Compile Data Set for Download or QSAR

Found 691 hits Enz. Inhib. hit(s) with Target = 'G-protein coupled receptor 6' AND taxid = 9606   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM412953 (US10406157, Compound Formula 1) Show SMILES CC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NC3CCOC3)nc2C1 Show InChI InChI=1S/C24H29F2N5O3/c1-15(32)31-10-6-20-21(13-31)28-23(27-17-7-11-33-14-17)24(29-20)30-8-4-18(5-9-30)34-22-3-2-16(25)12-19(22)26/h2-3,12,17-18H,4-11,13-14H2,1H3,(H,27,28)	UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	5.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The inhibition constant (Ki) from a GPR6 competition binding assay and the IC50 values from a hERG functional assay for the compound of Formula 1 (Ex...				US Patent US10406157 (2019) BindingDB Entry DOI: 10.7270/Q2J105HQ
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM191037 (US10077266, Example 149 | US10406157, Compound A |...) Show SMILES CC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(N[C@H]3CCOC3)nc2C1 |r| Show InChI InChI=1S/C24H29F2N5O3/c1-15(32)31-10-6-20-21(13-31)28-23(27-17-7-11-33-14-17)24(29-20)30-8-4-18(5-9-30)34-22-3-2-16(25)12-19(22)26/h2-3,12,17-18H,4-11,13-14H2,1H3,(H,27,28)/t17-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	US Patent	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The inhibition constant (Ki) from a GPR6 competition binding assay and the IC50 values from a hERG functional assay for the compound of Formula 1 (Ex...				US Patent US10406157 (2019) BindingDB Entry DOI: 10.7270/Q2J105HQ
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM50582430 (CHEMBL4598390) Show SMILES Fc1ccc(CN2CCN(CC2)c2nc3cnccc3nc2NC2CC2)c(F)c1 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of 3H-RL338 from human GPR6 expressed in T-REx-CHO-GPR6 cells assessed as inhibition constant by competition binding assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c02081 BindingDB Entry DOI: 10.7270/Q2JW8JSH
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM50582450 (CHEMBL4778540) Show SMILES CC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(N[C@@H]3CCOC3)nc2C1 |r| Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	9.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of 3H-RL338 from human GPR6 expressed in T-REx-CHO-GPR6 cells assessed as inhibition constant by competition binding assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c02081 BindingDB Entry DOI: 10.7270/Q2JW8JSH
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM50582449 (CHEMBL5093828) Show SMILES CC(C)Nc1nc2CN(C=Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O |c:9| Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of 3H-RL338 from human GPR6 expressed in T-REx-CHO-GPR6 cells assessed as inhibition constant by competition binding assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c02081 BindingDB Entry DOI: 10.7270/Q2JW8JSH
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM190939 (US10077266, Example 51 | US9181249, 51 | US9708313...) Show SMILES CO[C@H](C)C(=O)N1CCc2nc(NCC(F)F)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F |r| Show InChI InChI=1S/C24H29F4N5O3/c1-14(35-2)24(34)33-10-7-18-19(13-33)31-23(22(30-18)29-12-21(27)28)32-8-5-16(6-9-32)36-20-4-3-15(25)11-17(20)26/h3-4,11,14,16,21H,5-10,12-13H2,1-2H3,(H,29,30)/t14-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.00660	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM190986 (US10077266, Example 99 | US9181249, 99 | US9708313...) Show SMILES CO[C@@H](C)C(=O)N1CCc2nc(NCC(F)F)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F |r| Show InChI InChI=1S/C24H29F4N5O3/c1-14(35-2)24(34)33-10-7-18-19(13-33)31-23(22(30-18)29-12-21(27)28)32-8-5-16(6-9-32)36-20-4-3-15(25)11-17(20)26/h3-4,11,14,16,21H,5-10,12-13H2,1-2H3,(H,29,30)/t14-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.00830	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM190958 (US10077266, Example 71 | US9181249, 71 | US9708313...) Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)C(F)c1ccc(F)cc1F)C(C)=O Show InChI InChI=1S/C24H30F3N5O/c1-14(2)28-23-24(30-21-13-32(15(3)33)11-8-20(21)29-23)31-9-6-16(7-10-31)22(27)18-5-4-17(25)12-19(18)26/h4-5,12,14,16,22H,6-11,13H2,1-3H3,(H,28,29)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.00850	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM190965 (US10077266, Example 78 | US9181249, 78 | US9708313...) Show SMILES CC(C)Nc1nc2CCN(C)Cc2nc1N1CCC(CC1)C(=O)c1cc(Cl)ccc1F Show InChI InChI=1S/C23H29ClFN5O/c1-14(2)26-22-23(28-20-13-29(3)9-8-19(20)27-22)30-10-6-15(7-11-30)21(31)17-12-16(24)4-5-18(17)25/h4-5,12,14-15H,6-11,13H2,1-3H3,(H,26,27)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.00880	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM190937 (US10077266, Example 49 | US9181249, 49 | US9708313...) Show SMILES CN(C)C(=O)N1CCc2nc(NCC(F)F)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F Show InChI InChI=1S/C23H28F4N6O2/c1-31(2)23(34)33-10-7-17-18(13-33)30-22(21(29-17)28-12-20(26)27)32-8-5-15(6-9-32)35-19-4-3-14(24)11-16(19)25/h3-4,11,15,20H,5-10,12-13H2,1-2H3,(H,28,29)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.00910	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM190954 (US10077266, Example 67 | US9181249, 67 | US9708313...) Show SMILES CN1CCc2nc(NC3CC3)c(nc2C1)N1CCC(CC1)C(F)c1ccc(F)cc1F Show InChI InChI=1S/C23H28F3N5/c1-30-9-8-19-20(13-30)29-23(22(28-19)27-16-3-4-16)31-10-6-14(7-11-31)21(26)17-5-2-15(24)12-18(17)25/h2,5,12,14,16,21H,3-4,6-11,13H2,1H3,(H,27,28)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.00940	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM190969 (US10077266, Example 156 | US9181249, 156 | US91812...) Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O Show InChI InChI=1S/C23H29F2N5O2/c1-14(2)26-22-23(28-20-13-30(15(3)31)11-8-19(20)27-22)29-9-6-17(7-10-29)32-21-5-4-16(24)12-18(21)25/h4-5,12,14,17H,6-11,13H2,1-3H3,(H,26,27)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.00950	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM190966 (US10077266, Example 79 | US9181249, 79 | US9708313...) Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)C(=O)c1cc(Cl)ccc1F)C(C)=O Show InChI InChI=1S/C24H29ClFN5O2/c1-14(2)27-23-24(29-21-13-31(15(3)32)11-8-20(21)28-23)30-9-6-16(7-10-30)22(33)18-12-17(25)4-5-19(18)26/h4-5,12,14,16H,6-11,13H2,1-3H3,(H,27,28)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.00980	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM190972 (US10077266, Example 85 | US9181249, 85 | US9708313...) Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)N(C)C Show InChI InChI=1S/C24H32F2N6O2/c1-15(2)27-22-23(29-19-9-12-32(14-20(19)28-22)24(33)30(3)4)31-10-7-17(8-11-31)34-21-6-5-16(25)13-18(21)26/h5-6,13,15,17H,7-12,14H2,1-4H3,(H,27,28)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0104	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM190999 (US10077266, Example 112 | US9181249, 112 | US97083...) Show SMILES CC1Cc2nc(NCC(F)F)c(nc2CN1S(C)(=O)=O)N1CCC(CC1)Oc1ccc(F)cc1F Show InChI InChI=1S/C22H27F4N5O3S/c1-13-9-17-18(12-31(13)35(2,32)33)29-22(21(28-17)27-11-20(25)26)30-7-5-15(6-8-30)34-19-4-3-14(23)10-16(19)24/h3-4,10,13,15,20H,5-9,11-12H2,1-2H3,(H,27,28)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0104	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM191005 (US10077266, Example 118 | US9181249, 118 | US97083...) Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)[C@H](F)c1ccc(F)cc1F)C=O |r| Show InChI InChI=1S/C23H28F3N5O/c1-14(2)27-22-23(29-19-7-8-30(13-32)12-20(19)28-22)31-9-5-15(6-10-31)21(26)17-4-3-16(24)11-18(17)25/h3-4,11,13-15,21H,5-10,12H2,1-2H3,(H,27,28)/t21-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0114	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM190978 (US10077266, Example 91 | US9181249, 91 | US9708313...) Show SMILES CC(=O)N1CCc2nc(NCC(F)F)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F Show InChI InChI=1S/C22H25F4N5O2/c1-13(32)31-9-6-17-18(12-31)29-22(21(28-17)27-11-20(25)26)30-7-4-15(5-8-30)33-19-3-2-14(23)10-16(19)24/h2-3,10,15,20H,4-9,11-12H2,1H3,(H,27,28)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0115	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM190979 (US10077266, Example 92 | US9181249, 92 | US9708313...) Show SMILES COc1ccc(OC2CCN(CC2)c2nc3CN(CCc3nc2NC2CCC2)C(C)=O)c(F)c1 Show InChI InChI=1S/C25H32FN5O3/c1-16(32)31-13-10-21-22(15-31)29-25(24(28-21)27-17-4-3-5-17)30-11-8-18(9-12-30)34-23-7-6-19(33-2)14-20(23)26/h6-7,14,17-18H,3-5,8-13,15H2,1-2H3,(H,27,28)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0120	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM190963 (US10077266, Example 76 | US9181249, 76 | US9708313...) Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)C(F)c1ccc(F)cc1F)C(C)=O Show InChI InChI=1S/C24H30F3N5O/c1-14(2)28-23-24(30-20-8-11-32(15(3)33)13-21(20)29-23)31-9-6-16(7-10-31)22(27)18-5-4-17(25)12-19(18)26/h4-5,12,14,16,22H,6-11,13H2,1-3H3,(H,28,29)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0134	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM190973 (US9181249, 86 | US9708313, 86) Show SMILES CC(C)Nc1nc2CN(C)CCc2nc1N1CCC(CC1)C(=O)c1cc(Cl)ccc1F Show InChI InChI=1S/C23H29ClFN5O/c1-14(2)26-22-23(28-19-8-9-29(3)13-20(19)27-22)30-10-6-15(7-11-30)21(31)17-12-16(24)4-5-18(17)25/h4-5,12,14-15H,6-11,13H2,1-3H3,(H,26,27)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0137	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM190970 (US9181249, 83) Show SMILES CC(C)Nc1nc2C(C)CN(Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)N(C)C Show InChI InChI=1S/C25H34F2N6O2/c1-15(2)28-23-24(29-20-14-33(25(34)31(4)5)13-16(3)22(20)30-23)32-10-8-18(9-11-32)35-21-7-6-17(26)12-19(21)27/h6-7,12,15-16,18H,8-11,13-14H2,1-5H3,(H,28,30)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0138	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM190974 (US9181249, 87) Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)C(=O)c1cc(Cl)ccc1F)C(C)=O Show InChI InChI=1S/C24H29ClFN5O2/c1-14(2)27-23-24(29-20-8-11-31(15(3)32)13-21(20)28-23)30-9-6-16(7-10-30)22(33)18-12-17(25)4-5-19(18)26/h4-5,12,14,16H,6-11,13H2,1-3H3,(H,27,28)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0138	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM190980 (US10077266, Example 93 | US9181249, 93 | US9708313...) Show SMILES COc1ccc(OC2CCN(CC2)c2nc3CN(CCc3nc2NC2CCC2)C(=O)N(C)C)c(F)c1 Show InChI InChI=1S/C26H35FN6O3/c1-31(2)26(34)33-14-11-21-22(16-33)30-25(24(29-21)28-17-5-4-6-17)32-12-9-18(10-13-32)36-23-8-7-19(35-3)15-20(23)27/h7-8,15,17-18H,4-6,9-14,16H2,1-3H3,(H,28,29)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0138	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM190904 (US10077266, Example 15 | US9181249, 15 | US9708313...) Show SMILES COCCNC(=O)N1CCc2nc(NC(C)C)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F Show InChI InChI=1S/C25H34F2N6O3/c1-16(2)29-23-24(31-21-15-33(12-8-20(21)30-23)25(34)28-9-13-35-3)32-10-6-18(7-11-32)36-22-5-4-17(26)14-19(22)27/h4-5,14,16,18H,6-13,15H2,1-3H3,(H,28,34)(H,29,30)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0149	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM190955 (US10077266, Example 68 | US9181249, 68 | US9708313...) Show SMILES CN1CCc2nc(NC3CC3)c(nc2C1)N1CCC(CC1)[C@H](F)c1ccc(F)cc1F |r| Show InChI InChI=1S/C23H28F3N5/c1-30-9-8-19-20(13-30)29-23(22(28-19)27-16-3-4-16)31-10-6-14(7-11-31)21(26)17-5-2-15(24)12-18(17)25/h2,5,12,14,16,21H,3-4,6-11,13H2,1H3,(H,27,28)/t21-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0152	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM190960 (US10077266, Example 73 | US9181249, 73 | US9708313...) Show SMILES COc1ccc(OC2CCN(CC2)c2nc3CN(CCc3nc2NC(C)C)C(=O)N(C)C)c(F)c1 Show InChI InChI=1S/C25H35FN6O3/c1-16(2)27-23-24(29-21-15-32(25(33)30(3)4)13-10-20(21)28-23)31-11-8-17(9-12-31)35-22-7-6-18(34-5)14-19(22)26/h6-7,14,16-17H,8-13,15H2,1-5H3,(H,27,28)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0166	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM190897 (US10077266, Example 8 | US9181249, 8 | US9708313, ...) Show SMILES COC(C)C(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NC(C)C)nc2C1 Show InChI InChI=1S/C25H33F2N5O3/c1-15(2)28-23-24(30-20-9-12-32(14-21(20)29-23)25(33)16(3)34-4)31-10-7-18(8-11-31)35-22-6-5-17(26)13-19(22)27/h5-6,13,15-16,18H,7-12,14H2,1-4H3,(H,28,29)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0168	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM190957 (US10077266, Example 70 | US9181249, 70 | US9708313...) Show SMILES CC(C)Nc1nc2CCN(C)Cc2nc1N1CCC(CC1)C(F)c1ccc(F)cc1F Show InChI InChI=1S/C23H30F3N5/c1-14(2)27-22-23(29-20-13-30(3)9-8-19(20)28-22)31-10-6-15(7-11-31)21(26)17-5-4-16(24)12-18(17)25/h4-5,12,14-15,21H,6-11,13H2,1-3H3,(H,27,28)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0171	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM190899 (US10077266, Example 10 | US9181249, 10 | US9708313...) Show SMILES COCC(=O)N1CCc2nc(NC(C)C)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F Show InChI InChI=1S/C24H31F2N5O3/c1-15(2)27-23-24(29-20-13-31(22(32)14-33-3)11-8-19(20)28-23)30-9-6-17(7-10-30)34-21-5-4-16(25)12-18(21)26/h4-5,12,15,17H,6-11,13-14H2,1-3H3,(H,27,28)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0173	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM190894 (US10077266, Example 5 | US9181249, 5 | US9708313, ...) Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C1CCCO1 Show InChI InChI=1S/C26H33F2N5O3/c1-16(2)29-24-25(32-10-7-18(8-11-32)36-22-6-5-17(27)14-19(22)28)31-20-9-12-33(15-21(20)30-24)26(34)23-4-3-13-35-23/h5-6,14,16,18,23H,3-4,7-13,15H2,1-2H3,(H,29,30)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0179	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM190906 (US10077266, Example 17 | US9181249, 17 | US9708313...) Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)CC#N Show InChI InChI=1S/C24H28F2N6O2/c1-15(2)28-23-24(30-20-14-32(22(33)5-9-27)12-8-19(20)29-23)31-10-6-17(7-11-31)34-21-4-3-16(25)13-18(21)26/h3-4,13,15,17H,5-8,10-12,14H2,1-2H3,(H,28,29)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0180	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM191001 (US10077266, Example 114 | US9181249, 114 | US97083...) Show SMILES CO[C@H](C)C(=O)N1Cc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc2CC1C |r| Show InChI InChI=1S/C25H31F4N5O3/c1-14-10-19-20(13-34(14)25(35)15(2)36-3)32-24(23(31-19)30-12-22(28)29)33-8-6-17(7-9-33)37-21-5-4-16(26)11-18(21)27/h4-5,11,14-15,17,22H,6-10,12-13H2,1-3H3,(H,30,31)/t14?,15-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0185	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM190905 (US10077266, Example 16 | US9181249, 16 | US9708313...) Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C1CCCO1 Show InChI InChI=1S/C26H33F2N5O3/c1-16(2)29-24-25(32-10-7-18(8-11-32)36-22-6-5-17(27)14-19(22)28)31-21-15-33(12-9-20(21)30-24)26(34)23-4-3-13-35-23/h5-6,14,16,18,23H,3-4,7-13,15H2,1-2H3,(H,29,30)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0195	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM190964 (US10077266, Example 77 | US9181249, 77 | US9708313...) Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)C(F)c1ccc(F)cc1F)C(=O)N(C)C Show InChI InChI=1S/C25H33F3N6O/c1-15(2)29-23-24(31-20-9-12-34(14-21(20)30-23)25(35)32(3)4)33-10-7-16(8-11-33)22(28)18-6-5-17(26)13-19(18)27/h5-6,13,15-16,22H,7-12,14H2,1-4H3,(H,29,30)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0197	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM190981 (US10077266, Example 94 | US9181249, 94 | US9708313...) Show SMILES COc1ccc(OC2CCN(CC2)c2nc3CCN(Cc3nc2NC2CCC2)C(C)=O)c(F)c1 Show InChI InChI=1S/C25H32FN5O3/c1-16(32)31-13-10-21-22(15-31)28-24(27-17-4-3-5-17)25(29-21)30-11-8-18(9-12-30)34-23-7-6-19(33-2)14-20(23)26/h6-7,14,17-18H,3-5,8-13,15H2,1-2H3,(H,27,28)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0199	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM191000 (US10077266, Example 113 | US9181249, 113 | US97083...) Show SMILES CO[C@@H](C)C(=O)N1Cc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc2CC1C |r| Show InChI InChI=1S/C25H31F4N5O3/c1-14-10-19-20(13-34(14)25(35)15(2)36-3)32-24(23(31-19)30-12-22(28)29)33-8-6-17(7-9-33)37-21-5-4-16(26)11-18(21)27/h4-5,11,14-15,17,22H,6-10,12-13H2,1-3H3,(H,30,31)/t14?,15-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0209	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM190997 (US10077266, Example 110 | US9181249, 110 | US97083...) Show SMILES CC1Cc2nc(NCC(F)F)c(nc2CN1C(=O)C(F)F)N1CCC(CC1)Oc1ccc(F)cc1F Show InChI InChI=1S/C23H25F6N5O2/c1-12-8-16-17(11-34(12)23(35)20(28)29)32-22(21(31-16)30-10-19(26)27)33-6-4-14(5-7-33)36-18-3-2-13(24)9-15(18)25/h2-3,9,12,14,19-20H,4-8,10-11H2,1H3,(H,30,31)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0221	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM190998 (US10077266, Example 111 | US9181249, 111 | US97083...) Show SMILES COCC(=O)N1Cc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc2CC1C Show InChI InChI=1S/C24H29F4N5O3/c1-14-9-18-19(12-33(14)22(34)13-35-2)31-24(23(30-18)29-11-21(27)28)32-7-5-16(6-8-32)36-20-4-3-15(25)10-17(20)26/h3-4,10,14,16,21H,5-9,11-13H2,1-2H3,(H,29,30)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0230	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM190996 (US10077266, Example 109 | US9181249, 109 | US97083...) Show SMILES CC1Cc2nc(NCC(F)F)c(nc2CN1C)N1CCC(CC1)Oc1ccc(F)cc1F Show InChI InChI=1S/C22H27F4N5O/c1-13-9-17-18(12-30(13)2)29-22(21(28-17)27-11-20(25)26)31-7-5-15(6-8-31)32-19-4-3-14(23)10-16(19)24/h3-4,10,13,15,20H,5-9,11-12H2,1-2H3,(H,27,28)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0232	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM191006 (US10077266, Example 119 | US9181249, 119 | US97083...) Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)[C@@H](F)c1ccc(F)cc1F)C=O |r| Show InChI InChI=1S/C23H28F3N5O/c1-14(2)27-22-23(29-19-7-8-30(13-32)12-20(19)28-22)31-9-5-15(6-10-31)21(26)17-4-3-16(24)11-18(17)25/h3-4,11,13-15,21H,5-10,12H2,1-2H3,(H,27,28)/t21-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0236	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM190959 (US10077266, Example 72 | US9181249, 72 | US9708313...) Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)C(F)c1ccc(F)cc1F)C(=O)N(C)C Show InChI InChI=1S/C25H33F3N6O/c1-15(2)29-23-24(31-21-14-34(25(35)32(3)4)12-9-20(21)30-23)33-10-7-16(8-11-33)22(28)18-6-5-17(26)13-19(18)27/h5-6,13,15-16,22H,7-12,14H2,1-4H3,(H,29,30)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0237	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM191002 (US10077266, Example 115 | US9181249, 115 | US97083...) Show SMILES CC1Cc2nc(NCC(F)F)c(nc2CN1C(=O)C1CC1)N1CCC(CC1)Oc1ccc(F)cc1F Show InChI InChI=1S/C25H29F4N5O2/c1-14-10-19-20(13-34(14)25(35)15-2-3-15)32-24(23(31-19)30-12-22(28)29)33-8-6-17(7-9-33)36-21-5-4-16(26)11-18(21)27/h4-5,11,14-15,17,22H,2-3,6-10,12-13H2,1H3,(H,30,31)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0239	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM190936 (US10077266, Example 141 | US9181249, 141 | US91812...) Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O Show InChI InChI=1S/C23H29F2N5O2/c1-14(2)26-22-23(28-19-8-11-30(15(3)31)13-20(19)27-22)29-9-6-17(7-10-29)32-21-5-4-16(24)12-18(21)25/h4-5,12,14,17H,6-11,13H2,1-3H3,(H,26,27)	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0246	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM190967 (US10077266, Example 80 | US9181249, 80 | US9708313...) Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)C(=O)c1cc(Cl)ccc1F)C(=O)N(C)C Show InChI InChI=1S/C25H32ClFN6O2/c1-15(2)28-23-24(30-21-14-33(25(35)31(3)4)12-9-20(21)29-23)32-10-7-16(8-11-32)22(34)18-13-17(26)5-6-19(18)27/h5-6,13,15-16H,7-12,14H2,1-4H3,(H,28,29)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0249	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM190994 (US10077266, Example 107 | US9181249, 107 | US97083...) Show SMILES CC1Cc2nc(NCC(F)F)c(nc2CN1C(C)=O)N1CCC(CC1)Oc1ccc(F)cc1F Show InChI InChI=1S/C23H27F4N5O2/c1-13-9-18-19(12-32(13)14(2)33)30-23(22(29-18)28-11-21(26)27)31-7-5-16(6-8-31)34-20-4-3-15(24)10-17(20)25/h3-4,10,13,16,21H,5-9,11-12H2,1-2H3,(H,28,29)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0249	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM190956 (US10077266, Example 69 | US9181249, 69 | US9708313...) Show SMILES CN1CCc2nc(NC3CC3)c(nc2C1)N1CCC(CC1)[C@@H](F)c1ccc(F)cc1F |r| Show InChI InChI=1S/C23H28F3N5/c1-30-9-8-19-20(13-30)29-23(22(28-19)27-16-3-4-16)31-10-6-14(7-11-31)21(26)17-5-2-15(24)12-18(17)25/h2,5,12,14,16,21H,3-4,6-11,13H2,1H3,(H,27,28)/t21-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0265	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM190946 (US10077266, Example 58 | US9181249, 58 | US9708313...) Show SMILES COc1ccc(OC2CCN(CC2)c2nc3CN(C)CCc3nc2NC(C)C)c(F)c1 Show InChI InChI=1S/C23H32FN5O2/c1-15(2)25-22-23(27-20-14-28(3)10-9-19(20)26-22)29-11-7-16(8-12-29)31-21-6-5-17(30-4)13-18(21)24/h5-6,13,15-16H,7-12,14H2,1-4H3,(H,25,26)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0266	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM190983 (US10077266, Example 96 | US9181249, 96 | US9708313...) Show SMILES CN(C)C(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc2C1 Show InChI InChI=1S/C23H28F4N6O2/c1-31(2)23(34)33-10-7-17-18(13-33)29-21(28-12-20(26)27)22(30-17)32-8-5-15(6-9-32)35-19-4-3-14(24)11-16(19)25/h3-4,11,15,20H,5-10,12-13H2,1-2H3,(H,28,29)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0269	n/a	n/a	n/a	n/a	n/a	37
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM191022 (US10077266, Example 134 | US9181249, 134 | US97083...) Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCN(Cc2ccc(F)cc2F)CC1)C(C)=O Show InChI InChI=1S/C23H30F2N6O/c1-15(2)26-22-23(28-20-6-7-31(16(3)32)14-21(20)27-22)30-10-8-29(9-11-30)13-17-4-5-18(24)12-19(17)25/h4-5,12,15H,6-11,13-14H2,1-3H3,(H,26,27)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0270	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair
G-protein coupled receptor 6 (Homo sapiens (Human))	BDBM191004 (US10077266, Example 117 | US9181249, 117 | US97083...) Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)[C@H](F)c1ccc(F)cc1F)C(C)=O |r| Show InChI InChI=1S/C24H30F3N5O/c1-14(2)28-23-24(30-20-8-11-32(15(3)33)13-21(20)29-23)31-9-6-16(7-10-31)22(27)18-5-4-17(25)12-19(18)26/h4-5,12,14,16,22H,6-11,13H2,1-3H3,(H,28,29)/t22-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0274	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...				US Patent US9181249 (2015) BindingDB Entry DOI: 10.7270/Q2HM577D
					More data for this Ligand-Target Pair

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