Found 14 hits Enz. Inhib. hit(s) with Target = 'Phosphodiesterase/cAMP-specific 3',5'-cyclic phosphodiesterase 4A/cAMP-specific 3',5'-cyclic phosphodiesterase 4C/cAMP-specific 3',5'-cyclic phosphodiesterase 4D' AND taxid = 10116 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphodiesterase/cAMP-specific 3',5'-cyclic phosphodiesterase 4A/cAMP-specific 3',5'-cyclic phosphodiesterase 4C/cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Mus musculus-Mus musculus (Mouse)) | BDBM14361
((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18) | PDB
UniProtKB/SwissProt
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CHEMBL MCE PC cid PC sid PDB UniChem
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Similars
| PDB
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of [3H]-Rolipram from mouse brain homogenates |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2P84F2C |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Phosphodiesterase/cAMP-specific 3',5'-cyclic phosphodiesterase 4A/cAMP-specific 3',5'-cyclic phosphodiesterase 4C/cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Mus musculus-Mus musculus (Mouse)) | BDBM14361
((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid PDB UniChem
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| PDB
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of [3H]rolipram binding to Phosphodiesterase 4 (PDE IV) |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2T155SP |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Phosphodiesterase/cAMP-specific 3',5'-cyclic phosphodiesterase 4A/cAMP-specific 3',5'-cyclic phosphodiesterase 4C/cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Mus musculus-Mus musculus (Mouse)) | BDBM50213340
(CHEMBL58915)Show SMILES COc1ccc(cc1OC1Cc2ccccc2C1)-c1nc2cc(ccc2[nH]1)C(O)=O Show InChI InChI=1S/C24H20N2O4/c1-29-21-9-7-16(23-25-19-8-6-17(24(27)28)12-20(19)26-23)13-22(21)30-18-10-14-4-2-3-5-15(14)11-18/h2-9,12-13,18H,10-11H2,1H3,(H,25,26)(H,27,28) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| | n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of [3H]-Rolipram from mouse brain homogenates |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2P84F2C |
More data for this Ligand-Target Pair | |
Phosphodiesterase/cAMP-specific 3',5'-cyclic phosphodiesterase 4A/cAMP-specific 3',5'-cyclic phosphodiesterase 4C/cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Mus musculus-Mus musculus (Mouse)) | BDBM50213338
(CHEMBL294883)Show SMILES COc1ccc(cc1OC1CCCC1)-c1nc2cc(ccc2[nH]1)C(O)=O Show InChI InChI=1S/C20H20N2O4/c1-25-17-9-7-12(11-18(17)26-14-4-2-3-5-14)19-21-15-8-6-13(20(23)24)10-16(15)22-19/h6-11,14H,2-5H2,1H3,(H,21,22)(H,23,24) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| | n/a | n/a | 78 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of [3H]-Rolipram from mouse brain homogenates |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2P84F2C |
More data for this Ligand-Target Pair | |
Phosphodiesterase/cAMP-specific 3',5'-cyclic phosphodiesterase 4A/cAMP-specific 3',5'-cyclic phosphodiesterase 4C/cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Mus musculus-Mus musculus (Mouse)) | BDBM50213341
(CHEMBL59269)Show SMILES COc1ccc(cc1OC1CC2CCC1C2)-c1nc2cc(ccc2[nH]1)C(O)=O |THB:8:9:15:13.12| Show InChI InChI=1S/C22H22N2O4/c1-27-18-7-5-14(11-20(18)28-19-9-12-2-3-13(19)8-12)21-23-16-6-4-15(22(25)26)10-17(16)24-21/h4-7,10-13,19H,2-3,8-9H2,1H3,(H,23,24)(H,25,26) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| | n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of [3H]-Rolipram from mouse brain homogenates |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2P84F2C |
More data for this Ligand-Target Pair | |
Phosphodiesterase/cAMP-specific 3',5'-cyclic phosphodiesterase 4A/cAMP-specific 3',5'-cyclic phosphodiesterase 4C/cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Mus musculus-Mus musculus (Mouse)) | BDBM50213339
(CHEMBL291537)Show SMILES COc1ccc(cc1OCCc1ccccc1)-c1nc2cc(ccc2[nH]1)C(O)=O Show InChI InChI=1S/C23H20N2O4/c1-28-20-10-8-16(14-21(20)29-12-11-15-5-3-2-4-6-15)22-24-18-9-7-17(23(26)27)13-19(18)25-22/h2-10,13-14H,11-12H2,1H3,(H,24,25)(H,26,27) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| | n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of [3H]-Rolipram from mouse brain homogenates |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2P84F2C |
More data for this Ligand-Target Pair | |
Phosphodiesterase/cAMP-specific 3',5'-cyclic phosphodiesterase 4A/cAMP-specific 3',5'-cyclic phosphodiesterase 4C/cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Mus musculus-Mus musculus (Mouse)) | BDBM50213335
(CHEMBL60985)Show SMILES COc1ccc(\C=C2/C(=O)Nc3ccccc23)cc1OC1CC2CCC1C2 |THB:19:20:26:24.23| Show InChI InChI=1S/C23H23NO3/c1-26-20-9-7-15(11-18-17-4-2-3-5-19(17)24-23(18)25)13-22(20)27-21-12-14-6-8-16(21)10-14/h2-5,7,9,11,13-14,16,21H,6,8,10,12H2,1H3,(H,24,25)/b18-11- | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| | n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of [3H]rolipram binding to Phosphodiesterase 4 (PDE IV) |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2T155SP |
More data for this Ligand-Target Pair | |
Phosphodiesterase/cAMP-specific 3',5'-cyclic phosphodiesterase 4A/cAMP-specific 3',5'-cyclic phosphodiesterase 4C/cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Mus musculus-Mus musculus (Mouse)) | BDBM50213299
(CHEMBL291838)Show SMILES COc1ccc(\C=C2\C(=O)Nc3ccccc23)cc1OC1CC2CCC1C2 |THB:19:20:26:24.23| Show InChI InChI=1S/C23H23NO3/c1-26-20-9-7-15(11-18-17-4-2-3-5-19(17)24-23(18)25)13-22(20)27-21-12-14-6-8-16(21)10-14/h2-5,7,9,11,13-14,16,21H,6,8,10,12H2,1H3,(H,24,25)/b18-11+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| | n/a | n/a | 4.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of [3H]rolipram binding to Phosphodiesterase 4 (PDE IV) |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2T155SP |
More data for this Ligand-Target Pair | |
Phosphodiesterase/cAMP-specific 3',5'-cyclic phosphodiesterase 4A/cAMP-specific 3',5'-cyclic phosphodiesterase 4C/cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Mus musculus-Mus musculus (Mouse)) | BDBM50213337
(CHEMBL60073)Show SMILES COc1ccc(cc1OCc1ccccc1)-c1nc2cc(ccc2[nH]1)C(O)=O Show InChI InChI=1S/C22H18N2O4/c1-27-19-10-8-15(12-20(19)28-13-14-5-3-2-4-6-14)21-23-17-9-7-16(22(25)26)11-18(17)24-21/h2-12H,13H2,1H3,(H,23,24)(H,25,26) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| | n/a | n/a | 5.91E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of [3H]-Rolipram from mouse brain homogenates |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2P84F2C |
More data for this Ligand-Target Pair | |
Phosphodiesterase/cAMP-specific 3',5'-cyclic phosphodiesterase 4A/cAMP-specific 3',5'-cyclic phosphodiesterase 4C/cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Mus musculus-Mus musculus (Mouse)) | BDBM50213301
(CHEMBL61884)Show SMILES COc1ccc(\C=C2/C(=O)Nc3ccc(Br)cc23)cc1OC1CC2CCC1C2 |THB:20:21:27:25.24| Show InChI InChI=1S/C23H22BrNO3/c1-27-20-7-3-14(11-22(20)28-21-10-13-2-4-15(21)8-13)9-18-17-12-16(24)5-6-19(17)25-23(18)26/h3,5-7,9,11-13,15,21H,2,4,8,10H2,1H3,(H,25,26)/b18-9- | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| | n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of [3H]rolipram binding to Phosphodiesterase 4 (PDE IV) |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2T155SP |
More data for this Ligand-Target Pair | |
Phosphodiesterase/cAMP-specific 3',5'-cyclic phosphodiesterase 4A/cAMP-specific 3',5'-cyclic phosphodiesterase 4C/cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Mus musculus-Mus musculus (Mouse)) | BDBM50213300
(CHEMBL294606)Show SMILES COc1ccc(\C=C2/C(=O)N(C)c3ccc(Br)cc23)cc1OC1CC2CCC1C2 |THB:21:22:28:26.25| Show InChI InChI=1S/C24H24BrNO3/c1-26-20-7-6-17(25)13-18(20)19(24(26)27)10-15-4-8-21(28-2)23(12-15)29-22-11-14-3-5-16(22)9-14/h4,6-8,10,12-14,16,22H,3,5,9,11H2,1-2H3/b19-10- | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| | n/a | n/a | 5.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of [3H]rolipram binding to Phosphodiesterase 4 (PDE IV) |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2T155SP |
More data for this Ligand-Target Pair | |
Phosphodiesterase/cAMP-specific 3',5'-cyclic phosphodiesterase 4A/cAMP-specific 3',5'-cyclic phosphodiesterase 4C/cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Mus musculus-Mus musculus (Mouse)) | BDBM50213336
(CHEMBL60007)Show SMILES COc1ccc(\C=C2/C(=O)N(C)c3ccc(Cl)cc23)cc1OC1CC2CCC1C2 |THB:21:22:28:26.25| Show InChI InChI=1S/C24H24ClNO3/c1-26-20-7-6-17(25)13-18(20)19(24(26)27)10-15-4-8-21(28-2)23(12-15)29-22-11-14-3-5-16(22)9-14/h4,6-8,10,12-14,16,22H,3,5,9,11H2,1-2H3/b19-10- | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| | n/a | n/a | 5.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of [3H]rolipram binding to Phosphodiesterase 4 (PDE IV) |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2T155SP |
More data for this Ligand-Target Pair | |
Phosphodiesterase/cAMP-specific 3',5'-cyclic phosphodiesterase 4A/cAMP-specific 3',5'-cyclic phosphodiesterase 4C/cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Mus musculus-Mus musculus (Mouse)) | BDBM50213298
(CHEMBL59408)Show SMILES COc1ccc(\C=C2/C(=O)Nc3ccc(cc23)[N+]([O-])=O)cc1OC1CC2CCC1C2 |THB:22:23:29:27.26| Show InChI InChI=1S/C23H22N2O5/c1-29-20-7-3-14(11-22(20)30-21-10-13-2-4-15(21)8-13)9-18-17-12-16(25(27)28)5-6-19(17)24-23(18)26/h3,5-7,9,11-13,15,21H,2,4,8,10H2,1H3,(H,24,26)/b18-9- | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| | n/a | n/a | 6.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of [3H]rolipram binding to Phosphodiesterase 4 (PDE IV) |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2T155SP |
More data for this Ligand-Target Pair | |
Phosphodiesterase/cAMP-specific 3',5'-cyclic phosphodiesterase 4A/cAMP-specific 3',5'-cyclic phosphodiesterase 4C/cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Mus musculus-Mus musculus (Mouse)) | BDBM50213302
(CHEMBL60060)Show SMILES COc1ccc(\C=C2\C(=O)N(C)c3ccc(cc23)[N+]([O-])=O)cc1OC1CC2CCC1C2 |THB:23:24:30:28.27| Show InChI InChI=1S/C24H24N2O5/c1-25-20-7-6-17(26(28)29)13-18(20)19(24(25)27)10-15-4-8-21(30-2)23(12-15)31-22-11-14-3-5-16(22)9-14/h4,6-8,10,12-14,16,22H,3,5,9,11H2,1-2H3/b19-10+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| | n/a | n/a | 6.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of [3H]rolipram binding to Phosphodiesterase 4 (PDE IV) |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2T155SP |
More data for this Ligand-Target Pair | |