Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
E3 ubiquitin-protein ligase Mdm2 (Mus musculus) | BDBM50229787 ((4S,5R)-Nutlin-3 | (rac)-(4,5-bis(4-chlorophenyl)-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of mouse MDM2 by TR-FRET assay | J Med Chem 58: 6348-58 (2015) Article DOI: 10.1021/acs.jmedchem.5b00810 BindingDB Entry DOI: 10.7270/Q2HQ41QV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
E3 ubiquitin-protein ligase Mdm2 (Mus musculus) | BDBM162123 (US9051279, 106) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 66 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of mouse MDM2 by TR-FRET assay | J Med Chem 58: 6348-58 (2015) Article DOI: 10.1021/acs.jmedchem.5b00810 BindingDB Entry DOI: 10.7270/Q2HQ41QV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
E3 ubiquitin-protein ligase Mdm2 [2-188]/Protein Mdm4 [2-185] (Homo sapiens (Human)) | BDBM238901 (US9403827, 3) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.45E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
NOVARTIS AG US Patent | Assay Description Assay 1: This assay was used to evaluate compounds displaying inhibition of p53-MDM2 interaction and p53-MDM4 interaction at IC50s of 0.005 to 50 &mu... | US Patent US9403827 (2016) BindingDB Entry DOI: 10.7270/Q2Z31XKH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [2-188]/Protein Mdm4 [2-185] (Homo sapiens (Human)) | BDBM238899 (US9403827, 1) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.51E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
NOVARTIS AG US Patent | Assay Description Assay 1: This assay was used to evaluate compounds displaying inhibition of p53-MDM2 interaction and p53-MDM4 interaction at IC50s of 0.005 to 50 &mu... | US Patent US9403827 (2016) BindingDB Entry DOI: 10.7270/Q2Z31XKH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [2-188]/Protein Mdm4 [2-185] (Homo sapiens (Human)) | BDBM238900 (US9403827, 2) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.13E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
NOVARTIS AG US Patent | Assay Description Assay 1: This assay was used to evaluate compounds displaying inhibition of p53-MDM2 interaction and p53-MDM4 interaction at IC50s of 0.005 to 50 &mu... | US Patent US9403827 (2016) BindingDB Entry DOI: 10.7270/Q2Z31XKH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [2-188]/Protein Mdm4 [2-185] (Homo sapiens (Human)) | BDBM238904 (US9403827, 6) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | 25 |
NOVARTIS AG US Patent | Assay Description Assay 1: This assay was used to evaluate compounds displaying inhibition of p53-MDM2 interaction and p53-MDM4 interaction at IC50s of 0.005 to 50 &mu... | US Patent US9403827 (2016) BindingDB Entry DOI: 10.7270/Q2Z31XKH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 [2-188]/Protein Mdm4 [2-185] (Homo sapiens (Human)) | BDBM238902 (US9403827, 4) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.67E+4 | n/a | n/a | n/a | n/a | n/a | 25 |
NOVARTIS AG US Patent | Assay Description Assay 1: This assay was used to evaluate compounds displaying inhibition of p53-MDM2 interaction and p53-MDM4 interaction at IC50s of 0.005 to 50 &mu... | US Patent US9403827 (2016) BindingDB Entry DOI: 10.7270/Q2Z31XKH | |||||||||||
More data for this Ligand-Target Pair |