BindingDB PrimarySearch

Found 8 hits Enz. Inhib. hit(s) with Target = 'Hepatocyte growth factor receptor' AND taxid = 9615
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Hepatocyte growth factor receptor/Nucleoprotein TPR (Mus musculus)	BDBM163243 (US9062045, Comparator No. 1 (JNJ-38877605)) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.60	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences (CAS) Curated by ChEMBL					Assay Description Inhibition of TPR-MET in mouse BAF3 cells assessed as reduction in cell proliferation after 72 hrs by SRB or MTT assay				Eur J Med Chem 116: 239-251 (2016) Article DOI: 10.1016/j.ejmech.2016.03.076 BindingDB Entry DOI: 10.7270/Q2P27111
Chinese Academy of Sciences (CAS) Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor/Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM24470 (7-methoxy-4-({6-phenyl-[1,2,4]triazolo[4,3-a]pyrid...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University					Assay Description The c-Met kinase activity as tested with enzyme-linked immunosorbent assays (ELISAs) as previously reported protocol [Qiang et al., Bioorg. Med. Chem...				Bioorg Chem 70: 126-132 (2017) Article DOI: 10.1016/j.bioorg.2016.12.002 BindingDB Entry DOI: 10.7270/Q23X85HP
China Pharmaceutical University					More data for this Ligand-Target Pair				3D Structure (crystal)
Hepatocyte growth factor receptor (Canis familiaris)	BDBM50341636 ((3Z)-N-(3-CHLOROPHENYL)-3-({3,5-DIMETHYL-4-[(4-MET...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Milano Curated by ChEMBL					Assay Description Inhibition of Met-triggered cell scattering in HGF-stimulated MDCK cells preincubated for overnight before HGF challenge measured after 24 to 48 hrs				Bioorg Med Chem Lett 22: 4693-6 (2012) Article DOI: 10.1016/j.bmcl.2012.05.078 BindingDB Entry DOI: 10.7270/Q2PV6MF0
Universit£ degli Studi di Milano Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Canis familiaris)	BDBM50359981 (CHEMBL1927770) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Milano Curated by ChEMBL					Assay Description Inhibition of Met-triggered cell scattering in HGF-stimulated MDCK cells preincubated for overnight before HGF challenge measured after 24 to 48 hrs				Bioorg Med Chem Lett 22: 4693-6 (2012) Article DOI: 10.1016/j.bmcl.2012.05.078 BindingDB Entry DOI: 10.7270/Q2PV6MF0
Universit£ degli Studi di Milano Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Canis familiaris)	BDBM50359982 (CHEMBL1927771) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Milano Curated by ChEMBL					Assay Description Inhibition of Met-triggered cell scattering in HGF-stimulated MDCK cells preincubated for overnight before HGF challenge measured after 24 to 48 hrs				Bioorg Med Chem Lett 22: 4693-6 (2012) Article DOI: 10.1016/j.bmcl.2012.05.078 BindingDB Entry DOI: 10.7270/Q2PV6MF0
Universit£ degli Studi di Milano Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Canis familiaris)	BDBM50387355 (CHEMBL2046801) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Milano Curated by ChEMBL					Assay Description Inhibition of Met-triggered cell scattering in HGF-stimulated MDCK cells preincubated for overnight before HGF challenge measured after 24 to 48 hrs				Bioorg Med Chem Lett 22: 4693-6 (2012) Article DOI: 10.1016/j.bmcl.2012.05.078 BindingDB Entry DOI: 10.7270/Q2PV6MF0
Universit£ degli Studi di Milano Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor/Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM222078 (6-Chloro-3-((2-(2,4-dichlorophenyl)imidazo[1,2-a]p...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.22E+4	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University					Assay Description The c-Met kinase activity as tested with enzyme-linked immunosorbent assays (ELISAs) as previously reported protocol [Qiang et al., Bioorg. Med. Chem...				Bioorg Chem 70: 126-132 (2017) Article DOI: 10.1016/j.bioorg.2016.12.002 BindingDB Entry DOI: 10.7270/Q23X85HP
China Pharmaceutical University					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor/Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM222077 (6-chloro-3-((2-(2,5-dichlorophenyl)imidazo[1,2-a]p...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.23E+4	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University					Assay Description The c-Met kinase activity as tested with enzyme-linked immunosorbent assays (ELISAs) as previously reported protocol [Qiang et al., Bioorg. Med. Chem...				Bioorg Chem 70: 126-132 (2017) Article DOI: 10.1016/j.bioorg.2016.12.002 BindingDB Entry DOI: 10.7270/Q23X85HP
China Pharmaceutical University					More data for this Ligand-Target Pair