Compile Data Set for Download or QSAR

Found 262 hits Enz. Inhib. hit(s) with Target = 'Plasminogen' AND taxid = 10090   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasminogen (Mus musculus)	BDBM50499241 (CHEMBL3735513) Show SMILES [H][C@@]12CCCN1C(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC1CCN(CC1)C(N)=N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC2=O)C(O)=O |r| Show InChI InChI=1S/C56H84N16O11S2/c1-31(2)25-39-49(77)69-42(27-35-15-9-6-10-16-35)51(79)70-43(54(82)83)30-85-84-29-37(57)53(81)72-22-12-18-44(72)52(80)64-33(4)45(73)65-38(17-11-21-62-55(58)59)47(75)67-41(26-34-13-7-5-8-14-34)50(78)68-40(48(76)63-32(3)46(74)66-39)28-36-19-23-71(24-20-36)56(60)61/h5-10,13-16,31-33,36-44H,11-12,17-30,57H2,1-4H3,(H3,60,61)(H,63,76)(H,64,80)(H,65,73)(H,66,74)(H,67,75)(H,68,78)(H,69,77)(H,70,79)(H,82,83)(H4,58,59,62)/t32-,33-,37-,38-,39-,40-,41-,42-,43-,44-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	2.97E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aarhus University Curated by ChEMBL					Assay Description Inhibition of mouse plasmin after 15 mins using H-D-Ile-Pro-Arg-p-nitroanilide as substrate				J Med Chem 58: 8868-76 (2015) Article DOI: 10.1021/acs.jmedchem.5b01128 BindingDB Entry DOI: 10.7270/Q2XK8JH7
					More data for this Ligand-Target Pair
Plasminogen (Mus musculus)	BDBM50499237 (CHEMBL3735217) Show SMILES [H][C@@]12CCCN1C(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC1CCN(CC1)C(N)=N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC2=O)C(O)=O |r| Show InChI InChI=1S/C59H91N17O11S2/c1-34(2)28-42-52(81)73-45(30-37-16-8-5-9-17-37)54(83)74-46(57(86)87)33-89-88-32-39(61)56(85)76-25-13-20-47(76)55(84)69-40(18-10-11-23-60)49(78)68-41(19-12-24-66-58(62)63)50(79)71-44(29-36-14-6-4-7-15-36)53(82)72-43(51(80)67-35(3)48(77)70-42)31-38-21-26-75(27-22-38)59(64)65/h4-9,14-17,34-35,38-47H,10-13,18-33,60-61H2,1-3H3,(H3,64,65)(H,67,80)(H,68,78)(H,69,84)(H,70,77)(H,71,79)(H,72,82)(H,73,81)(H,74,83)(H,86,87)(H4,62,63,66)/t35-,39-,40-,41-,42-,43-,44-,45-,46-,47-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	3.42E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aarhus University Curated by ChEMBL					Assay Description Inhibition of mouse plasmin after 15 mins using H-D-Ile-Pro-Arg-p-nitroanilide as substrate				J Med Chem 58: 8868-76 (2015) Article DOI: 10.1021/acs.jmedchem.5b01128 BindingDB Entry DOI: 10.7270/Q2XK8JH7
					More data for this Ligand-Target Pair
Plasminogen (Mus musculus)	BDBM50499238 (CHEMBL3735263) Show SMILES [H][C@@]12CCCN1C(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC1CCN(CC1)C(N)=N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC2=O)C(O)=O |r| Show InChI InChI=1S/C58H85N17O11S2/c1-31(2)24-41-51(80)72-44(27-36-28-65-39-15-9-8-14-37(36)39)53(82)73-45(56(85)86)30-88-87-29-38(59)55(84)75-21-11-17-46(75)54(83)67-33(4)47(76)68-40(16-10-20-64-57(60)61)49(78)70-43(25-34-12-6-5-7-13-34)52(81)71-42(50(79)66-32(3)48(77)69-41)26-35-18-22-74(23-19-35)58(62)63/h5-9,12-15,28,31-33,35,38,40-46,65H,10-11,16-27,29-30,59H2,1-4H3,(H3,62,63)(H,66,79)(H,67,83)(H,68,76)(H,69,77)(H,70,78)(H,71,81)(H,72,80)(H,73,82)(H,85,86)(H4,60,61,64)/t32-,33-,38-,40-,41-,42-,43-,44-,45-,46-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	3.67E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aarhus University Curated by ChEMBL					Assay Description Inhibition of mouse plasmin after 15 mins using H-D-Ile-Pro-Arg-p-nitroanilide as substrate				J Med Chem 58: 8868-76 (2015) Article DOI: 10.1021/acs.jmedchem.5b01128 BindingDB Entry DOI: 10.7270/Q2XK8JH7
					More data for this Ligand-Target Pair
Plasminogen (Mus musculus)	BDBM50531924 (CHEMBL4464577) Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CSSC[C@H](NC(=O)CNC1=O)C(O)=O |r| Show InChI InChI=1S/C49H71N13O14S2/c1-4-25(2)39-46(73)54-21-38(66)56-36(48(75)76)24-78-77-23-31(50)47(74)62-18-6-8-37(62)45(72)55-26(3)40(67)58-33(19-27-9-13-29(64)14-10-27)42(69)60-35(22-63)44(71)57-32(7-5-17-53-49(51)52)41(68)59-34(43(70)61-39)20-28-11-15-30(65)16-12-28/h9-16,25-26,31-37,39,63-65H,4-8,17-24,50H2,1-3H3,(H,54,73)(H,55,72)(H,56,66)(H,57,71)(H,58,67)(H,59,68)(H,60,69)(H,61,70)(H,75,76)(H4,51,52,53)/t25-,26-,31-,32-,33-,34-,35-,36-,37-,39-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of mouse plasmin preincubated for 15 mins followed by chromogenic substrate addition				J Med Chem 62: 2172-2183 (2019) Article DOI: 10.1021/acs.jmedchem.8b01908 BindingDB Entry DOI: 10.7270/Q24F1V6R
					More data for this Ligand-Target Pair
Plasminogen (Mus musculus)	BDBM50531926 (CHEMBL4550668) Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CSSC[C@H](NC(=O)CNC1=O)C(N)=O)NC(C)=O |r| Show InChI InChI=1S/C51H74N14O14S2/c1-5-26(2)41-49(78)56-22-40(70)59-37(42(52)71)24-80-81-25-38(58-28(4)67)50(79)65-19-7-9-39(65)48(77)57-27(3)43(72)61-34(20-29-10-14-31(68)15-11-29)45(74)63-36(23-66)47(76)60-33(8-6-18-55-51(53)54)44(73)62-35(46(75)64-41)21-30-12-16-32(69)17-13-30/h10-17,26-27,33-39,41,66,68-69H,5-9,18-25H2,1-4H3,(H2,52,71)(H,56,78)(H,57,77)(H,58,67)(H,59,70)(H,60,76)(H,61,72)(H,62,73)(H,63,74)(H,64,75)(H4,53,54,55)/t26-,27-,33-,34-,35-,36-,37-,38-,39-,41-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of mouse plasmin preincubated for 15 mins followed by chromogenic substrate addition				J Med Chem 62: 2172-2183 (2019) Article DOI: 10.1021/acs.jmedchem.8b01908 BindingDB Entry DOI: 10.7270/Q24F1V6R
					More data for this Ligand-Target Pair
Plasminogen (Mus musculus)	BDBM50531925 (CHEMBL4522772) Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC1=O)C(N)=O)NC(C)=O |r| Show InChI InChI=1S/C53H76N14O16S2/c1-26(2)19-34-46(77)64-37(22-42(72)73)49(80)66-39(43(54)74)24-84-85-25-40(59-28(4)69)52(83)67-18-6-8-41(67)51(82)58-27(3)44(75)61-35(20-29-9-13-31(70)14-10-29)48(79)65-38(23-68)50(81)60-33(7-5-17-57-53(55)56)45(76)63-36(47(78)62-34)21-30-11-15-32(71)16-12-30/h9-16,26-27,33-41,68,70-71H,5-8,17-25H2,1-4H3,(H2,54,74)(H,58,82)(H,59,69)(H,60,81)(H,61,75)(H,62,78)(H,63,76)(H,64,77)(H,65,79)(H,66,80)(H,72,73)(H4,55,56,57)/t27-,33-,34-,35-,36-,37-,38-,39-,40-,41-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of mouse plasmin preincubated for 15 mins followed by chromogenic substrate addition				J Med Chem 62: 2172-2183 (2019) Article DOI: 10.1021/acs.jmedchem.8b01908 BindingDB Entry DOI: 10.7270/Q24F1V6R
					More data for this Ligand-Target Pair
Plasminogen (Mus musculus)	BDBM50499240 (CHEMBL3735080) Show SMILES [H][C@@]12CCCN1C(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC1CCN(CC1)C(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC2=O)C(O)=O |r| Show InChI InChI=1S/C54H77N13O16S2/c1-27(2)19-35-45(74)63-39(23-43(71)72)49(78)65-41(53(82)83)26-85-84-25-34(55)52(81)67-16-4-5-42(67)51(80)58-28(3)44(73)59-36(20-29-6-10-32(69)11-7-29)48(77)64-40(24-68)50(79)62-38(22-31-14-17-66(18-15-31)54(56)57)47(76)61-37(46(75)60-35)21-30-8-12-33(70)13-9-30/h6-13,27-28,31,34-42,68-70H,4-5,14-26,55H2,1-3H3,(H3,56,57)(H,58,80)(H,59,73)(H,60,75)(H,61,76)(H,62,79)(H,63,74)(H,64,77)(H,65,78)(H,71,72)(H,82,83)/t28-,34-,35-,36-,37-,38-,39-,40-,41-,42-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aarhus University Curated by ChEMBL					Assay Description Inhibition of mouse plasmin after 15 mins using H-D-Ile-Pro-Arg-p-nitroanilide as substrate				J Med Chem 58: 8868-76 (2015) Article DOI: 10.1021/acs.jmedchem.5b01128 BindingDB Entry DOI: 10.7270/Q2XK8JH7
					More data for this Ligand-Target Pair
Plasminogen (Mus musculus)	BDBM50499239 (CHEMBL3734777) Show SMILES [H][C@@]12CCCN1C(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC2=O)C(O)=O |r| Show InChI InChI=1S/C51H73N13O16S2/c1-25(2)18-33-43(72)61-36(21-40(68)69)46(75)63-38(50(79)80)24-82-81-23-31(52)49(78)64-17-5-7-39(64)48(77)56-26(3)41(70)58-34(19-27-8-12-29(66)13-9-27)45(74)62-37(22-65)47(76)57-32(6-4-16-55-51(53)54)42(71)60-35(44(73)59-33)20-28-10-14-30(67)15-11-28/h8-15,25-26,31-39,65-67H,4-7,16-24,52H2,1-3H3,(H,56,77)(H,57,76)(H,58,70)(H,59,73)(H,60,71)(H,61,72)(H,62,74)(H,63,75)(H,68,69)(H,79,80)(H4,53,54,55)/t26-,31-,32-,33-,34-,35-,36-,37-,38-,39-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aarhus University Curated by ChEMBL					Assay Description Inhibition of mouse plasmin after 15 mins using H-D-Ile-Pro-Arg-p-nitroanilide as substrate				J Med Chem 58: 8868-76 (2015) Article DOI: 10.1021/acs.jmedchem.5b01128 BindingDB Entry DOI: 10.7270/Q2XK8JH7
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM264615 (US9718760, C182) Show SMILES CCCCCCCN(S(=O)(=O)c1ccc(O)c(O)c1)S(=O)(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C19H25NO8S2/c1-2-3-4-5-6-11-20(29(25,26)14-7-9-16(21)18(23)12-14)30(27,28)15-8-10-17(22)19(24)13-15/h7-10,12-13,21-24H,2-6,11H2,1H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	7.4	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM264650 (US9718760, C204) Show SMILES Oc1ccc(cc1O)C(=O)OCC(CNS(=O)(=O)c1cccc(c1)C(F)(F)F)OC(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C24H20F3NO10S/c25-24(26,27)15-2-1-3-17(10-15)39(35,36)28-11-16(38-23(34)14-5-7-19(30)21(32)9-14)12-37-22(33)13-4-6-18(29)20(31)8-13/h1-10,16,28-32H,11-12H2	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	35	n/a	n/a	n/a	n/a	7.4	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM264630 (US9718760, C198) Show SMILES Oc1ccc(CCNS(=O)(=O)c2ccc(O)c(O)c2)cc1O Show InChI InChI=1S/C14H15NO6S/c16-11-3-1-9(7-13(11)18)5-6-15-22(20,21)10-2-4-12(17)14(19)8-10/h1-4,7-8,15-19H,5-6H2	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	51	n/a	n/a	n/a	n/a	7.4	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM264611 (US9718760, C188) Show SMILES CCCCCCc1ccc(cc1)N(S(=O)(=O)c1ccc(O)c(O)c1)S(=O)(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C24H27NO8S2/c1-2-3-4-5-6-17-7-9-18(10-8-17)25(34(30,31)19-11-13-21(26)23(28)15-19)35(32,33)20-12-14-22(27)24(29)16-20/h7-16,26-29H,2-6H2,1H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	7.4	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM264602 (US9718760, C197) Show SMILES Oc1ccc(CCN(S(=O)(=O)c2ccccc2)S(=O)(=O)c2ccc(O)c(O)c2)cc1O Show InChI InChI=1S/C20H19NO8S2/c22-17-8-6-14(12-19(17)24)10-11-21(30(26,27)15-4-2-1-3-5-15)31(28,29)16-7-9-18(23)20(25)13-16/h1-9,12-13,22-25H,10-11H2	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	173	n/a	n/a	n/a	n/a	7.4	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM264616 (US9718760, C183) Show SMILES CCCCCCCCCN(S(=O)(=O)c1ccc(O)c(O)c1)S(=O)(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C21H29NO8S2/c1-2-3-4-5-6-7-8-13-22(31(27,28)16-9-11-18(23)20(25)14-16)32(29,30)17-10-12-19(24)21(26)15-17/h9-12,14-15,23-26H,2-8,13H2,1H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	180	n/a	n/a	n/a	n/a	7.4	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM264613 (US9718760, C157) Show SMILES CCCCCCCCCCN(S(=O)(=O)c1ccc(O)c(O)c1)S(=O)(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C22H31NO8S2/c1-2-3-4-5-6-7-8-9-14-23(32(28,29)17-10-12-19(24)21(26)15-17)33(30,31)18-11-13-20(25)22(27)16-18/h10-13,15-16,24-27H,2-9,14H2,1H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	250	n/a	n/a	n/a	n/a	7.4	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM264609 (US9718760, C163) Show SMILES Oc1ccc(cc1O)S(=O)(=O)N(c1cccc(c1)C(F)(F)F)S(=O)(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C19H14F3NO8S2/c20-19(21,22)11-2-1-3-12(8-11)23(32(28,29)13-4-6-15(24)17(26)9-13)33(30,31)14-5-7-16(25)18(27)10-14/h1-10,24-27H	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	288	n/a	n/a	n/a	n/a	7.4	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM264610 (US9718760, C165) Show SMILES Oc1ccc(cc1O)S(=O)(=O)N(c1ccc(cc1)-c1ccccc1)S(=O)(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C24H19NO8S2/c26-21-12-10-19(14-23(21)28)34(30,31)25(35(32,33)20-11-13-22(27)24(29)15-20)18-8-6-17(7-9-18)16-4-2-1-3-5-16/h1-15,26-29H	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	350	n/a	n/a	n/a	n/a	7.4	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM264645 (US9718760, C185) Show SMILES CCCCCCCCCN(CCN(CCCCCCCCC)S(=O)(=O)c1ccc(O)c(O)c1)S(=O)(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C32H52N2O8S2/c1-3-5-7-9-11-13-15-21-33(43(39,40)27-17-19-29(35)31(37)25-27)23-24-34(22-16-14-12-10-8-6-4-2)44(41,42)28-18-20-30(36)32(38)26-28/h17-20,25-26,35-38H,3-16,21-24H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	420	n/a	n/a	n/a	n/a	7.4	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM264646 (US9718760, C196) Show SMILES CCCCCCCCCCN(CCN(C)S(=O)(=O)c1ccc(O)c(O)c1)S(=O)(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C25H38N2O8S2/c1-3-4-5-6-7-8-9-10-15-27(37(34,35)21-12-14-23(29)25(31)19-21)17-16-26(2)36(32,33)20-11-13-22(28)24(30)18-20/h11-14,18-19,28-31H,3-10,15-17H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	450	n/a	n/a	n/a	n/a	7.4	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM264610 (US9718760, C165) Show SMILES Oc1ccc(cc1O)S(=O)(=O)N(c1ccc(cc1)-c1ccccc1)S(=O)(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C24H19NO8S2/c26-21-12-10-19(14-23(21)28)34(30,31)25(35(32,33)20-11-13-22(27)24(29)15-20)18-8-6-17(7-9-18)16-4-2-1-3-5-16/h1-15,26-29H	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	510	n/a	n/a	n/a	n/a	n/a	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description PAI-1 inhibitor compounds were dissolved in DMSO to a final concentration of (10-50 mM), depending upon solubility. Compounds were then diluted in ph...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM264644 (US9718760, C184) Show SMILES CCCCCCCN(CCN(CCCCCCC)S(=O)(=O)c1ccc(O)c(O)c1)S(=O)(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C28H44N2O8S2/c1-3-5-7-9-11-17-29(39(35,36)23-13-15-25(31)27(33)21-23)19-20-30(18-12-10-8-6-4-2)40(37,38)24-14-16-26(32)28(34)22-24/h13-16,21-22,31-34H,3-12,17-20H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	590	n/a	n/a	n/a	n/a	7.4	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM264609 (US9718760, C163) Show SMILES Oc1ccc(cc1O)S(=O)(=O)N(c1cccc(c1)C(F)(F)F)S(=O)(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C19H14F3NO8S2/c20-19(21,22)11-2-1-3-12(8-11)23(32(28,29)13-4-6-15(24)17(26)9-13)33(30,31)14-5-7-16(25)18(27)10-14/h1-10,24-27H	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	611	n/a	n/a	n/a	n/a	n/a	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description PAI-1 inhibitor compounds were dissolved in DMSO to a final concentration of (10-50 mM), depending upon solubility. Compounds were then diluted in ph...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM264643 (US9718760, C176) Show SMILES CCCCCCCCN(CCN(CCCCCCCC)S(=O)(=O)c1ccc(O)c(O)c1)S(=O)(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C30H48N2O8S2/c1-3-5-7-9-11-13-19-31(41(37,38)25-15-17-27(33)29(35)23-25)21-22-32(20-14-12-10-8-6-4-2)42(39,40)26-16-18-28(34)30(36)24-26/h15-18,23-24,33-36H,3-14,19-22H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	620	n/a	n/a	n/a	n/a	7.4	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM264607 (US9718760, C153) Show SMILES Oc1ccc(cc1O)S(=O)(=O)N(c1ccccc1)S(=O)(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C18H15NO8S2/c20-15-8-6-13(10-17(15)22)28(24,25)19(12-4-2-1-3-5-12)29(26,27)14-7-9-16(21)18(23)11-14/h1-11,20-23H	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	700	n/a	n/a	n/a	n/a	7.4	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM264628 (US9718760, C187) Show SMILES CCCCCCc1ccc(NS(=O)(=O)c2ccc(O)c(O)c2)cc1 Show InChI InChI=1S/C18H23NO4S/c1-2-3-4-5-6-14-7-9-15(10-8-14)19-24(22,23)16-11-12-17(20)18(21)13-16/h7-13,19-21H,2-6H2,1H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	910	n/a	n/a	n/a	n/a	7.4	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM264612 (US9718760, C195) Show SMILES CCCCCCCCCCCCc1ccc(cc1)N(S(=O)(=O)c1ccc(O)c(O)c1)S(=O)(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C30H39NO8S2/c1-2-3-4-5-6-7-8-9-10-11-12-23-13-15-24(16-14-23)31(40(36,37)25-17-19-27(32)29(34)21-25)41(38,39)26-18-20-28(33)30(35)22-26/h13-22,32-35H,2-12H2,1H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	920	n/a	n/a	n/a	n/a	7.4	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM264613 (US9718760, C157) Show SMILES CCCCCCCCCCN(S(=O)(=O)c1ccc(O)c(O)c1)S(=O)(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C22H31NO8S2/c1-2-3-4-5-6-7-8-9-14-23(32(28,29)17-10-12-19(24)21(26)15-17)33(30,31)18-11-13-20(25)22(27)16-18/h10-13,15-16,24-27H,2-9,14H2,1H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	980	n/a	n/a	n/a	n/a	n/a	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description PAI-1 inhibitor compounds were dissolved in DMSO to a final concentration of (10-50 mM), depending upon solubility. Compounds were then diluted in ph...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM264607 (US9718760, C153) Show SMILES Oc1ccc(cc1O)S(=O)(=O)N(c1ccccc1)S(=O)(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C18H15NO8S2/c20-15-8-6-13(10-17(15)22)28(24,25)19(12-4-2-1-3-5-12)29(26,27)14-7-9-16(21)18(23)11-14/h1-11,20-23H	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.02E+3	n/a	n/a	n/a	n/a	n/a	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description PAI-1 inhibitor compounds were dissolved in DMSO to a final concentration of (10-50 mM), depending upon solubility. Compounds were then diluted in ph...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM264601 (US9718760, C191) Show SMILES CCCCCCCCN(S(=O)(=O)c1ccc(CCCCC)cc1)S(=O)(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C25H37NO6S2/c1-3-5-7-8-9-11-19-26(34(31,32)23-17-18-24(27)25(28)20-23)33(29,30)22-15-13-21(14-16-22)12-10-6-4-2/h13-18,20,27-28H,3-12,19H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.28E+3	n/a	n/a	n/a	n/a	7.4	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM264623 (US9718760, C180) Show SMILES CCCCCCCCN(CCCCCC)S(=O)(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C20H35NO4S/c1-3-5-7-9-10-12-16-21(15-11-8-6-4-2)26(24,25)18-13-14-19(22)20(23)17-18/h13-14,17,22-23H,3-12,15-16H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.34E+3	n/a	n/a	n/a	n/a	7.4	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM264614 (US9718760, C158) Show SMILES CCCCCCCCCCCCN(S(=O)(=O)c1ccc(O)c(O)c1)S(=O)(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C24H35NO8S2/c1-2-3-4-5-6-7-8-9-10-11-16-25(34(30,31)19-12-14-21(26)23(28)17-19)35(32,33)20-13-15-22(27)24(29)18-20/h12-15,17-18,26-29H,2-11,16H2,1H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.44E+3	n/a	n/a	n/a	n/a	n/a	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description PAI-1 inhibitor compounds were dissolved in DMSO to a final concentration of (10-50 mM), depending upon solubility. Compounds were then diluted in ph...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM264597 (US9718760, C152) Show SMILES CCCCCCCCN(S(=O)(=O)c1ccc(O)c(O)c1)S(=O)(=O)c1cc(F)c(O)c(F)c1 Show InChI InChI=1S/C20H25F2NO7S2/c1-2-3-4-5-6-7-10-23(31(27,28)14-8-9-18(24)19(25)13-14)32(29,30)15-11-16(21)20(26)17(22)12-15/h8-9,11-13,24-26H,2-7,10H2,1H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.57E+3	n/a	n/a	n/a	n/a	7.4	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen (Mus musculus)	BDBM50467212 (CHEMBL4285028) Show SMILES CC[C@@H](Oc1nc(Oc2cc(C)cc(c2)-c2cccc(CN)c2)c(F)cc1F)C(O)=O |r| Show InChI InChI=1S/C23H22F2N2O4/c1-3-20(23(28)29)31-22-19(25)11-18(24)21(27-22)30-17-8-13(2)7-16(10-17)15-6-4-5-14(9-15)12-26/h4-11,20H,3,12,26H2,1-2H3,(H,28,29)/t20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abdulaziz University for Health Sciences Curated by ChEMBL					Assay Description Inhibition of mouse plasmin				Bioorg Med Chem Lett 28: 3372-3375 (2018) Article DOI: 10.1016/j.bmcl.2018.09.001 BindingDB Entry DOI: 10.7270/Q24Q7XNF
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM264618 (US9718760, C171) Show SMILES CCCCCCN(CCCCCC)S(=O)(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C18H31NO4S/c1-3-5-7-9-13-19(14-10-8-6-4-2)24(22,23)16-11-12-17(20)18(21)15-16/h11-12,15,20-21H,3-10,13-14H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.67E+3	n/a	n/a	n/a	n/a	7.4	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM264597 (US9718760, C152) Show SMILES CCCCCCCCN(S(=O)(=O)c1ccc(O)c(O)c1)S(=O)(=O)c1cc(F)c(O)c(F)c1 Show InChI InChI=1S/C20H25F2NO7S2/c1-2-3-4-5-6-7-10-23(31(27,28)14-8-9-18(24)19(25)13-14)32(29,30)15-11-16(21)20(26)17(22)12-15/h8-9,11-13,24-26H,2-7,10H2,1H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.71E+3	n/a	n/a	n/a	n/a	n/a	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description PAI-1 inhibitor compounds were dissolved in DMSO to a final concentration of (10-50 mM), depending upon solubility. Compounds were then diluted in ph...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM264635 (US9718760, C271) Show SMILES OC(=O)CCCCCNS(=O)(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C12H17NO6S/c14-10-6-5-9(8-11(10)15)20(18,19)13-7-3-1-2-4-12(16)17/h5-6,8,13-15H,1-4,7H2,(H,16,17)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.82E+3	n/a	n/a	n/a	n/a	7.4	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM264619 (US9718760, C172) Show SMILES CCCCCCCCN(Cc1cc(Cl)c(O)c(Cl)c1)S(=O)(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C21H27Cl2NO5S/c1-2-3-4-5-6-7-10-24(14-15-11-17(22)21(27)18(23)12-15)30(28,29)16-8-9-19(25)20(26)13-16/h8-9,11-13,25-27H,2-7,10,14H2,1H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.98E+3	n/a	n/a	n/a	n/a	7.4	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM264642 (US9718760, C168) Show SMILES CCCCCCCCCCN(CCN(CCCCCCCCCC)S(=O)(=O)c1ccc(O)c(O)c1)S(=O)(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C34H56N2O8S2/c1-3-5-7-9-11-13-15-17-23-35(45(41,42)29-19-21-31(37)33(39)27-29)25-26-36(24-18-16-14-12-10-8-6-4-2)46(43,44)30-20-22-32(38)34(40)28-30/h19-22,27-28,37-40H,3-18,23-26H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.98E+3	n/a	n/a	n/a	n/a	7.4	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM264648 (US9718760, C161) Show SMILES CCCCCCCCNC(=O)c1cc(O)c(O)c(O)c1 Show InChI InChI=1S/C15H23NO4/c1-2-3-4-5-6-7-8-16-15(20)11-9-12(17)14(19)13(18)10-11/h9-10,17-19H,2-8H2,1H3,(H,16,20)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.21E+3	n/a	n/a	n/a	n/a	n/a	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description PAI-1 inhibitor compounds were dissolved in DMSO to a final concentration of (10-50 mM), depending upon solubility. Compounds were then diluted in ph...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM264600 (US9718760, C189) Show SMILES CCCCCCc1ccc(cc1)N(S(=O)(=O)c1ccc(CCC)cc1)S(=O)(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C27H33NO6S2/c1-3-5-6-7-9-22-10-14-23(15-11-22)28(36(33,34)25-18-19-26(29)27(30)20-25)35(31,32)24-16-12-21(8-4-2)13-17-24/h10-20,29-30H,3-9H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.29E+3	n/a	n/a	n/a	n/a	7.4	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM264622 (US9718760, C179) Show SMILES CCCCCCCCN(Cc1cccc(c1)C(F)(F)F)S(=O)(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C22H28F3NO4S/c1-2-3-4-5-6-7-13-26(16-17-9-8-10-18(14-17)22(23,24)25)31(29,30)19-11-12-20(27)21(28)15-19/h8-12,14-15,27-28H,2-7,13,16H2,1H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	7.4	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM264614 (US9718760, C158) Show SMILES CCCCCCCCCCCCN(S(=O)(=O)c1ccc(O)c(O)c1)S(=O)(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C24H35NO8S2/c1-2-3-4-5-6-7-8-9-10-11-16-25(34(30,31)19-12-14-21(26)23(28)17-19)35(32,33)20-13-15-22(27)24(29)18-20/h12-15,17-18,26-29H,2-11,16H2,1H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	7.4	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM264648 (US9718760, C161) Show SMILES CCCCCCCCNC(=O)c1cc(O)c(O)c(O)c1 Show InChI InChI=1S/C15H23NO4/c1-2-3-4-5-6-7-8-16-15(20)11-9-12(17)14(19)13(18)10-11/h9-10,17-19H,2-8H2,1H3,(H,16,20)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	7.4	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM264608 (US9718760, C162) Show SMILES Oc1ccc(cc1O)S(=O)(=O)N(CCc1ccccn1)S(=O)(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C19H18N2O8S2/c22-16-6-4-14(11-18(16)24)30(26,27)21(10-8-13-3-1-2-9-20-13)31(28,29)15-5-7-17(23)19(25)12-15/h1-7,9,11-12,22-25H,8,10H2	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	7.4	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM264603 (US9718760, C224) Show SMILES CCCCCCCCN(S(=O)(=O)c1ccc(O)cc1)S(=O)(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C20H27NO7S2/c1-2-3-4-5-6-7-14-21(29(25,26)17-10-8-16(22)9-11-17)30(27,28)18-12-13-19(23)20(24)15-18/h8-13,15,22-24H,2-7,14H2,1H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.34E+3	n/a	n/a	n/a	n/a	7.4	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen (Mus musculus)	BDBM50228412 (CHEMBL393979 | methyl 1-(bis(4-acetamidophenoxy)ph...) Show SMILES [#6]-[#8]-[#6](=O)-[#7]-[#6](-[#6]-c1ccc(cc1)\[#7]=[#6](\[#7])-[#7])P(=O)([#8]-c1ccc(-[#7]-[#6](-[#6])=O)cc1)[#8]-c1ccc(-[#7]-[#6](-[#6])=O)cc1 Show InChI InChI=1S/C27H31N6O7P/c1-17(34)30-20-8-12-23(13-9-20)39-41(37,40-24-14-10-21(11-15-24)31-18(2)35)25(33-27(36)38-3)16-19-4-6-22(7-5-19)32-26(28)29/h4-15,25H,16H2,1-3H3,(H,30,34)(H,31,35)(H,33,36)(H4,28,29,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of mouse plasmin				J Med Chem 50: 6638-46 (2007) Article DOI: 10.1021/jm700962j BindingDB Entry DOI: 10.7270/Q2MW2J0J
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM264660 (US9718760, C206) Show SMILES Oc1ccc(\C=C2/SC(=O)N(Cc3cccc(Br)c3)C2=O)cc1O Show InChI InChI=1S/C17H12BrNO4S/c18-12-3-1-2-11(6-12)9-19-16(22)15(24-17(19)23)8-10-4-5-13(20)14(21)7-10/h1-8,20-21H,9H2/b15-8-	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.96E+3	n/a	n/a	n/a	n/a	7.4	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM264626 (US9718760, C205) Show SMILES Oc1ccc(cc1O)S(=O)(=O)N1CCc2ccccc12 Show InChI InChI=1S/C14H13NO4S/c16-13-6-5-11(9-14(13)17)20(18,19)15-8-7-10-3-1-2-4-12(10)15/h1-6,9,16-17H,7-8H2	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.05E+3	n/a	n/a	n/a	n/a	7.4	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM264621 (US9718760, C177) Show SMILES CCCCCCCCN(Cc1cccc(Cl)c1)S(=O)(=O)c1ccc(O)c(O)c1 Show InChI InChI=1S/C21H28ClNO4S/c1-2-3-4-5-6-7-13-23(16-17-9-8-10-18(22)14-17)28(26,27)19-11-12-20(24)21(25)15-19/h8-12,14-15,24-25H,2-7,13,16H2,1H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.11E+3	n/a	n/a	n/a	n/a	7.4	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair
Plasminogen activator inhibitor 1/Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM264658 (US9718760, C199) Show SMILES Oc1ccc(\C=C2/SC(=O)N(Cc3ccccc3)C2=O)cc1O Show InChI InChI=1S/C17H13NO4S/c19-13-7-6-12(8-14(13)20)9-15-16(21)18(17(22)23-15)10-11-4-2-1-3-5-11/h1-9,19-20H,10H2/b15-9-	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.36E+3	n/a	n/a	n/a	n/a	7.4	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent					Assay Description To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...				US Patent US9718760 (2017) BindingDB Entry DOI: 10.7270/Q2K939HK
					More data for this Ligand-Target Pair

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