Found 372 hits Enz. Inhib. hit(s) with Target = 'Protein kinase C zeta type' AND taxid = 9606 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50427363
(CHEMBL2326002)Show SMILES CC(C)[C@@](C)(O)[C@@H]1CN(CCN1)c1nc(-c2n[nH]c3ncccc23)c(F)cc1Cl |r| Show InChI InChI=1S/C20H24ClFN6O/c1-11(2)20(3,29)15-10-28(8-7-23-15)19-13(21)9-14(22)17(25-19)16-12-5-4-6-24-18(12)27-26-16/h4-6,9,11,15,23,29H,7-8,10H2,1-3H3,(H,24,26,27)/t15-,20+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals (Europe) Ltd.
Curated by ChEMBL
| Assay Description Inhibition of PKC zeta (unknown origin) |
J Med Chem 56: 1799-810 (2013)
Article DOI: 10.1021/jm301465a BindingDB Entry DOI: 10.7270/Q2M046R2 |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50224883
(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)Show SMILES Clc1cc2NC(=O)Nc3cnc(C#N)c(OCCCCOc2cc1NCc1cncs1)n3 Show InChI InChI=1S/C20H18ClN7O3S/c21-13-5-15-17(6-14(13)24-9-12-8-23-11-32-12)30-3-1-2-4-31-19-16(7-22)25-10-18(27-19)28-20(29)26-15/h5-6,8,10-11,24H,1-4,9H2,(H2,26,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| >8.33E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of PKC zeta |
Bioorg Med Chem Lett 17: 6593-601 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.063 BindingDB Entry DOI: 10.7270/Q2X067WT |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50542127
(CHEMBL4635482)Show SMILES Nc1ccc(c(F)c1)-c1cc(N[C@H]2CCCCNC2)c2ccncc2c1 |r| Show InChI InChI=1S/C21H23FN4/c22-20-11-16(23)4-5-18(20)14-9-15-12-25-8-6-19(15)21(10-14)26-17-3-1-2-7-24-13-17/h4-6,8-12,17,24,26H,1-3,7,13,23H2/t17-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method |
J Med Chem 63: 7143-7162 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00449 BindingDB Entry DOI: 10.7270/Q24T6NWX |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50542127
(CHEMBL4635482)Show SMILES Nc1ccc(c(F)c1)-c1cc(N[C@H]2CCCCNC2)c2ccncc2c1 |r| Show InChI InChI=1S/C21H23FN4/c22-20-11-16(23)4-5-18(20)14-9-15-12-25-8-6-19(15)21(10-14)26-17-3-1-2-7-24-13-17/h4-6,8-12,17,24,26H,1-3,7,13,23H2/t17-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01803 BindingDB Entry DOI: 10.7270/Q2KD22XQ |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50542123
(CHEMBL4636488)Show SMILES C1CNC[C@H](C1)Nc1cc(cc2cnccc12)-c1ccccc1 |r| Show InChI InChI=1S/C20H21N3/c1-2-5-15(6-3-1)16-11-17-13-22-10-8-19(17)20(12-16)23-18-7-4-9-21-14-18/h1-3,5-6,8,10-13,18,21,23H,4,7,9,14H2/t18-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method |
J Med Chem 63: 7143-7162 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00449 BindingDB Entry DOI: 10.7270/Q24T6NWX |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50542116
(CHEMBL4646995)Show InChI InChI=1S/C20H22N4/c21-17-5-3-14(4-6-17)15-10-16-12-23-9-7-19(16)20(11-15)24-18-2-1-8-22-13-18/h3-7,9-12,18,22,24H,1-2,8,13,21H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method |
J Med Chem 63: 7143-7162 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00449 BindingDB Entry DOI: 10.7270/Q24T6NWX |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50542119
(CHEMBL4644939)Show InChI InChI=1S/C20H21N3O/c24-18-5-3-14(4-6-18)15-10-16-12-22-9-7-19(16)20(11-15)23-17-2-1-8-21-13-17/h3-7,9-12,17,21,23-24H,1-2,8,13H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method |
J Med Chem 63: 7143-7162 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00449 BindingDB Entry DOI: 10.7270/Q24T6NWX |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50542128
(CHEMBL4636337)Show SMILES Nc1ccc(c(F)c1F)-c1cc(N[C@H]2CCCCNC2)c2ccncc2c1 |r| Show InChI InChI=1S/C21H22F2N4/c22-20-17(4-5-18(24)21(20)23)13-9-14-11-26-8-6-16(14)19(10-13)27-15-3-1-2-7-25-12-15/h4-6,8-11,15,25,27H,1-3,7,12,24H2/t15-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method |
J Med Chem 63: 7143-7162 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00449 BindingDB Entry DOI: 10.7270/Q24T6NWX |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50542132
(CHEMBL4632523)Show SMILES Nc1ccc(cn1)-c1cc(N[C@H]2CCCCNC2)c2ccncc2c1 |r| Show InChI InChI=1S/C20H23N5/c21-20-5-4-14(12-24-20)15-9-16-11-23-8-6-18(16)19(10-15)25-17-3-1-2-7-22-13-17/h4-6,8-12,17,22,25H,1-3,7,13H2,(H2,21,24)/t17-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method |
J Med Chem 63: 7143-7162 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00449 BindingDB Entry DOI: 10.7270/Q24T6NWX |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50542133
(CHEMBL4643553)Show SMILES Nc1ccc(c(F)n1)-c1cc(N[C@H]2CCCCNC2)c2ccncc2c1 |r| Show InChI InChI=1S/C20H22FN5/c21-20-17(4-5-19(22)26-20)13-9-14-11-24-8-6-16(14)18(10-13)25-15-3-1-2-7-23-12-15/h4-6,8-11,15,23,25H,1-3,7,12H2,(H2,22,26)/t15-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method |
J Med Chem 63: 7143-7162 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00449 BindingDB Entry DOI: 10.7270/Q24T6NWX |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50542126
(CHEMBL4642166)Show SMILES Nc1ccc(cc1)-c1cc(N[C@H]2CCCCNC2)c2ccncc2c1 |r| Show InChI InChI=1S/C21H24N4/c22-18-6-4-15(5-7-18)16-11-17-13-24-10-8-20(17)21(12-16)25-19-3-1-2-9-23-14-19/h4-8,10-13,19,23,25H,1-3,9,14,22H2/t19-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method |
J Med Chem 63: 7143-7162 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00449 BindingDB Entry DOI: 10.7270/Q24T6NWX |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50542129
(CHEMBL4637452)Show SMILES Nc1cc(F)c(cc1F)-c1cc(N[C@H]2CCCCNC2)c2ccncc2c1 |r| Show InChI InChI=1S/C21H22F2N4/c22-18-10-20(24)19(23)9-17(18)13-7-14-11-26-6-4-16(14)21(8-13)27-15-3-1-2-5-25-12-15/h4,6-11,15,25,27H,1-3,5,12,24H2/t15-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method |
J Med Chem 63: 7143-7162 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00449 BindingDB Entry DOI: 10.7270/Q24T6NWX |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM35167
(indazole-benzimidazole, 3)Show SMILES COc1cc(ccc1O)-c1ccc2c(n[nH]c2c1)-c1nc2c(cccc2[nH]1)N1CCN(C)CC1 Show InChI InChI=1S/C26H26N6O2/c1-31-10-12-32(13-11-31)21-5-3-4-19-25(21)28-26(27-19)24-18-8-6-16(14-20(18)29-30-24)17-7-9-22(33)23(15-17)34-2/h3-9,14-15,33H,10-13H2,1-2H3,(H,27,28)(H,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.26 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Pfizer
| Assay Description Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ... |
Bioorg Med Chem Lett 19: 908-11 (2009)
Article DOI: 10.1016/j.bmcl.2008.11.105 BindingDB Entry DOI: 10.7270/Q2G73C1H |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50542134
(CHEMBL4647780)Show SMILES Nc1cc(F)c(cn1)-c1cc(N[C@H]2CCCCNC2)c2ccncc2c1 |r| Show InChI InChI=1S/C20H22FN5/c21-18-9-20(22)25-12-17(18)13-7-14-10-24-6-4-16(14)19(8-13)26-15-3-1-2-5-23-11-15/h4,6-10,12,15,23,26H,1-3,5,11H2,(H2,22,25)/t15-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method |
J Med Chem 63: 7143-7162 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00449 BindingDB Entry DOI: 10.7270/Q24T6NWX |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50542125
(CHEMBL4643470)Show InChI InChI=1S/C17H17N3/c18-7-9-20-17-11-14(13-4-2-1-3-5-13)10-15-12-19-8-6-16(15)17/h1-6,8,10-12,20H,7,9,18H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method |
J Med Chem 63: 7143-7162 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00449 BindingDB Entry DOI: 10.7270/Q24T6NWX |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM35173
(indazole-benzimidazole, 9)Show SMILES CN1CCN(CC1)c1cccc2[nH]c(nc12)-c1n[nH]c2cc(ccc12)-c1ccc(N)cc1 Show InChI InChI=1S/C25H25N7/c1-31-11-13-32(14-12-31)22-4-2-3-20-24(22)28-25(27-20)23-19-10-7-17(15-21(19)29-30-23)16-5-8-18(26)9-6-16/h2-10,15H,11-14,26H2,1H3,(H,27,28)(H,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 5.18 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Pfizer
| Assay Description Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ... |
Bioorg Med Chem Lett 19: 908-11 (2009)
Article DOI: 10.1016/j.bmcl.2008.11.105 BindingDB Entry DOI: 10.7270/Q2G73C1H |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM35168
(indazole-benzimidazole, 4)Show SMILES CN1CCN(CC1)c1cccc2[nH]c(nc12)-c1n[nH]c2cc(ccc12)-c1ccc(O)cc1 Show InChI InChI=1S/C25H24N6O/c1-30-11-13-31(14-12-30)22-4-2-3-20-24(22)27-25(26-20)23-19-10-7-17(15-21(19)28-29-23)16-5-8-18(32)9-6-16/h2-10,15,32H,11-14H2,1H3,(H,26,27)(H,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.60 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Pfizer
| Assay Description Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ... |
Bioorg Med Chem Lett 19: 908-11 (2009)
Article DOI: 10.1016/j.bmcl.2008.11.105 BindingDB Entry DOI: 10.7270/Q2G73C1H |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50542121
(CHEMBL4641918)Show InChI InChI=1S/C20H21N3/c1-2-5-15(6-3-1)16-11-17-13-22-10-8-19(17)20(12-16)23-18-7-4-9-21-14-18/h1-3,5-6,8,10-13,18,21,23H,4,7,9,14H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 6.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method |
J Med Chem 63: 7143-7162 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00449 BindingDB Entry DOI: 10.7270/Q24T6NWX |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50542130
(CHEMBL4632384)Show SMILES C1CC[C@@H](CNC1)Nc1cc(cc2cnccc12)-c1ccccc1 |r| Show InChI InChI=1S/C21H23N3/c1-2-6-16(7-3-1)17-12-18-14-23-11-9-20(18)21(13-17)24-19-8-4-5-10-22-15-19/h1-3,6-7,9,11-14,19,22,24H,4-5,8,10,15H2/t19-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 9.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method |
J Med Chem 63: 7143-7162 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00449 BindingDB Entry DOI: 10.7270/Q24T6NWX |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50455589
(CHEMBL4213984)Show SMILES COc1cc2CNCc2cc1-n1cnc2ccc(cc12)-c1ccnc2[nH]ccc12 Show InChI InChI=1S/C23H19N5O/c1-29-22-10-16-12-24-11-15(16)9-21(22)28-13-27-19-3-2-14(8-20(19)28)17-4-6-25-23-18(17)5-7-26-23/h2-10,13,24H,11-12H2,1H3,(H,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
| Assay Description Inhibition of full-length N-terminal GST-fused human PKC-zeta expressed in baculovirus expression system using (5FAM) RFARKGSLRQKNV as substrate afte... |
J Med Chem 61: 4386-4396 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00060 BindingDB Entry DOI: 10.7270/Q2V69N5Z |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50543625
(CHEMBL3732444)Show InChI InChI=1S/C19H21N5S/c1-2-4-15-14(3-1)16-18(24-11-9-21-10-12-24)22-17(23-19(16)25-15)13-5-7-20-8-6-13/h5-8,21H,1-4,9-12H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description Inhibition of recombinant full-length human aPKCzeta expressed in Sf21 insect cells using 5FAM-ERMRPRKRQGSVRRRV-NH2 as substrate in presence of ATP a... |
Bioorg Med Chem 28: (2020)
Article DOI: 10.1016/j.bmc.2020.115480 BindingDB Entry DOI: 10.7270/Q2HM5D1S |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50542122
(CHEMBL4642061)Show SMILES CC(=O)Nc1ccc(cc1)-c1cc(NC2CCCNC2)c2ccncc2c1 Show InChI InChI=1S/C22H24N4O/c1-15(27)25-19-6-4-16(5-7-19)17-11-18-13-24-10-8-21(18)22(12-17)26-20-3-2-9-23-14-20/h4-8,10-13,20,23,26H,2-3,9,14H2,1H3,(H,25,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method |
J Med Chem 63: 7143-7162 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00449 BindingDB Entry DOI: 10.7270/Q24T6NWX |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50542111
(CHEMBL4644763)Show SMILES C1C[C@@H](CN1)Oc1ccc2cncc(-c3cnc4[nH]ccc4c3)c2c1 |r| Show InChI InChI=1S/C20H18N4O/c1-2-16(25-17-4-5-21-11-17)8-18-14(1)9-22-12-19(18)15-7-13-3-6-23-20(13)24-10-15/h1-3,6-10,12,17,21H,4-5,11H2,(H,23,24)/t17-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method |
J Med Chem 63: 7143-7162 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00449 BindingDB Entry DOI: 10.7270/Q24T6NWX |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50542111
(CHEMBL4644763)Show SMILES C1C[C@@H](CN1)Oc1ccc2cncc(-c3cnc4[nH]ccc4c3)c2c1 |r| Show InChI InChI=1S/C20H18N4O/c1-2-16(25-17-4-5-21-11-17)8-18-14(1)9-22-12-19(18)15-7-13-3-6-23-20(13)24-10-15/h1-3,6-10,12,17,21H,4-5,11H2,(H,23,24)/t17-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01803 BindingDB Entry DOI: 10.7270/Q2KD22XQ |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50542131
(CHEMBL4634517)Show SMILES Fc1cccc(F)c1-c1cc(N[C@H]2CCCCNC2)c2ccncc2c1 |r| Show InChI InChI=1S/C21H21F2N3/c22-18-5-3-6-19(23)21(18)14-10-15-12-25-9-7-17(15)20(11-14)26-16-4-1-2-8-24-13-16/h3,5-7,9-12,16,24,26H,1-2,4,8,13H2/t16-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method |
J Med Chem 63: 7143-7162 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00449 BindingDB Entry DOI: 10.7270/Q24T6NWX |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM35166
(indazole-benzimidazole, 1)Show SMILES COc1cc(O)ccc1-c1ccc2c(n[nH]c2c1)-c1nc2c(cccc2[nH]1)N1CCN(C)CC1 Show InChI InChI=1S/C26H26N6O2/c1-31-10-12-32(13-11-31)22-5-3-4-20-25(22)28-26(27-20)24-19-8-6-16(14-21(19)29-30-24)18-9-7-17(33)15-23(18)34-2/h3-9,14-15,33H,10-13H2,1-2H3,(H,27,28)(H,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Pfizer
| Assay Description Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ... |
Bioorg Med Chem Lett 19: 908-11 (2009)
Article DOI: 10.1016/j.bmcl.2008.11.105 BindingDB Entry DOI: 10.7270/Q2G73C1H |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM35181
(indazole-benzimidazole, 17)Show SMILES COc1cc(N)ccc1-c1ccc2c(n[nH]c2c1)-c1nc2c(cccc2[nH]1)N1CCN(C)CC1 Show InChI InChI=1S/C26H27N7O/c1-32-10-12-33(13-11-32)22-5-3-4-20-25(22)29-26(28-20)24-19-8-6-16(14-21(19)30-31-24)18-9-7-17(27)15-23(18)34-2/h3-9,14-15H,10-13,27H2,1-2H3,(H,28,29)(H,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 23.3 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Pfizer
| Assay Description Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ... |
Bioorg Med Chem Lett 19: 908-11 (2009)
Article DOI: 10.1016/j.bmcl.2008.11.105 BindingDB Entry DOI: 10.7270/Q2G73C1H |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50542100
(CHEMBL4645728)Show SMILES Nc1ccc(cc1)-c1cncc2ccc(O[C@H]3CCNC3)cc12 |r| Show InChI InChI=1S/C19H19N3O/c20-15-4-1-13(2-5-15)19-12-22-10-14-3-6-16(9-18(14)19)23-17-7-8-21-11-17/h1-6,9-10,12,17,21H,7-8,11,20H2/t17-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method |
J Med Chem 63: 7143-7162 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00449 BindingDB Entry DOI: 10.7270/Q24T6NWX |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50542124
(CHEMBL4641607)Show SMILES C1CNC[C@@H](C1)Nc1cc(cc2cnccc12)-c1ccccc1 |r| Show InChI InChI=1S/C20H21N3/c1-2-5-15(6-3-1)16-11-17-13-22-10-8-19(17)20(12-16)23-18-7-4-9-21-14-18/h1-3,5-6,8,10-13,18,21,23H,4,7,9,14H2/t18-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method |
J Med Chem 63: 7143-7162 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00449 BindingDB Entry DOI: 10.7270/Q24T6NWX |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM2579
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 39.4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human PKCzeta using ERMRPRKRQGSVRRRV as substrate by [gamma-33P]-ATP assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2018.02.022 BindingDB Entry DOI: 10.7270/Q2DJ5KB8 |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50536679
(CHEMBL4568087)Show SMILES Cn1cc(cn1)-c1cnc2c(cnn2c1)-c1csc(c1)C(=O)N[C@@H]1CCCC[C@@H]1N |r| Show InChI InChI=1S/C21H23N7OS/c1-27-10-15(8-24-27)14-7-23-20-16(9-25-28(20)11-14)13-6-19(30-12-13)21(29)26-18-5-3-2-4-17(18)22/h6-12,17-18H,2-5,22H2,1H3,(H,26,29)/t17-,18+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description Inhibition of full-length recombinant human PRKCZ expressed in baculovirus expression system by Z'-LYTE assay |
Bioorg Med Chem Lett 26: 4362-6 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.003 BindingDB Entry DOI: 10.7270/Q2NP27X5 |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50542127
(CHEMBL4635482)Show SMILES Nc1ccc(c(F)c1)-c1cc(N[C@H]2CCCCNC2)c2ccncc2c1 |r| Show InChI InChI=1S/C21H23FN4/c22-20-11-16(23)4-5-18(20)14-9-15-12-25-8-6-19(15)21(10-14)26-17-3-1-2-7-24-13-17/h4-6,8-12,17,24,26H,1-3,7,13,23H2/t17-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of PKCzeta in human THP1 cells assessed as reduction in LPS-induced TNFalpha production pre-incubated for 60 mins before LPS simulations f... |
J Med Chem 63: 7143-7162 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00449 BindingDB Entry DOI: 10.7270/Q24T6NWX |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM35176
(indazole-benzimidazole, 12)Show SMILES COc1cc(ccc1N)-c1ccc2c(n[nH]c2c1)-c1nc2c(cccc2[nH]1)N1CCN(C)CC1 Show InChI InChI=1S/C26H27N7O/c1-32-10-12-33(13-11-32)22-5-3-4-20-25(22)29-26(28-20)24-18-8-6-16(14-21(18)30-31-24)17-7-9-19(27)23(15-17)34-2/h3-9,14-15H,10-13,27H2,1-2H3,(H,28,29)(H,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 51.3 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Pfizer
| Assay Description Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ... |
Bioorg Med Chem Lett 19: 908-11 (2009)
Article DOI: 10.1016/j.bmcl.2008.11.105 BindingDB Entry DOI: 10.7270/Q2G73C1H |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50542120
(CHEMBL4648006)Show InChI InChI=1S/C20H21N3O/c24-20-6-2-1-5-18(20)14-10-15-12-22-9-7-17(15)19(11-14)23-16-4-3-8-21-13-16/h1-2,5-7,9-12,16,21,23-24H,3-4,8,13H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 54 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method |
J Med Chem 63: 7143-7162 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00449 BindingDB Entry DOI: 10.7270/Q24T6NWX |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM35175
(indazole-benzimidazole, 11)Show SMILES CN1CCN(CC1)c1cccc2[nH]c(nc12)-c1n[nH]c2cc(ccc12)-c1ccc(N)c(F)c1 Show InChI InChI=1S/C25H24FN7/c1-32-9-11-33(12-10-32)22-4-2-3-20-24(22)29-25(28-20)23-17-7-5-16(14-21(17)30-31-23)15-6-8-19(27)18(26)13-15/h2-8,13-14H,9-12,27H2,1H3,(H,28,29)(H,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 55.5 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Pfizer
| Assay Description Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ... |
Bioorg Med Chem Lett 19: 908-11 (2009)
Article DOI: 10.1016/j.bmcl.2008.11.105 BindingDB Entry DOI: 10.7270/Q2G73C1H |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM2579
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 76.8 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida
Curated by ChEMBL
| Assay Description Inhibition of human PKCzeta using ERMRPRKRQGSVRRRV as substrate by [gamma-33P]-ATP assay |
Eur J Med Chem 161: 456-467 (2019)
Article DOI: 10.1016/j.ejmech.2018.10.052 BindingDB Entry DOI: 10.7270/Q2W380MT |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50497871
(CHEMBL3323359)Show SMILES Oc1ccc(cc1O)C1CC(=NN1c1ccc(Cl)cc1)c1ccccc1O |c:11| Show InChI InChI=1S/C21H17ClN2O3/c22-14-6-8-15(9-7-14)24-18(13-5-10-20(26)21(27)11-13)12-17(23-24)16-3-1-2-4-19(16)25/h1-11,18,25-27H,12H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University
Curated by ChEMBL
| Assay Description Inhibition of human PKCzeta assessed as phosphorylation reaction after 4 mins incubation by cell-free assay |
J Med Chem 57: 6513-30 (2014)
Article DOI: 10.1021/jm500521n BindingDB Entry DOI: 10.7270/Q2028VJV |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50497884
(CHEMBL3323361)Show SMILES Oc1ccc(C2=NN(C(C2)c2ccc(O)c(F)c2)c2cccc(Cl)c2)c(O)c1 |t:5| Show InChI InChI=1S/C21H16ClFN2O3/c22-13-2-1-3-14(9-13)25-19(12-4-7-20(27)17(23)8-12)11-18(24-25)16-6-5-15(26)10-21(16)28/h1-10,19,26-28H,11H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University
Curated by ChEMBL
| Assay Description Inhibition of human PKCzeta assessed as phosphorylation reaction after 4 mins incubation by cell-free assay |
J Med Chem 57: 6513-30 (2014)
Article DOI: 10.1021/jm500521n BindingDB Entry DOI: 10.7270/Q2028VJV |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50542114
(CHEMBL4646074)Show InChI InChI=1S/C20H21N3O/c21-16-4-1-14(2-5-16)20-13-23-12-15-3-6-18(11-19(15)20)24-17-7-9-22-10-8-17/h1-6,11-13,17,22H,7-10,21H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 109 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method |
J Med Chem 63: 7143-7162 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00449 BindingDB Entry DOI: 10.7270/Q24T6NWX |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50252375
(CHEMBL446072 | Spheciosterol sulfate C)Show SMILES C[C@H](CCC(C)C(C)(C)C(C)=C)[C@H]1CC[C@@]2(C)[C@@H]3C[C@H](OS([O-])(=O)=O)[C@H]4[C@@H](O)[C@H](OS([O-])(=O)=O)[C@H](C[C@]4(C)C3=CC[C@]12C)OS([O-])(=O)=O |r,c:40| Show InChI InChI=1S/C32H54O13S3/c1-18(2)29(5,6)20(4)11-10-19(3)21-12-14-32(9)23-16-24(43-46(34,35)36)26-27(33)28(45-48(40,41)42)25(44-47(37,38)39)17-30(26,7)22(23)13-15-31(21,32)8/h13,19-21,23-28,33H,1,10-12,14-17H2,2-9H3,(H,34,35,36)(H,37,38,39)(H,40,41,42)/p-3/t19-,20?,21-,23-,24+,25+,26+,27-,28-,30-,31-,32+/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Utah
Curated by ChEMBL
| Assay Description Inhibition of PKCzeta (unknown origin) by TR-FRET based lanthascreen assay |
J Nat Prod 71: 1213-7 (2008)
Article DOI: 10.1021/np8001628 BindingDB Entry DOI: 10.7270/Q25H7G17 |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50542103
(CHEMBL4639268)Show SMILES C1C[C@@H](CN1)Oc1ccc2cncc(-c3ccsc3)c2c1 |r| Show InChI InChI=1S/C17H16N2OS/c1-2-14(20-15-3-5-18-9-15)7-16-12(1)8-19-10-17(16)13-4-6-21-11-13/h1-2,4,6-8,10-11,15,18H,3,5,9H2/t15-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 141 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method |
J Med Chem 63: 7143-7162 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00449 BindingDB Entry DOI: 10.7270/Q24T6NWX |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50542101
(CHEMBL4641149)Show SMILES Oc1cccc(c1)-c1cncc2ccc(O[C@H]3CCNC3)cc12 |r| Show InChI InChI=1S/C19H18N2O2/c22-15-3-1-2-13(8-15)19-12-21-10-14-4-5-16(9-18(14)19)23-17-6-7-20-11-17/h1-5,8-10,12,17,20,22H,6-7,11H2/t17-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 142 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method |
J Med Chem 63: 7143-7162 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00449 BindingDB Entry DOI: 10.7270/Q24T6NWX |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50542102
(CHEMBL4633764)Show SMILES C1C[C@@H](CN1)Oc1ccc2cncc(-c3cccs3)c2c1 |r| Show InChI InChI=1S/C17H16N2OS/c1-2-17(21-7-1)16-11-19-9-12-3-4-13(8-15(12)16)20-14-5-6-18-10-14/h1-4,7-9,11,14,18H,5-6,10H2/t14-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 147 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method |
J Med Chem 63: 7143-7162 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00449 BindingDB Entry DOI: 10.7270/Q24T6NWX |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50285251
(4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benz...)Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@H]1CNCC1NC(=O)c1ccc(O)cc1 Show InChI InChI=1S/C26H22N2O10/c29-14-6-4-12(5-7-14)24(34)28-16-10-27-11-20(16)38-26(37)13-8-18(31)22(19(32)9-13)23(33)21-15(25(35)36)2-1-3-17(21)30/h1-9,16,20,27,29-32H,10-11H2,(H,28,34)(H,35,36)/t16?,20-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | >150 | n/a | n/a | n/a | n/a | n/a | n/a |
Sphinx Laboratories
| Assay Description Inhibition of Protein kinase C zeta |
Bioorg Med Chem Lett 5: 2211-6 (1995)
Article DOI: 10.1016/0960-894X(95)00382-4
BindingDB Entry DOI: 10.7270/Q2QR4V9M |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM3152
(2-{[2,6-dihydroxy-4-({[(3R,4R)-4-[(4-hydroxybenzen...)Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1 |r| Show InChI InChI=1S/C26H22N2O10/c29-14-6-4-12(5-7-14)24(34)28-16-10-27-11-20(16)38-26(37)13-8-18(31)22(19(32)9-13)23(33)21-15(25(35)36)2-1-3-17(21)30/h1-9,16,20,27,29-32H,10-11H2,(H,28,34)(H,35,36)/t16-,20-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | >150 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Protein kinase C zeta |
Bioorg Med Chem Lett 5: 2155-2160 (1995)
Article DOI: 10.1016/0960-894X(95)00367-3 BindingDB Entry DOI: 10.7270/Q22N52RC |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM3152
(2-{[2,6-dihydroxy-4-({[(3R,4R)-4-[(4-hydroxybenzen...)Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1 |r| Show InChI InChI=1S/C26H22N2O10/c29-14-6-4-12(5-7-14)24(34)28-16-10-27-11-20(16)38-26(37)13-8-18(31)22(19(32)9-13)23(33)21-15(25(35)36)2-1-3-17(21)30/h1-9,16,20,27,29-32H,10-11H2,(H,28,34)(H,35,36)/t16-,20-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >150 | n/a | n/a | n/a | n/a | n/a | n/a |
A Division of Eli Lilly & Company
Curated by ChEMBL
| Assay Description Inhibitory concentration against recombinant human Protein kinase C zeta isozyme |
J Med Chem 40: 226-35 (1997)
Article DOI: 10.1021/jm960497g BindingDB Entry DOI: 10.7270/Q2J965HR |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM3152
(2-{[2,6-dihydroxy-4-({[(3R,4R)-4-[(4-hydroxybenzen...)Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1 |r| Show InChI InChI=1S/C26H22N2O10/c29-14-6-4-12(5-7-14)24(34)28-16-10-27-11-20(16)38-26(37)13-8-18(31)22(19(32)9-13)23(33)21-15(25(35)36)2-1-3-17(21)30/h1-9,16,20,27,29-32H,10-11H2,(H,28,34)(H,35,36)/t16-,20-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | >150 | n/a | n/a | n/a | n/a | n/a | n/a |
Sphinx Laboratories
| Assay Description PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs. |
Bioorg Med Chem Lett 5: 2151-4 (1995)
Article DOI: 10.1016/0960-894X(95)00365-Z
BindingDB Entry DOI: 10.7270/Q2VH5M1B |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50542118
(CHEMBL4645229)Show InChI InChI=1S/C20H22N4/c21-19-6-2-1-5-17(19)14-10-15-12-23-9-7-18(15)20(11-14)24-16-4-3-8-22-13-16/h1-2,5-7,9-12,16,22,24H,3-4,8,13,21H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 153 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method |
J Med Chem 63: 7143-7162 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00449 BindingDB Entry DOI: 10.7270/Q24T6NWX |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50542117
(CHEMBL4640042)Show InChI InChI=1S/C20H22N4/c21-17-4-1-3-14(10-17)15-9-16-12-23-8-6-19(16)20(11-15)24-18-5-2-7-22-13-18/h1,3-4,6,8-12,18,22,24H,2,5,7,13,21H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 162 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method |
J Med Chem 63: 7143-7162 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00449 BindingDB Entry DOI: 10.7270/Q24T6NWX |
More data for this Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM50446982
(CHEMBL3116050)Show SMILES C[C@H](Nc1nc(Nc2cn(C)cn2)c2cc[nH]c2n1)c1ncc(F)cn1 |r| Show InChI InChI=1S/C16H16FN9/c1-9(13-19-5-10(17)6-20-13)22-16-24-14-11(3-4-18-14)15(25-16)23-12-7-26(2)8-21-12/h3-9H,1-2H3,(H3,18,22,23,24,25)/t9-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human PKCzeta |
J Med Chem 57: 144-58 (2014)
Article DOI: 10.1021/jm401546n BindingDB Entry DOI: 10.7270/Q2CR5VTM |
More data for this Ligand-Target Pair | |