Entry DOI: 10.7270/Q2GB27BJ |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)Show SMILES Cc1nc2CCCCn2c(=O)c1CCN1CCC(CC1)c1noc2cc(F)ccc12 Show InChI InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3 | PDB
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| 0.25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto
Curated by PDSP Ki Database
| |
Mol Psychiatry 3: 123-34 (1998)
Article DOI: 10.1038/sj.mp.4000336
BindingDB Entry DOI: 10.7270/Q2G15ZCQ |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50189854
(6-bromo-2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl...)Show InChI InChI=1S/C19H21BrN4O/c1-25-18-5-3-2-4-17(18)23-10-8-22(9-11-23)13-16-14-24-12-15(20)6-7-19(24)21-16/h2-7,12,14H,8-11,13H2,1H3 | PDB
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| 0.25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Palack£ University
Curated by ChEMBL
| Assay Description
Agonist activity at dopamine D4 receptor (unknown origin) |
Eur J Med Chem 181: (2019)
Article DOI: 10.1016/j.ejmech.2019.111569
BindingDB Entry DOI: 10.7270/Q2H41VXG |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)Show SMILES Cc1nc2CCCCn2c(=O)c1CCN1CCC(CC1)c1noc2cc(F)ccc12 Show InChI InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3 | PDB
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Article
PubMed
| 0.25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto
Curated by PDSP Ki Database
| |
Neuropsychopharmacology 16: 93 (1997)
Article DOI: 10.1016/S0893-133X(96)00187-X
BindingDB Entry DOI: 10.7270/Q2513WR8 |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50189854
(6-bromo-2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl...)Show InChI InChI=1S/C19H21BrN4O/c1-25-18-5-3-2-4-17(18)23-10-8-22(9-11-23)13-16-14-24-12-15(20)6-7-19(24)21-16/h2-7,12,14H,8-11,13H2,1H3 | PDB
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| 0.25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Palack£ University
Curated by ChEMBL
| Assay Description
Agonist activity at dopamine D4 receptor (unknown origin) |
Eur J Med Chem 181: (2019)
Article DOI: 10.1016/j.ejmech.2019.111569
BindingDB Entry DOI: 10.7270/Q2H41VXG |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50122047
(CHEMBL157388 | N-{2-[4-(3-Chloro-phenyl)-piperazin...)Show InChI InChI=1S/C20H24ClN3O2/c1-26-19-7-2-4-16(14-19)20(25)22-8-9-23-10-12-24(13-11-23)18-6-3-5-17(21)15-18/h2-7,14-15H,8-13H2,1H3,(H,22,25) | PDB
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| 0.260 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Bari
Curated by ChEMBL
| Assay Description
Binding affinity towards human Dopamine receptor D4 using [3H]spiroperidol as radioligand |
J Med Chem 45: 5727-35 (2002)
BindingDB Entry DOI: 10.7270/Q2TT4RQC |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50184795
(1-(2-methoxyphenyl)-4-((1-phenyl-1H-pyrazol-4-yl)m...)Show InChI InChI=1S/C21H24N4O/c1-26-21-10-6-5-9-20(21)24-13-11-23(12-14-24)16-18-15-22-25(17-18)19-7-3-2-4-8-19/h2-10,15,17H,11-14,16H2,1H3 | PDB
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| 0.280 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich-Alexander University
Curated by ChEMBL
| Assay Description
Displacement of [3H]spiperone from human cloned dopamine D4 receptor expressed in CHO cells |
Bioorg Med Chem Lett 16: 2955-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.075
BindingDB Entry DOI: 10.7270/Q21N80QX |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM85222
(CAS_441351-20-8 | Lurasidone | SM 13496)Show SMILES O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1C[C@@H]1CCCC[C@H]1CN1CCN(CC1)c1nsc2ccccc12 Show InChI InChI=1S/C28H36N4O2S/c33-27-24-18-9-10-19(15-18)25(24)28(34)32(27)17-21-6-2-1-5-20(21)16-30-11-13-31(14-12-30)26-22-7-3-4-8-23(22)35-29-26/h3-4,7-8,18-21,24-25H,1-2,5-6,9-17H2/t18-,19+,20-,21-,24+,25-/m0/s1 | PDB
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| 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto
Curated by PDSP Ki Database
| |
Mol Psychiatry 3: 123-34 (1998)
Article DOI: 10.1038/sj.mp.4000336
BindingDB Entry DOI: 10.7270/Q2G15ZCQ |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50061349
(CHEMBL129534 | [2-(3-Chloro-phenoxy)-ethyl]-(3-phe...)Show InChI InChI=1S/C17H20ClNO2/c18-15-6-4-9-17(14-15)21-13-11-19-10-5-12-20-16-7-2-1-3-8-16/h1-4,6-9,14,19H,5,10-13H2 | PDB
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| 0.309 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pomona College
Curated by ChEMBL
| Assay Description
Binding affinity to displace [3H]spiperone from cloned human dopamine receptor D4 was determined |
Bioorg Med Chem Lett 15: 2149-57 (2005)
Article DOI: 10.1016/j.bmcl.2005.02.012
BindingDB Entry DOI: 10.7270/Q2RR20G2 |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM21397
(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)Show SMILES Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)N(CNC2=O)c1ccccc1 Show InChI InChI=1S/C23H26FN3O2/c24-19-10-8-18(9-11-19)21(28)7-4-14-26-15-12-23(13-16-26)22(29)25-17-27(23)20-5-2-1-3-6-20/h1-3,5-6,8-11H,4,7,12-17H2,(H,25,29) | PDB
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| 0.310 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto
Curated by PDSP Ki Database
| |
Eur J Pharmacol 291: 59-66 (1995)
Article DOI: 10.1016/0922-4106(95)90125-6
BindingDB Entry DOI: 10.7270/Q2TT4PHV |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50061349
(CHEMBL129534 | [2-(3-Chloro-phenoxy)-ethyl]-(3-phe...)Show InChI InChI=1S/C17H20ClNO2/c18-15-6-4-9-17(14-15)21-13-11-19-10-5-12-20-16-7-2-1-3-8-16/h1-4,6-9,14,19H,5,10-13H2 | PDB
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| 0.310 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Binding affinity to recombinant human dopamine receptor D4 expressed in CHO cells by displacement of [3H]-spiperone |
J Med Chem 40: 4026-9 (1998)
Article DOI: 10.1021/jm970422s
BindingDB Entry DOI: 10.7270/Q22J69Z9 |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM21397
(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)Show SMILES Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)N(CNC2=O)c1ccccc1 Show InChI InChI=1S/C23H26FN3O2/c24-19-10-8-18(9-11-19)21(28)7-4-14-26-15-12-23(13-16-26)22(29)25-17-27(23)20-5-2-1-3-6-20/h1-3,5-6,8-11H,4,7,12-17H2,(H,25,29) | PDB
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| 0.310 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 282: 1011-9 (1997)
BindingDB Entry DOI: 10.7270/Q2CC0Z63 |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50189841
(6-iodo-2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]...)Show InChI InChI=1S/C19H21IN4O/c1-25-18-5-3-2-4-17(18)23-10-8-22(9-11-23)13-16-14-24-12-15(20)6-7-19(24)21-16/h2-7,12,14H,8-11,13H2,1H3 | PDB
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| 0.330 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Palack£ University
Curated by ChEMBL
| Assay Description
Agonist activity at dopamine D4 receptor (unknown origin) |
Eur J Med Chem 181: (2019)
Article DOI: 10.1016/j.ejmech.2019.111569
BindingDB Entry DOI: 10.7270/Q2H41VXG |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50257034
(CHEMBL4096543)Show InChI InChI=1S/C21H28IN3O/c1-16(2)26-20-5-4-12-23-21(20)24(3)19-10-13-25(14-11-19)15-17-6-8-18(22)9-7-17/h4-9,12,16,19H,10-11,13-15H2,1-3H3 | PDB
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| | 0.330 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM21397
(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)Show SMILES Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)N(CNC2=O)c1ccccc1 Show InChI InChI=1S/C23H26FN3O2/c24-19-10-8-18(9-11-19)21(28)7-4-14-26-15-12-23(13-16-26)22(29)25-17-27(23)20-5-2-1-3-6-20/h1-3,5-6,8-11H,4,7,12-17H2,(H,25,29) | PDB
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| 0.330 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich-Alexander University
Curated by ChEMBL
| Assay Description
Biniding affinity for Dopamine receptor D4 |
J Med Chem 48: 694-709 (2005)
Article DOI: 10.1021/jm049612a
BindingDB Entry DOI: 10.7270/Q2H131HW |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50079161
(5-Methyl-1-[1-(3-methyl-benzyl)-piperidin-4-yl]-4-...)Show SMILES Cc1c([nH]c(=O)n1C1CCN(Cc2cccc(C)c2)CC1)-c1ccccc1 Show InChI InChI=1S/C23H27N3O/c1-17-7-6-8-19(15-17)16-25-13-11-21(12-14-25)26-18(2)22(24-23(26)27)20-9-4-3-5-10-20/h3-10,15,21H,11-14,16H2,1-2H3,(H,24,27) | PDB
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| 0.330 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
| Assay Description
Affinity to displace [3H]-spiperone from cloned human Dopamine receptor D4 stably expressed in HEK-393 cell lines |
J Med Chem 42: 2706-15 (1999)
Article DOI: 10.1021/jm991029k
BindingDB Entry DOI: 10.7270/Q2P55MPV |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50189841
(6-iodo-2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]...)Show InChI InChI=1S/C19H21IN4O/c1-25-18-5-3-2-4-17(18)23-10-8-22(9-11-23)13-16-14-24-12-15(20)6-7-19(24)21-16/h2-7,12,14H,8-11,13H2,1H3 | PDB
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| 0.330 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoire de Chimie Th�rapeutique
Curated by ChEMBL
| Assay Description
Displacement of [3H]spiperone from human dopamine receptor D4.4 in CHO cell membrane |
J Med Chem 49: 3938-47 (2006)
Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5 |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50257034
(CHEMBL4096543)Show InChI InChI=1S/C21H28IN3O/c1-16(2)26-20-5-4-12-23-21(20)24(3)19-10-13-25(14-11-19)15-17-6-8-18(22)9-7-17/h4-9,12,16,19H,10-11,13-15H2,1-3H3 | PDB
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| 0.330 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center , Omaha, Nebraska 68198-6125, United States.
Curated by ChEMBL
| Assay Description
Inhibition of human dopamine D4 receptor |
J Med Chem 60: 7233-7243 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00151
BindingDB Entry DOI: 10.7270/Q2P84FBZ |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50189841
(6-iodo-2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]...)Show InChI InChI=1S/C19H21IN4O/c1-25-18-5-3-2-4-17(18)23-10-8-22(9-11-23)13-16-14-24-12-15(20)6-7-19(24)21-16/h2-7,12,14H,8-11,13H2,1H3 | PDB
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| 0.330 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Palack£ University
Curated by ChEMBL
| Assay Description
Agonist activity at dopamine D4 receptor (unknown origin) |
Eur J Med Chem 181: (2019)
Article DOI: 10.1016/j.ejmech.2019.111569
BindingDB Entry DOI: 10.7270/Q2H41VXG |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50257034
(CHEMBL4096543)Show InChI InChI=1S/C21H28IN3O/c1-16(2)26-20-5-4-12-23-21(20)24(3)19-10-13-25(14-11-19)15-17-6-8-18(22)9-7-17/h4-9,12,16,19H,10-11,13-15H2,1-3H3 | PDB
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| 0.331 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Scuola di Scienze del Farmaco e dei Prodotti della Salute , Università di Camerino , Via S. Agostino 1 , 62032 Camerino , Italy.
Curated by ChEMBL
| Assay Description
Displacement of [3H]N-methylspiperone from human dopamine D4 receptor expressed in HEK293 cell membranes after 1 hr by scintillation counting method |
J Med Chem 61: 3712-3725 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00265
BindingDB Entry DOI: 10.7270/Q20K2C2P |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50061345
(CHEMBL129927 | [2-(3,4-Dimethyl-phenoxy)-ethyl]-(3...)Show InChI InChI=1S/C19H25NO2/c1-16-9-10-19(15-17(16)2)22-14-12-20-11-6-13-21-18-7-4-3-5-8-18/h3-5,7-10,15,20H,6,11-14H2,1-2H3 | PDB
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| 0.347 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pomona College
Curated by ChEMBL
| Assay Description
Binding affinity to displace [3H]spiperone from cloned human dopamine receptor D4 was determined |
Bioorg Med Chem Lett 15: 2149-57 (2005)
Article DOI: 10.1016/j.bmcl.2005.02.012
BindingDB Entry DOI: 10.7270/Q2RR20G2 |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM81493
(CAS_749-13-3 | TRIFLUORPERIDOL)Show SMILES OC1(CCN(CC1)C(F)CCC(=O)c1ccccc1)c1cccc(c1)C(F)(F)F Show InChI InChI=1S/C22H23F4NO2/c23-20(10-9-19(28)16-5-2-1-3-6-16)27-13-11-21(29,12-14-27)17-7-4-8-18(15-17)22(24,25)26/h1-8,15,20,29H,9-14H2 | PDB
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| 0.350 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto
Curated by PDSP Ki Database
| |
Mol Psychiatry 3: 123-34 (1998)
Article DOI: 10.1038/sj.mp.4000336
BindingDB Entry DOI: 10.7270/Q2G15ZCQ |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50061345
(CHEMBL129927 | [2-(3,4-Dimethyl-phenoxy)-ethyl]-(3...)Show InChI InChI=1S/C19H25NO2/c1-16-9-10-19(15-17(16)2)22-14-12-20-11-6-13-21-18-7-4-3-5-8-18/h3-5,7-10,15,20H,6,11-14H2,1-2H3 | PDB
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| 0.350 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Binding affinity to recombinant human dopamine receptor D4 expressed in CHO cells by displacement of [3H]-spiperone |
J Med Chem 40: 4026-9 (1998)
Article DOI: 10.1021/jm970422s
BindingDB Entry DOI: 10.7270/Q22J69Z9 |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM21398
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2 | PDB
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| 0.350 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research Foundation
Curated by PDSP Ki Database
| |
Psychopharmacology (Berl) 124: 57-73 (1996)
Article DOI: 10.1007/bf02245606
BindingDB Entry DOI: 10.7270/Q2610XV6 |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50167934
(CHEMBL191962 | N-{4-[4-(2-methoxyphenyl)piperazin-...)Show SMILES [Ru]123456789C%10C1=C2C3=C4%10.N(CCCCN1CCN(CC1)c1c(cccc1)OC)C(C51C6=C7C8=C91)=O |c:3,7,35,39,(.22,-2.99,;-1.96,-4.82,;-.88,-5.18,;-.23,-4.26,;-.89,-3.35,;-1.96,-3.7,;5.2,-1.55,;6.53,-.78,;7.86,-1.57,;9.21,-.8,;10.55,-1.57,;11.89,-.8,;13.22,-1.59,;14.57,-.83,;14.55,.72,;13.22,1.5,;11.89,.74,;15.9,1.49,;17.23,.72,;18.57,1.49,;18.57,3.03,;17.23,3.8,;15.9,3.03,;17.23,-.83,;18.57,-1.6,;3.87,-.77,;2.53,-1.55,;2.53,-2.67,;1.45,-3.02,;.78,-2.11,;1.45,-1.2,;3.86,.77,)| Show InChI InChI=1S/C21H24N3O2.C5H.Ru/c1-26-20-11-5-4-10-19(20)24-16-14-23(15-17-24)13-7-6-12-22-21(25)18-8-2-3-9-18;1-2-4-5-3-1;/h4-5,10-11H,6-7,12-17H2,1H3,(H,22,25);1H; | PDB
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| 0.370 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich Alexander University
Curated by ChEMBL
| Assay Description
Inhibition of [3H]spiperone binding to human dopamine receptor D4.4 expressed in Chinese hamster ovary cells |
J Med Chem 48: 3696-9 (2005)
Article DOI: 10.1021/jm050170s
BindingDB Entry DOI: 10.7270/Q20K29BF |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50077001
(1-Benzyl-4-(3-methyl-4-phenyl-pyrazol-1-yl)-piperi...)Show InChI InChI=1S/C22H25N3/c1-18-22(20-10-6-3-7-11-20)17-25(23-18)21-12-14-24(15-13-21)16-19-8-4-2-5-9-19/h2-11,17,21H,12-16H2,1H3 | PDB
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| 0.390 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johann Wolfgang Goethe-Universität
Curated by ChEMBL
| Assay Description
Binding affinity of compound towards human Dopamine receptor D4 by displacing [125I]-iodosulpiride expressed in CHO cells |
J Med Chem 46: 3883-99 (2003)
Article DOI: 10.1021/jm030836n
BindingDB Entry DOI: 10.7270/Q23F4P18 |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50077001
(1-Benzyl-4-(3-methyl-4-phenyl-pyrazol-1-yl)-piperi...)Show InChI InChI=1S/C22H25N3/c1-18-22(20-10-6-3-7-11-20)17-25(23-18)21-12-14-24(15-13-21)16-19-8-4-2-5-9-19/h2-11,17,21H,12-16H2,1H3 | PDB
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| 0.390 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of [3H]-spiperone from human Dopamine receptor D4 expressed in HEK-293 cells |
Bioorg Med Chem Lett 9: 1285-90 (1999)
BindingDB Entry DOI: 10.7270/Q2C53K1C |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50401953
(CHEMBL2207643)Show InChI InChI=1S/C22H24N2O/c1-25-22-10-6-5-9-21(22)24-15-13-23(14-16-24)17-19-12-11-18-7-3-2-4-8-20(18)19/h2-12H,13-17H2,1H3 | PDB
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| | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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Citation and Details
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More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM22872
(1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...)Show InChI InChI=1S/C19H21ClN2S/c1-21-8-10-22(11-9-21)17-12-14-4-2-3-5-18(14)23-19-7-6-15(20)13-16(17)19/h2-7,13,17H,8-12H2,1H3 | PDB
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| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
ACADIA Pharmaceuticals
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 315: 1278-87 (2005)
Article DOI: 10.1124/jpet.105.092155
BindingDB Entry DOI: 10.7270/Q2Z60MNB |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM85093
(CAS_3853 | CHEMBL267014 | CHEMBL555670 | L 745,870...)Show InChI InChI=1S/C18H19ClN4/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18/h1-7,12H,8-11,13H2,(H,20,21) | PDB
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| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against human Dopamine receptor D4 by [3H]-spiperone displacement. |
J Med Chem 47: 2348-55 (2004)
Article DOI: 10.1021/jm0305669
BindingDB Entry DOI: 10.7270/Q2M61M03 |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM50589760
(CHEMBL5198170)Show SMILES OC(=O)C(O)=O.[O-][N+](=O)c1ccccc1N1CCN(CCCN2C(=O)CCc3ccccc23)CC1 | PDB
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| 0.407 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00840
BindingDB Entry DOI: 10.7270/Q2ST7TTC |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM85093
(CAS_3853 | CHEMBL267014 | CHEMBL555670 | L 745,870...)Show InChI InChI=1S/C18H19ClN4/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18/h1-7,12H,8-11,13H2,(H,20,21) | PDB
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TBA
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Ligand-Target Pair | |
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