Found 169 hits Enz. Inhib. hit(s) with Target = 'Glycine receptor subunit alpha-1' AND taxid = 10116 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Glycine receptor subunit alpha-1
(RAT) | BDBM50225707
(CHEBI:28973 | Strychnine)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])CC(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |c:5| Show InChI InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1 | PDB
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| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The German University in Cairo
Curated by ChEMBL
| Assay Description
Displacement of [3H]strychnine from glycine receptor alpha 1 in rat brain synaptic membranes |
J Nat Prod 79: 2997-3005 (2016)
Article DOI: 10.1021/acs.jnatprod.6b00479
BindingDB Entry DOI: 10.7270/Q2QZ2D66 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Glycine receptor subunit alpha-1
(RAT) | BDBM50232884
(CHEMBL4060962)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])CC(=O)N6c7ccc(N)cc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |r,c:5| Show InChI InChI=1S/C21H23N3O2/c22-12-1-2-15-14(7-12)21-4-5-23-10-11-3-6-26-16-9-18(25)24(15)20(21)19(16)13(11)8-17(21)23/h1-3,7,13,16-17,19-20H,4-6,8-10,22H2/t13-,16-,17-,19-,20-,21+/m0/s1 | PDB
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| 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The German University in Cairo
Curated by ChEMBL
| Assay Description
Displacement of [3H]strychnine from glycine receptor alpha 1 in rat brain synaptic membranes |
J Nat Prod 79: 2997-3005 (2016)
Article DOI: 10.1021/acs.jnatprod.6b00479
BindingDB Entry DOI: 10.7270/Q2QZ2D66 |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1
(RAT) | BDBM84745
(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)Show InChI InChI=1S/C18H19NOS/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16/h2-10,13,17,19H,11-12H2,1H3/t17-/m0/s1 | PDB
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| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by PDSP Ki Database
| |
Neuropsychopharmacology 25: 871-80 (2001)
Article DOI: 10.1016/S0893-133X(01)00298-6
BindingDB Entry DOI: 10.7270/Q25M648W |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1
(RAT) | BDBM82071
(CAS_93413-69-5 | CAS_99300-78-4 | NSC_62923 | VENL...)Show InChI InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3 | PDB
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| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by PDSP Ki Database
| |
Neuropsychopharmacology 25: 871-80 (2001)
Article DOI: 10.1016/S0893-133X(01)00298-6
BindingDB Entry DOI: 10.7270/Q25M648W |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1
(RAT) | BDBM82071
(CAS_93413-69-5 | CAS_99300-78-4 | NSC_62923 | VENL...)Show InChI InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3 | PDB
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| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by PDSP Ki Database
| |
Neuropsychopharmacology 25: 871-80 (2001)
Article DOI: 10.1016/S0893-133X(01)00298-6
BindingDB Entry DOI: 10.7270/Q25M648W |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1
(RAT) | BDBM50022784
((R)-N-methyl-3-phenyl-3-(o-tolyloxy)propan-1-amine...)Show InChI InChI=1S/C17H21NO/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15/h3-11,17-18H,12-13H2,1-2H3 | PDB
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| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by PDSP Ki Database
| |
Neuropsychopharmacology 27: 699-711 (2002)
Article DOI: 10.1016/S0893-133X(02)00346-9
BindingDB Entry DOI: 10.7270/Q2GQ6W98 |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1
(RAT) | BDBM84745
(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)Show InChI InChI=1S/C18H19NOS/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16/h2-10,13,17,19H,11-12H2,1H3/t17-/m0/s1 | PDB
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| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by PDSP Ki Database
| |
Neuropsychopharmacology 25: 871-80 (2001)
Article DOI: 10.1016/S0893-133X(01)00298-6
BindingDB Entry DOI: 10.7270/Q25M648W |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1
(RAT) | BDBM21398
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2 | PDB
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Synthélabo Recherche
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 280: 83-97 (1997)
BindingDB Entry DOI: 10.7270/Q2NZ865X |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1
(RAT) | BDBM22869
(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)Show SMILES CN1CCN(CC1)C1=c2ccccc2=Nc2ccc(Cl)cc2N1 |c:8,15| Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,21H,8-11H2,1H3 | PDB
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Synthélabo Recherche
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 280: 83-97 (1997)
BindingDB Entry DOI: 10.7270/Q2NZ865X |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1
(RAT) | BDBM81790
(Amisulpride | CAS_71675-85-9 | NSC_2159 | US101672...)Show InChI InChI=1S/C17H27N3O4S/c1-4-20-8-6-7-12(20)11-19-17(21)13-9-16(25(22,23)5-2)14(18)10-15(13)24-3/h9-10,12H,4-8,11,18H2,1-3H3,(H,19,21) | PDB
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Synthélabo Recherche
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 280: 83-97 (1997)
BindingDB Entry DOI: 10.7270/Q2NZ865X |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1
(RAT) | BDBM22913
(CHEMBL1237146 | CHEMBL498770 | Iodophenpropit | {[...)Show SMILES NC(SCCCc1cnc[nH]1)=NCCc1ccc(I)cc1 |w:11.12| Show InChI InChI=1S/C15H19IN4S/c16-13-5-3-12(4-6-13)7-8-19-15(17)21-9-1-2-14-10-18-11-20-14/h3-6,10-11H,1-2,7-9H2,(H2,17,19)(H,18,20) | PDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit
Curated by PDSP Ki Database
| |
Br J Pharmacol 116: 2315-21 (1995)
Article DOI: 10.1111/j.1476-5381.1995.tb15071.x
BindingDB Entry DOI: 10.7270/Q2ZK5F64 |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1
(RAT) | BDBM22914
(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)Show InChI InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20) | PDB
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Vrije Universiteit
Curated by PDSP Ki Database
| |
Br J Pharmacol 116: 2315-21 (1995)
Article DOI: 10.1111/j.1476-5381.1995.tb15071.x
BindingDB Entry DOI: 10.7270/Q2ZK5F64 |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1
(RAT) | BDBM50133817
(4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic ...)Show SMILES CC(C)(C)c1ccc(NC(=O)N2CCN(CC2)c2ncccc2Cl)cc1 Show InChI InChI=1S/C20H25ClN4O/c1-20(2,3)15-6-8-16(9-7-15)23-19(26)25-13-11-24(12-14-25)18-17(21)5-4-10-22-18/h4-10H,11-14H2,1-3H3,(H,23,26) | PDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pudue Pharma Discovery Research
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 306: 377-86 (2003)
Article DOI: 10.1124/jpet.102.045674
BindingDB Entry DOI: 10.7270/Q2TX3CX5 |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1
(RAT) | BDBM50304335
(3alpha-(1'-Methyl-2'-Indolecarbonyloxy)-nortropane...)Show SMILES Cn1c(cc2ccccc12)C(=O)OC1C[C@H]2CC[C@H](C1)N2 |r,TLB:12:13:20:16.17| Show InChI InChI=1S/C17H20N2O2/c1-19-15-5-3-2-4-11(15)8-16(19)17(20)21-14-9-12-6-7-13(10-14)18-12/h2-5,8,12-14,18H,6-7,9-10H2,1H3/t12-,13-/m1/s1 | PDB
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| n/a | n/a | 1.07 | n/a | n/a | n/a | n/a | n/a | n/a |
Hungarian Academy of Sciences
Curated by ChEMBL
| Assay Description
Displacement of [3H]strychnine from GlyR high affinity site in Wistar rat spinal cord by scintillation spectrometry in presence of 10 uM glycine |
Bioorg Med Chem 17: 6872-8 (2009)
Article DOI: 10.1016/j.bmc.2009.08.029
BindingDB Entry DOI: 10.7270/Q2DJ5FQJ |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1
(RAT) | BDBM50304334
(3alpha-(1'-Methyl-2'-Indolecarbonyloxy)-tropane | ...)Show SMILES CN1[C@@H]2CC[C@@H]1CC(C2)OC(=O)c1cc2ccccc2n1C |r,THB:9:7:1:3.4| Show InChI InChI=1S/C18H22N2O2/c1-19-13-7-8-14(19)11-15(10-13)22-18(21)17-9-12-5-3-4-6-16(12)20(17)2/h3-6,9,13-15H,7-8,10-11H2,1-2H3/t13-,14-/m1/s1 | PDB
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| n/a | n/a | 10.2 | n/a | n/a | n/a | n/a | n/a | n/a |
Hungarian Academy of Sciences
Curated by ChEMBL
| Assay Description
Displacement of [3H]strychnine from GlyR high affinity site in Wistar rat spinal cord by scintillation spectrometry |
Bioorg Med Chem 17: 6872-8 (2009)
Article DOI: 10.1016/j.bmc.2009.08.029
BindingDB Entry DOI: 10.7270/Q2DJ5FQJ |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1
(RAT) | BDBM50304335
(3alpha-(1'-Methyl-2'-Indolecarbonyloxy)-nortropane...)Show SMILES Cn1c(cc2ccccc12)C(=O)OC1C[C@H]2CC[C@H](C1)N2 |r,TLB:12:13:20:16.17| Show InChI InChI=1S/C17H20N2O2/c1-19-15-5-3-2-4-11(15)8-16(19)17(20)21-14-9-12-6-7-13(10-14)18-12/h2-5,8,12-14,18H,6-7,9-10H2,1H3/t12-,13-/m1/s1 | PDB
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| n/a | n/a | 11.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Hungarian Academy of Sciences
Curated by ChEMBL
| Assay Description
Displacement of [3H]strychnine from GlyR high affinity site in Wistar rat spinal cord by scintillation spectrometry |
Bioorg Med Chem 17: 6872-8 (2009)
Article DOI: 10.1016/j.bmc.2009.08.029
BindingDB Entry DOI: 10.7270/Q2DJ5FQJ |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1
(RAT) | BDBM50304335
(3alpha-(1'-Methyl-2'-Indolecarbonyloxy)-nortropane...)Show SMILES Cn1c(cc2ccccc12)C(=O)OC1C[C@H]2CC[C@H](C1)N2 |r,TLB:12:13:20:16.17| Show InChI InChI=1S/C17H20N2O2/c1-19-15-5-3-2-4-11(15)8-16(19)17(20)21-14-9-12-6-7-13(10-14)18-12/h2-5,8,12-14,18H,6-7,9-10H2,1H3/t12-,13-/m1/s1 | PDB
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| n/a | n/a | 33.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Hungarian Academy of Sciences
Curated by ChEMBL
| Assay Description
Displacement of [3H]strychnine from GlyR in Wistar rat spinal cord by scintillation spectrometry |
Bioorg Med Chem 17: 6872-8 (2009)
Article DOI: 10.1016/j.bmc.2009.08.029
BindingDB Entry DOI: 10.7270/Q2DJ5FQJ |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1
(RAT) | BDBM50415201
(CHEMBL611364)Show SMILES CN1[C@@H]2CC[C@@H]1CC(C2)OC(=O)c1ccc[nH]1 |r,THB:9:7:1:3.4| Show InChI InChI=1S/C13H18N2O2/c1-15-9-4-5-10(15)8-11(7-9)17-13(16)12-3-2-6-14-12/h2-3,6,9-11,14H,4-5,7-8H2,1H3/t9-,10-/m1/s1 | PDB
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| n/a | n/a | 33.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Hungarian Academy of Sciences
Curated by ChEMBL
| Assay Description
Displacement of [3H]strychnine from GlyR high affinity site in Wistar rat spinal cord by scintillation spectrometry |
Bioorg Med Chem 17: 6872-8 (2009)
Article DOI: 10.1016/j.bmc.2009.08.029
BindingDB Entry DOI: 10.7270/Q2DJ5FQJ |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1
(RAT) | BDBM50415204
(CHEMBL596443)Show SMILES O=C(OC1C[C@H]2CC[C@H](C1)N2)c1cccs1 |r,TLB:2:3:10:6.7| Show InChI InChI=1S/C12H15NO2S/c14-12(11-2-1-5-16-11)15-10-6-8-3-4-9(7-10)13-8/h1-2,5,8-10,13H,3-4,6-7H2/t8-,9-/m1/s1 | PDB
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| n/a | n/a | 41.7 | n/a | n/a | n/a | n/a | n/a | n/a |
Hungarian Academy of Sciences
Curated by ChEMBL
| Assay Description
Displacement of [3H]strychnine from GlyR in Wistar rat spinal cord by scintillation spectrometry |
Bioorg Med Chem 17: 6872-8 (2009)
Article DOI: 10.1016/j.bmc.2009.08.029
BindingDB Entry DOI: 10.7270/Q2DJ5FQJ |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1/beta
(Homo sapiens (Human)) | BDBM50232889
(CHEMBL4103909)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])\C(=N/OCC#C)C(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |r,c:5| Show InChI InChI=1S/C24H23N3O3/c1-2-10-30-25-20-21-19-15-12-18-24(8-9-26(18)13-14(15)7-11-29-21)16-5-3-4-6-17(16)27(22(19)24)23(20)28/h1,3-7,15,18-19,21-22H,8-13H2/b25-20+/t15-,18-,19-,21+,22-,24+/m0/s1 | PDB
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| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
The German University in Cairo
Curated by ChEMBL
| Assay Description
Antagonist activity at recombinant human glycine receptor alpha 1 beta expressed in HEK293 cells assessed as inhibition of glycine-induced current at... |
J Nat Prod 79: 2997-3005 (2016)
Article DOI: 10.1021/acs.jnatprod.6b00479
BindingDB Entry DOI: 10.7270/Q2QZ2D66 |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1/beta
(Homo sapiens (Human)) | BDBM50232896
(CHEMBL4079657)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])\C(=N/OCC=C)C(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |r,c:5| Show InChI InChI=1S/C24H25N3O3/c1-2-10-30-25-20-21-19-15-12-18-24(8-9-26(18)13-14(15)7-11-29-21)16-5-3-4-6-17(16)27(22(19)24)23(20)28/h2-7,15,18-19,21-22H,1,8-13H2/b25-20+/t15-,18-,19-,21+,22-,24+/m0/s1 | PDB
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The German University in Cairo
Curated by ChEMBL
| Assay Description
Antagonist activity at recombinant human glycine receptor alpha 1 beta expressed in HEK293 cells assessed as inhibition of glycine-induced current at... |
J Nat Prod 79: 2997-3005 (2016)
Article DOI: 10.1021/acs.jnatprod.6b00479
BindingDB Entry DOI: 10.7270/Q2QZ2D66 |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1
(RAT) | BDBM50415205
(CHEMBL595797)Show SMILES CN1[C@@H]2CC[C@@H]1CC(C2)OC(=O)c1ccco1 |r,THB:9:7:1:3.4| Show InChI InChI=1S/C13H17NO3/c1-14-9-4-5-10(14)8-11(7-9)17-13(15)12-3-2-6-16-12/h2-3,6,9-11H,4-5,7-8H2,1H3/t9-,10-/m1/s1 | PDB
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Hungarian Academy of Sciences
Curated by ChEMBL
| Assay Description
Displacement of [3H]strychnine from GlyR high affinity site in Wistar rat spinal cord by scintillation spectrometry |
Bioorg Med Chem 17: 6872-8 (2009)
Article DOI: 10.1016/j.bmc.2009.08.029
BindingDB Entry DOI: 10.7270/Q2DJ5FQJ |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1/beta
(Homo sapiens (Human)) | BDBM50232890
(CHEMBL4102677)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])\C(=N/OC)C(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |r,c:5| Show InChI InChI=1S/C22H23N3O3/c1-27-23-18-19-17-13-10-16-22(7-8-24(16)11-12(13)6-9-28-19)14-4-2-3-5-15(14)25(20(17)22)21(18)26/h2-6,13,16-17,19-20H,7-11H2,1H3/b23-18+/t13-,16-,17-,19+,20-,22+/m0/s1 | PDB
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The German University in Cairo
Curated by ChEMBL
| Assay Description
Antagonist activity at recombinant human glycine receptor alpha 1 beta expressed in HEK293 cells assessed as inhibition of glycine-induced current at... |
J Nat Prod 79: 2997-3005 (2016)
Article DOI: 10.1021/acs.jnatprod.6b00479
BindingDB Entry DOI: 10.7270/Q2QZ2D66 |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1/beta
(Homo sapiens (Human)) | BDBM50225707
(CHEBI:28973 | Strychnine)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])CC(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |c:5| Show InChI InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1 | PDB
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The German University in Cairo
Curated by ChEMBL
| Assay Description
Antagonist activity at recombinant human glycine receptor alpha 1 beta expressed in HEK293 cells assessed as inhibition of glycine-induced current at... |
J Nat Prod 79: 2997-3005 (2016)
Article DOI: 10.1021/acs.jnatprod.6b00479
BindingDB Entry DOI: 10.7270/Q2QZ2D66 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Glycine receptor subunit alpha-1/beta
(Homo sapiens (Human)) | BDBM50225707
(CHEBI:28973 | Strychnine)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])CC(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |c:5| Show InChI InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1 | PDB
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The German University in Cairo
Curated by ChEMBL
| Assay Description
Antagonist activity at human glycine receptor subunit alpha-1beta expressed in HEK293 cells assessed as reduction in glycine-induced whole cell curre... |
J Nat Prod 82: 2332-2336 (2019)
Article DOI: 10.1021/acs.jnatprod.9b00180
BindingDB Entry DOI: 10.7270/Q2571GB7 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Glycine receptor subunit alpha-1
(RAT) | BDBM50415208
(CHEMBL608418)Show SMILES CN1[C@@H]2CC[C@@H]1CC(C2)OC(=O)c1cccnc1 |r,THB:9:7:1:3.4| Show InChI InChI=1S/C14H18N2O2/c1-16-11-4-5-12(16)8-13(7-11)18-14(17)10-3-2-6-15-9-10/h2-3,6,9,11-13H,4-5,7-8H2,1H3/t11-,12-/m1/s1 | PDB
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Hungarian Academy of Sciences
Curated by ChEMBL
| Assay Description
Displacement of [3H]strychnine from GlyR high affinity site in Wistar rat spinal cord by scintillation spectrometry |
Bioorg Med Chem 17: 6872-8 (2009)
Article DOI: 10.1016/j.bmc.2009.08.029
BindingDB Entry DOI: 10.7270/Q2DJ5FQJ |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1/beta
(Homo sapiens (Human)) | BDBM50225707
(CHEBI:28973 | Strychnine)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])CC(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |c:5| Show InChI InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1 | PDB
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TBA
| Assay Description
Antagonist activity at human glycine receptor subunit alpha-1beta expressed in HEK293 cells assessed as reduction in glycine-induced currents by whol... |
Citation and Details
Article DOI: 10.1021/acs.jnatprod.0c01030
BindingDB Entry DOI: 10.7270/Q2HH6PV6 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Glycine receptor subunit alpha-1
(RAT) | BDBM50415210
(CHEMBL608417)Show SMILES CN1[C@@H]2CC[C@@H]1CC(C2)OC(=O)c1cc2ccccc2[nH]1 |r,THB:9:7:1:3.4| Show InChI InChI=1S/C17H20N2O2/c1-19-12-6-7-13(19)10-14(9-12)21-17(20)16-8-11-4-2-3-5-15(11)18-16/h2-5,8,12-14,18H,6-7,9-10H2,1H3/t12-,13-/m1/s1 | PDB
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Hungarian Academy of Sciences
Curated by ChEMBL
| Assay Description
Displacement of [3H]strychnine from GlyR high affinity site in Wistar rat spinal cord by scintillation spectrometry |
Bioorg Med Chem 17: 6872-8 (2009)
Article DOI: 10.1016/j.bmc.2009.08.029
BindingDB Entry DOI: 10.7270/Q2DJ5FQJ |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1
(RAT) | BDBM50304335
(3alpha-(1'-Methyl-2'-Indolecarbonyloxy)-nortropane...)Show SMILES Cn1c(cc2ccccc12)C(=O)OC1C[C@H]2CC[C@H](C1)N2 |r,TLB:12:13:20:16.17| Show InChI InChI=1S/C17H20N2O2/c1-19-15-5-3-2-4-11(15)8-16(19)17(20)21-14-9-12-6-7-13(10-14)18-12/h2-5,8,12-14,18H,6-7,9-10H2,1H3/t12-,13-/m1/s1 | PDB
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Hungarian Academy of Sciences
Curated by ChEMBL
| Assay Description
Displacement of [3H]strychnine from GlyR in Wistar rat spinal cord by scintillation spectrometry in presence of 10 uM glycine |
Bioorg Med Chem 17: 6872-8 (2009)
Article DOI: 10.1016/j.bmc.2009.08.029
BindingDB Entry DOI: 10.7270/Q2DJ5FQJ |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1
(RAT) | BDBM50415211
(CHEMBL595791)Show SMILES CN1[C@@H]2CC[C@@H]1CC(C2)OC(=O)c1cnc2ccccc2c1 |r,THB:9:7:1:3.4| Show InChI InChI=1S/C18H20N2O2/c1-20-14-6-7-15(20)10-16(9-14)22-18(21)13-8-12-4-2-3-5-17(12)19-11-13/h2-5,8,11,14-16H,6-7,9-10H2,1H3/t14-,15-/m1/s1 | PDB
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Hungarian Academy of Sciences
Curated by ChEMBL
| Assay Description
Displacement of [3H]strychnine from GlyR high affinity site in Wistar rat spinal cord by scintillation spectrometry |
Bioorg Med Chem 17: 6872-8 (2009)
Article DOI: 10.1016/j.bmc.2009.08.029
BindingDB Entry DOI: 10.7270/Q2DJ5FQJ |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1
(RAT) | BDBM50415206
(CHEMBL596257)Show SMILES O=C(OC1C[C@H]2CC[C@H](C1)N2)c1ccco1 |r,TLB:2:3:10:6.7| Show InChI InChI=1S/C12H15NO3/c14-12(11-2-1-5-15-11)16-10-6-8-3-4-9(7-10)13-8/h1-2,5,8-10,13H,3-4,6-7H2/t8-,9-/m1/s1 | PDB
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Hungarian Academy of Sciences
Curated by ChEMBL
| Assay Description
Displacement of [3H]strychnine from GlyR in Wistar rat spinal cord by scintillation spectrometry |
Bioorg Med Chem 17: 6872-8 (2009)
Article DOI: 10.1016/j.bmc.2009.08.029
BindingDB Entry DOI: 10.7270/Q2DJ5FQJ |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1/beta
(Homo sapiens (Human)) | BDBM50232885
(CHEMBL4089150)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])\C(=N/O)C(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |r,c:5| Show InChI InChI=1S/C21H21N3O3/c25-20-17(22-26)18-16-12-9-15-21(6-7-23(15)10-11(12)5-8-27-18)13-3-1-2-4-14(13)24(20)19(16)21/h1-5,12,15-16,18-19,26H,6-10H2/b22-17+/t12-,15-,16-,18+,19-,21+/m0/s1 | PDB
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The German University in Cairo
Curated by ChEMBL
| Assay Description
Antagonist activity at recombinant human glycine receptor alpha 1 beta expressed in HEK293 cells assessed as inhibition of glycine-induced current at... |
J Nat Prod 79: 2997-3005 (2016)
Article DOI: 10.1021/acs.jnatprod.6b00479
BindingDB Entry DOI: 10.7270/Q2QZ2D66 |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1
(RAT) | BDBM50415203
(CHEMBL595116)Show SMILES CN1[C@@H]2CC[C@@H]1CC(C2)OC(=O)c1cccs1 |r,THB:9:7:1:3.4| Show InChI InChI=1S/C13H17NO2S/c1-14-9-4-5-10(14)8-11(7-9)16-13(15)12-3-2-6-17-12/h2-3,6,9-11H,4-5,7-8H2,1H3/t9-,10-/m1/s1 | PDB
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Hungarian Academy of Sciences
Curated by ChEMBL
| Assay Description
Displacement of [3H]strychnine from GlyR high affinity site in Wistar rat spinal cord by scintillation spectrometry |
Bioorg Med Chem 17: 6872-8 (2009)
Article DOI: 10.1016/j.bmc.2009.08.029
BindingDB Entry DOI: 10.7270/Q2DJ5FQJ |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1/beta
(Homo sapiens (Human)) | BDBM50232884
(CHEMBL4060962)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])CC(=O)N6c7ccc(N)cc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |r,c:5| Show InChI InChI=1S/C21H23N3O2/c22-12-1-2-15-14(7-12)21-4-5-23-10-11-3-6-26-16-9-18(25)24(15)20(21)19(16)13(11)8-17(21)23/h1-3,7,13,16-17,19-20H,4-6,8-10,22H2/t13-,16-,17-,19-,20-,21+/m0/s1 | PDB
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The German University in Cairo
Curated by ChEMBL
| Assay Description
Antagonist activity at recombinant human glycine receptor alpha 1 beta expressed in HEK293 cells assessed as inhibition of glycine-induced current at... |
J Nat Prod 79: 2997-3005 (2016)
Article DOI: 10.1021/acs.jnatprod.6b00479
BindingDB Entry DOI: 10.7270/Q2QZ2D66 |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1
(RAT) | BDBM50415209
(CHEMBL596237)Show SMILES O=C(OC1C[C@H]2CC[C@H](C1)N2)c1cccnc1 |r,TLB:2:3:10:6.7| Show InChI InChI=1S/C13H16N2O2/c16-13(9-2-1-5-14-8-9)17-12-6-10-3-4-11(7-12)15-10/h1-2,5,8,10-12,15H,3-4,6-7H2/t10-,11-/m1/s1 | PDB
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Hungarian Academy of Sciences
Curated by ChEMBL
| Assay Description
Displacement of [3H]strychnine from GlyR in Wistar rat spinal cord by scintillation spectrometry |
Bioorg Med Chem 17: 6872-8 (2009)
Article DOI: 10.1016/j.bmc.2009.08.029
BindingDB Entry DOI: 10.7270/Q2DJ5FQJ |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1/beta
(Homo sapiens (Human)) | BDBM50232897
(CHEMBL4068867)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])\C(=N/OCCC)C(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |r,c:5| Show InChI InChI=1S/C24H27N3O3/c1-2-10-30-25-20-21-19-15-12-18-24(8-9-26(18)13-14(15)7-11-29-21)16-5-3-4-6-17(16)27(22(19)24)23(20)28/h3-7,15,18-19,21-22H,2,8-13H2,1H3/b25-20+/t15-,18-,19-,21+,22-,24+/m0/s1 | PDB
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The German University in Cairo
Curated by ChEMBL
| Assay Description
Antagonist activity at recombinant human glycine receptor alpha 1 beta expressed in HEK293 cells assessed as inhibition of glycine-induced current at... |
J Nat Prod 79: 2997-3005 (2016)
Article DOI: 10.1021/acs.jnatprod.6b00479
BindingDB Entry DOI: 10.7270/Q2QZ2D66 |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1
(RAT) | BDBM50304335
(3alpha-(1'-Methyl-2'-Indolecarbonyloxy)-nortropane...)Show SMILES Cn1c(cc2ccccc12)C(=O)OC1C[C@H]2CC[C@H](C1)N2 |r,TLB:12:13:20:16.17| Show InChI InChI=1S/C17H20N2O2/c1-19-15-5-3-2-4-11(15)8-16(19)17(20)21-14-9-12-6-7-13(10-14)18-12/h2-5,8,12-14,18H,6-7,9-10H2,1H3/t12-,13-/m1/s1 | PDB
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Hungarian Academy of Sciences
Curated by ChEMBL
| Assay Description
Displacement of [3H]strychnine from GlyR low affinity site in Wistar rat spinal cord by scintillation spectrometry |
Bioorg Med Chem 17: 6872-8 (2009)
Article DOI: 10.1016/j.bmc.2009.08.029
BindingDB Entry DOI: 10.7270/Q2DJ5FQJ |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1
(RAT) | BDBM50415202
(CHEMBL611365)Show SMILES O=C(OC1C[C@H]2CC[C@H](C1)N2)c1ccc[nH]1 |r,TLB:2:3:10:6.7| Show InChI InChI=1S/C12H16N2O2/c15-12(11-2-1-5-13-11)16-10-6-8-3-4-9(7-10)14-8/h1-2,5,8-10,13-14H,3-4,6-7H2/t8-,9-/m1/s1 | PDB
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| n/a | n/a | 129 | n/a | n/a | n/a | n/a | n/a | n/a |
Hungarian Academy of Sciences
Curated by ChEMBL
| Assay Description
Displacement of [3H]strychnine from GlyR in Wistar rat spinal cord by scintillation spectrometry |
Bioorg Med Chem 17: 6872-8 (2009)
Article DOI: 10.1016/j.bmc.2009.08.029
BindingDB Entry DOI: 10.7270/Q2DJ5FQJ |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1
(RAT) | BDBM50304335
(3alpha-(1'-Methyl-2'-Indolecarbonyloxy)-nortropane...)Show SMILES Cn1c(cc2ccccc12)C(=O)OC1C[C@H]2CC[C@H](C1)N2 |r,TLB:12:13:20:16.17| Show InChI InChI=1S/C17H20N2O2/c1-19-15-5-3-2-4-11(15)8-16(19)17(20)21-14-9-12-6-7-13(10-14)18-12/h2-5,8,12-14,18H,6-7,9-10H2,1H3/t12-,13-/m1/s1 | PDB
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| n/a | n/a | 135 | n/a | n/a | n/a | n/a | n/a | n/a |
Hungarian Academy of Sciences
Curated by ChEMBL
| Assay Description
Displacement of [3H]strychnine from GlyR low affinity site in Wistar rat spinal cord by scintillation spectrometry in presence of 10 uM glycine |
Bioorg Med Chem 17: 6872-8 (2009)
Article DOI: 10.1016/j.bmc.2009.08.029
BindingDB Entry DOI: 10.7270/Q2DJ5FQJ |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1/beta
(Homo sapiens (Human)) | BDBM50510757
(CHEMBL4518537)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])[C@H](NC(=O)CC)C(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |r,c:5| Show InChI InChI=1S/C24H27N3O3/c1-2-18(28)25-20-21-19-14-11-17-24(8-9-26(17)12-13(14)7-10-30-21)15-5-3-4-6-16(15)27(22(19)24)23(20)29/h3-7,14,17,19-22H,2,8-12H2,1H3,(H,25,28)/t14-,17-,19-,20-,21+,22-,24+/m0/s1 | PDB
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The German University in Cairo
Curated by ChEMBL
| Assay Description
Antagonist activity at human glycine receptor subunit alpha-1beta expressed in HEK293 cells assessed as reduction in glycine-induced whole cell curre... |
J Nat Prod 82: 2332-2336 (2019)
Article DOI: 10.1021/acs.jnatprod.9b00180
BindingDB Entry DOI: 10.7270/Q2571GB7 |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1/beta
(Homo sapiens (Human)) | BDBM50232896
(CHEMBL4079657)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])\C(=N/OCC=C)C(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |r,c:5| Show InChI InChI=1S/C24H25N3O3/c1-2-10-30-25-20-21-19-15-12-18-24(8-9-26(18)13-14(15)7-11-29-21)16-5-3-4-6-17(16)27(22(19)24)23(20)28/h2-7,15,18-19,21-22H,1,8-13H2/b25-20+/t15-,18-,19-,21+,22-,24+/m0/s1 | PDB
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UniChem
| Article
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| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
The German University in Cairo
Curated by ChEMBL
| Assay Description
Antagonist activity at recombinant human glycine receptor alpha 1 beta expressed in human tsA201 cells assessed as inhibition of glycine-induced rece... |
J Nat Prod 79: 2997-3005 (2016)
Article DOI: 10.1021/acs.jnatprod.6b00479
BindingDB Entry DOI: 10.7270/Q2QZ2D66 |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1/beta
(Homo sapiens (Human)) | BDBM50232896
(CHEMBL4079657)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])\C(=N/OCC=C)C(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |r,c:5| Show InChI InChI=1S/C24H25N3O3/c1-2-10-30-25-20-21-19-15-12-18-24(8-9-26(18)13-14(15)7-11-29-21)16-5-3-4-6-17(16)27(22(19)24)23(20)28/h2-7,15,18-19,21-22H,1,8-13H2/b25-20+/t15-,18-,19-,21+,22-,24+/m0/s1 | PDB
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UniChem
| Article
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| n/a | n/a | 158 | n/a | n/a | n/a | n/a | n/a | n/a |
The German University in Cairo
Curated by ChEMBL
| Assay Description
Antagonist activity at recombinant human glycine receptor alpha 1 beta expressed in human tsA201 cells assessed as inhibition of glycine-induced rece... |
J Nat Prod 79: 2997-3005 (2016)
Article DOI: 10.1021/acs.jnatprod.6b00479
BindingDB Entry DOI: 10.7270/Q2QZ2D66 |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1
(RAT) | BDBM50415200
(CHEMBL610170)Show SMILES O=C(OC1C[C@H]2CC[C@H](C1)N2)c1cnc2ccccc2c1 |r,TLB:2:3:10:6.7| Show InChI InChI=1S/C17H18N2O2/c20-17(21-15-8-13-5-6-14(9-15)19-13)12-7-11-3-1-2-4-16(11)18-10-12/h1-4,7,10,13-15,19H,5-6,8-9H2/t13-,14-/m1/s1 | PDB
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| n/a | n/a | 166 | n/a | n/a | n/a | n/a | n/a | n/a |
Hungarian Academy of Sciences
Curated by ChEMBL
| Assay Description
Displacement of [3H]strychnine from GlyR in Wistar rat spinal cord by scintillation spectrometry |
Bioorg Med Chem 17: 6872-8 (2009)
Article DOI: 10.1016/j.bmc.2009.08.029
BindingDB Entry DOI: 10.7270/Q2DJ5FQJ |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1/beta
(Homo sapiens (Human)) | BDBM50225707
(CHEBI:28973 | Strychnine)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])CC(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |c:5| Show InChI InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1 | PDB
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| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
The German University in Cairo
Curated by ChEMBL
| Assay Description
Antagonist activity at recombinant human glycine receptor alpha 1 beta expressed in human tsA201 cells assessed as inhibition of glycine-induced rece... |
J Nat Prod 79: 2997-3005 (2016)
Article DOI: 10.1021/acs.jnatprod.6b00479
BindingDB Entry DOI: 10.7270/Q2QZ2D66 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Glycine receptor subunit alpha-1/beta
(Homo sapiens (Human)) | BDBM50225707
(CHEBI:28973 | Strychnine)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])CC(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |c:5| Show InChI InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1 | PDB
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| PDB
Article
PubMed
| n/a | n/a | 182 | n/a | n/a | n/a | n/a | n/a | n/a |
The German University in Cairo
Curated by ChEMBL
| Assay Description
Antagonist activity at recombinant human glycine receptor alpha 1 beta expressed in human tsA201 cells assessed as inhibition of glycine-induced rece... |
J Nat Prod 79: 2997-3005 (2016)
Article DOI: 10.1021/acs.jnatprod.6b00479
BindingDB Entry DOI: 10.7270/Q2QZ2D66 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Glycine receptor subunit alpha-1/beta
(Homo sapiens (Human)) | BDBM50570340
(CHEMBL4865584)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])CC(=O)N6c7ccc(NC(=O)CCCCCCCCCCCCC(=O)Nc8ccc9N%10C(=O)C[C@]%11([H])OCC=C%12CN%13CC[C@@]%14(c9c8)[C@]%13([H])C[C@]%12([H])[C@]%11([H])[C@]%10%14[H])cc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |r,c:5,t:49| | PDB
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TBA
| Assay Description
Antagonist activity at human glycine receptor subunit alpha-1beta expressed in human tsA201 cells assessed as reduction in glycine-induced response i... |
Citation and Details
Article DOI: 10.1021/acs.jnatprod.0c01030
BindingDB Entry DOI: 10.7270/Q2HH6PV6 |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1/beta
(Homo sapiens (Human)) | BDBM50570340
(CHEMBL4865584)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])CC(=O)N6c7ccc(NC(=O)CCCCCCCCCCCCC(=O)Nc8ccc9N%10C(=O)C[C@]%11([H])OCC=C%12CN%13CC[C@@]%14(c9c8)[C@]%13([H])C[C@]%12([H])[C@]%11([H])[C@]%10%14[H])cc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |r,c:5,t:49| | PDB
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TBA
| Assay Description
Antagonist activity at human glycine receptor subunit alpha-1beta expressed in human tsA201 cells assessed as reduction in glycine-induced response i... |
Citation and Details
Article DOI: 10.1021/acs.jnatprod.0c01030
BindingDB Entry DOI: 10.7270/Q2HH6PV6 |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1/beta
(Homo sapiens (Human)) | BDBM50232885
(CHEMBL4089150)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])\C(=N/O)C(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |r,c:5| Show InChI InChI=1S/C21H21N3O3/c25-20-17(22-26)18-16-12-9-15-21(6-7-23(15)10-11(12)5-8-27-18)13-3-1-2-4-14(13)24(20)19(16)21/h1-5,12,15-16,18-19,26H,6-10H2/b22-17+/t12-,15-,16-,18+,19-,21+/m0/s1 | PDB
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| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
The German University in Cairo
Curated by ChEMBL
| Assay Description
Antagonist activity at recombinant human glycine receptor alpha 1 beta expressed in human tsA201 cells assessed as inhibition of glycine-induced rece... |
J Nat Prod 79: 2997-3005 (2016)
Article DOI: 10.1021/acs.jnatprod.6b00479
BindingDB Entry DOI: 10.7270/Q2QZ2D66 |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1/beta
(Homo sapiens (Human)) | BDBM50232890
(CHEMBL4102677)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])\C(=N/OC)C(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |r,c:5| Show InChI InChI=1S/C22H23N3O3/c1-27-23-18-19-17-13-10-16-22(7-8-24(16)11-12(13)6-9-28-19)14-4-2-3-5-15(14)25(20(17)22)21(18)26/h2-6,13,16-17,19-20H,7-11H2,1H3/b23-18+/t13-,16-,17-,19+,20-,22+/m0/s1 | PDB
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| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
The German University in Cairo
Curated by ChEMBL
| Assay Description
Antagonist activity at recombinant human glycine receptor alpha 1 beta expressed in human tsA201 cells assessed as inhibition of glycine-induced rece... |
J Nat Prod 79: 2997-3005 (2016)
Article DOI: 10.1021/acs.jnatprod.6b00479
BindingDB Entry DOI: 10.7270/Q2QZ2D66 |
More data for this
Ligand-Target Pair | |
Glycine receptor subunit alpha-1/beta
(Homo sapiens (Human)) | BDBM50232890
(CHEMBL4102677)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])\C(=N/OC)C(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |r,c:5| Show InChI InChI=1S/C22H23N3O3/c1-27-23-18-19-17-13-10-16-22(7-8-24(16)11-12(13)6-9-28-19)14-4-2-3-5-15(14)25(20(17)22)21(18)26/h2-6,13,16-17,19-20H,7-11H2,1H3/b23-18+/t13-,16-,17-,19+,20-,22+/m0/s1 | PDB
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The German University in Cairo
Curated by ChEMBL
| Assay Description
Antagonist activity at recombinant human glycine receptor alpha 1 beta expressed in human tsA201 cells assessed as inhibition of glycine-induced rece... |
J Nat Prod 79: 2997-3005 (2016)
Article DOI: 10.1021/acs.jnatprod.6b00479
BindingDB Entry DOI: 10.7270/Q2QZ2D66 |
More data for this
Ligand-Target Pair | |
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