Found 12 hits Enz. Inhib. hit(s) with Target = 'Potassium voltage-gated channel subfamily KQT member 3' AND taxid = 9606 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Potassium voltage-gated channel subfamily KQT member 3
(Homo sapiens (Human)) | BDBM50212239
(5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-...)Show SMILES COc1cc(NC(=O)c2ccc(o2)-c2ccc(Cl)cc2)cc(OC)c1 Show InChI InChI=1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22) | PDB
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| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of KCNQ3 channel |
Proc Natl Acad Sci USA 104: 8520-5 (2007)
Article DOI: 10.1073/pnas.0611364104
BindingDB Entry DOI: 10.7270/Q2J10411 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 3/5
(Homo sapiens (Human)) | BDBM50465777
(CHEMBL4288707)Show SMILES C[C@H](NC(=O)c1cc(F)c(F)cc1Oc1ccccc1)c1cccc(c1)S(C)(=O)=O |r| Show InChI InChI=1S/C22H19F2NO4S/c1-14(15-7-6-10-17(11-15)30(2,27)28)25-22(26)18-12-19(23)20(24)13-21(18)29-16-8-4-3-5-9-16/h3-14H,1-2H3,(H,25,26)/t14-/m0/s1 | PDB
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 200 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Activation of human Kv7.3/7.5 by patch clamp method |
Bioorg Med Chem Lett 28: 3793-3797 (2018)
Article DOI: 10.1016/j.bmcl.2018.09.036
BindingDB Entry DOI: 10.7270/Q28W3H0D |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 3/5
(Homo sapiens (Human)) | BDBM50465774
(CHEMBL4287894)Show SMILES OC[C@H](NC(=O)[C@H]1CC(F)(F)CC[C@@H]1c1ccccc1)c1cccc(Cl)c1 |r| Show InChI InChI=1S/C21H22ClF2NO2/c22-16-8-4-7-15(11-16)19(13-26)25-20(27)18-12-21(23,24)10-9-17(18)14-5-2-1-3-6-14/h1-8,11,17-19,26H,9-10,12-13H2,(H,25,27)/t17-,18+,19+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
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GoogleScholar
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 360 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Activation of human Kv7.3/7.5 by patch clamp method |
Bioorg Med Chem Lett 28: 3793-3797 (2018)
Article DOI: 10.1016/j.bmcl.2018.09.036
BindingDB Entry DOI: 10.7270/Q28W3H0D |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 3/5
(Homo sapiens (Human)) | BDBM50465779
(CHEMBL4278049)Show SMILES CS(=O)(=O)c1cccc(c1)[C@H](CO)NC(=O)c1cc(ccc1Oc1ccccc1)S(F)(F)(F)(F)F |r| Show InChI InChI=1S/C22H20F5NO5S2/c1-34(31,32)17-9-5-6-15(12-17)20(14-29)28-22(30)19-13-18(35(23,24,25,26)27)10-11-21(19)33-16-7-3-2-4-8-16/h2-13,20,29H,14H2,1H3,(H,28,30)/t20-/m0/s1 | PDB
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GoogleScholar
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 80 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Activation of human Kv7.3/7.5 by patch clamp method |
Bioorg Med Chem Lett 28: 3793-3797 (2018)
Article DOI: 10.1016/j.bmcl.2018.09.036
BindingDB Entry DOI: 10.7270/Q28W3H0D |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 3
(Homo sapiens (Human)) | BDBM50526877
(CHEMBL4545892)Show SMILES CCCCCCC(=O)Nc1ccc2n(Cc3ccc(cc3)C(F)(F)F)ccc2c1 Show InChI InChI=1S/C23H25F3N2O/c1-2-3-4-5-6-22(29)27-20-11-12-21-18(15-20)13-14-28(21)16-17-7-9-19(10-8-17)23(24,25)26/h7-15H,2-6,16H2,1H3,(H,27,29) | PDB
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.05E+4 | n/a | n/a | n/a | n/a |
University Federico II of Naples
Curated by ChEMBL
| Assay Description
Activation of human Kv7.3 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology assay |
J Med Chem 63: 163-185 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00796
BindingDB Entry DOI: 10.7270/Q2KW5KG2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 3/5
(Homo sapiens (Human)) | BDBM50465773
(CHEMBL4277250)Show SMILES OC[C@H](NC(=O)[C@H]1CC(F)(F)CC[C@@H]1c1ccccc1)c1cccc(c1)C(F)(F)F |r| Show InChI InChI=1S/C22H22F5NO2/c23-21(24)10-9-17(14-5-2-1-3-6-14)18(12-21)20(30)28-19(13-29)15-7-4-8-16(11-15)22(25,26)27/h1-8,11,17-19,29H,9-10,12-13H2,(H,28,30)/t17-,18+,19+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 250 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Activation of human Kv7.3/7.5 by patch clamp method |
Bioorg Med Chem Lett 28: 3793-3797 (2018)
Article DOI: 10.1016/j.bmcl.2018.09.036
BindingDB Entry DOI: 10.7270/Q28W3H0D |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 3/5
(Homo sapiens (Human)) | BDBM50420049
(CHEMBL402146)Show InChI InChI=1S/C12H7ClF2N2O/c13-11-4-2-8(6-16-11)17-12(18)7-1-3-9(14)10(15)5-7/h1-6H,(H,17,18) | PDB
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CHEMBL
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PC sid
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Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Activation of human Kv7.3/7.5 by patch clamp method |
Bioorg Med Chem Lett 28: 3793-3797 (2018)
Article DOI: 10.1016/j.bmcl.2018.09.036
BindingDB Entry DOI: 10.7270/Q28W3H0D |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 3/5
(Homo sapiens (Human)) | BDBM50465775
(CHEMBL1703636)Show SMILES Cc1cc(C)c(NC(=O)C2CC3CCC2C3)c(C)c1 |TLB:7:9:15:13.12| Show InChI InChI=1S/C17H23NO/c1-10-6-11(2)16(12(3)7-10)18-17(19)15-9-13-4-5-14(15)8-13/h6-7,13-15H,4-5,8-9H2,1-3H3,(H,18,19) | PDB
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PC cid
PC sid
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| Article
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| n/a | n/a | n/a | n/a | 500 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Activation of human Kv7.3/7.5 by patch clamp method |
Bioorg Med Chem Lett 28: 3793-3797 (2018)
Article DOI: 10.1016/j.bmcl.2018.09.036
BindingDB Entry DOI: 10.7270/Q28W3H0D |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 3
(Homo sapiens (Human)) | BDBM50143558
(CHEMBL41355 | EZOGABINE | N-(2-amino-4-(4-fluorobe...)Show InChI InChI=1S/C16H18FN3O2/c1-2-22-16(21)20-15-8-7-13(9-14(15)18)19-10-11-3-5-12(17)6-4-11/h3-9,19H,2,10,18H2,1H3,(H,20,21) | PDB
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| DrugBank
Article
PubMed
| n/a | n/a | n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a |
University Federico II of Naples
Curated by ChEMBL
| Assay Description
Activation of human Kv7.3 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology assay |
J Med Chem 63: 163-185 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00796
BindingDB Entry DOI: 10.7270/Q2KW5KG2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 3
(Homo sapiens (Human)) | BDBM50526876
(CHEMBL4457044)Show SMILES CC(C)(C)CC(=O)Nc1ccc2n(Cc3ccc(cc3)C(F)(F)F)ccc2c1 Show InChI InChI=1S/C22H23F3N2O/c1-21(2,3)13-20(28)26-18-8-9-19-16(12-18)10-11-27(19)14-15-4-6-17(7-5-15)22(23,24)25/h4-12H,13-14H2,1-3H3,(H,26,28) | PDB
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| PC cid
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| Article
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| n/a | n/a | n/a | n/a | 920 | n/a | n/a | n/a | n/a |
University Federico II of Naples
Curated by ChEMBL
| Assay Description
Activation of human Kv7.3 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology assay |
J Med Chem 63: 163-185 (2020)
Article DOI: 10.1021/acs.jmedchem.9b00796
BindingDB Entry DOI: 10.7270/Q2KW5KG2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 3
(Homo sapiens (Human)) | BDBM50426567
(BMS-204352 | FLINDOKALNER | MaxiPost)Show SMILES COc1ccc(Cl)cc1[C@]1(F)C(=O)Nc2cc(ccc12)C(F)(F)F Show InChI InChI=1S/C16H10ClF4NO2/c1-24-13-5-3-9(17)7-11(13)15(18)10-4-2-8(16(19,20)21)6-12(10)22-14(15)23/h2-7H,1H3,(H,22,23)/t15-/m0/s1 | PDB
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| n/a | n/a | n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Positive modulatory activity at voltage-gated K channel 7.3 (unknown origin) |
J Med Chem 56: 593-624 (2013)
Article DOI: 10.1021/jm3011433
BindingDB Entry DOI: 10.7270/Q23B61GZ |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 3/5
(Homo sapiens (Human)) | BDBM50465778
(CHEMBL4287478)Show SMILES C[C@H](NC(=O)[C@H]1CC(F)(F)CC[C@@H]1c1ccccc1)c1ccccc1 |r| Show InChI InChI=1S/C21H23F2NO/c1-15(16-8-4-2-5-9-16)24-20(25)19-14-21(22,23)13-12-18(19)17-10-6-3-7-11-17/h2-11,15,18-19H,12-14H2,1H3,(H,24,25)/t15-,18+,19-/m0/s1 | PDB
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| PC cid
PC sid
UniChem
| Article
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| n/a | n/a | n/a | n/a | 400 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Activation of human Kv7.3/7.5 by patch clamp method |
Bioorg Med Chem Lett 28: 3793-3797 (2018)
Article DOI: 10.1016/j.bmcl.2018.09.036
BindingDB Entry DOI: 10.7270/Q28W3H0D |
More data for this
Ligand-Target Pair | |
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