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Compile Data Set for Download or QSAR

Found 104 hits Enz. Inhib. hit(s) with Target = 'P2Y purinoceptor 14' AND taxid = 10090   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
P2Y purinoceptor 14


(Mus musculus)		BDBM50343888
PNG
((R)-4-(4-(2,2-difluoro-1-hydroxyethyl)phenyl)-7-(4...)
Show SMILES O[C@@H](C(F)F)c1ccc(cc1)-c1cc(cc2cc(ccc12)-c1ccc(cc1)C(F)(F)F)C(O)=O |r|
Show InChI InChI=1S/C26H17F5O3/c27-24(28)23(32)16-3-1-15(2-4-16)22-13-19(25(33)34)12-18-11-17(7-10-21(18)22)14-5-8-20(9-6-14)26(29,30)31/h1-13,23-24,32H,(H,33,34)/t23-/m1/s1
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 4n/an/an/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of mouse P2Y14 receptor

Eur J Med Chem 175: 34-39 (2019)


Article DOI: 10.1016/j.ejmech.2019.04.068
BindingDB Entry DOI: 10.7270/Q29C71R4
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50456168
PNG
(CHEMBL1800685)
Show SMILES OC(=O)c1cc(-c2ccc(cc2)C2CCNCC2)c2ccc(cc2c1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C29H24F3NO2/c30-29(31,32)25-8-5-19(6-9-25)22-7-10-26-23(15-22)16-24(28(34)35)17-27(26)21-3-1-18(2-4-21)20-11-13-33-14-12-20/h1-10,15-17,20,33H,11-14H2,(H,34,35)
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 35n/an/an/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of mouse P2Y14 receptor in presence of 2% HSA

Eur J Med Chem 175: 34-39 (2019)


Article DOI: 10.1016/j.ejmech.2019.04.068
BindingDB Entry DOI: 10.7270/Q29C71R4
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50343888
PNG
((R)-4-(4-(2,2-difluoro-1-hydroxyethyl)phenyl)-7-(4...)
Show SMILES O[C@@H](C(F)F)c1ccc(cc1)-c1cc(cc2cc(ccc12)-c1ccc(cc1)C(F)(F)F)C(O)=O |r|
Show InChI InChI=1S/C26H17F5O3/c27-24(28)23(32)16-3-1-15(2-4-16)22-13-19(25(33)34)12-18-11-17(7-10-21(18)22)14-5-8-20(9-6-14)26(29,30)31/h1-13,23-24,32H,(H,33,34)/t23-/m1/s1
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 1.29E+3n/an/an/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of mouse P2Y14 receptor in presence of 2% HSA

Eur J Med Chem 175: 34-39 (2019)


Article DOI: 10.1016/j.ejmech.2019.04.068
BindingDB Entry DOI: 10.7270/Q29C71R4
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50343131
PNG
(2-(2-cyanopyrimidin-5-yl)-N-(3-ethylphenyl)-4-o-to...)
Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2C)-c2cnc(nc2)C#N)c1
Show InChI InChI=1S/C28H25N7O/c1-3-19-8-6-9-21(13-19)32-28(36)35-12-11-24-23(17-35)26(22-10-5-4-7-18(22)2)34-27(33-24)20-15-30-25(14-29)31-16-20/h4-10,13,15-16H,3,11-12,17H2,1-2H3,(H,32,36)
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n/an/a 1n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...

Bioorg Med Chem Lett 21: 2832-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.084
BindingDB Entry DOI: 10.7270/Q20865N7
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50343129
PNG
(2-(4-cyanopyridin-3-yl)-N-(3-ethylphenyl)-4-o-toly...)
Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2C)-c2cnccc2C#N)c1
Show InChI InChI=1S/C29H26N6O/c1-3-20-8-6-9-22(15-20)32-29(36)35-14-12-26-25(18-35)27(23-10-5-4-7-19(23)2)34-28(33-26)24-17-31-13-11-21(24)16-30/h4-11,13,15,17H,3,12,14,18H2,1-2H3,(H,32,36)
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n/an/a 3n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...

Bioorg Med Chem Lett 21: 2832-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.084
BindingDB Entry DOI: 10.7270/Q20865N7
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50343132
PNG
(2-(3,5-dimethylisoxazol-4-yl)-N-(3-ethylphenyl)-4-...)
Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2C)-c2c(C)noc2C)c1
Show InChI InChI=1S/C28H29N5O2/c1-5-20-10-8-11-21(15-20)29-28(34)33-14-13-24-23(16-33)26(22-12-7-6-9-17(22)2)31-27(30-24)25-18(3)32-35-19(25)4/h6-12,15H,5,13-14,16H2,1-4H3,(H,29,34)
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n/an/a 4n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...

Bioorg Med Chem Lett 21: 2832-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.084
BindingDB Entry DOI: 10.7270/Q20865N7
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50343886
PNG
((R)-4-(4-(2,2,2-trifluoro-1-hydroxyethyl)phenyl)-7...)
Show SMILES O[C@H](c1ccc(cc1)-c1cc(cc2cc(ccc12)-c1ccc(cc1)C(F)(F)F)C(O)=O)C(F)(F)F |r|
Show InChI InChI=1S/C26H16F6O3/c27-25(28,29)20-8-5-14(6-9-20)17-7-10-21-18(11-17)12-19(24(34)35)13-22(21)15-1-3-16(4-2-15)23(33)26(30,31)32/h1-13,23,33H,(H,34,35)/t23-/m1/s1
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n/an/a 4n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay

Bioorg Med Chem Lett 21: 2836-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.081
BindingDB Entry DOI: 10.7270/Q2NP24S4
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50343888
PNG
((R)-4-(4-(2,2-difluoro-1-hydroxyethyl)phenyl)-7-(4...)
Show SMILES O[C@@H](C(F)F)c1ccc(cc1)-c1cc(cc2cc(ccc12)-c1ccc(cc1)C(F)(F)F)C(O)=O |r|
Show InChI InChI=1S/C26H17F5O3/c27-24(28)23(32)16-3-1-15(2-4-16)22-13-19(25(33)34)12-18-11-17(7-10-21(18)22)14-5-8-20(9-6-14)26(29,30)31/h1-13,23-24,32H,(H,33,34)/t23-/m1/s1
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n/an/a 8n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay

Bioorg Med Chem Lett 21: 2836-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.081
BindingDB Entry DOI: 10.7270/Q2NP24S4
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50343120
PNG
(4-(2,6-dimethylphenyl)-N-(3-ethylphenyl)-2-(pyridi...)
Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2c(C)cccc2C)-c2cccnc2)c1 |(10.19,-.57,;8.86,.2,;7.53,-.58,;7.53,-2.13,;6.2,-2.9,;4.86,-2.13,;4.87,-.59,;3.53,.18,;2.2,-.59,;2.2,-2.13,;.87,.18,;.86,1.73,;-.48,2.51,;-1.81,1.73,;-3.15,2.49,;-4.47,1.72,;-4.47,.18,;-3.14,-.59,;-1.81,.18,;-.48,-.59,;-3.14,-2.12,;-4.47,-2.89,;-5.81,-2.12,;-4.47,-4.43,;-3.13,-5.2,;-1.8,-4.42,;-1.81,-2.89,;-.47,-2.11,;-5.8,2.49,;-7.14,1.71,;-8.47,2.48,;-8.47,4.03,;-7.14,4.8,;-5.81,4.04,;6.19,.19,)|
Show InChI InChI=1S/C29H29N5O/c1-4-21-10-6-12-23(16-21)31-29(35)34-15-13-25-24(18-34)27(26-19(2)8-5-9-20(26)3)33-28(32-25)22-11-7-14-30-17-22/h5-12,14,16-17H,4,13,15,18H2,1-3H3,(H,31,35)
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n/an/a 9n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...

Bioorg Med Chem Lett 21: 2832-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.084
BindingDB Entry DOI: 10.7270/Q20865N7
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50343128
PNG
(2-(benzo[d][1,3]dioxol-5-yl)-N-(3-ethylphenyl)-4-o...)
Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2C)-c2ccc3OCOc3c2)c1
Show InChI InChI=1S/C30H28N4O3/c1-3-20-8-6-9-22(15-20)31-30(35)34-14-13-25-24(17-34)28(23-10-5-4-7-19(23)2)33-29(32-25)21-11-12-26-27(16-21)37-18-36-26/h4-12,15-16H,3,13-14,17-18H2,1-2H3,(H,31,35)
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n/an/a 10n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...

Bioorg Med Chem Lett 21: 2832-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.084
BindingDB Entry DOI: 10.7270/Q20865N7
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50343130
PNG
(CHEMBL1771458 | N-(3-ethylphenyl)-2-(pyrimidin-5-y...)
Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2C)-c2cncnc2)c1
Show InChI InChI=1S/C27H26N6O/c1-3-19-8-6-9-21(13-19)30-27(34)33-12-11-24-23(16-33)25(22-10-5-4-7-18(22)2)32-26(31-24)20-14-28-17-29-15-20/h4-10,13-15,17H,3,11-12,16H2,1-2H3,(H,30,34)
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n/an/a 12n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...

Bioorg Med Chem Lett 21: 2832-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.084
BindingDB Entry DOI: 10.7270/Q20865N7
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50343127
PNG
(CHEMBL1771455 | N-(3-ethylphenyl)-2-(quinolin-3-yl...)
Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2C)-c2cnc3ccccc3c2)c1
Show InChI InChI=1S/C32H29N5O/c1-3-22-10-8-12-25(17-22)34-32(38)37-16-15-29-27(20-37)30(26-13-6-4-9-21(26)2)36-31(35-29)24-18-23-11-5-7-14-28(23)33-19-24/h4-14,17-19H,3,15-16,20H2,1-2H3,(H,34,38)
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n/an/a 13n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...

Bioorg Med Chem Lett 21: 2832-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.084
BindingDB Entry DOI: 10.7270/Q20865N7
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50584883
PNG
(CHEMBL5074765)
Show SMILES [H][C@]12C[C@@H](c3ccc(cc3)-c3cc(cc4cc(ccc34)-c3ccc(cc3)C(F)(F)F)C(O)=O)[C@]([H])(CN1)C2 |r|
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TBA

Assay Description
Inhibition of fluorescent antagonist binding to mouse P2Y14R expressed in HEK293 cells preincubated for 30 mins followed by addition of 6-amino-9-(2-...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01964
BindingDB Entry DOI: 10.7270/Q2611470
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50343885
PNG
(4-(4-(2,2,2-trifluoro-1-hydroxyethyl)phenyl)-7-(4-...)
Show SMILES OC(c1ccc(cc1)-c1cc(cc2cc(ccc12)-c1ccc(cc1)C(F)(F)F)C(O)=O)C(F)(F)F
Show InChI InChI=1S/C26H16F6O3/c27-25(28,29)20-8-5-14(6-9-20)17-7-10-21-18(11-17)12-19(24(34)35)13-22(21)15-1-3-16(4-2-15)23(33)26(30,31)32/h1-13,23,33H,(H,34,35)
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n/an/a 13n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay

Bioorg Med Chem Lett 21: 2836-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.081
BindingDB Entry DOI: 10.7270/Q2NP24S4
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50343877
PNG
(7-(4-fluoro-2,6-dimethylbenzyloxy)-4-(thiophen-3-y...)
Show SMILES Cc1cc(F)cc(C)c1COc1ccc2c(cc(cc2c1)C(O)=O)-c1ccsc1
Show InChI InChI=1S/C24H19FO3S/c1-14-7-19(25)8-15(2)23(14)12-28-20-3-4-21-17(10-20)9-18(24(26)27)11-22(21)16-5-6-29-13-16/h3-11,13H,12H2,1-2H3,(H,26,27)
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n/an/a 14n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of mouse P2Y14 receptor

Eur J Med Chem 175: 34-39 (2019)


Article DOI: 10.1016/j.ejmech.2019.04.068
BindingDB Entry DOI: 10.7270/Q29C71R4
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50343877
PNG
(7-(4-fluoro-2,6-dimethylbenzyloxy)-4-(thiophen-3-y...)
Show SMILES Cc1cc(F)cc(C)c1COc1ccc2c(cc(cc2c1)C(O)=O)-c1ccsc1
Show InChI InChI=1S/C24H19FO3S/c1-14-7-19(25)8-15(2)23(14)12-28-20-3-4-21-17(10-20)9-18(24(26)27)11-22(21)16-5-6-29-13-16/h3-11,13H,12H2,1-2H3,(H,26,27)
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n/an/a 14n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay

Bioorg Med Chem Lett 21: 2836-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.081
BindingDB Entry DOI: 10.7270/Q2NP24S4
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50343094
PNG
(2-(4-cyanophenyl)-N-(3-ethylphenyl)-4-o-tolyl-7,8-...)
Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2C)-c2ccc(cc2)C#N)c1
Show InChI InChI=1S/C30H27N5O/c1-3-21-8-6-9-24(17-21)32-30(36)35-16-15-27-26(19-35)28(25-10-5-4-7-20(25)2)34-29(33-27)23-13-11-22(18-31)12-14-23/h4-14,17H,3,15-16,19H2,1-2H3,(H,32,36)
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n/an/a 16n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...

Bioorg Med Chem Lett 21: 2832-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.084
BindingDB Entry DOI: 10.7270/Q20865N7
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50584890
PNG
(CHEMBL5079102)
Show SMILES [H][C@]12CC[C@@]([H])(CNC1)C2(O)c1ccc(cc1)-c1cc(cc2cc(ccc12)-c1ccc(cc1)C(F)(F)F)C(O)=O |r|
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TBA

Assay Description
Inhibition of fluorescent antagonist binding to mouse P2Y14R expressed in HEK293 cells preincubated for 30 mins followed by addition of 6-amino-9-(2-...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01964
BindingDB Entry DOI: 10.7270/Q2611470
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50584893
PNG
(CHEMBL5083619)
Show SMILES N[C@@H]1C[C@H](CO)[C@H](C1)c1ccc(cc1)-c1cc(cc2cc(ccc12)-c1ccc(cc1)C(F)(F)F)C(O)=O |r|
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TBA

Assay Description
Inhibition of fluorescent antagonist binding to mouse P2Y14R expressed in HEK293 cells preincubated for 30 mins followed by addition of 6-amino-9-(2-...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01964
BindingDB Entry DOI: 10.7270/Q2611470
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50566405
PNG
(CHEMBL4864408)
Show SMILES OCc1cc(no1)-c1ccc(cc1)-c1cc(cc2cc(ccc12)-c1ccc(cc1)C(F)(F)F)C(O)=O
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TBA

Assay Description
Inhibition of fluorescent antagonist binding to mouse P2Y14 receptor expressed in HEK293 cells preincubated with compound for 30 mins followed by flu...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00164
BindingDB Entry DOI: 10.7270/Q2BZ69SP
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50343884
PNG
(4-(4-(methylsulfonyl)phenyl)-7-(4-(trifluoromethyl...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cc(cc2cc(ccc12)-c1ccc(cc1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C25H17F3O4S/c1-33(31,32)21-9-4-16(5-10-21)23-14-19(24(29)30)13-18-12-17(6-11-22(18)23)15-2-7-20(8-3-15)25(26,27)28/h2-14H,1H3,(H,29,30)
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Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay

Bioorg Med Chem Lett 21: 2836-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.081
BindingDB Entry DOI: 10.7270/Q2NP24S4
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50543257
PNG
(CHEMBL4645216)
Show SMILES OC(=O)c1cc(-c2ccc(cc2)C23CCN(CC2)CC3)c2ccc(cc2c1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C31H26F3NO2/c32-31(33,34)26-8-1-20(2-9-26)22-5-10-27-23(17-22)18-24(29(36)37)19-28(27)21-3-6-25(7-4-21)30-11-14-35(15-12-30)16-13-30/h1-10,17-19H,11-16H2,(H,36,37)
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n/an/a 21n/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Inhibition of MRS4174 binding to mouse P2Y14R expressed in HEK293 cells pre-incubated for 30 mins before MRS4174 addition and further incubated for 3...

J Med Chem 63: 9563-9589 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00745
BindingDB Entry DOI: 10.7270/Q20R9SZP
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50456168
PNG
(CHEMBL1800685)
Show SMILES OC(=O)c1cc(-c2ccc(cc2)C2CCNCC2)c2ccc(cc2c1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C29H24F3NO2/c30-29(31,32)25-8-5-19(6-9-25)22-7-10-26-23(15-22)16-24(28(34)35)17-27(26)21-3-1-18(2-4-21)20-11-13-33-14-12-20/h1-10,15-17,20,33H,11-14H2,(H,34,35)
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n/an/a 22n/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Inhibition of MRS4174 binding to mouse P2Y14R expressed in HEK293 cells pre-incubated for 30 mins before MRS4174 addition and further incubated for 3...

J Med Chem 63: 9563-9589 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00745
BindingDB Entry DOI: 10.7270/Q20R9SZP
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50456168
PNG
(CHEMBL1800685)
Show SMILES OC(=O)c1cc(-c2ccc(cc2)C2CCNCC2)c2ccc(cc2c1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C29H24F3NO2/c30-29(31,32)25-8-5-19(6-9-25)22-7-10-26-23(15-22)16-24(28(34)35)17-27(26)21-3-1-18(2-4-21)20-11-13-33-14-12-20/h1-10,15-17,20,33H,11-14H2,(H,34,35)
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n/an/a 22n/an/an/an/an/an/a



Saint Louis University School of Medicine

Curated by ChEMBL


Assay Description
Displacement of Alexafluor488 labeled 4-(4-(1-(4-(1-(6-(4-(6-amino-3-imino-4,5-disulfo-3H-xanthen-9-yl)-3-carboxybenzamido)hexyl)-1H-1,2,3-triazol-4-...

ACS Med Chem Lett 11: 1281-1286 (2020)


Article DOI: 10.1021/acsmedchemlett.0c00115
BindingDB Entry DOI: 10.7270/Q2222Z99
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50343095
PNG
(CHEMBL1771452 | N-(3-ethylphenyl)-2-(4-fluoropheny...)
Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2C)-c2ccc(F)cc2)c1
Show InChI InChI=1S/C29H27FN4O/c1-3-20-8-6-9-23(17-20)31-29(35)34-16-15-26-25(18-34)27(24-10-5-4-7-19(24)2)33-28(32-26)21-11-13-22(30)14-12-21/h4-14,17H,3,15-16,18H2,1-2H3,(H,31,35)
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n/an/a 25n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...

Bioorg Med Chem Lett 21: 2832-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.084
BindingDB Entry DOI: 10.7270/Q20865N7
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50343876
PNG
(7-(2,6-dimethylbenzyloxy)-4-(thiophen-3-yl)-2-naph...)
Show SMILES Cc1cccc(C)c1COc1ccc2c(cc(cc2c1)C(O)=O)-c1ccsc1
Show InChI InChI=1S/C24H20O3S/c1-15-4-3-5-16(2)23(15)13-27-20-6-7-21-18(11-20)10-19(24(25)26)12-22(21)17-8-9-28-14-17/h3-12,14H,13H2,1-2H3,(H,25,26)
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n/an/a 26n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay

Bioorg Med Chem Lett 21: 2836-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.081
BindingDB Entry DOI: 10.7270/Q2NP24S4
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50584894
PNG
(CHEMBL5076127)
Show SMILES [H][C@@]12C[C@@H](c3ccc(cc3)-c3cc(cc4cc(ccc34)-c3ccc(cc3)C(F)(F)F)C(O)=O)[C@@]([H])(C1)C(=O)N2 |r|
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TBA

Assay Description
Inhibition of fluorescent antagonist binding to mouse P2Y14R expressed in HEK293 cells preincubated for 30 mins followed by addition of 6-amino-9-(2-...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01964
BindingDB Entry DOI: 10.7270/Q2611470
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50343109
PNG
(CHEMBL1771244 | N-(3-(1-fluoroethyl)phenyl)-2-(pyr...)
Show SMILES CC(F)c1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2C)-c2cccnc2)c1
Show InChI InChI=1S/C28H26FN5O/c1-18-7-3-4-11-23(18)26-24-17-34(28(35)31-22-10-5-8-20(15-22)19(2)29)14-12-25(24)32-27(33-26)21-9-6-13-30-16-21/h3-11,13,15-16,19H,12,14,17H2,1-2H3,(H,31,35)
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n/an/a 29n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...

Bioorg Med Chem Lett 21: 2832-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.084
BindingDB Entry DOI: 10.7270/Q20865N7
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50541998
PNG
(CHEMBL4642592)
Show SMILES CC(=O)N1CCC(CC1)c1ccc(cc1)-c1cc(cc2cc(ccc12)-c1ccc(cc1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C31H26F3NO3/c1-19(36)35-14-12-22(13-15-35)20-2-4-23(5-3-20)29-18-26(30(37)38)17-25-16-24(8-11-28(25)29)21-6-9-27(10-7-21)31(32,33)34/h2-11,16-18,22H,12-15H2,1H3,(H,37,38)
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National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Inhibition of MRS4174 binding to mouse P2Y14R expressed in HEK293 cells pre-incubated for 30 mins before MRS4174 addition and further incubated for 3...

J Med Chem 63: 9563-9589 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00745
BindingDB Entry DOI: 10.7270/Q20R9SZP
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50343125
PNG
(CHEMBL1771453 | N-(3-ethylphenyl)-2-(3-fluoropheny...)
Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2C)-c2cccc(F)c2)c1
Show InChI InChI=1S/C29H27FN4O/c1-3-20-9-6-12-23(16-20)31-29(35)34-15-14-26-25(18-34)27(24-13-5-4-8-19(24)2)33-28(32-26)21-10-7-11-22(30)17-21/h4-13,16-17H,3,14-15,18H2,1-2H3,(H,31,35)
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Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...

Bioorg Med Chem Lett 21: 2832-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.084
BindingDB Entry DOI: 10.7270/Q20865N7
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50541998
PNG
(CHEMBL4642592)
Show SMILES CC(=O)N1CCC(CC1)c1ccc(cc1)-c1cc(cc2cc(ccc12)-c1ccc(cc1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C31H26F3NO3/c1-19(36)35-14-12-22(13-15-35)20-2-4-23(5-3-20)29-18-26(30(37)38)17-25-16-24(8-11-28(25)29)21-6-9-27(10-7-21)31(32,33)34/h2-11,16-18,22H,12-15H2,1H3,(H,37,38)
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Saint Louis University School of Medicine

Curated by ChEMBL


Assay Description
Displacement of Alexafluor488 labeled 4-(4-(1-(4-(1-(6-(4-(6-amino-3-imino-4,5-disulfo-3H-xanthen-9-yl)-3-carboxybenzamido)hexyl)-1H-1,2,3-triazol-4-...

ACS Med Chem Lett 11: 1281-1286 (2020)


Article DOI: 10.1021/acsmedchemlett.0c00115
BindingDB Entry DOI: 10.7270/Q2222Z99
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50584891
PNG
(CHEMBL5085823)
Show SMILES [H][C@@]12C[C@H](c3ccc(cc3)-c3cc(cc4cc(ccc34)-c3ccc(cc3)C(F)(F)F)C(O)=O)[C@@]([H])(CN1)C2 |r|
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n/an/a 34n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of fluorescent antagonist binding to mouse P2Y14R expressed in HEK293 cells preincubated for 30 mins followed by addition of 6-amino-9-(2-...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01964
BindingDB Entry DOI: 10.7270/Q2611470
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50541997
PNG
(CHEMBL4649855)
Show SMILES CCC(=O)N1CCC(CC1)c1ccc(cc1)-c1cc(cc2cc(ccc12)-c1ccc(cc1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C32H28F3NO3/c1-2-30(37)36-15-13-22(14-16-36)20-3-5-23(6-4-20)29-19-26(31(38)39)18-25-17-24(9-12-28(25)29)21-7-10-27(11-8-21)32(33,34)35/h3-12,17-19,22H,2,13-16H2,1H3,(H,38,39)
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Saint Louis University School of Medicine

Curated by ChEMBL


Assay Description
Displacement of Alexafluor488 labeled 4-(4-(1-(4-(1-(6-(4-(6-amino-3-imino-4,5-disulfo-3H-xanthen-9-yl)-3-carboxybenzamido)hexyl)-1H-1,2,3-triazol-4-...

ACS Med Chem Lett 11: 1281-1286 (2020)


Article DOI: 10.1021/acsmedchemlett.0c00115
BindingDB Entry DOI: 10.7270/Q2222Z99
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50584895
PNG
(CHEMBL5076678)
Show SMILES N[C@@H]1C[C@@H]([C@H](C1)c1ccc(cc1)-c1cc(cc2cc(ccc12)-c1ccc(cc1)C(F)(F)F)C(O)=O)C(O)=O |r|
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TBA

Assay Description
Inhibition of fluorescent antagonist binding to mouse P2Y14R expressed in HEK293 cells preincubated for 30 mins followed by addition of 6-amino-9-(2-...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01964
BindingDB Entry DOI: 10.7270/Q2611470
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50584889
PNG
(CHEMBL5083773)
Show SMILES [H][C@@]12C[C@@]([H])(C[C@H]1c1ccc(cc1)-c1cc(cc3cc(ccc13)-c1ccc(cc1)C(F)(F)F)C(O)=O)C(=O)N2 |r|
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TBA

Assay Description
Inhibition of fluorescent antagonist binding to mouse P2Y14R expressed in HEK293 cells preincubated for 30 mins followed by addition of 6-amino-9-(2-...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01964
BindingDB Entry DOI: 10.7270/Q2611470
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50343121
PNG
(4-(2-chloro-6-methylphenyl)-N-(3-ethylphenyl)-2-(p...)
Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2c(C)cccc2Cl)-c2cccnc2)c1 |(33.06,-2.47,;31.72,-1.7,;30.39,-2.48,;30.4,-4.02,;29.06,-4.79,;27.73,-4.02,;27.73,-2.49,;26.4,-1.72,;25.07,-2.49,;25.07,-4.03,;23.73,-1.72,;23.73,-.17,;22.39,.61,;21.05,-.17,;19.72,.59,;18.39,-.18,;18.39,-1.72,;19.73,-2.49,;21.05,-1.72,;22.39,-2.49,;19.73,-4.02,;18.4,-4.79,;17.06,-4.02,;18.4,-6.33,;19.73,-7.1,;21.07,-6.32,;21.06,-4.78,;22.39,-4.01,;17.06,.59,;15.73,-.18,;14.39,.59,;14.39,2.13,;15.72,2.9,;17.06,2.14,;29.06,-1.71,)|
Show InChI InChI=1S/C28H26ClN5O/c1-3-19-8-5-10-21(15-19)31-28(35)34-14-12-24-22(17-34)26(25-18(2)7-4-11-23(25)29)33-27(32-24)20-9-6-13-30-16-20/h4-11,13,15-16H,3,12,14,17H2,1-2H3,(H,31,35)
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n/an/a 50n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...

Bioorg Med Chem Lett 21: 2832-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.084
BindingDB Entry DOI: 10.7270/Q20865N7
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50343122
PNG
(4-(2,6-dichlorophenyl)-N-(3-ethylphenyl)-2-(pyridi...)
Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2c(Cl)cccc2Cl)-c2cccnc2)c1 |(11.19,-15.22,;9.85,-14.45,;8.52,-15.23,;8.53,-16.78,;7.19,-17.55,;5.86,-16.78,;5.86,-15.24,;4.53,-14.47,;3.2,-15.24,;3.2,-16.78,;1.86,-14.47,;1.86,-12.92,;.52,-12.14,;-.82,-12.92,;-2.15,-12.16,;-3.48,-12.93,;-3.48,-14.48,;-2.15,-15.24,;-.82,-14.47,;.52,-15.24,;-2.14,-16.77,;-3.48,-17.54,;-4.81,-16.78,;-3.47,-19.08,;-2.14,-19.85,;-.8,-19.07,;-.81,-17.54,;.52,-16.76,;-4.81,-12.17,;-6.14,-12.94,;-7.48,-12.17,;-7.48,-10.62,;-6.15,-9.85,;-4.81,-10.62,;7.19,-14.47,)|
Show InChI InChI=1S/C27H23Cl2N5O/c1-2-17-6-3-8-19(14-17)31-27(35)34-13-11-23-20(16-34)25(24-21(28)9-4-10-22(24)29)33-26(32-23)18-7-5-12-30-15-18/h3-10,12,14-15H,2,11,13,16H2,1H3,(H,31,35)
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Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...

Bioorg Med Chem Lett 21: 2832-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.084
BindingDB Entry DOI: 10.7270/Q20865N7
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50343887
PNG
((S)-4-(4-(2,2,2-trifluoro-1-hydroxyethyl)phenyl)-7...)
Show SMILES O[C@@H](c1ccc(cc1)-c1cc(cc2cc(ccc12)-c1ccc(cc1)C(F)(F)F)C(O)=O)C(F)(F)F |r|
Show InChI InChI=1S/C26H16F6O3/c27-25(28,29)20-8-5-14(6-9-20)17-7-10-21-18(11-17)12-19(24(34)35)13-22(21)15-1-3-16(4-2-15)23(33)26(30,31)32/h1-13,23,33H,(H,34,35)/t23-/m0/s1
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n/an/a 51n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay

Bioorg Med Chem Lett 21: 2836-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.081
BindingDB Entry DOI: 10.7270/Q2NP24S4
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50343878
PNG
(4-(thiophen-3-yl)-7-(4-(trifluoromethoxy)phenyl)-2...)
Show SMILES OC(=O)c1cc(-c2ccsc2)c2ccc(cc2c1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C22H13F3O3S/c23-22(24,25)28-18-4-1-13(2-5-18)14-3-6-19-16(9-14)10-17(21(26)27)11-20(19)15-7-8-29-12-15/h1-12H,(H,26,27)
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n/an/a 54n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay

Bioorg Med Chem Lett 21: 2836-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.081
BindingDB Entry DOI: 10.7270/Q2NP24S4
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50543255
PNG
(CHEMBL4640370)
Show SMILES C[N+]12CCC(CC1)(CC2)c1ccc(cc1)-c1cc(cc2cc(ccc12)-c1ccc(cc1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C32H28F3NO2/c1-36-15-12-31(13-16-36,14-17-36)26-7-4-22(5-8-26)29-20-25(30(37)38)19-24-18-23(6-11-28(24)29)21-2-9-27(10-3-21)32(33,34)35/h2-11,18-20H,12-17H2,1H3/p+1
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n/an/a 56n/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Inhibition of MRS4174 binding to mouse P2Y14R expressed in HEK293 cells pre-incubated for 30 mins before MRS4174 addition and further incubated for 3...

J Med Chem 63: 9563-9589 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00745
BindingDB Entry DOI: 10.7270/Q20R9SZP
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50343090
PNG
(CHEMBL1771446 | N-(3-ethylphenyl)-4-o-tolyl-2-p-to...)
Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2C)-c2ccc(C)cc2)c1
Show InChI InChI=1S/C30H30N4O/c1-4-22-9-7-10-24(18-22)31-30(35)34-17-16-27-26(19-34)28(25-11-6-5-8-21(25)3)33-29(32-27)23-14-12-20(2)13-15-23/h5-15,18H,4,16-17,19H2,1-3H3,(H,31,35)
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n/an/a 62n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...

Bioorg Med Chem Lett 21: 2832-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.084
BindingDB Entry DOI: 10.7270/Q20865N7
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50343103
PNG
(CHEMBL1771238 | N-(3-ethylphenyl)-2-(pyridin-3-yl)...)
Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2C)-c2cccnc2)c1
Show InChI InChI=1S/C28H27N5O/c1-3-20-9-6-11-22(16-20)30-28(34)33-15-13-25-24(18-33)26(23-12-5-4-8-19(23)2)32-27(31-25)21-10-7-14-29-17-21/h4-12,14,16-17H,3,13,15,18H2,1-2H3,(H,30,34)
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n/an/a 81n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...

Bioorg Med Chem Lett 21: 2832-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.084
BindingDB Entry DOI: 10.7270/Q20865N7
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50343089
PNG
(CHEMBL1771445 | N-(3-ethylphenyl)-2-phenyl-4-o-tol...)
Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2C)-c2ccccc2)c1
Show InChI InChI=1S/C29H28N4O/c1-3-21-11-9-14-23(18-21)30-29(34)33-17-16-26-25(19-33)27(24-15-8-7-10-20(24)2)32-28(31-26)22-12-5-4-6-13-22/h4-15,18H,3,16-17,19H2,1-2H3,(H,30,34)
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n/an/a 87n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...

Bioorg Med Chem Lett 21: 2832-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.084
BindingDB Entry DOI: 10.7270/Q20865N7
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50584896
PNG
(CHEMBL5087295)
Show SMILES [H][C@]12CN[C@]([H])(C1)[C@@H](C2)c1ccc(cc1)-c1cc(cc2cc(ccc12)-c1ccc(cc1)C(F)(F)F)C(O)=O |r|
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n/an/a 91n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of fluorescent antagonist binding to mouse P2Y14R expressed in HEK293 cells preincubated for 30 mins followed by addition of 6-amino-9-(2-...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01964
BindingDB Entry DOI: 10.7270/Q2611470
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50584904
PNG
(CHEMBL5093465)
Show SMILES [H][C@@]12CN(C(C)=O)[C@@]([H])(C[C@@H]1c1ccc(cc1)-c1cc(cc3cc(ccc13)-c1ccc(cc1)C(F)(F)F)C(O)=O)C2 |r|
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n/an/a 102n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of fluorescent antagonist binding to mouse P2Y14R expressed in HEK293 cells preincubated for 30 mins followed by addition of 6-amino-9-(2-...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01964
BindingDB Entry DOI: 10.7270/Q2611470
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50584886
PNG
(CHEMBL5090079)
Show SMILES [H][C@@]12CC([C@@]([H])(C[C@@H]1c1ccc(cc1)-c1cc(cc3cc(ccc13)-c1ccc(cc1)C(F)(F)F)C(O)=O)C2)S(C)(=O)=O |r|
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n/an/a 103n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of fluorescent antagonist binding to mouse P2Y14R expressed in HEK293 cells preincubated for 30 mins followed by addition of 6-amino-9-(2-...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01964
BindingDB Entry DOI: 10.7270/Q2611470
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50343875
PNG
(4-(benzyloxy)-7-(2,6-dimethylbenzyloxy)-2-naphthoi...)
Show SMILES Cc1cccc(C)c1COc1ccc2c(OCc3ccccc3)cc(cc2c1)C(O)=O
Show InChI InChI=1S/C27H24O4/c1-18-7-6-8-19(2)25(18)17-30-23-11-12-24-21(14-23)13-22(27(28)29)15-26(24)31-16-20-9-4-3-5-10-20/h3-15H,16-17H2,1-2H3,(H,28,29)
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n/an/a 110n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay

Bioorg Med Chem Lett 21: 2836-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.081
BindingDB Entry DOI: 10.7270/Q2NP24S4
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50343872
PNG
(7-(2,6-dimethylbenzyloxy)-4-phenyl-2-naphthoic aci...)
Show SMILES Cc1cccc(C)c1COc1ccc2c(cc(cc2c1)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C26H22O3/c1-17-7-6-8-18(2)25(17)16-29-22-11-12-23-20(14-22)13-21(26(27)28)15-24(23)19-9-4-3-5-10-19/h3-15H,16H2,1-2H3,(H,27,28)
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n/an/a 110n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay

Bioorg Med Chem Lett 21: 2836-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.081
BindingDB Entry DOI: 10.7270/Q2NP24S4
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50456170
PNG
(CHEMBL4212441)
Show SMILES OC(=O)c1cc(-c2ccc(cc2)C2CCN(CCCCC#C)CC2)c2ccc(cc2c1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C35H32F3NO2/c1-2-3-4-5-18-39-19-16-26(17-20-39)24-6-8-27(9-7-24)33-23-30(34(40)41)22-29-21-28(12-15-32(29)33)25-10-13-31(14-11-25)35(36,37)38/h1,6-15,21-23,26H,3-5,16-20H2,(H,40,41)
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n/an/a 130n/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Inhibition of MRS4174 binding to mouse P2Y14R expressed in HEK293 cells pre-incubated for 30 mins before MRS4174 addition and further incubated for 3...

J Med Chem 63: 9563-9589 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00745
BindingDB Entry DOI: 10.7270/Q20R9SZP
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)		BDBM50456170
PNG
(CHEMBL4212441)
Show SMILES OC(=O)c1cc(-c2ccc(cc2)C2CCN(CCCCC#C)CC2)c2ccc(cc2c1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C35H32F3NO2/c1-2-3-4-5-18-39-19-16-26(17-20-39)24-6-8-27(9-7-24)33-23-30(34(40)41)22-29-21-28(12-15-32(29)33)25-10-13-31(14-11-25)35(36,37)38/h1,6-15,21-23,26H,3-5,16-20H2,(H,40,41)
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n/an/a 130n/an/an/an/an/an/a



Saint Louis University School of Medicine

Curated by ChEMBL


Assay Description
Displacement of Alexafluor488 labeled 4-(4-(1-(4-(1-(6-(4-(6-amino-3-imino-4,5-disulfo-3H-xanthen-9-yl)-3-carboxybenzamido)hexyl)-1H-1,2,3-triazol-4-...

ACS Med Chem Lett 11: 1281-1286 (2020)


Article DOI: 10.1021/acsmedchemlett.0c00115
BindingDB Entry DOI: 10.7270/Q2222Z99
More data for this
Ligand-Target Pair
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