Found 8 hits Enz. Inhib. hit(s) with Target = 'Proteasome subunit beta type-4' AND taxid = 9606 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Proteasome subunit beta type-4
(Homo sapiens (Human)) | BDBM50577134
(CHEMBL4877708)Show SMILES CO[C@@H]1CCCN(C1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(OC)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@@]1(C)CO1 |r| | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human trypsin-like activity of 20s proteasome beta 2c subunit using SUC-KQL-AMC as flurogenic substrate preincubated for 15 mins follow... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113556
BindingDB Entry DOI: 10.7270/Q2BR8WZN |
More data for this
Ligand-Target Pair | |
Proteasome subunit beta type-4
(Homo sapiens (Human)) | BDBM50007203
(CHEMBL3237875)Show SMILES COc1ccc(C[C@H](NC(=O)[C@H](C)NC(=O)CN2CCOCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)[C@@]2(C)CO2)cc1 |r| Show InChI InChI=1S/C31H40N4O7/c1-21(32-27(36)19-35-13-15-41-16-14-35)29(38)34-26(18-23-9-11-24(40-3)12-10-23)30(39)33-25(28(37)31(2)20-42-31)17-22-7-5-4-6-8-22/h4-12,21,25-26H,13-20H2,1-3H3,(H,32,36)(H,33,39)(H,34,38)/t21-,25-,26-,31+/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human trypsin-like activity of 20s proteasome beta 2c subunit using SUC-KQL-AMC as flurogenic substrate preincubated for 15 mins follow... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113556
BindingDB Entry DOI: 10.7270/Q2BR8WZN |
More data for this
Ligand-Target Pair | |
Proteasome subunit beta type-4
(Homo sapiens (Human)) | BDBM50577131
(CHEMBL4855915)Show SMILES COC1CCN(CC1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(OC)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@@]1(C)CO1 |r| | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human trypsin-like activity of 20s proteasome beta 2c subunit using SUC-KQL-AMC as flurogenic substrate preincubated for 15 mins follow... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113556
BindingDB Entry DOI: 10.7270/Q2BR8WZN |
More data for this
Ligand-Target Pair | |
Proteasome subunit beta type-4
(Homo sapiens (Human)) | BDBM50577116
(CHEMBL4872258)Show SMILES C[C@H](NC(=O)N1CCC(CC1)NC(=O)c1nccs1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@@]1(C)CO1 |r| | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human trypsin-like activity of 20s proteasome beta 2c subunit using SUC-KQL-AMC as flurogenic substrate preincubated for 15 mins follow... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113556
BindingDB Entry DOI: 10.7270/Q2BR8WZN |
More data for this
Ligand-Target Pair | |
Proteasome subunit beta type-4
(Homo sapiens (Human)) | BDBM50577133
(CHEMBL4870115)Show SMILES CO[C@H]1CCN(C1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(OC)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@@]1(C)CO1 |r| | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human trypsin-like activity of 20s proteasome beta 2c subunit using SUC-KQL-AMC as flurogenic substrate preincubated for 15 mins follow... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113556
BindingDB Entry DOI: 10.7270/Q2BR8WZN |
More data for this
Ligand-Target Pair | |
Proteasome subunit beta type-4
(Homo sapiens (Human)) | BDBM50604305
(CHEMBL5209480)Show SMILES CC(C)(C)NC(=O)CC[C@H](NC(=O)CCNC(=O)CCl)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCc1cccc2ccccc12 |r| | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114252
BindingDB Entry DOI: 10.7270/Q2J1077Z |
More data for this
Ligand-Target Pair | |
Proteasome subunit beta type-4
(Homo sapiens (Human)) | BDBM50604324
(CHEMBL5183361)Show SMILES Cc1ccc(CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(=O)NC(C)(C)C)NC(=O)CCNC(=O)C(=C\c2ccco2)\C#N)cc1 |r| | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114252
BindingDB Entry DOI: 10.7270/Q2J1077Z |
More data for this
Ligand-Target Pair | |
Proteasome subunit beta type-4
(Homo sapiens (Human)) | BDBM50604328
(CHEMBL5180795)Show SMILES CC(C)(C)NC(=O)CC[C@H](NC(=O)CCNC(=O)CCl)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)NCc1cccc2ccccc12 |r| | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114252
BindingDB Entry DOI: 10.7270/Q2J1077Z |
More data for this
Ligand-Target Pair | |
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