Compile Data Set for Download or QSAR

Found 385 hits Enz. Inhib. hit(s) with Target = 'Isoform 1 of Metabotropic glutamate receptor 5 (5a)' AND taxid = 9606   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM224627 (US9328070, 2) Show SMILES CN(C(=O)c1ccc(cn1)C#Cc1cccc(Cl)c1)C(C)(C)C Show InChI InChI=1S/C19H19ClN2O/c1-19(2,3)22(4)18(23)17-11-10-15(13-21-17)9-8-14-6-5-7-16(20)12-14/h5-7,10-13H,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	15	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger an...				US Patent US9328070 (2016) BindingDB Entry DOI: 10.7270/Q27943JT
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM199988 (US9227959, 2) Show SMILES Clc1cccc(c1)C#Cc1ccc(nc1)C(=O)N1CCOCC1 Show InChI InChI=1S/C18H15ClN2O2/c19-16-3-1-2-14(12-16)4-5-15-6-7-17(20-13-15)18(22)21-8-10-23-11-9-21/h1-3,6-7,12-13H,8-11H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	19	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
Hoffman-La Roche Inc. US Patent					Assay Description For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger ...				US Patent US9227959 (2016) BindingDB Entry DOI: 10.7270/Q25D8QNJ
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM199989 (US9227959, 3) Show SMILES CC1(C)COCCN1C(=O)c1ccc(cn1)C#Cc1cccc(Cl)c1 Show InChI InChI=1S/C20H19ClN2O2/c1-20(2)14-25-11-10-23(20)19(24)18-9-8-16(13-22-18)7-6-15-4-3-5-17(21)12-15/h3-5,8-9,12-13H,10-11,14H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	23	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
Hoffman-La Roche Inc. US Patent					Assay Description For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger ...				US Patent US9227959 (2016) BindingDB Entry DOI: 10.7270/Q25D8QNJ
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM234211 (US9359301, 2) Show SMILES CCN(C(=O)c1ccc(cn1)C#Cc1cccc(Cl)c1)C(C)(C)C Show InChI InChI=1S/C20H21ClN2O/c1-5-23(20(2,3)4)19(24)18-12-11-16(14-22-18)10-9-15-7-6-8-17(21)13-15/h6-8,11-14H,5H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	24	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger an...				US Patent US9359301 (2016) BindingDB Entry DOI: 10.7270/Q2KK99ND
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM224626 (US9328070, 1) Show SMILES CN(C(=O)c1ccc(cn1)C#Cc1ccnc(Cl)c1)C(C)(C)C Show InChI InChI=1S/C18H18ClN3O/c1-18(2,3)22(4)17(23)15-8-7-14(12-21-15)6-5-13-9-10-20-16(19)11-13/h7-12H,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	28	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger an...				US Patent US9328070 (2016) BindingDB Entry DOI: 10.7270/Q27943JT
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM224623 (US9328070, Reference compound 1 | US9359301, Refer...) Show SMILES CN(C(=O)c1ccc(cn1)C#Cc1cccc(F)c1)C(C)(C)C Show InChI InChI=1S/C19H19FN2O/c1-19(2,3)22(4)18(23)17-11-10-15(13-21-17)9-8-14-6-5-7-16(20)12-14/h5-7,10-13H,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	29	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger an...				US Patent US9359301 (2016) BindingDB Entry DOI: 10.7270/Q2KK99ND
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM224623 (US9328070, Reference compound 1 | US9359301, Refer...) Show SMILES CN(C(=O)c1ccc(cn1)C#Cc1cccc(F)c1)C(C)(C)C Show InChI InChI=1S/C19H19FN2O/c1-19(2,3)22(4)18(23)17-11-10-15(13-21-17)9-8-14-6-5-7-16(20)12-14/h5-7,10-13H,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	29	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger an...				US Patent US9328070 (2016) BindingDB Entry DOI: 10.7270/Q27943JT
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM224624 (US9328070, Reference compound 2) Show SMILES CN(C(=O)c1ccc(cn1)C#Cc1cncc(Cl)c1)C(C)(C)C Show InChI InChI=1S/C18H18ClN3O/c1-18(2,3)22(4)17(23)16-8-7-13(11-21-16)5-6-14-9-15(19)12-20-10-14/h7-12H,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	42	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger an...				US Patent US9328070 (2016) BindingDB Entry DOI: 10.7270/Q27943JT
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM234210 (US9359301, 1) Show SMILES CCN(C(=O)c1ccc(cn1)C#Cc1cccc(F)c1)C(C)(C)C Show InChI InChI=1S/C20H21FN2O/c1-5-23(20(2,3)4)19(24)18-12-11-16(14-22-18)10-9-15-7-6-8-17(21)13-15/h6-8,11-14H,5H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	42	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger an...				US Patent US9359301 (2016) BindingDB Entry DOI: 10.7270/Q2KK99ND
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM234213 (US9359301, 4) Show SMILES CCN(C(=O)c1ncc(cn1)C#Cc1cccc(Cl)c1)C(C)(C)C Show InChI InChI=1S/C19H20ClN3O/c1-5-23(19(2,3)4)18(24)17-21-12-15(13-22-17)10-9-14-7-6-8-16(20)11-14/h6-8,11-13H,5H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	46	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger an...				US Patent US9359301 (2016) BindingDB Entry DOI: 10.7270/Q2KK99ND
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM234209 (US9359301, Reference compound 2) Show SMILES CN(C(=O)c1ncc(cn1)C#Cc1cccc(F)c1)C(C)(C)C Show InChI InChI=1S/C18H18FN3O/c1-18(2,3)22(4)17(23)16-20-11-14(12-21-16)9-8-13-6-5-7-15(19)10-13/h5-7,10-12H,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	51	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger an...				US Patent US9359301 (2016) BindingDB Entry DOI: 10.7270/Q2KK99ND
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM224625 (US9328070, Reference compound 3) Show SMILES CC(C)(NC(=O)c1ccc(cn1)C#Cc1ccnc(Cl)c1)C(F)(F)F Show InChI InChI=1S/C17H13ClF3N3O/c1-16(2,17(19,20)21)24-15(25)13-6-5-12(10-23-13)4-3-11-7-8-22-14(18)9-11/h5-10H,1-2H3,(H,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	58	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger an...				US Patent US9328070 (2016) BindingDB Entry DOI: 10.7270/Q27943JT
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM199990 (US9227959, 4) Show SMILES CC1(C)COCCN1C(=O)c1ncc(cn1)C#Cc1cccc(Cl)c1 Show InChI InChI=1S/C19H18ClN3O2/c1-19(2)13-25-9-8-23(19)18(24)17-21-11-15(12-22-17)7-6-14-4-3-5-16(20)10-14/h3-5,10-12H,8-9,13H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	67	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
Hoffman-La Roche Inc. US Patent					Assay Description For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger ...				US Patent US9227959 (2016) BindingDB Entry DOI: 10.7270/Q25D8QNJ
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM199987 (US9227959, 1) Show SMILES CC1(C)COCCN1C(=O)c1ccc(cn1)C#Cc1cccc(F)c1 Show InChI InChI=1S/C20H19FN2O2/c1-20(2)14-25-11-10-23(20)19(24)18-9-8-16(13-22-18)7-6-15-4-3-5-17(21)12-15/h3-5,8-9,12-13H,10-11,14H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	72	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
Hoffman-La Roche Inc. US Patent					Assay Description For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger ...				US Patent US9227959 (2016) BindingDB Entry DOI: 10.7270/Q25D8QNJ
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM234212 (US9359301, 3) Show SMILES CCN(C(=O)c1ncc(cn1)C#Cc1cccc(F)c1)C(C)(C)C Show InChI InChI=1S/C19H20FN3O/c1-5-23(19(2,3)4)18(24)17-21-12-15(13-22-17)10-9-14-7-6-8-16(20)11-14/h6-8,11-13H,5H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	94	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger an...				US Patent US9359301 (2016) BindingDB Entry DOI: 10.7270/Q2KK99ND
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM199985 (US9227959, Reference Compound 1, Ex. 35) Show SMILES CC1(C)CN(CCO1)C(=O)c1ccc(cn1)C#Cc1cccc(F)c1 Show InChI InChI=1S/C20H19FN2O2/c1-20(2)14-23(10-11-25-20)19(24)18-9-8-16(13-22-18)7-6-15-4-3-5-17(21)12-15/h3-5,8-9,12-13H,10-11,14H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	201	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
Hoffman-La Roche Inc. US Patent					Assay Description For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger ...				US Patent US9227959 (2016) BindingDB Entry DOI: 10.7270/Q25D8QNJ
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM199986 (US9227959, Reference Compound 2, Ex. 46) Show SMILES CC1(C)CCCN(C1)C(=O)c1ncc(cn1)C#Cc1ccccc1 Show InChI InChI=1S/C20H21N3O/c1-20(2)11-6-12-23(15-20)19(24)18-21-13-17(14-22-18)10-9-16-7-4-3-5-8-16/h3-5,7-8,13-14H,6,11-12,15H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	315	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
Hoffman-La Roche Inc. US Patent					Assay Description For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger ...				US Patent US9227959 (2016) BindingDB Entry DOI: 10.7270/Q25D8QNJ
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM198909 (US9221802, Ref. Ex. 20 | US9315498, 20) Show SMILES CC1(C)COC(=O)N(C1)c1ccc(cn1)C#Cc1ccccc1 Show InChI InChI=1S/C19H18N2O2/c1-19(2)13-21(18(22)23-14-19)17-11-10-16(12-20-17)9-8-15-6-4-3-5-7-15/h3-7,10-12H,13-14H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	27	n/a	n/a	n/a	37
Hoffman-La Roche Inc. US Patent					Assay Description About 24 hrs before an experiment, 5x104 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded...				US Patent US9221802 (2015) BindingDB Entry DOI: 10.7270/Q2RF5SVJ
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM198910 (US9221802, Ref. Ex. 72 | US9315498, 72) Show SMILES CC1(C)CCN(C(=O)O1)c1ccc(cn1)C#Cc1ccccc1 Show InChI InChI=1S/C19H18N2O2/c1-19(2)12-13-21(18(22)23-19)17-11-10-16(14-20-17)9-8-15-6-4-3-5-7-15/h3-7,10-11,14H,12-13H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	37
Hoffman-La Roche Inc. US Patent					Assay Description About 24 hrs before an experiment, 5x104 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded...				US Patent US9221802 (2015) BindingDB Entry DOI: 10.7270/Q2RF5SVJ
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM198911 (US9221802, Ref. Ex. 76 | US9315498, 76) Show SMILES CC1(C)CCN(C(=O)O1)c1ccc(cn1)C#Cc1cccc(F)c1 Show InChI InChI=1S/C19H17FN2O2/c1-19(2)10-11-22(18(23)24-19)17-9-8-15(13-21-17)7-6-14-4-3-5-16(20)12-14/h3-5,8-9,12-13H,10-11H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	37
Hoffman-La Roche Inc. US Patent					Assay Description About 24 hrs before an experiment, 5x104 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded...				US Patent US9221802 (2015) BindingDB Entry DOI: 10.7270/Q2RF5SVJ
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM198912 (US9221802, Ref. Ex. 79 | US9315498, 79) Show SMILES CC1(C)CCN(C(=O)O1)c1ccc(cn1)C#Cc1ccc(F)cc1 Show InChI InChI=1S/C19H17FN2O2/c1-19(2)11-12-22(18(23)24-19)17-10-7-15(13-21-17)4-3-14-5-8-16(20)9-6-14/h5-10,13H,11-12H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	22	n/a	n/a	n/a	37
Hoffman-La Roche Inc. US Patent					Assay Description About 24 hrs before an experiment, 5x104 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded...				US Patent US9221802 (2015) BindingDB Entry DOI: 10.7270/Q2RF5SVJ
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM198913 (US9221802, Ref. Ex. 81 | US9315498, 81) Show SMILES CC1(C)CCN(C(=O)O1)c1ccc(cn1)C#Cc1cc(F)ccc1F Show InChI InChI=1S/C19H16F2N2O2/c1-19(2)9-10-23(18(24)25-19)17-8-4-13(12-22-17)3-5-14-11-15(20)6-7-16(14)21/h4,6-8,11-12H,9-10H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	12	n/a	n/a	n/a	37
Hoffman-La Roche Inc. US Patent					Assay Description About 24 hrs before an experiment, 5x104 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded...				US Patent US9221802 (2015) BindingDB Entry DOI: 10.7270/Q2RF5SVJ
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM198914 (US9221802, Ref. Ex. 103 | US9315498, 103) Show SMILES O=C1O[C@H]2CCC[C@H]2CN1c1ccc(cn1)C#Cc1ccccc1 |r| Show InChI InChI=1S/C20H18N2O2/c23-20-22(14-17-7-4-8-18(17)24-20)19-12-11-16(13-21-19)10-9-15-5-2-1-3-6-15/h1-3,5-6,11-13,17-18H,4,7-8,14H2/t17-,18-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	27	n/a	n/a	n/a	37
Hoffman-La Roche Inc. US Patent					Assay Description About 24 hrs before an experiment, 5x104 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded...				US Patent US9221802 (2015) BindingDB Entry DOI: 10.7270/Q2RF5SVJ
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM198915 (US9221802, Ex. 1) Show SMILES O=C1OC[C@H]2CCC[C@H]2N1c1ccc(cn1)C#Cc1ccccc1 |r| Show InChI InChI=1S/C20H18N2O2/c23-20-22(18-8-4-7-17(18)14-24-20)19-12-11-16(13-21-19)10-9-15-5-2-1-3-6-15/h1-3,5-6,11-13,17-18H,4,7-8,14H2/t17-,18-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	22	n/a	n/a	n/a	37
Hoffman-La Roche Inc. US Patent					Assay Description About 24 hrs before an experiment, 5x104 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded...				US Patent US9221802 (2015) BindingDB Entry DOI: 10.7270/Q2RF5SVJ
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM198916 (US9221802, Ex. 2) Show SMILES Fc1cccc(c1)C#Cc1ccc(nc1)N1[C@@H]2CCC[C@@H]2COC1=O |r| Show InChI InChI=1S/C20H17FN2O2/c21-17-5-1-3-14(11-17)7-8-15-9-10-19(22-12-15)23-18-6-2-4-16(18)13-25-20(23)24/h1,3,5,9-12,16,18H,2,4,6,13H2/t16-,18-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	37
Hoffman-La Roche Inc. US Patent					Assay Description About 24 hrs before an experiment, 5x104 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded...				US Patent US9221802 (2015) BindingDB Entry DOI: 10.7270/Q2RF5SVJ
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM198917 (US9221802, Ex. 3) Show SMILES Fc1ccc(cc1)C#Cc1ccc(nc1)N1[C@@H]2CCC[C@@H]2COC1=O |r| Show InChI InChI=1S/C20H17FN2O2/c21-17-9-6-14(7-10-17)4-5-15-8-11-19(22-12-15)23-18-3-1-2-16(18)13-25-20(23)24/h6-12,16,18H,1-3,13H2/t16-,18-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	37
Hoffman-La Roche Inc. US Patent					Assay Description About 24 hrs before an experiment, 5x104 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded...				US Patent US9221802 (2015) BindingDB Entry DOI: 10.7270/Q2RF5SVJ
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM198918 (US9221802, Ex. 4) Show SMILES Fc1ccc(F)c(c1)C#Cc1ccc(nc1)N1[C@@H]2CCC[C@@H]2COC1=O |r| Show InChI InChI=1S/C20H16F2N2O2/c21-16-7-8-17(22)14(10-16)6-4-13-5-9-19(23-11-13)24-18-3-1-2-15(18)12-26-20(24)25/h5,7-11,15,18H,1-3,12H2/t15-,18-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	15	n/a	n/a	n/a	37
Hoffman-La Roche Inc. US Patent					Assay Description About 24 hrs before an experiment, 5x104 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded...				US Patent US9221802 (2015) BindingDB Entry DOI: 10.7270/Q2RF5SVJ
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM196676 (US9212171, 1) Show SMILES CN1C(=O)C(CC1(C)C)c1ccc(cn1)C#Cc1ccccc1 Show InChI InChI=1S/C20H20N2O/c1-20(2)13-17(19(23)22(20)3)18-12-11-16(14-21-18)10-9-15-7-5-4-6-8-15/h4-8,11-12,14,17H,13H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	60	n/a	n/a	n/a	37
HOFFMANN-LA ROCHE INC. US Patent					Assay Description A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...				US Patent US9212171 (2015) BindingDB Entry DOI: 10.7270/Q25Q4TWH
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM196677 (US9212171, 2) Show SMILES CN1C(=O)C(CC1(C)C)c1ccc(cn1)C#Cc1cccnc1 Show InChI InChI=1S/C19H19N3O/c1-19(2)11-16(18(23)22(19)3)17-9-8-15(13-21-17)7-6-14-5-4-10-20-12-14/h4-5,8-10,12-13,16H,11H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	981	n/a	n/a	n/a	37
HOFFMANN-LA ROCHE INC. US Patent					Assay Description A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...				US Patent US9212171 (2015) BindingDB Entry DOI: 10.7270/Q25Q4TWH
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM196678 (US9212171, 3) Show SMILES CN1C(=O)C(CC1(C)C)c1ccc(cn1)C#Cc1cccc(Cl)c1 Show InChI InChI=1S/C20H19ClN2O/c1-20(2)12-17(19(24)23(20)3)18-10-9-15(13-22-18)8-7-14-5-4-6-16(21)11-14/h4-6,9-11,13,17H,12H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	38	n/a	n/a	n/a	37
HOFFMANN-LA ROCHE INC. US Patent					Assay Description A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...				US Patent US9212171 (2015) BindingDB Entry DOI: 10.7270/Q25Q4TWH
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM196679 (US9212171, 4) Show SMILES CN1C(=O)C(CC1(C)C)c1ccc(cn1)C#Cc1cccc(F)c1 Show InChI InChI=1S/C20H19FN2O/c1-20(2)12-17(19(24)23(20)3)18-10-9-15(13-22-18)8-7-14-5-4-6-16(21)11-14/h4-6,9-11,13,17H,12H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	61	n/a	n/a	n/a	37
HOFFMANN-LA ROCHE INC. US Patent					Assay Description A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...				US Patent US9212171 (2015) BindingDB Entry DOI: 10.7270/Q25Q4TWH
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM196680 (US9212171, 5) Show SMILES CN1C(=O)C(CC1(C)C)(C(=O)OCc1ccccc1)c1ncc(cn1)C#Cc1ccccc1 Show InChI InChI=1S/C27H25N3O3/c1-26(2)19-27(24(31)30(26)3,25(32)33-18-21-12-8-5-9-13-21)23-28-16-22(17-29-23)15-14-20-10-6-4-7-11-20/h4-13,16-17H,18-19H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	528	n/a	n/a	n/a	37
HOFFMANN-LA ROCHE INC. US Patent					Assay Description A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...				US Patent US9212171 (2015) BindingDB Entry DOI: 10.7270/Q25Q4TWH
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM196681 (US9212171, 6) Show SMILES CN1C(=O)C(CC1(C)C)c1ncc(cn1)C#Cc1ccccc1 Show InChI InChI=1S/C19H19N3O/c1-19(2)11-16(18(23)22(19)3)17-20-12-15(13-21-17)10-9-14-7-5-4-6-8-14/h4-8,12-13,16H,11H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	130	n/a	n/a	n/a	37
HOFFMANN-LA ROCHE INC. US Patent					Assay Description A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...				US Patent US9212171 (2015) BindingDB Entry DOI: 10.7270/Q25Q4TWH
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM196682 (US9212171, 7) Show SMILES CN1C(=O)C(CC1(C)C)c1ncc(cn1)C#Cc1cccc(F)c1 Show InChI InChI=1S/C19H18FN3O/c1-19(2)10-16(18(24)23(19)3)17-21-11-14(12-22-17)8-7-13-5-4-6-15(20)9-13/h4-6,9,11-12,16H,10H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	137	n/a	n/a	n/a	37
HOFFMANN-LA ROCHE INC. US Patent					Assay Description A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...				US Patent US9212171 (2015) BindingDB Entry DOI: 10.7270/Q25Q4TWH
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM196683 (US9212171, 8) Show SMILES CN1C(=O)C(CC1(C)C)c1ncc(cn1)C#Cc1ccc(F)cc1 Show InChI InChI=1S/C19H18FN3O/c1-19(2)10-16(18(24)23(19)3)17-21-11-14(12-22-17)5-4-13-6-8-15(20)9-7-13/h6-9,11-12,16H,10H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	390	n/a	n/a	n/a	37
HOFFMANN-LA ROCHE INC. US Patent					Assay Description A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...				US Patent US9212171 (2015) BindingDB Entry DOI: 10.7270/Q25Q4TWH
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM196684 (US9212171, 9) Show SMILES CN1C(=O)C(CC1(C)C)c1ccc(nn1)C#Cc1cccc(F)c1 Show InChI InChI=1S/C19H18FN3O/c1-19(2)12-16(18(24)23(19)3)17-10-9-15(21-22-17)8-7-13-5-4-6-14(20)11-13/h4-6,9-11,16H,12H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	34	n/a	n/a	n/a	37
HOFFMANN-LA ROCHE INC. US Patent					Assay Description A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...				US Patent US9212171 (2015) BindingDB Entry DOI: 10.7270/Q25Q4TWH
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM196685 (US9212171, 10) Show SMILES CN1C(=O)C(CC1(C)C)c1ccc(nn1)C#Cc1ccc(F)cc1 Show InChI InChI=1S/C19H18FN3O/c1-19(2)12-16(18(24)23(19)3)17-11-10-15(21-22-17)9-6-13-4-7-14(20)8-5-13/h4-5,7-8,10-11,16H,12H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	247	n/a	n/a	n/a	37
HOFFMANN-LA ROCHE INC. US Patent					Assay Description A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...				US Patent US9212171 (2015) BindingDB Entry DOI: 10.7270/Q25Q4TWH
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM196686 (US9212171, 11) Show SMILES CN1C(=O)C(CC1(C)C)c1ccc(nn1)C#Cc1ccccc1 Show InChI InChI=1S/C19H19N3O/c1-19(2)13-16(18(23)22(19)3)17-12-11-15(20-21-17)10-9-14-7-5-4-6-8-14/h4-8,11-12,16H,13H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	58	n/a	n/a	n/a	37
HOFFMANN-LA ROCHE INC. US Patent					Assay Description A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...				US Patent US9212171 (2015) BindingDB Entry DOI: 10.7270/Q25Q4TWH
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM196687 (US9212171, 12) Show SMILES CN1C(=O)C(CCC1(C)C)c1ccc(cn1)C#Cc1ccccc1 Show InChI InChI=1S/C21H22N2O/c1-21(2)14-13-18(20(24)23(21)3)19-12-11-17(15-22-19)10-9-16-7-5-4-6-8-16/h4-8,11-12,15,18H,13-14H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	113	n/a	n/a	n/a	37
HOFFMANN-LA ROCHE INC. US Patent					Assay Description A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...				US Patent US9212171 (2015) BindingDB Entry DOI: 10.7270/Q25Q4TWH
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM196688 (US9212171, 13) Show SMILES CN1C(=O)C(CCC1(C)C)c1ccc(cn1)C#Cc1cccc(F)c1 Show InChI InChI=1S/C21H21FN2O/c1-21(2)12-11-18(20(25)24(21)3)19-10-9-16(14-23-19)8-7-15-5-4-6-17(22)13-15/h4-6,9-10,13-14,18H,11-12H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	98	n/a	n/a	n/a	37
HOFFMANN-LA ROCHE INC. US Patent					Assay Description A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...				US Patent US9212171 (2015) BindingDB Entry DOI: 10.7270/Q25Q4TWH
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM196689 (US9212171, 14) Show SMILES CN1C(=O)C(CCC1(C)C)c1ccc(cn1)C#Cc1ccc(F)cc1 Show InChI InChI=1S/C21H21FN2O/c1-21(2)13-12-18(20(25)24(21)3)19-11-8-16(14-23-19)5-4-15-6-9-17(22)10-7-15/h6-11,14,18H,12-13H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	212	n/a	n/a	n/a	37
HOFFMANN-LA ROCHE INC. US Patent					Assay Description A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...				US Patent US9212171 (2015) BindingDB Entry DOI: 10.7270/Q25Q4TWH
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM196690 (US9212171, 15) Show SMILES CN1C(=O)C(CCC1(C)C)c1ncc(cn1)C#Cc1ccccc1 Show InChI InChI=1S/C20H21N3O/c1-20(2)12-11-17(19(24)23(20)3)18-21-13-16(14-22-18)10-9-15-7-5-4-6-8-15/h4-8,13-14,17H,11-12H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	179	n/a	n/a	n/a	37
HOFFMANN-LA ROCHE INC. US Patent					Assay Description A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...				US Patent US9212171 (2015) BindingDB Entry DOI: 10.7270/Q25Q4TWH
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM196691 (US9212171, 16) Show SMILES CN1C(=O)C(CCC1(C)C)c1ncc(cn1)C#Cc1ccc(F)cc1 Show InChI InChI=1S/C20H20FN3O/c1-20(2)11-10-17(19(25)24(20)3)18-22-12-15(13-23-18)5-4-14-6-8-16(21)9-7-14/h6-9,12-13,17H,10-11H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	573	n/a	n/a	n/a	37
HOFFMANN-LA ROCHE INC. US Patent					Assay Description A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...				US Patent US9212171 (2015) BindingDB Entry DOI: 10.7270/Q25Q4TWH
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM196692 (US9212171, 17) Show SMILES CN1C(=O)C(CCC1(C)C)c1ncc(cn1)C#Cc1cccc(F)c1 Show InChI InChI=1S/C20H20FN3O/c1-20(2)10-9-17(19(25)24(20)3)18-22-12-15(13-23-18)8-7-14-5-4-6-16(21)11-14/h4-6,11-13,17H,9-10H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	132	n/a	n/a	n/a	37
HOFFMANN-LA ROCHE INC. US Patent					Assay Description A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...				US Patent US9212171 (2015) BindingDB Entry DOI: 10.7270/Q25Q4TWH
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM196693 (US9212171, 18) Show SMILES CN1C(=O)C(O)(CC1(C)C)c1ccc(cn1)C#Cc1ccccc1 Show InChI InChI=1S/C20H20N2O2/c1-19(2)14-20(24,18(23)22(19)3)17-12-11-16(13-21-17)10-9-15-7-5-4-6-8-15/h4-8,11-13,24H,14H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	414	n/a	n/a	n/a	37
HOFFMANN-LA ROCHE INC. US Patent					Assay Description A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...				US Patent US9212171 (2015) BindingDB Entry DOI: 10.7270/Q25Q4TWH
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM196694 (US9212171, 19) Show SMILES COC1(CC(C)(C)N(C)C1=O)c1ccc(cn1)C#Cc1ccccc1 Show InChI InChI=1S/C21H22N2O2/c1-20(2)15-21(25-4,19(24)23(20)3)18-13-12-17(14-22-18)11-10-16-8-6-5-7-9-16/h5-9,12-14H,15H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	96	n/a	n/a	n/a	37
HOFFMANN-LA ROCHE INC. US Patent					Assay Description A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...				US Patent US9212171 (2015) BindingDB Entry DOI: 10.7270/Q25Q4TWH
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM196695 (US9212171, 20) Show SMILES CN1C(=O)C(C)(CC1(C)C)c1ccc(cn1)C#Cc1ccccc1 Show InChI InChI=1S/C21H22N2O/c1-20(2)15-21(3,19(24)23(20)4)18-13-12-17(14-22-18)11-10-16-8-6-5-7-9-16/h5-9,12-14H,15H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	90	n/a	n/a	n/a	37
HOFFMANN-LA ROCHE INC. US Patent					Assay Description A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...				US Patent US9212171 (2015) BindingDB Entry DOI: 10.7270/Q25Q4TWH
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM196696 (US9212171, 21) Show SMILES CN1C(=O)C(CC1(C)C)c1ncc(cc1F)C#Cc1cccc(F)c1 Show InChI InChI=1S/C20H18F2N2O/c1-20(2)11-16(19(25)24(20)3)18-17(22)10-14(12-23-18)8-7-13-5-4-6-15(21)9-13/h4-6,9-10,12,16H,11H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	188	n/a	n/a	n/a	37
HOFFMANN-LA ROCHE INC. US Patent					Assay Description A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...				US Patent US9212171 (2015) BindingDB Entry DOI: 10.7270/Q25Q4TWH
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM196697 (US9212171, 22) Show SMILES CN1CCCCC(c2ccc(cn2)C#Cc2ccccc2)C1=O Show InChI InChI=1S/C20H20N2O/c1-22-14-6-5-9-18(20(22)23)19-13-12-17(15-21-19)11-10-16-7-3-2-4-8-16/h2-4,7-8,12-13,15,18H,5-6,9,14H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	59	n/a	n/a	n/a	37
HOFFMANN-LA ROCHE INC. US Patent					Assay Description A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...				US Patent US9212171 (2015) BindingDB Entry DOI: 10.7270/Q25Q4TWH
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM196698 (US9212171, 23) Show SMILES CN1CCCCC(c2ccc(cn2)C#Cc2ccc(F)cc2)C1=O Show InChI InChI=1S/C20H19FN2O/c1-23-13-3-2-4-18(20(23)24)19-12-9-16(14-22-19)6-5-15-7-10-17(21)11-8-15/h7-12,14,18H,2-4,13H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	90	n/a	n/a	n/a	37
HOFFMANN-LA ROCHE INC. US Patent					Assay Description A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...				US Patent US9212171 (2015) BindingDB Entry DOI: 10.7270/Q25Q4TWH
					More data for this Ligand-Target Pair

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