BindingDB PrimarySearch

Found 13 hits Enz. Inhib. hit(s) with Target = 'Progesterone receptor' AND taxid = 10116
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Progesterone receptor (Rattus norvegicus)	BDBM18656 ((2R,5S)-4-[4-cyano-3-(trifluoromethyl)phenyl]-2,5-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc.					Assay Description The Ki values were determined by the application of the Cheng-Prusoff equation: Ki=IC50/(1+[L]/Kd] where [L] is the concentration of labeled ligand a...				J Med Chem 49: 716-26 (2006) Article DOI: 10.1021/jm050293c BindingDB Entry DOI: 10.7270/Q2P84952
Astellas Pharma Inc.					More data for this Ligand-Target Pair
Progesterone receptor (Rattus norvegicus)	BDBM18525 (Bicalutamide \| CHEMBL409 \| N-[4-cyano-3-(trifluoro...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	7.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc.					Assay Description The Ki values were determined by the application of the Cheng-Prusoff equation: Ki=IC50/(1+[L]/Kd] where [L] is the concentration of labeled ligand a...				J Med Chem 49: 716-26 (2006) Article DOI: 10.1021/jm050293c BindingDB Entry DOI: 10.7270/Q2P84952
Astellas Pharma Inc.					More data for this Ligand-Target Pair
Progesterone receptor (Rattus norvegicus)	BDBM50366382 (CHEMBL57078) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of [3H]R5020 binding to cytosolic progesterone receptor (PRc) of rat uterus				Bioorg Med Chem Lett 5: 1899-1902 (1995) Article DOI: 10.1016/0960-894X(95)00320-S BindingDB Entry DOI: 10.7270/Q2KP82N5
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Progesterone receptor (Rattus norvegicus)	BDBM18627 ((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of [3H]R5020 binding to cytosolic progesterone receptor (PRc) of rat uterus				Bioorg Med Chem Lett 5: 1899-1902 (1995) Article DOI: 10.1016/0960-894X(95)00320-S BindingDB Entry DOI: 10.7270/Q2KP82N5
TBA Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Progesterone receptor (Rattus norvegicus)	BDBM50366381 (CHEMBL301446) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of [3H]R5020 binding to cytosolic progesterone receptor (PRc) of rat uterus				Bioorg Med Chem Lett 5: 1899-1902 (1995) Article DOI: 10.1016/0960-894X(95)00320-S BindingDB Entry DOI: 10.7270/Q2KP82N5
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Progesterone receptor (Rattus norvegicus)	BDBM50126158 (3-fluoro-5-(2'-thioxo-1',2'-dihydrospiro[cyclohexa...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	7.43	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibitory progestational activity on oral administration in uterine C3 model				Bioorg Med Chem Lett 13: 1317-20 (2003) BindingDB Entry DOI: 10.7270/Q2WS8SNP
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Progesterone receptor (Rattus norvegicus)	BDBM50366380 (CHEMBL56509) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of [3H]R5020 binding to cytosolic progesterone receptor (PRc) of rat uterus				Bioorg Med Chem Lett 5: 1899-1902 (1995) Article DOI: 10.1016/0960-894X(95)00320-S BindingDB Entry DOI: 10.7270/Q2KP82N5
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Progesterone receptor (Rattus norvegicus)	BDBM50067678 ((6alpha)-17-(Acetyloxy)-6-methylpreg-4-ene-3,20-di...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	67.3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibitory progestational activity on oral administration in uterine C3 model				Bioorg Med Chem Lett 13: 1317-20 (2003) BindingDB Entry DOI: 10.7270/Q2WS8SNP
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Progesterone receptor (Rattus norvegicus)	BDBM50404222 (CHEMBL417475) Show SMILES S=C1Nc2ccc(cc2C11CCCCC1)-c1ccc(s1)C#N Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	92.5	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Effective concnetration against Androgen receptor in mouse fibroblast L929 cells				Bioorg Med Chem Lett 13: 1317-20 (2003) BindingDB Entry DOI: 10.7270/Q2WS8SNP
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Progesterone receptor (Rattus norvegicus)	BDBM50375837 (CHEMBL270976) Show SMILES S=C1Nc2ccc(cc2C11CCCCC1)-c1cccc(c1)C#N Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	942	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Effective concentration of progesterone receptor agonist induction of alkaline phosphatase activity in human T47D breast carcinoma cells				Bioorg Med Chem Lett 13: 1317-20 (2003) BindingDB Entry DOI: 10.7270/Q2WS8SNP
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Progesterone receptor (Rattus norvegicus)	BDBM50404229 (CHEMBL24089) Show SMILES Clc1cccc(c1)-c1ccc2NC(=S)C3(CCCCC3)c2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.12E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibitory progestational activity on oral administration in uterine C3 model				Bioorg Med Chem Lett 13: 1317-20 (2003) BindingDB Entry DOI: 10.7270/Q2WS8SNP
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Progesterone receptor (Rattus norvegicus)	BDBM50107347 ((+)5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	126	n/a	n/a	n/a	n/a
Forschungszentrum Dresden-Rossendorf e.V. Curated by ChEMBL					Assay Description Binding affinity to progesterone receptor				Bioorg Med Chem Lett 17: 4035-9 (2007) Article DOI: 10.1016/j.bmcl.2007.04.094 BindingDB Entry DOI: 10.7270/Q25X2CRN
					More data for this Ligand-Target Pair
Progesterone receptor (Rattus norvegicus)	BDBM18627 ((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	16	n/a	n/a	n/a	n/a
Forschungszentrum Dresden-Rossendorf e.V. Curated by ChEMBL					Assay Description Binding affinity to progesterone receptor				Bioorg Med Chem Lett 17: 4035-9 (2007) Article DOI: 10.1016/j.bmcl.2007.04.094 BindingDB Entry DOI: 10.7270/Q25X2CRN
					More data for this Ligand-Target Pair				3D Structure (crystal)