Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Progesterone receptor (Rattus norvegicus) | BDBM18656 ((2R,5S)-4-[4-cyano-3-(trifluoromethyl)phenyl]-2,5-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc. | Assay Description The Ki values were determined by the application of the Cheng-Prusoff equation: Ki=IC50/(1+[L]/Kd] where [L] is the concentration of labeled ligand a... | J Med Chem 49: 716-26 (2006) Article DOI: 10.1021/jm050293c BindingDB Entry DOI: 10.7270/Q2P84952 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Progesterone receptor (Rattus norvegicus) | BDBM18525 (Bicalutamide | CHEMBL409 | N-[4-cyano-3-(trifluoro...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 7.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc. | Assay Description The Ki values were determined by the application of the Cheng-Prusoff equation: Ki=IC50/(1+[L]/Kd] where [L] is the concentration of labeled ligand a... | J Med Chem 49: 716-26 (2006) Article DOI: 10.1021/jm050293c BindingDB Entry DOI: 10.7270/Q2P84952 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Progesterone receptor (Rattus norvegicus) | BDBM50366382 (CHEMBL57078) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of [3H]R5020 binding to cytosolic progesterone receptor (PRc) of rat uterus | Bioorg Med Chem Lett 5: 1899-1902 (1995) Article DOI: 10.1016/0960-894X(95)00320-S BindingDB Entry DOI: 10.7270/Q2KP82N5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Progesterone receptor (Rattus norvegicus) | BDBM18627 ((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article | n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of [3H]R5020 binding to cytosolic progesterone receptor (PRc) of rat uterus | Bioorg Med Chem Lett 5: 1899-1902 (1995) Article DOI: 10.1016/0960-894X(95)00320-S BindingDB Entry DOI: 10.7270/Q2KP82N5 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Progesterone receptor (Rattus norvegicus) | BDBM50366381 (CHEMBL301446) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of [3H]R5020 binding to cytosolic progesterone receptor (PRc) of rat uterus | Bioorg Med Chem Lett 5: 1899-1902 (1995) Article DOI: 10.1016/0960-894X(95)00320-S BindingDB Entry DOI: 10.7270/Q2KP82N5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Progesterone receptor (Rattus norvegicus) | BDBM50126158 (3-fluoro-5-(2'-thioxo-1',2'-dihydrospiro[cyclohexa...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 7.43 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Inhibitory progestational activity on oral administration in uterine C3 model | Bioorg Med Chem Lett 13: 1317-20 (2003) BindingDB Entry DOI: 10.7270/Q2WS8SNP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Progesterone receptor (Rattus norvegicus) | BDBM50366380 (CHEMBL56509) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of [3H]R5020 binding to cytosolic progesterone receptor (PRc) of rat uterus | Bioorg Med Chem Lett 5: 1899-1902 (1995) Article DOI: 10.1016/0960-894X(95)00320-S BindingDB Entry DOI: 10.7270/Q2KP82N5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Progesterone receptor (Rattus norvegicus) | BDBM50067678 ((6alpha)-17-(Acetyloxy)-6-methylpreg-4-ene-3,20-di...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 67.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Inhibitory progestational activity on oral administration in uterine C3 model | Bioorg Med Chem Lett 13: 1317-20 (2003) BindingDB Entry DOI: 10.7270/Q2WS8SNP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Progesterone receptor (Rattus norvegicus) | BDBM50404222 (CHEMBL417475) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 92.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Effective concnetration against Androgen receptor in mouse fibroblast L929 cells | Bioorg Med Chem Lett 13: 1317-20 (2003) BindingDB Entry DOI: 10.7270/Q2WS8SNP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Progesterone receptor (Rattus norvegicus) | BDBM50375837 (CHEMBL270976) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 942 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Effective concentration of progesterone receptor agonist induction of alkaline phosphatase activity in human T47D breast carcinoma cells | Bioorg Med Chem Lett 13: 1317-20 (2003) BindingDB Entry DOI: 10.7270/Q2WS8SNP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Progesterone receptor (Rattus norvegicus) | BDBM50404229 (CHEMBL24089) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.12E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Inhibitory progestational activity on oral administration in uterine C3 model | Bioorg Med Chem Lett 13: 1317-20 (2003) BindingDB Entry DOI: 10.7270/Q2WS8SNP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Progesterone receptor (Rattus norvegicus) | BDBM50107347 ((+)5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 126 | n/a | n/a | n/a | n/a |
Forschungszentrum Dresden-Rossendorf e.V. Curated by ChEMBL | Assay Description Binding affinity to progesterone receptor | Bioorg Med Chem Lett 17: 4035-9 (2007) Article DOI: 10.1016/j.bmcl.2007.04.094 BindingDB Entry DOI: 10.7270/Q25X2CRN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Progesterone receptor (Rattus norvegicus) | BDBM18627 ((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 16 | n/a | n/a | n/a | n/a |
Forschungszentrum Dresden-Rossendorf e.V. Curated by ChEMBL | Assay Description Binding affinity to progesterone receptor | Bioorg Med Chem Lett 17: 4035-9 (2007) Article DOI: 10.1016/j.bmcl.2007.04.094 BindingDB Entry DOI: 10.7270/Q25X2CRN | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |