Compile Data Set for Download or QSAR

Found 202 hits Enz. Inhib. hit(s) with Target = 'Gamma-aminobutyric acid receptor subunit alpha-5' AND taxid = 10116   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50599949 (CHEMBL3274851) Show SMILES Fc1ccccc1C1=NCC(=O)Nc2ccc(Br)cc12 |t:8| Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.260	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmcl.2022.128637 BindingDB Entry DOI: 10.7270/Q24B35B0
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50599953 (CHEMBL1451229) Show SMILES Cc1nnc2CN=C(c3ccccc3Cl)c3cc(Br)ccc3-n12 |t:6| Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmcl.2022.128637 BindingDB Entry DOI: 10.7270/Q24B35B0
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5 [32-462]/beta-3 [26-473]/gamma-2 [40-467] (Homo sapiens (Human))	BDBM25877 (CHEMBL286594 | RY-80, 1 | ethyl 12-ethynyl-8-methy...) Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(ccc-21)C#C Show InChI InChI=1S/C17H15N3O3/c1-4-11-6-7-13-12(8-11)16(21)19(3)9-14-15(17(22)23-5-2)18-10-20(13)14/h1,6-8,10H,5,9H2,2-3H3	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.490	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Milwaukee					Assay Description The affinity of compounds for human recombinant GABA (A) receptors was measured by competition binding using [3H]flunitrazepam. Assays were carried o...				Bioorg Med Chem 16: 8853-62 (2008) Article DOI: 10.1016/j.bmc.2008.08.072 BindingDB Entry DOI: 10.7270/Q2GX48WR
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1 (Homo sapiens (Human))	BDBM643722 ((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-...) Show SMILES C[C@@H]1N=C(c2c(F)cccc2F)c2c(Cl)c(Cl)ccc2-n2c1n[nH]c2=O |r,t:2| Show InChI	GoogleScholar AffyNet	PC cid PC sid UniChem		0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1 (Homo sapiens (Human))	BDBM643732 ((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-1,4-dimet...) Show SMILES C[C@@H]1N=C(c2c(F)cccc2F)c2c(Cl)c(Cl)ccc2-n2c(C)nnc12 |r,t:2| Show InChI	GoogleScholar AffyNet	PC cid PC sid UniChem		0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50599957 (CHEMBL5179977) Show SMILES Cc1nnc2CN=C(c3ccccc3F)c3cc(ccc3-n12)C#C |t:6| Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmcl.2022.128637 BindingDB Entry DOI: 10.7270/Q24B35B0
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50599952 (CHEMBL3246832) Show SMILES Cc1nnc2CN=C(c3ccccc3)c3cc(Br)ccc3-n12 |t:6| Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmcl.2022.128637 BindingDB Entry DOI: 10.7270/Q24B35B0
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50599948 (PHENAZEPAM) Show SMILES Clc1ccccc1C1=NCC(=O)Nc2ccc(Br)cc12 |t:8| Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.680	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmcl.2022.128637 BindingDB Entry DOI: 10.7270/Q24B35B0
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1 (Homo sapiens (Human))	BDBM643720 ((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-...) Show SMILES C[C@@H]1N=C(c2c(F)cccc2F)c2c(Cl)c(Cl)ccc2-n2c1nnc2-c1cccnn1 |r,t:2| Show InChI	GoogleScholar AffyNet	PC cid PC sid UniChem		0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1 (Homo sapiens (Human))	BDBM643717 ((4S)-8-bromo-7-chloro-6-(2,6-difluorophenyl)-4-met...) Show SMILES C[C@@H]1N=C(c2c(F)cccc2F)c2c(Cl)c(Br)ccc2-n2cnnc12 |r,t:2| Show InChI	GoogleScholar AffyNet	PC cid PC sid UniChem		0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50599947 (CHEMBL5192472) Show SMILES CN1c2ccc(cc2C(=NCC1=O)c1ccccc1F)C#C |c:9| Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmcl.2022.128637 BindingDB Entry DOI: 10.7270/Q24B35B0
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1 (Homo sapiens (Human))	BDBM643750 ((4S)-7-chloro-6-(2,6-difluorophenyl)-8-iodo-1,4-di...) Show SMILES C[C@@H]1N=C(c2c(F)cccc2F)c2c(Cl)c(I)ccc2-n2c(C)nnc12 |r,t:2| Show InChI	GoogleScholar AffyNet	PC cid PC sid UniChem		0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1 (Homo sapiens (Human))	BDBM643728 ((4S)-8-bromo-7-chloro-6-(2,6-difluorophenyl)-1,4-d...) Show SMILES C[C@@H]1N=C(c2c(F)cccc2F)c2c(Cl)c(Br)ccc2-n2c(C)nnc12 |r,t:2| Show InChI	GoogleScholar AffyNet	PC cid PC sid UniChem		0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5 (RAT)	BDBM26263 (Anexate | CHEMBL407 | FLUMAZENIL | Ro15-1788 | Rom...) Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(F)ccc-21 Show InChI InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	0.810	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Synthélabo Curated by PDSP Ki Database									J Biol Chem 274: 13370-4 (1999) Article DOI: 10.1074/jbc.274.19.13370 BindingDB Entry DOI: 10.7270/Q2765CWZ
					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-5 (RAT)	BDBM50049735 (5-Methyl-6-oxo-8-trimethylsilanylethynyl-5,6-dihyd...) Show SMILES CN1Cc2c(ncn2-c2ccc(cc2C1=O)C#C[Si](C)(C)C)C(=O)OC(C)(C)C Show InChI InChI=1S/C22H27N3O3Si/c1-22(2,3)28-21(27)19-18-13-24(4)20(26)16-12-15(10-11-29(5,6)7)8-9-17(16)25(18)14-23-19/h8-9,12,14H,13H2,1-7H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.830	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Diabetes and Digestive and Kidney Diseases Curated by PDSP Ki Database									J Pharmacol Exp Ther 283: 488-93 (1997) BindingDB Entry DOI: 10.7270/Q2PN945P
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5 [32-462]/beta-3 [26-473]/gamma-2 [40-467] (Homo sapiens (Human))	US20240043418, Example 3 (1-(6-{[3-(4-fluorophenyl)-5-methyl-1,2-oxazol-4-yl...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	UniChem		0.900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1 (Homo sapiens (Human))	BDBM643749 (US20240002393, Example 101 | [(4R)-8-bromo-7-chlor...) Show SMILES Cc1nnc2[C@H](CO)N=C(c3c(F)cccc3F)c3c(Cl)c(Br)ccc3-n12 |r,t:8| Show InChI	GoogleScholar AffyNet	PC cid PC sid UniChem		1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5 (RAT)	BDBM50049735 (5-Methyl-6-oxo-8-trimethylsilanylethynyl-5,6-dihyd...) Show SMILES CN1Cc2c(ncn2-c2ccc(cc2C1=O)C#C[Si](C)(C)C)C(=O)OC(C)(C)C Show InChI InChI=1S/C22H27N3O3Si/c1-22(2,3)28-21(27)19-18-13-24(4)20(26)16-12-15(10-11-29(5,6)7)8-9-17(16)25(18)14-23-19/h8-9,12,14H,13H2,1-7H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.03	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Diabetes and Digestive and Kidney Diseases Curated by PDSP Ki Database									J Pharmacol Exp Ther 283: 488-93 (1997) BindingDB Entry DOI: 10.7270/Q2PN945P
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1 (Homo sapiens (Human))	BDBM643719 ((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-...) Show SMILES C[C@@H]1N=C(c2c(F)cccc2F)c2c(Cl)c(Cl)ccc2-n2c1nnc2-c1cnn(C)c1 |r,t:2| Show InChI	GoogleScholar AffyNet	PC cid PC sid UniChem		1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1 (Homo sapiens (Human))	BDBM643718 ((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-...) Show SMILES C[C@@H]1N=C(c2c(F)cccc2F)c2c(Cl)c(Cl)ccc2-n2c1nnc2-c1ccncn1 |r,t:2| Show InChI	GoogleScholar AffyNet	PC cid PC sid UniChem		1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1 (Homo sapiens (Human))	BDBM643715 ((4S)-8-bromo-7-chloro-6-(2-fluorophenyl)-4-methyl-...) Show SMILES C[C@@H]1N=C(c2ccccc2F)c2c(Cl)c(Br)ccc2-n2c1nnc2-c1cccnn1 |r,t:2| Show InChI	GoogleScholar AffyNet	PC cid PC sid UniChem		1.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5 (RAT)	BDBM26263 (Anexate | CHEMBL407 | FLUMAZENIL | Ro15-1788 | Rom...) Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(F)ccc-21 Show InChI InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	1.39	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Synthélabo Curated by PDSP Ki Database									J Biol Chem 274: 13370-4 (1999) Article DOI: 10.1074/jbc.274.19.13370 BindingDB Entry DOI: 10.7270/Q2765CWZ
					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1 (Homo sapiens (Human))	BDBM643736 ((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-...) Show SMILES C[C@@H]1N=C(c2c(F)cccc2F)c2c(Cl)c(Cl)ccc2-n2c1nnc2-c1ccc(C)nn1 |r,t:2| Show InChI	GoogleScholar AffyNet	PC cid PC sid UniChem		1.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1 (Homo sapiens (Human))	BDBM643743 ((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-...) Show SMILES C[C@@H]1N=C(c2c(F)cccc2F)c2c(Cl)c(Cl)ccc2-n2c1nnc2-c1ccnc(C)n1 |r,t:2| Show InChI	GoogleScholar AffyNet	PC cid PC sid UniChem		1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50001728 (8-Chloro-1-methyl-6-phenyl-4H-s-triazolo(4,3-a)(1,...) Show SMILES Cc1nnc2CN=C(c3ccccc3)c3cc(Cl)ccc3-n12 |t:6| Show InChI InChI=1S/C17H13ClN4/c1-11-20-21-16-10-19-17(12-5-3-2-4-6-12)14-9-13(18)7-8-15(14)22(11)16/h2-9H,10H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmcl.2022.128637 BindingDB Entry DOI: 10.7270/Q24B35B0
					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-5 (RAT)	BDBM26263 (Anexate | CHEMBL407 | FLUMAZENIL | Ro15-1788 | Rom...) Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(F)ccc-21 Show InChI InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	1.52	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Synthélabo Curated by PDSP Ki Database									J Biol Chem 274: 13370-4 (1999) Article DOI: 10.1074/jbc.274.19.13370 BindingDB Entry DOI: 10.7270/Q2765CWZ
					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-5 (RAT)	BDBM26263 (Anexate | CHEMBL407 | FLUMAZENIL | Ro15-1788 | Rom...) Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(F)ccc-21 Show InChI InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	1.79	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Synthélabo Curated by PDSP Ki Database									J Biol Chem 274: 13370-4 (1999) Article DOI: 10.1074/jbc.274.19.13370 BindingDB Entry DOI: 10.7270/Q2765CWZ
					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1 (Homo sapiens (Human))	BDBM643740 ((4S)-7-chloro-6-(2,6-difluorophenyl)-1,4-dimethyl-...) Show SMILES C[C@@H]1N=C(c2c(F)cccc2F)c2c(Cl)c(ccc2-n2c(C)nnc12)C(F)(F)F |r,t:2| Show InChI	GoogleScholar AffyNet	PC cid PC sid UniChem		1.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50599950 (CHEMBL5179487) Show SMILES C[C@@H]1N=C(c2ccccc2)c2cc(Br)ccc2NC1=O |r,t:2| Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmcl.2022.128637 BindingDB Entry DOI: 10.7270/Q24B35B0
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5 [32-462]/beta-2 [26-512]/gamma-2 [40-467] (Homo sapiens (Human))	BDBM26263 (Anexate | CHEMBL407 | FLUMAZENIL | Ro15-1788 | Rom...) Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(F)ccc-21 Show InChI InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	2	-49.2	n/a	n/a	n/a	n/a	n/a	7.4	22
University of Wisconsin at Madison					Assay Description Membrane homogenates were incubated at room temperature with a sub-Kd concentration of radioligand in the absence or presence of seven different conc...				J Med Chem 51: 7243-52 (2008) Article DOI: 10.1021/jm800889m BindingDB Entry DOI: 10.7270/Q2R78CJM
					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50599946 (CHEMBL5170217) Show SMILES CN1c2ccc(cc2C(=NCC1=O)c1ccccc1Cl)C#C |c:9| Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmcl.2022.128637 BindingDB Entry DOI: 10.7270/Q24B35B0
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1 (Homo sapiens (Human))	BDBM643742 ((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-...) Show SMILES C[C@@H]1N=C(c2c(F)cccc2F)c2c(Cl)c(Cl)ccc2-n2c1nnc2-c1cc(C)ncn1 |r,t:2| Show InChI	GoogleScholar AffyNet	PC cid PC sid UniChem		2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1 (Homo sapiens (Human))	BDBM643726 ((4S)-7-bromo-8-chloro-6-(2,6-difluorophenyl)-4-met...) Show SMILES C[C@@H]1N=C(c2c(F)cccc2F)c2c(Br)c(Cl)ccc2-n2c1nnc2-c1cccnn1 |r,t:2| Show InChI	GoogleScholar AffyNet	PC cid PC sid UniChem		2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1 (Homo sapiens (Human))	BDBM643755 ((4S)-7-chloro-6-(2,6-difluorophenyl)-1-ethyl-4-met...) Show SMILES CCc1nnc2[C@H](C)N=C(c3c(F)cccc3F)c3c(Cl)c(ccc3-n12)C(F)(F)F |r,t:8| Show InChI	GoogleScholar AffyNet	PC cid PC sid UniChem		2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1 (Homo sapiens (Human))	BDBM643737 (5-[(4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-meth...) Show SMILES C[C@@H]1N=C(c2c(F)cccc2F)c2c(Cl)c(Cl)ccc2-n2c1nnc2-c1cc(C)no1 |r,t:2| Show InChI	GoogleScholar AffyNet	PC cid PC sid UniChem		2.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2 (Homo sapiens (Human))	BDBM25878 (5-(2-fluorophenyl)-1-methyl-7-nitro-2,3-dihydro-1H...) Show SMILES CN1c2ccc(cc2C(=NCC1=O)c1ccccc1F)[N+]([O-])=O |c:9| Show InChI InChI=1S/C16H12FN3O3/c1-19-14-7-6-10(20(22)23)8-12(14)16(18-9-15(19)21)11-4-2-3-5-13(11)17/h2-8H,9H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank PC cid PC sid UniChem Patents Similars	Article PubMed	2.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmcl.2022.128637 BindingDB Entry DOI: 10.7270/Q24B35B0
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Gamma-aminobutyric acid receptor subunit alpha-5 (RAT)	BDBM50293263 (2-(5-benzyl-2-hydroxyphenyl)-6-methyl-4H-chromen-4...) Show SMILES Cc1ccc2oc(cc(=O)c2c1)-c1cc(Cc2ccccc2)ccc1O Show InChI InChI=1S/C23H18O3/c1-15-7-10-22-18(11-15)21(25)14-23(26-22)19-13-17(8-9-20(19)24)12-16-5-3-2-4-6-16/h2-11,13-14,24H,12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lund University Curated by ChEMBL					Assay Description Displacement of [3H]flumazenil in rat GABAAalpha5beta3gamma2 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 18: 5713-6 (2009) Article DOI: 10.1016/j.bmcl.2008.09.092 BindingDB Entry DOI: 10.7270/Q2CF9Q3Z
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Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1 (Homo sapiens (Human))	BDBM643745 ((4S)-7-chloro-6-(2,6-difluorophenyl)-1,4,8-trimeth...) Show SMILES C[C@@H]1N=C(c2c(F)cccc2F)c2c(Cl)c(C)ccc2-n2c(C)nnc12 |r,t:2| Show InChI	GoogleScholar AffyNet	PC cid PC sid UniChem		2.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1 (Homo sapiens (Human))	BDBM643727 ((4S)-7-bromo-8-chloro-6-(2,6-difluorophenyl)-4-met...) Show SMILES C[C@@H]1N=C(c2c(F)cccc2F)c2c(Br)c(Cl)ccc2-n2c1nnc2-c1ccncn1 |r,t:2| Show InChI	GoogleScholar AffyNet	PC cid PC sid UniChem		2.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1 (Homo sapiens (Human))	BDBM643713 ((4S)-8-bromo-7-chloro-6-(2-fluorophenyl)-4-methyl-...) Show SMILES C[C@@H]1N=C(c2ccccc2F)c2c(Cl)c(Br)ccc2-n2cnnc12 |r,t:2| Show InChI	GoogleScholar AffyNet	PC cid PC sid UniChem		2.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1 (Homo sapiens (Human))	BDBM643733 ((4S)-8-bromo-7-chloro-1-cyclopropyl-6-(3-fluoro-2-...) Show SMILES C[C@@H]1N=C(c2ncccc2F)c2c(Cl)c(Br)ccc2-n2c(nnc12)C1CC1 |r,t:2| Show InChI	GoogleScholar AffyNet	PC cid PC sid UniChem		2.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1 (Homo sapiens (Human))	BDBM643714 (8-bromo-7-chloro-6-(2,6-difluorophenyl)-4H-[1,2,4]...) Show SMILES OC1N=C(c2c(F)cccc2F)c2c(Cl)c(Br)ccc2-n2cnnc12 |t:2| Show InChI	GoogleScholar AffyNet	PC cid PC sid UniChem		2.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1 (Homo sapiens (Human))	BDBM643754 ((4S)-7-chloro-6-(2,6-difluorophenyl)-4-methyl-8-(t...) Show SMILES C[C@@H]1N=C(c2c(F)cccc2F)c2c(Cl)c(ccc2-n2cnnc12)C(F)(F)F |r,t:2| Show InChI	GoogleScholar AffyNet	PC cid PC sid UniChem		3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1 (Homo sapiens (Human))	BDBM643744 ((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-1-(2,6-di...) Show SMILES C[C@@H]1N=C(c2c(F)cccc2F)c2c(Cl)c(Cl)ccc2-n2c1nnc2-c1cc(C)nc(C)n1 |r,t:2| Show InChI	GoogleScholar AffyNet	PC cid PC sid UniChem		3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1 (Homo sapiens (Human))	BDBM643730 ((4S)-7-bromo-8-chloro-6-(2,6-difluorophenyl)-1,4-d...) Show SMILES C[C@@H]1N=C(c2c(F)cccc2F)c2c(Br)c(Cl)ccc2-n2c(C)nnc12 |r,t:2| Show InChI	GoogleScholar AffyNet	PC cid PC sid UniChem		3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1 (Homo sapiens (Human))	BDBM643741 ((4S)-7-chloro-8-(1,1-difluoroethyl)-6-(2,6-difluor...) Show SMILES C[C@@H]1N=C(c2c(F)cccc2F)c2c(Cl)c(ccc2-n2c(C)nnc12)C(C)(F)F |r,t:2| Show InChI	GoogleScholar AffyNet	PC cid PC sid UniChem		3.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1 (Homo sapiens (Human))	BDBM643747 ((4S)-7-chloro-8-(difluoromethyl)-6-(2,6-difluoroph...) Show SMILES C[C@@H]1N=C(c2c(F)cccc2F)c2c(Cl)c(ccc2-n2c(C)nnc12)C(F)F |r,t:2| Show InChI	GoogleScholar AffyNet	PC cid PC sid UniChem		3.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1 (Homo sapiens (Human))	BDBM643724 ((4S)-7,8-dichloro-6-(3-fluoro-2-pyridyl)-4-methyl-...) Show SMILES C[C@@H]1N=C(c2ncccc2F)c2c(Cl)c(Cl)ccc2-n2c1nnc2-c1cnn(C)c1 |r,t:2| Show InChI	GoogleScholar AffyNet	PC cid PC sid UniChem		3.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1 (Homo sapiens (Human))	BDBM643735 ((4S)-8-bromo-7-chloro-6-(3-fluoro-2-pyridyl)-1,4-d...) Show SMILES C[C@@H]1N=C(c2ncccc2F)c2c(Cl)c(Br)ccc2-n2c(C)nnc12 |r,t:2| Show InChI	GoogleScholar AffyNet	PC cid PC sid UniChem		3.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1 (Homo sapiens (Human))	BDBM643748 ((4R)-8-bromo-7-chloro-6-(2,6-difluorophenyl)-4-(me...) Show SMILES COC[C@@H]1N=C(c2c(F)cccc2F)c2c(Cl)c(Br)ccc2-n2c(C)nnc12 |r,t:4| Show InChI	GoogleScholar AffyNet	PC cid PC sid UniChem		3.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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