Compile Data Set for Download or QSAR

Found 33 hits Enz. Inhib. hit(s) with Target = 'Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless' AND taxid = 9606   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless (Homo sapiens (Human))	BDBM242886 (US9427442, 14) Show SMILES NC(=O)[C@@H](CC1CC(F)(F)C1)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(F)c2NC1=O |r,t:23| Show InChI InChI=1S/C27H26F6N4O3/c28-19-8-4-7-17-20(15-5-2-1-3-6-15)35-23(25(40)36-21(17)19)37-24(39)16(9-10-27(31,32)33)18(22(34)38)11-14-12-26(29,30)13-14/h1-8,14,16,18,23H,9-13H2,(H2,34,38)(H,36,40)(H,37,39)/t16-,18+,23-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...				US Patent US9427442 (2016) BindingDB Entry DOI: 10.7270/Q2ZP452P
					More data for this Ligand-Target Pair
Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless (Homo sapiens (Human))	BDBM242879 (US9427442, 7) Show SMILES NC(=O)[C@@H](CC1CC(F)(F)C1)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(OC3CC3)c2NC1=O |r,t:23| Show InChI InChI=1S/C30H31F5N4O4/c31-29(32)14-16(15-29)13-21(25(36)40)19(11-12-30(33,34)35)27(41)39-26-28(42)38-24-20(7-4-8-22(24)43-18-9-10-18)23(37-26)17-5-2-1-3-6-17/h1-8,16,18-19,21,26H,9-15H2,(H2,36,40)(H,38,42)(H,39,41)/t19-,21+,26-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...				US Patent US9427442 (2016) BindingDB Entry DOI: 10.7270/Q2ZP452P
					More data for this Ligand-Target Pair
Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless (Homo sapiens (Human))	BDBM242883 (US9427442, 11) Show SMILES Cc1cccc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CC2CC(F)(F)C2)C(N)=O)C(=O)Nc2c(F)cccc12 |r,t:8| Show InChI InChI=1S/C28H28F6N4O3/c1-14-4-2-5-16(10-14)21-18-6-3-7-20(29)22(18)37-26(41)24(36-21)38-25(40)17(8-9-28(32,33)34)19(23(35)39)11-15-12-27(30,31)13-15/h2-7,10,15,17,19,24H,8-9,11-13H2,1H3,(H2,35,39)(H,37,41)(H,38,40)/t17-,19+,24-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...				US Patent US9427442 (2016) BindingDB Entry DOI: 10.7270/Q2ZP452P
					More data for this Ligand-Target Pair
Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless (Homo sapiens (Human))	BDBM242873 (US9427442, 1) Show SMILES Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CC1CC(F)(F)C1)C(N)=O)N=C2c1ccccc1 |r,c:34| Show InChI InChI=1S/C28H29F5N4O3/c1-15-6-5-9-19-21(15)36-26(40)24(35-22(19)17-7-3-2-4-8-17)37-25(39)18(10-11-28(31,32)33)20(23(34)38)12-16-13-27(29,30)14-16/h2-9,16,18,20,24H,10-14H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t18-,20+,24-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...				US Patent US9427442 (2016) BindingDB Entry DOI: 10.7270/Q2ZP452P
					More data for this Ligand-Target Pair
Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless (Homo sapiens (Human))	BDBM242885 (US9427442, 13) Show SMILES NC(=O)[C@@H](CC1CC(F)(F)C1)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(Cl)c2NC1=O |r,t:23| Show InChI InChI=1S/C27H26ClF5N4O3/c28-19-8-4-7-17-20(15-5-2-1-3-6-15)35-23(25(40)36-21(17)19)37-24(39)16(9-10-27(31,32)33)18(22(34)38)11-14-12-26(29,30)13-14/h1-8,14,16,18,23H,9-13H2,(H2,34,38)(H,36,40)(H,37,39)/t16-,18+,23-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...				US Patent US9427442 (2016) BindingDB Entry DOI: 10.7270/Q2ZP452P
					More data for this Ligand-Target Pair
Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless (Homo sapiens (Human))	BDBM242891 (US9427442, 19) Show SMILES C[C@@H](C[C@@H]([C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(F)c2NC1=O)C(N)=O)C(F)(F)F |r,t:15| Show InChI InChI=1S/C26H25F7N4O3/c1-13(26(31,32)33)12-17(21(34)38)15(10-11-25(28,29)30)23(39)37-22-24(40)36-20-16(8-5-9-18(20)27)19(35-22)14-6-3-2-4-7-14/h2-9,13,15,17,22H,10-12H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t13-,15+,17-,22+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...				US Patent US9427442 (2016) BindingDB Entry DOI: 10.7270/Q2ZP452P
					More data for this Ligand-Target Pair
Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless (Homo sapiens (Human))	BDBM242895 (US9427442, 23) Show SMILES C[C@@H](C[C@@H]([C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(Cl)c2NC1=O)C(N)=O)C(F)(F)F |r,t:15| Show InChI InChI=1S/C26H25ClF6N4O3/c1-13(26(31,32)33)12-17(21(34)38)15(10-11-25(28,29)30)23(39)37-22-24(40)36-20-16(8-5-9-18(20)27)19(35-22)14-6-3-2-4-7-14/h2-9,13,15,17,22H,10-12H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t13-,15+,17-,22+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...				US Patent US9427442 (2016) BindingDB Entry DOI: 10.7270/Q2ZP452P
					More data for this Ligand-Target Pair
Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless (Homo sapiens (Human))	BDBM242881 (US9427442, 9) Show SMILES Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CC1CC(F)(F)C1)C(N)=O)N=C2c1cccc(F)c1 |r,c:34| Show InChI InChI=1S/C28H28F6N4O3/c1-14-4-2-7-19-21(14)37-26(41)24(36-22(19)16-5-3-6-17(29)11-16)38-25(40)18(8-9-28(32,33)34)20(23(35)39)10-15-12-27(30,31)13-15/h2-7,11,15,18,20,24H,8-10,12-13H2,1H3,(H2,35,39)(H,37,41)(H,38,40)/t18-,20+,24-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...				US Patent US9427442 (2016) BindingDB Entry DOI: 10.7270/Q2ZP452P
					More data for this Ligand-Target Pair
Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless (Homo sapiens (Human))	BDBM242887 (US9427442, 15) Show SMILES NC(=O)[C@@H](CC1CC(F)(F)C1)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2NC1=O |r,t:23| Show InChI InChI=1S/C27H27F5N4O3/c28-26(29)13-15(14-26)12-19(22(33)37)17(10-11-27(30,31)32)24(38)36-23-25(39)34-20-9-5-4-8-18(20)21(35-23)16-6-2-1-3-7-16/h1-9,15,17,19,23H,10-14H2,(H2,33,37)(H,34,39)(H,36,38)/t17-,19+,23-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...				US Patent US9427442 (2016) BindingDB Entry DOI: 10.7270/Q2ZP452P
					More data for this Ligand-Target Pair
Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless (Homo sapiens (Human))	BDBM242880 (US9427442, 8) Show SMILES COc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CC1CC(F)(F)C1)C(N)=O)N=C2c1ccccc1 |r,c:35| Show InChI InChI=1S/C28H29F5N4O4/c1-41-20-9-5-8-18-21(16-6-3-2-4-7-16)35-24(26(40)36-22(18)20)37-25(39)17(10-11-28(31,32)33)19(23(34)38)12-15-13-27(29,30)14-15/h2-9,15,17,19,24H,10-14H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t17-,19+,24-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...				US Patent US9427442 (2016) BindingDB Entry DOI: 10.7270/Q2ZP452P
					More data for this Ligand-Target Pair
Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless (Homo sapiens (Human))	BDBM242884 (US9427442, 12) Show SMILES NC(=O)[C@@H](CC1CC(F)(F)C1)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(C3CC3)c2NC1=O |r,t:23| Show InChI InChI=1S/C30H31F5N4O3/c31-29(32)14-16(15-29)13-22(25(36)40)20(11-12-30(33,34)35)27(41)39-26-28(42)38-24-19(17-9-10-17)7-4-8-21(24)23(37-26)18-5-2-1-3-6-18/h1-8,16-17,20,22,26H,9-15H2,(H2,36,40)(H,38,42)(H,39,41)/t20-,22+,26-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...				US Patent US9427442 (2016) BindingDB Entry DOI: 10.7270/Q2ZP452P
					More data for this Ligand-Target Pair
Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless (Homo sapiens (Human))	BDBM242882 (US9427442, 10) Show SMILES Cc1cccc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CC2CC(F)(F)C2)C(N)=O)C(=O)Nc2c(Cl)cccc12 |r,t:8| Show InChI InChI=1S/C28H28ClF5N4O3/c1-14-4-2-5-16(10-14)21-18-6-3-7-20(29)22(18)37-26(41)24(36-21)38-25(40)17(8-9-28(32,33)34)19(23(35)39)11-15-12-27(30,31)13-15/h2-7,10,15,17,19,24H,8-9,11-13H2,1H3,(H2,35,39)(H,37,41)(H,38,40)/t17-,19+,24-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...				US Patent US9427442 (2016) BindingDB Entry DOI: 10.7270/Q2ZP452P
					More data for this Ligand-Target Pair
Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless (Homo sapiens (Human))	BDBM242896 (US9427442, 24) Show SMILES CC(F)(F)CC[C@@H]([C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(Cl)c2NC1=O)C(N)=O |r,t:18| Show InChI InChI=1S/C26H26ClF5N4O3/c1-25(28,29)12-10-15(21(33)37)16(11-13-26(30,31)32)23(38)36-22-24(39)35-20-17(8-5-9-18(20)27)19(34-22)14-6-3-2-4-7-14/h2-9,15-16,22H,10-13H2,1H3,(H2,33,37)(H,35,39)(H,36,38)/t15-,16+,22+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.40	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...				US Patent US9427442 (2016) BindingDB Entry DOI: 10.7270/Q2ZP452P
					More data for this Ligand-Target Pair
Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless (Homo sapiens (Human))	BDBM242874 (US9427442, 2) Show SMILES COc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](C1CCC(F)(F)CC1)C(N)=O)N=C2c1ccccc1 |r,c:36| Show InChI InChI=1S/C29H31F5N4O4/c1-42-20-9-5-8-19-22(17-6-3-2-4-7-17)36-25(27(41)37-23(19)20)38-26(40)18(12-15-29(32,33)34)21(24(35)39)16-10-13-28(30,31)14-11-16/h2-9,16,18,21,25H,10-15H2,1H3,(H2,35,39)(H,37,41)(H,38,40)/t18-,21+,25-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...				US Patent US9427442 (2016) BindingDB Entry DOI: 10.7270/Q2ZP452P
					More data for this Ligand-Target Pair
Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless (Homo sapiens (Human))	BDBM242877 (US9427442, 5) Show SMILES NC(=O)[C@H]([C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(Cl)c2NC1=O)C1CCC(F)(F)CC1 |r,t:15| Show InChI InChI=1S/C28H28ClF5N4O3/c29-19-8-4-7-18-21(16-5-2-1-3-6-16)36-24(26(41)37-22(18)19)38-25(40)17(11-14-28(32,33)34)20(23(35)39)15-9-12-27(30,31)13-10-15/h1-8,15,17,20,24H,9-14H2,(H2,35,39)(H,37,41)(H,38,40)/t17-,20+,24-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.30	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...				US Patent US9427442 (2016) BindingDB Entry DOI: 10.7270/Q2ZP452P
					More data for this Ligand-Target Pair
Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless (Homo sapiens (Human))	BDBM242875 (US9427442, 3) Show SMILES NC(=O)[C@H]([C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2cccc(F)c2)c2cccc(OC3CC3)c2NC1=O)C1CCC(F)(F)CC1 |r,t:15| Show InChI InChI=1S/C31H32F6N4O4/c32-18-4-1-3-17(15-18)24-21-5-2-6-22(45-19-7-8-19)25(21)40-29(44)27(39-24)41-28(43)20(11-14-31(35,36)37)23(26(38)42)16-9-12-30(33,34)13-10-16/h1-6,15-16,19-20,23,27H,7-14H2,(H2,38,42)(H,40,44)(H,41,43)/t20-,23+,27-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.90	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...				US Patent US9427442 (2016) BindingDB Entry DOI: 10.7270/Q2ZP452P
					More data for this Ligand-Target Pair
Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless (Homo sapiens (Human))	BDBM242894 (US9427442, 22) Show SMILES C[C@H](C[C@@H]([C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(Cl)c2NC1=O)C(N)=O)C(F)(F)F |r,t:15| Show InChI InChI=1S/C26H25ClF6N4O3/c1-13(26(31,32)33)12-17(21(34)38)15(10-11-25(28,29)30)23(39)37-22-24(40)36-20-16(8-5-9-18(20)27)19(35-22)14-6-3-2-4-7-14/h2-9,13,15,17,22H,10-12H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t13-,15-,17+,22-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.30	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...				US Patent US9427442 (2016) BindingDB Entry DOI: 10.7270/Q2ZP452P
					More data for this Ligand-Target Pair
Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless (Homo sapiens (Human))	BDBM242890 (US9427442, 18) Show SMILES CC(F)(F)C[C@@H]([C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2NC1=O)C(N)=O |r,t:17| Show InChI InChI=1S/C25H25F5N4O3/c1-24(26,27)13-17(20(31)35)15(11-12-25(28,29)30)22(36)34-21-23(37)32-18-10-6-5-9-16(18)19(33-21)14-7-3-2-4-8-14/h2-10,15,17,21H,11-13H2,1H3,(H2,31,35)(H,32,37)(H,34,36)/t15-,17+,21-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.8	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...				US Patent US9427442 (2016) BindingDB Entry DOI: 10.7270/Q2ZP452P
					More data for this Ligand-Target Pair
Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless (Homo sapiens (Human))	BDBM242889 (US9427442, 17) Show SMILES COc1ccc2c(NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCCF)C(N)=O)N=C2c2ccccc2)c1 |r,c:29| Show InChI InChI=1S/C26H28F4N4O4/c1-38-16-9-10-19-20(14-16)32-25(37)23(33-21(19)15-6-3-2-4-7-15)34-24(36)18(11-12-26(28,29)30)17(22(31)35)8-5-13-27/h2-4,6-7,9-10,14,17-18,23H,5,8,11-13H2,1H3,(H2,31,35)(H,32,37)(H,34,36)/t17-,18+,23+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...				US Patent US9427442 (2016) BindingDB Entry DOI: 10.7270/Q2ZP452P
					More data for this Ligand-Target Pair
Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless (Homo sapiens (Human))	BDBM209912 (US9273014, Comparative Compound 48 | US9427442, Co...) Show SMILES CCCN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CC(C)C)[C@H](CC=C)C(N)=O)C1=O)c1ccccc1 |r,c:11| Show InChI InChI=1S/C29H36N4O3/c1-5-12-21(26(30)34)23(18-19(3)4)28(35)32-27-29(36)33(17-6-2)24-16-11-10-15-22(24)25(31-27)20-13-8-7-9-14-20/h5,7-11,13-16,19,21,23,27H,1,6,12,17-18H2,2-4H3,(H2,30,34)(H,32,35)/t21-,23+,27+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...				US Patent US9273014 (2016) BindingDB Entry DOI: 10.7270/Q2KW5DVX
					More data for this Ligand-Target Pair
Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless (Homo sapiens (Human))	BDBM209912 (US9273014, Comparative Compound 48 | US9427442, Co...) Show SMILES CCCN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CC(C)C)[C@H](CC=C)C(N)=O)C1=O)c1ccccc1 |r,c:11| Show InChI InChI=1S/C29H36N4O3/c1-5-12-21(26(30)34)23(18-19(3)4)28(35)32-27-29(36)33(17-6-2)24-16-11-10-15-22(24)25(31-27)20-13-8-7-9-14-20/h5,7-11,13-16,19,21,23,27H,1,6,12,17-18H2,2-4H3,(H2,30,34)(H,32,35)/t21-,23+,27+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...				US Patent US9427442 (2016) BindingDB Entry DOI: 10.7270/Q2ZP452P
					More data for this Ligand-Target Pair
Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless (Homo sapiens (Human))	BDBM209911 (US9273014, Comparative Compound 47 | US9427442, Co...) Show SMILES CCCC[C@@H]([C@@H](CC(C)C)C(=O)N[C@H]1N=C(c2ccc(Cl)cc2)c2ccccc2N(C)C1=O)C(N)=O |r,t:14| Show InChI InChI=1S/C28H35ClN4O3/c1-5-6-9-20(25(30)34)22(16-17(2)3)27(35)32-26-28(36)33(4)23-11-8-7-10-21(23)24(31-26)18-12-14-19(29)15-13-18/h7-8,10-15,17,20,22,26H,5-6,9,16H2,1-4H3,(H2,30,34)(H,32,35)/t20-,22+,26+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13.5	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...				US Patent US9273014 (2016) BindingDB Entry DOI: 10.7270/Q2KW5DVX
					More data for this Ligand-Target Pair
Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless (Homo sapiens (Human))	BDBM209911 (US9273014, Comparative Compound 47 | US9427442, Co...) Show SMILES CCCC[C@@H]([C@@H](CC(C)C)C(=O)N[C@H]1N=C(c2ccc(Cl)cc2)c2ccccc2N(C)C1=O)C(N)=O |r,t:14| Show InChI InChI=1S/C28H35ClN4O3/c1-5-6-9-20(25(30)34)22(16-17(2)3)27(35)32-26-28(36)33(4)23-11-8-7-10-21(23)24(31-26)18-12-14-19(29)15-13-18/h7-8,10-15,17,20,22,26H,5-6,9,16H2,1-4H3,(H2,30,34)(H,32,35)/t20-,22+,26+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13.5	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...				US Patent US9427442 (2016) BindingDB Entry DOI: 10.7270/Q2ZP452P
					More data for this Ligand-Target Pair
Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless (Homo sapiens (Human))	BDBM242893 (US9427442, 21) Show SMILES COc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(C)(F)F)C(N)=O)N=C2c1ccccc1 |r,c:33| Show InChI InChI=1S/C27H29F5N4O4/c1-26(28,29)13-11-16(22(33)37)17(12-14-27(30,31)32)24(38)36-23-25(39)35-21-18(9-6-10-19(21)40-2)20(34-23)15-7-4-3-5-8-15/h3-10,16-17,23H,11-14H2,1-2H3,(H2,33,37)(H,35,39)(H,36,38)/t16-,17+,23+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13.8	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...				US Patent US9427442 (2016) BindingDB Entry DOI: 10.7270/Q2ZP452P
					More data for this Ligand-Target Pair
Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless (Homo sapiens (Human))	BDBM242888 (US9427442, 16) Show SMILES NOc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCCF)C(N)=O)N=C2c1ccccc1 |r,c:31| Show InChI InChI=1S/C25H27F4N5O4/c26-13-5-9-15(21(30)35)16(11-12-25(27,28)29)23(36)34-22-24(37)33-20-17(8-4-10-18(20)38-31)19(32-22)14-6-2-1-3-7-14/h1-4,6-8,10,15-16,22H,5,9,11-13,31H2,(H2,30,35)(H,33,37)(H,34,36)/t15-,16+,22+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15.4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...				US Patent US9427442 (2016) BindingDB Entry DOI: 10.7270/Q2ZP452P
					More data for this Ligand-Target Pair
Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless (Homo sapiens (Human))	BDBM242892 (US9427442, 20) Show SMILES NC(=O)[C@@H](CCCF)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(Cl)c2NC1=O |r,t:19| Show InChI InChI=1S/C25H25ClF4N4O3/c26-18-10-4-8-17-19(14-6-2-1-3-7-14)32-22(24(37)33-20(17)18)34-23(36)16(11-12-25(28,29)30)15(21(31)35)9-5-13-27/h1-4,6-8,10,15-16,22H,5,9,11-13H2,(H2,31,35)(H,33,37)(H,34,36)/t15-,16+,22+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16.5	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...				US Patent US9427442 (2016) BindingDB Entry DOI: 10.7270/Q2ZP452P
					More data for this Ligand-Target Pair
Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless (Homo sapiens (Human))	BDBM242878 (US9427442, 6) Show SMILES NC(=O)[C@H]([C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2NC1=O)C1CC(F)(F)C1 |r,t:15| Show InChI InChI=1S/C26H25F5N4O3/c27-25(28)12-15(13-25)19(21(32)36)17(10-11-26(29,30)31)23(37)35-22-24(38)33-18-9-5-4-8-16(18)20(34-22)14-6-2-1-3-7-14/h1-9,15,17,19,22H,10-13H2,(H2,32,36)(H,33,38)(H,35,37)/t17-,19+,22-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18.9	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...				US Patent US9427442 (2016) BindingDB Entry DOI: 10.7270/Q2ZP452P
					More data for this Ligand-Target Pair
Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless (Homo sapiens (Human))	BDBM242897 (US9427442, 25) Show SMILES Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CC1(F)CCC1)C(N)=O)N=C2c1ccccc1 |r,c:33| Show InChI InChI=1S/C28H30F4N4O3/c1-16-7-5-10-19-21(16)35-26(39)24(34-22(19)17-8-3-2-4-9-17)36-25(38)18(11-14-28(30,31)32)20(23(33)37)15-27(29)12-6-13-27/h2-5,7-10,18,20,24H,6,11-15H2,1H3,(H2,33,37)(H,35,39)(H,36,38)/t18-,20+,24-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20.1	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...				US Patent US9427442 (2016) BindingDB Entry DOI: 10.7270/Q2ZP452P
					More data for this Ligand-Target Pair
Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless (Homo sapiens (Human))	BDBM242876 (US9427442, 4) Show SMILES NC(=O)[C@H]([C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(Cl)c2NC1=O)C1CCC(CC1)C(F)(F)F |r,wU:14.13,4.10,wD:3.2,t:15,(7.12,-.37,;5.79,-1.14,;5.79,-2.68,;4.46,-.37,;3.12,-1.14,;3.12,-2.68,;1.79,-3.45,;1.79,-4.99,;.25,-4.99,;3.33,-4.99,;1.79,-6.53,;1.79,-.37,;1.79,1.17,;.46,-1.14,;-1.08,-1.14,;-1.75,-2.53,;-3.25,-2.87,;-3.65,-4.36,;-5.14,-4.75,;-5.54,-6.24,;-4.45,-7.33,;-2.96,-6.93,;-2.56,-5.45,;-4.46,-1.91,;-5.79,-2.68,;-7.12,-1.91,;-7.12,-.37,;-5.79,.4,;-5.79,1.94,;-4.46,-.37,;-3.25,.59,;-1.75,.25,;-.98,1.58,;4.46,1.17,;5.79,1.94,;5.79,3.48,;4.46,4.31,;3.12,3.48,;3.12,1.94,;4.46,5.85,;4.46,7.39,;6,5.85,;2.92,5.85,)| Show InChI InChI=1S/C29H29ClF6N4O3/c30-20-8-4-7-19-22(16-5-2-1-3-6-16)38-25(27(43)39-23(19)20)40-26(42)18(13-14-28(31,32)33)21(24(37)41)15-9-11-17(12-10-15)29(34,35)36/h1-8,15,17-18,21,25H,9-14H2,(H2,37,41)(H,39,43)(H,40,42)/t15?,17?,18-,21+,25-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21.2	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...				US Patent US9427442 (2016) BindingDB Entry DOI: 10.7270/Q2ZP452P
					More data for this Ligand-Target Pair
Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless (Homo sapiens (Human))	BDBM209909 (US9273014, Comparative Compound 45 | US9427442, Co...) Show SMILES CCC[C@@H]([C@@H](CC(C)C)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O)C(N)=O |r,t:13| Show InChI InChI=1S/C27H34N4O3/c1-5-11-19(24(28)32)21(16-17(2)3)26(33)30-25-27(34)31(4)22-15-10-9-14-20(22)23(29-25)18-12-7-6-8-13-18/h6-10,12-15,17,19,21,25H,5,11,16H2,1-4H3,(H2,28,32)(H,30,33)/t19-,21+,25+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	48.3	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...				US Patent US9427442 (2016) BindingDB Entry DOI: 10.7270/Q2ZP452P
					More data for this Ligand-Target Pair
Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless (Homo sapiens (Human))	BDBM209909 (US9273014, Comparative Compound 45 | US9427442, Co...) Show SMILES CCC[C@@H]([C@@H](CC(C)C)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O)C(N)=O |r,t:13| Show InChI InChI=1S/C27H34N4O3/c1-5-11-19(24(28)32)21(16-17(2)3)26(33)30-25-27(34)31(4)22-15-10-9-14-20(22)23(29-25)18-12-7-6-8-13-18/h6-10,12-15,17,19,21,25H,5,11,16H2,1-4H3,(H2,28,32)(H,30,33)/t19-,21+,25+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	48.3	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...				US Patent US9273014 (2016) BindingDB Entry DOI: 10.7270/Q2KW5DVX
					More data for this Ligand-Target Pair
Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless (Homo sapiens (Human))	BDBM209910 (US9273014, Comparative Compound 46 | US9427442, Co...) Show SMILES CC(C)C[C@H]([C@H](CC=C)C(N)=O)C(=O)N[C@H]1N=C(c2ccccc2)c2cc(Cl)ccc2N(C)C1=O |r,t:16| Show InChI InChI=1S/C27H31ClN4O3/c1-5-9-19(24(29)33)20(14-16(2)3)26(34)31-25-27(35)32(4)22-13-12-18(28)15-21(22)23(30-25)17-10-7-6-8-11-17/h5-8,10-13,15-16,19-20,25H,1,9,14H2,2-4H3,(H2,29,33)(H,31,34)/t19-,20+,25+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	74.5	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...				US Patent US9427442 (2016) BindingDB Entry DOI: 10.7270/Q2ZP452P
					More data for this Ligand-Target Pair
Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless (Homo sapiens (Human))	BDBM209910 (US9273014, Comparative Compound 46 | US9427442, Co...) Show SMILES CC(C)C[C@H]([C@H](CC=C)C(N)=O)C(=O)N[C@H]1N=C(c2ccccc2)c2cc(Cl)ccc2N(C)C1=O |r,t:16| Show InChI InChI=1S/C27H31ClN4O3/c1-5-9-19(24(29)33)20(14-16(2)3)26(34)31-25-27(35)32(4)22-13-12-18(28)15-21(22)23(30-25)17-10-7-6-8-11-17/h5-8,10-13,15-16,19-20,25H,1,9,14H2,2-4H3,(H2,29,33)(H,31,34)/t19-,20+,25+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	74.5	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...				US Patent US9273014 (2016) BindingDB Entry DOI: 10.7270/Q2KW5DVX
					More data for this Ligand-Target Pair