Found 33 hits Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5' AND taxid = 9606 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5
(Homo sapiens (Human)) | BDBM25077
(6-{[(5Z)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-y...)Show SMILES FC(F)(F)c1ccc(CCN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)cc1 Show InChI InChI=1S/C21H15F3N2O3S2/c22-21(23,24)14-4-1-12(2-5-14)7-8-26-15-9-13(3-6-16(15)29-11-18(26)27)10-17-19(28)25-20(30)31-17/h1-6,9-10H,7-8,11H2,(H,25,28,30)/b17-10- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.92 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer
| Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa... |
Bioorg Med Chem Lett 17: 756-60 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5
(Homo sapiens (Human)) | BDBM25073
(4-[2-(4-bromophenyl)ethyl]-6-{[(5Z)-4-oxo-2-sulfan...)Show SMILES Brc1ccc(CCN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)cc1 Show InChI InChI=1S/C20H15BrN2O3S2/c21-14-4-1-12(2-5-14)7-8-23-15-9-13(3-6-16(15)26-11-18(23)24)10-17-19(25)22-20(27)28-17/h1-6,9-10H,7-8,11H2,(H,22,25,27)/b17-10- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.34 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer
| Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa... |
Bioorg Med Chem Lett 17: 756-60 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5
(Homo sapiens (Human)) | BDBM25061
(4-[(4-tert-butylphenyl)methyl]-6-{[(5Z)-4-oxo-2-su...)Show SMILES CC(C)(C)c1ccc(CN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)cc1 Show InChI InChI=1S/C23H22N2O3S2/c1-23(2,3)16-7-4-14(5-8-16)12-25-17-10-15(6-9-18(17)28-13-20(25)26)11-19-21(27)24-22(29)30-19/h4-11H,12-13H2,1-3H3,(H,24,27,29)/b19-11- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.42 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer
| Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa... |
Bioorg Med Chem Lett 17: 756-60 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5
(Homo sapiens (Human)) | BDBM25066
(4-[(3,4-dimethylphenyl)methyl]-6-{[(5Z)-4-oxo-2-su...)Show SMILES Cc1ccc(CN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)cc1C Show InChI InChI=1S/C21H18N2O3S2/c1-12-3-4-15(7-13(12)2)10-23-16-8-14(5-6-17(16)26-11-19(23)24)9-18-20(25)22-21(27)28-18/h3-9H,10-11H2,1-2H3,(H,22,25,27)/b18-9- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.59 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer
| Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa... |
Bioorg Med Chem Lett 17: 756-60 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5
(Homo sapiens (Human)) | BDBM25068
(4-[2-(3,5-dimethylphenyl)ethyl]-6-{[(5Z)-4-oxo-2-s...)Show SMILES Cc1cc(C)cc(CCN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)c1 Show InChI InChI=1S/C22H20N2O3S2/c1-13-7-14(2)9-16(8-13)5-6-24-17-10-15(3-4-18(17)27-12-20(24)25)11-19-21(26)23-22(28)29-19/h3-4,7-11H,5-6,12H2,1-2H3,(H,23,26,28)/b19-11- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.65 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer
| Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa... |
Bioorg Med Chem Lett 17: 756-60 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5
(Homo sapiens (Human)) | BDBM25080
(4-[2-(3-methoxyphenyl)ethyl]-6-{[(5Z)-4-oxo-2-sulf...)Show SMILES COc1cccc(CCN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)c1 Show InChI InChI=1S/C21H18N2O4S2/c1-26-15-4-2-3-13(9-15)7-8-23-16-10-14(5-6-17(16)27-12-19(23)24)11-18-20(25)22-21(28)29-18/h2-6,9-11H,7-8,12H2,1H3,(H,22,25,28)/b18-11- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.66 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer
| Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa... |
Bioorg Med Chem Lett 17: 756-60 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5
(Homo sapiens (Human)) | BDBM25069
(4-[2-(3,5-dimethoxyphenyl)ethyl]-6-{[(5Z)-4-oxo-2-...)Show SMILES COc1cc(CCN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)cc(OC)c1 Show InChI InChI=1S/C22H20N2O5S2/c1-27-15-7-14(8-16(11-15)28-2)5-6-24-17-9-13(3-4-18(17)29-12-20(24)25)10-19-21(26)23-22(30)31-19/h3-4,7-11H,5-6,12H2,1-2H3,(H,23,26,30)/b19-10- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.79 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer
| Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa... |
Bioorg Med Chem Lett 17: 756-60 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5
(Homo sapiens (Human)) | BDBM25074
(4-[2-(3-chlorophenyl)ethyl]-6-{[(5Z)-4-oxo-2-sulfa...)Show SMILES Clc1cccc(CCN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)c1 Show InChI InChI=1S/C20H15ClN2O3S2/c21-14-3-1-2-12(8-14)6-7-23-15-9-13(4-5-16(15)26-11-18(23)24)10-17-19(25)22-20(27)28-17/h1-5,8-10H,6-7,11H2,(H,22,25,27)/b17-10- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.27 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer
| Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa... |
Bioorg Med Chem Lett 17: 756-60 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5
(Homo sapiens (Human)) | BDBM25078
(4-[2-(2,4-dichlorophenyl)ethyl]-6-{[(5Z)-4-oxo-2-s...)Show SMILES Clc1ccc(CCN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)c(Cl)c1 Show InChI InChI=1S/C20H14Cl2N2O3S2/c21-13-3-2-12(14(22)9-13)5-6-24-15-7-11(1-4-16(15)27-10-18(24)25)8-17-19(26)23-20(28)29-17/h1-4,7-9H,5-6,10H2,(H,23,26,28)/b17-8- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.28 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer
| Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa... |
Bioorg Med Chem Lett 17: 756-60 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5
(Homo sapiens (Human)) | BDBM25075
(4-[2-(3,4-dichlorophenyl)ethyl]-6-{[(5Z)-4-oxo-2-s...)Show SMILES Clc1ccc(CCN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)cc1Cl Show InChI InChI=1S/C20H14Cl2N2O3S2/c21-13-3-1-11(7-14(13)22)5-6-24-15-8-12(2-4-16(15)27-10-18(24)25)9-17-19(26)23-20(28)29-17/h1-4,7-9H,5-6,10H2,(H,23,26,28)/b17-9- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.36 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer
| Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa... |
Bioorg Med Chem Lett 17: 756-60 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5
(Homo sapiens (Human)) | BDBM25070
(4-[2-(4-chlorophenyl)ethyl]-6-{[(5Z)-4-oxo-2-sulfa...)Show SMILES Clc1ccc(CCN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)cc1 Show InChI InChI=1S/C20H15ClN2O3S2/c21-14-4-1-12(2-5-14)7-8-23-15-9-13(3-6-16(15)26-11-18(23)24)10-17-19(25)22-20(27)28-17/h1-6,9-10H,7-8,11H2,(H,22,25,27)/b17-10- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.76 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer
| Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa... |
Bioorg Med Chem Lett 17: 756-60 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5
(Homo sapiens (Human)) | BDBM25081
(4-[2-(3,4-difluorophenyl)ethyl]-6-{[(5Z)-4-oxo-2-s...)Show SMILES Fc1ccc(CCN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)cc1F Show InChI InChI=1S/C20H14F2N2O3S2/c21-13-3-1-11(7-14(13)22)5-6-24-15-8-12(2-4-16(15)27-10-18(24)25)9-17-19(26)23-20(28)29-17/h1-4,7-9H,5-6,10H2,(H,23,26,28)/b17-9- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.84 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer
| Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa... |
Bioorg Med Chem Lett 17: 756-60 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5
(Homo sapiens (Human)) | BDBM25079
(4-[2-(3-methylphenyl)ethyl]-6-{[(5Z)-4-oxo-2-sulfa...)Show SMILES Cc1cccc(CCN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)c1 Show InChI InChI=1S/C21H18N2O3S2/c1-13-3-2-4-14(9-13)7-8-23-16-10-15(5-6-17(16)26-12-19(23)24)11-18-20(25)22-21(27)28-18/h2-6,9-11H,7-8,12H2,1H3,(H,22,25,27)/b18-11- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.96 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer
| Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa... |
Bioorg Med Chem Lett 17: 756-60 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5
(Homo sapiens (Human)) | BDBM25071
(4-[2-(4-methoxyphenyl)ethyl]-6-{[(5Z)-4-oxo-2-sulf...)Show SMILES COc1ccc(CCN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)cc1 Show InChI InChI=1S/C21H18N2O4S2/c1-26-15-5-2-13(3-6-15)8-9-23-16-10-14(4-7-17(16)27-12-19(23)24)11-18-20(25)22-21(28)29-18/h2-7,10-11H,8-9,12H2,1H3,(H,22,25,28)/b18-11- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.57 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer
| Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa... |
Bioorg Med Chem Lett 17: 756-60 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5
(Homo sapiens (Human)) | BDBM25062
(4-[(4-chlorophenyl)methyl]-6-{[(5Z)-4-oxo-2-sulfan...)Show SMILES Clc1ccc(CN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)cc1 Show InChI InChI=1S/C19H13ClN2O3S2/c20-13-4-1-11(2-5-13)9-22-14-7-12(3-6-15(14)25-10-17(22)23)8-16-18(24)21-19(26)27-16/h1-8H,9-10H2,(H,21,24,26)/b16-8- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.16 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer
| Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa... |
Bioorg Med Chem Lett 17: 756-60 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5
(Homo sapiens (Human)) | BDBM21036
((2R,3S,6Z,14S,15S,17R)-6-({[3-(dimethylamino)propy...)Show SMILES COC[C@H]1OC(=O)C(=CN(C)CCCN(C)C)C2C(=O)C(=O)C3=C([C@@H](C[C@]4(C)[C@@H](O)CCC34)OC(C)=O)[C@@]12C |r,w:8.8,t:22| Show InChI InChI=1S/C29H42N2O8/c1-16(32)38-19-13-28(2)18(9-10-20(28)33)22-24(19)29(3)21(15-37-7)39-27(36)17(23(29)26(35)25(22)34)14-31(6)12-8-11-30(4)5/h14,18-21,23,33H,8-13,15H2,1-7H3/t18?,19-,20+,21-,23?,28+,29+/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Wyeth Research
| Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. |
J Med Chem 51: 1319-23 (2008)
Article DOI: 10.1021/jm7012858
BindingDB Entry DOI: 10.7270/Q2NP22QD |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5
(Homo sapiens (Human)) | BDBM25072
(4-[2-(4-methylphenyl)ethyl]-6-{[(5Z)-4-oxo-2-sulfa...)Show SMILES Cc1ccc(CCN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)cc1 Show InChI InChI=1S/C21H18N2O3S2/c1-13-2-4-14(5-3-13)8-9-23-16-10-15(6-7-17(16)26-12-19(23)24)11-18-20(25)22-21(27)28-18/h2-7,10-11H,8-9,12H2,1H3,(H,22,25,27)/b18-11- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.83 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer
| Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa... |
Bioorg Med Chem Lett 17: 756-60 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5
(Homo sapiens (Human)) | BDBM15234
((1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-...)Show SMILES [H][C@@]12CCC(=O)[C@@]1(C)C[C@@H](OC(C)=O)C1=C2C(=O)c2occ3c2[C@]1(C)[C@@H](COC)OC3=O |r,c:15| Show InChI InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
KEGG
PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
PDB
Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer
| Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa... |
Bioorg Med Chem Lett 17: 756-60 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5
(Homo sapiens (Human)) | BDBM25059
(4-benzyl-6-{[(5Z)-4-oxo-2-sulfanylidene-1,3-thiazo...)Show SMILES O=C1NC(=S)S\C1=C/c1ccc2OCC(=O)N(Cc3ccccc3)c2c1 Show InChI InChI=1S/C19H14N2O3S2/c22-17-11-24-15-7-6-13(9-16-18(23)20-19(25)26-16)8-14(15)21(17)10-12-4-2-1-3-5-12/h1-9H,10-11H2,(H,20,23,25)/b16-9- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer
| Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa... |
Bioorg Med Chem Lett 17: 756-60 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5
(Homo sapiens (Human)) | BDBM25067
(6-{[(5Z)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-y...)Show SMILES O=C1NC(=S)S\C1=C/c1ccc2OCC(=O)N(CCc3ccccc3)c2c1 Show InChI InChI=1S/C20H16N2O3S2/c23-18-12-25-16-7-6-14(11-17-19(24)21-20(26)27-17)10-15(16)22(18)9-8-13-4-2-1-3-5-13/h1-7,10-11H,8-9,12H2,(H,21,24,26)/b17-11- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 24.5 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer
| Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa... |
Bioorg Med Chem Lett 17: 756-60 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5
(Homo sapiens (Human)) | BDBM25064
(6-{[(5Z)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-y...)Show SMILES FC(F)(F)c1ccc(CN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)cc1 Show InChI InChI=1S/C20H13F3N2O3S2/c21-20(22,23)13-4-1-11(2-5-13)9-25-14-7-12(3-6-15(14)28-10-17(25)26)8-16-18(27)24-19(29)30-16/h1-8H,9-10H2,(H,24,27,29)/b16-8- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 27.5 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer
| Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa... |
Bioorg Med Chem Lett 17: 756-60 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5
(Homo sapiens (Human)) | BDBM25060
(4-[(4-methylphenyl)methyl]-6-{[(5Z)-4-oxo-2-sulfan...)Show SMILES Cc1ccc(CN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)cc1 Show InChI InChI=1S/C20H16N2O3S2/c1-12-2-4-13(5-3-12)10-22-15-8-14(6-7-16(15)25-11-18(22)23)9-17-19(24)21-20(26)27-17/h2-9H,10-11H2,1H3,(H,21,24,26)/b17-9- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 29.5 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer
| Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa... |
Bioorg Med Chem Lett 17: 756-60 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5
(Homo sapiens (Human)) | BDBM25076
(4-[2-(4-tert-butylphenyl)ethyl]-6-{[(5Z)-4-oxo-2-s...)Show SMILES CC(C)(C)c1ccc(CCN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)cc1 Show InChI InChI=1S/C24H24N2O3S2/c1-24(2,3)17-7-4-15(5-8-17)10-11-26-18-12-16(6-9-19(18)29-14-21(26)27)13-20-22(28)25-23(30)31-20/h4-9,12-13H,10-11,14H2,1-3H3,(H,25,28,30)/b20-13- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 33.2 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer
| Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa... |
Bioorg Med Chem Lett 17: 756-60 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5
(Homo sapiens (Human)) | BDBM25063
(4-[(3-oxo-6-{[(5Z)-4-oxo-2-sulfanylidene-1,3-thiaz...)Show SMILES O=C1NC(=S)S\C1=C/c1ccc2OCC(=O)N(Cc3ccc(cc3)C#N)c2c1 Show InChI InChI=1S/C20H13N3O3S2/c21-9-12-1-3-13(4-2-12)10-23-15-7-14(5-6-16(15)26-11-18(23)24)8-17-19(25)22-20(27)28-17/h1-8H,10-11H2,(H,22,25,27)/b17-8- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 36.1 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer
| Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa... |
Bioorg Med Chem Lett 17: 756-60 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5
(Homo sapiens (Human)) | BDBM25065
(4-[(3-methylphenyl)methyl]-6-{[(5Z)-4-oxo-2-sulfan...)Show SMILES Cc1cccc(CN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)c1 Show InChI InChI=1S/C20H16N2O3S2/c1-12-3-2-4-14(7-12)10-22-15-8-13(5-6-16(15)25-11-18(22)23)9-17-19(24)21-20(26)27-17/h2-9H,10-11H2,1H3,(H,21,24,26)/b17-9- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 43.7 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer
| Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa... |
Bioorg Med Chem Lett 17: 756-60 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5
(Homo sapiens (Human)) | BDBM25058
((5Z)-5-[(3-hydroxy-5-methoxyphenyl)methylidene]-2-...)Show InChI InChI=1S/C11H9NO3S2/c1-15-8-3-6(2-7(13)5-8)4-9-10(14)12-11(16)17-9/h2-5,13H,1H3,(H,12,14,16)/b9-4- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 77.7 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer
| Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa... |
Bioorg Med Chem Lett 17: 756-60 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5
(Homo sapiens (Human)) | BDBM50533531
(CHEMBL4555071)Show SMILES CS(=O)(=O)N1CCN(CC1)C(=O)c1ccc(Nc2nc(cc(n2)-c2cnc(N)cc2C(F)(F)F)N2CCOCC2)cc1 Show InChI InChI=1S/C26H29F3N8O4S/c1-42(39,40)37-8-6-36(7-9-37)24(38)17-2-4-18(5-3-17)32-25-33-21(15-23(34-25)35-10-12-41-13-11-35)19-16-31-22(30)14-20(19)26(27,28)29/h2-5,14-16H,6-13H2,1H3,(H2,30,31)(H,32,33,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University
Curated by ChEMBL
| Assay Description
Inhibition of PI3K p110gamma/p101 (unknown origin) using PIP2/ATP as substrate after 1 hr by kinase glo luminescent assay |
J Med Chem 59: 7268-74 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00235
BindingDB Entry DOI: 10.7270/Q2F76H2F |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5
(Homo sapiens (Human)) | BDBM50233666
(CHEMBL4097625)Show SMILES COc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1)-c1ccc2ncn([C@H]3CCN(C3)C(=O)C3CC3)c(=O)c2c1 |r| Show InChI InChI=1S/C28H26FN5O5S/c1-39-26-25(32-40(37,38)22-7-5-20(29)6-8-22)13-19(14-30-26)18-4-9-24-23(12-18)28(36)34(16-31-24)21-10-11-33(15-21)27(35)17-2-3-17/h4-9,12-14,16-17,21,32H,2-3,10-11,15H2,1H3/t21-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 116 | n/a | n/a | n/a | n/a | n/a | n/a |
Xi'an Jiaotong University
Curated by ChEMBL
| Assay Description
Inhibition of P110gamma/PIK3R5 (unknown origin) using L-alpha-phosphatidylinositol as substrate after 40 mins by ATP depletion assay |
Bioorg Med Chem 23: 7765-76 (2015)
Article DOI: 10.1016/j.bmc.2015.11.027
BindingDB Entry DOI: 10.7270/Q2222X19 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5
(Homo sapiens (Human)) | BDBM50380363
(CHEMBL2017974 | US10173995, Compound 1)Show SMILES Nc1cc(c(cn1)-c1cc(nc(n1)N1CCOCC1)N1CCOCC1)C(F)(F)F Show InChI InChI=1S/C18H21F3N6O2/c19-18(20,21)13-9-15(22)23-11-12(13)14-10-16(26-1-5-28-6-2-26)25-17(24-14)27-3-7-29-8-4-27/h9-11H,1-8H2,(H2,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 129 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University
Curated by ChEMBL
| Assay Description
Inhibition of PI3K p110gamma/p101 (unknown origin) using PIP2/ATP as substrate after 1 hr by kinase glo luminescent assay |
J Med Chem 59: 7268-74 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00235
BindingDB Entry DOI: 10.7270/Q2F76H2F |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5
(Homo sapiens (Human)) | BDBM50533532
(CHEMBL4446205)Show SMILES [H][C@]12CN(C[C@]1([H])OCCO2)c1nc(cc(n1)-c1cnc(N)cc1C(F)(F)F)N1CCOCC1 |r| Show InChI InChI=1S/C20H23F3N6O3/c21-20(22,23)13-7-17(24)25-9-12(13)14-8-18(28-1-3-30-4-2-28)27-19(26-14)29-10-15-16(11-29)32-6-5-31-15/h7-9,15-16H,1-6,10-11H2,(H2,24,25)/t15-,16-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 158 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University
Curated by ChEMBL
| Assay Description
Inhibition of PI3K p110gamma/p101 (unknown origin) using PIP2/ATP as substrate after 1 hr by kinase glo luminescent assay |
J Med Chem 59: 7268-74 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00235
BindingDB Entry DOI: 10.7270/Q2F76H2F |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5
(Homo sapiens (Human)) | BDBM92862
(US9284315, BEZ-235 | mTOR Inhibitor, BEZ235)Show SMILES Cn1c2cnc3ccc(cc3c2n(-c2ccc(cc2)C(C)(C)C#N)c1=O)-c1cnc2ccccc2c1 Show InChI InChI=1S/C30H23N5O/c1-30(2,18-31)22-9-11-23(12-10-22)35-28-24-15-19(21-14-20-6-4-5-7-25(20)32-16-21)8-13-26(24)33-17-27(28)34(3)29(35)36/h4-17H,1-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 169 | n/a | n/a | n/a | n/a | n/a | n/a |
Xi'an Jiaotong University
Curated by ChEMBL
| Assay Description
Inhibition of P110gamma/PIK3R5 (unknown origin) using L-alpha-phosphatidylinositol as substrate after 40 mins by ATP depletion assay |
Bioorg Med Chem 23: 7765-76 (2015)
Article DOI: 10.1016/j.bmc.2015.11.027
BindingDB Entry DOI: 10.7270/Q2222X19 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5
(Homo sapiens (Human)) | BDBM50233667
(CHEMBL4088969)Show SMILES COc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1)-c1ccc2ncn([C@H]3CCN(CC4CC4)C3)c(=O)c2c1 |r| Show InChI InChI=1S/C28H28FN5O4S/c1-38-27-26(32-39(36,37)23-7-5-21(29)6-8-23)13-20(14-30-27)19-4-9-25-24(12-19)28(35)34(17-31-25)22-10-11-33(16-22)15-18-2-3-18/h4-9,12-14,17-18,22,32H,2-3,10-11,15-16H2,1H3/t22-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 181 | n/a | n/a | n/a | n/a | n/a | n/a |
Xi'an Jiaotong University
Curated by ChEMBL
| Assay Description
Inhibition of P110gamma/PIK3R5 (unknown origin) using L-alpha-phosphatidylinositol as substrate after 40 mins by ATP depletion assay |
Bioorg Med Chem 23: 7765-76 (2015)
Article DOI: 10.1016/j.bmc.2015.11.027
BindingDB Entry DOI: 10.7270/Q2222X19 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5
(Homo sapiens (Human)) | BDBM12915
(2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |...)Show InChI InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2 | PDB
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| DrugBank
PDB
Article
PubMed
| n/a | n/a | 1.72E+3 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer
| Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa... |
Bioorg Med Chem Lett 17: 756-60 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N |
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Ligand-Target Pair |
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