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Compile Data Set for Download or QSAR

Found 251 hits Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase N2' AND taxid = 9606   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM50596594
PNG
(CHEMBL5182936)
Show SMILES CCCn1c2CCNC(=O)c2cc1-c1ccncc1
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 7n/an/an/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1016/j.bmcl.2022.128588
BindingDB Entry DOI: 10.7270/Q25D8WV9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM27344
PNG
(2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyri...)
Show SMILES O=C1NCCc2[nH]c(cc12)-c1ccncc1
Show InChI InChI=1S/C12H11N3O/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12/h1-2,4-5,7,15H,3,6H2,(H,14,16)
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 8n/an/an/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1016/j.bmcl.2022.128588
BindingDB Entry DOI: 10.7270/Q25D8WV9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM27400
PNG
(1-ethyl-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,...)
Show SMILES CCn1c2CCNC(=O)c2cc1-c1ccncc1
Show InChI InChI=1S/C14H15N3O/c1-2-17-12-5-8-16-14(18)11(12)9-13(17)10-3-6-15-7-4-10/h3-4,6-7,9H,2,5,8H2,1H3,(H,16,18)
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TBA



Citation and Details

Article DOI: 10.1016/j.bmcl.2022.128588
BindingDB Entry DOI: 10.7270/Q25D8WV9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM27401
PNG
(1-(2-hydroxyethyl)-2-(pyridin-4-yl)-1H,4H,5H,6H,7H...)
Show SMILES OCCn1c2CCNC(=O)c2cc1-c1ccncc1
Show InChI InChI=1S/C14H15N3O2/c18-8-7-17-12-3-6-16-14(19)11(12)9-13(17)10-1-4-15-5-2-10/h1-2,4-5,9,18H,3,6-8H2,(H,16,19)
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TBA



Citation and Details

Article DOI: 10.1016/j.bmcl.2022.128588
BindingDB Entry DOI: 10.7270/Q25D8WV9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM50596601
PNG
(CHEMBL5175087)
Show SMILES O=C1NC(Cc2[nH]c(cc12)-c1ccncc1)c1ccccc1
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Citation and Details

Article DOI: 10.1016/j.bmcl.2022.128588
BindingDB Entry DOI: 10.7270/Q25D8WV9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM50545100
PNG
(CHEMBL1990482)
Show SMILES NC(=O)c1cccc2[nH]c(nc12)-c1ccncc1
Show InChI InChI=1S/C13H10N4O/c14-12(18)9-2-1-3-10-11(9)17-13(16-10)8-4-6-15-7-5-8/h1-7H,(H2,14,18)(H,16,17)
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 30n/an/an/an/an/an/an/an/a



University of Sussex

Curated by ChEMBL


Assay Description
Displacement of tracer from PKN2 (unknown origin) by TR-FRET assay

Bioorg Med Chem Lett 30: (2020)


Article DOI: 10.1016/j.bmcl.2020.127040
BindingDB Entry DOI: 10.7270/Q2SJ1Q61
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM50596600
PNG
(CHEMBL5202568)
Show SMILES O=C1CCCc2[nH]c(cc12)-c1ccncc1
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Citation and Details

Article DOI: 10.1016/j.bmcl.2022.128588
BindingDB Entry DOI: 10.7270/Q25D8WV9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM50545100
PNG
(CHEMBL1990482)
Show SMILES NC(=O)c1cccc2[nH]c(nc12)-c1ccncc1
Show InChI InChI=1S/C13H10N4O/c14-12(18)9-2-1-3-10-11(9)17-13(16-10)8-4-6-15-7-5-8/h1-7H,(H2,14,18)(H,16,17)
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 40n/an/an/an/an/an/an/an/a



University of Sussex

Curated by ChEMBL


Assay Description
Inhibition of His/GST-tagged PKN2 (unknown origin) using biotinylated peptide as substrate measured after 1 hr in presence of [gamma-33P]-ATP by fluo...

Bioorg Med Chem Lett 30: (2020)


Article DOI: 10.1016/j.bmcl.2020.127040
BindingDB Entry DOI: 10.7270/Q2SJ1Q61
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM50596595
PNG
(CHEMBL5187643)
Show SMILES CC(C)n1c2CCNC(=O)c2cc1-c1ccncc1
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Citation and Details

Article DOI: 10.1016/j.bmcl.2022.128588
BindingDB Entry DOI: 10.7270/Q25D8WV9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM50463479
PNG
(CHEMBL4249925)
Show SMILES CS(=O)(=O)Nc1cccc(CC(=O)Nc2nc(cs2)-c2c[nH]c3ncccc23)c1
Show InChI InChI=1S/C19H17N5O3S2/c1-29(26,27)24-13-5-2-4-12(8-13)9-17(25)23-19-22-16(11-28-19)15-10-21-18-14(15)6-3-7-20-18/h2-8,10-11,24H,9H2,1H3,(H,20,21)(H,22,23,25)
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 77n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of PRK2 (unknown origin)

Bioorg Med Chem Lett 28: 2622-2626 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.040
BindingDB Entry DOI: 10.7270/Q2ZC85HX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM50545113
PNG
(CHEMBL4647033)
Show SMILES NC(=O)c1cc(Br)cc2[nH]c(nc12)-c1ccncc1
Show InChI InChI=1S/C13H9BrN4O/c14-8-5-9(12(15)19)11-10(6-8)17-13(18-11)7-1-3-16-4-2-7/h1-6H,(H2,15,19)(H,17,18)
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 80n/an/an/an/an/an/an/an/a



University of Sussex

Curated by ChEMBL


Assay Description
Displacement of tracer from PKN2 (unknown origin) by TR-FRET assay

Bioorg Med Chem Lett 30: (2020)


Article DOI: 10.1016/j.bmcl.2020.127040
BindingDB Entry DOI: 10.7270/Q2SJ1Q61
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM27394
PNG
(1-methyl-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3...)
Show SMILES Cn1c2CCNC(=O)c2cc1-c1ccncc1
Show InChI InChI=1S/C13H13N3O/c1-16-11-4-7-15-13(17)10(11)8-12(16)9-2-5-14-6-3-9/h2-3,5-6,8H,4,7H2,1H3,(H,15,17)
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TBA



Citation and Details

Article DOI: 10.1016/j.bmcl.2022.128588
BindingDB Entry DOI: 10.7270/Q25D8WV9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM50596597
PNG
(CHEMBL5182853)
Show SMILES CCn1c2CCN(C)C(=O)c2cc1-c1ccncc1
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Citation and Details

Article DOI: 10.1016/j.bmcl.2022.128588
BindingDB Entry DOI: 10.7270/Q25D8WV9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM50596596
PNG
(CHEMBL5170263)
Show SMILES O=C1NCCc2c1cc(-c1ccncc1)n2Cc1ccccc1
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Citation and Details

Article DOI: 10.1016/j.bmcl.2022.128588
BindingDB Entry DOI: 10.7270/Q25D8WV9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM50341519
PNG
((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)
Show SMILES CNc1cncc(n1)-c1c[nH]c(=O)c(NC(=O)c2ccc(cc2)N2CCC[C@H]2CN2CCCC2)c1 |r|
Show InChI InChI=1S/C26H31N7O2/c1-27-24-16-28-15-23(30-24)19-13-22(26(35)29-14-19)31-25(34)18-6-8-20(9-7-18)33-12-4-5-21(33)17-32-10-2-3-11-32/h6-9,13-16,21H,2-5,10-12,17H2,1H3,(H,27,30)(H,29,35)(H,31,34)/t21-/m0/s1
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>1.00E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of PRK2

J Med Chem 54: 2341-50 (2011)


Article DOI: 10.1021/jm101499u
BindingDB Entry DOI: 10.7270/Q2KH0NPW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM50545105
PNG
(CHEMBL4635777)
Show SMILES CNC(=O)c1cccc2[nH]c(nc12)-c1ccncc1
Show InChI InChI=1S/C14H12N4O/c1-15-14(19)10-3-2-4-11-12(10)18-13(17-11)9-5-7-16-8-6-9/h2-8H,1H3,(H,15,19)(H,17,18)
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 1.06E+3n/an/an/an/an/an/an/an/a



University of Sussex

Curated by ChEMBL


Assay Description
Displacement of tracer from PKN2 (unknown origin) by TR-FRET assay

Bioorg Med Chem Lett 30: (2020)


Article DOI: 10.1016/j.bmcl.2020.127040
BindingDB Entry DOI: 10.7270/Q2SJ1Q61
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM50596599
PNG
(CHEMBL5187274)
Show SMILES C1Cc2[nH]c(cc2CN1)-c1ccncc1
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 1.10E+3n/an/an/an/an/an/an/an/a


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Citation and Details

Article DOI: 10.1016/j.bmcl.2022.128588
BindingDB Entry DOI: 10.7270/Q25D8WV9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM50545108
PNG
(CHEMBL4646744)
Show SMILES [O-][N+](=O)c1cccc2[nH]c(nc12)-c1ccncc1
Show InChI InChI=1S/C12H8N4O2/c17-16(18)10-3-1-2-9-11(10)15-12(14-9)8-4-6-13-7-5-8/h1-7H,(H,14,15)
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 1.25E+3n/an/an/an/an/an/an/an/a



University of Sussex

Curated by ChEMBL


Assay Description
Displacement of tracer from PKN2 (unknown origin) by TR-FRET assay

Bioorg Med Chem Lett 30: (2020)


Article DOI: 10.1016/j.bmcl.2020.127040
BindingDB Entry DOI: 10.7270/Q2SJ1Q61
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM50596598
PNG
(CHEMBL5176291)
Show SMILES CCCN1CCc2c(cc(-c3ccncc3)n2CC)C1=O
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 1.30E+3n/an/an/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1016/j.bmcl.2022.128588
BindingDB Entry DOI: 10.7270/Q25D8WV9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM27381
PNG
(2-(pyridin-3-yl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyri...)
Show SMILES O=C1NCCc2[nH]c(cc12)-c1cccnc1
Show InChI InChI=1S/C12H11N3O/c16-12-9-6-11(8-2-1-4-13-7-8)15-10(9)3-5-14-12/h1-2,4,6-7,15H,3,5H2,(H,14,16)
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 1.60E+3n/an/an/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1016/j.bmcl.2022.128588
BindingDB Entry DOI: 10.7270/Q25D8WV9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM50545111
PNG
(CHEMBL4634210)
Show SMILES N#Cc1ccc2[nH]c(nc2c1)-c1ccncc1
Show InChI InChI=1S/C13H8N4/c14-8-9-1-2-11-12(7-9)17-13(16-11)10-3-5-15-6-4-10/h1-7H,(H,16,17)
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 2.51E+3n/an/an/an/an/an/an/an/a



University of Sussex

Curated by ChEMBL


Assay Description
Displacement of tracer from PKN2 (unknown origin) by TR-FRET assay

Bioorg Med Chem Lett 30: (2020)


Article DOI: 10.1016/j.bmcl.2020.127040
BindingDB Entry DOI: 10.7270/Q2SJ1Q61
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM50545101
PNG
(CHEMBL4636367)
Show SMILES COC(=O)Cn1c(nc2c(cccc12)C(N)=O)-c1ccncc1
Show InChI InChI=1S/C16H14N4O3/c1-23-13(21)9-20-12-4-2-3-11(15(17)22)14(12)19-16(20)10-5-7-18-8-6-10/h2-8H,9H2,1H3,(H2,17,22)
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 2.69E+3n/an/an/an/an/an/an/an/a



University of Sussex

Curated by ChEMBL


Assay Description
Displacement of tracer from PKN2 (unknown origin) by TR-FRET assay

Bioorg Med Chem Lett 30: (2020)


Article DOI: 10.1016/j.bmcl.2020.127040
BindingDB Entry DOI: 10.7270/Q2SJ1Q61
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM55759
PNG
(2-(4-pyridyl)-1H-benzimidazole | 2-pyridin-4-yl-1H...)
Show SMILES c1ccc2[nH]c(nc2c1)-c1ccncc1
Show InChI InChI=1S/C12H9N3/c1-2-4-11-10(3-1)14-12(15-11)9-5-7-13-8-6-9/h1-8H,(H,14,15)
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 3.85E+3n/an/an/an/an/an/an/an/a



University of Sussex

Curated by ChEMBL


Assay Description
Displacement of tracer from PKN2 (unknown origin) by TR-FRET assay

Bioorg Med Chem Lett 30: (2020)


Article DOI: 10.1016/j.bmcl.2020.127040
BindingDB Entry DOI: 10.7270/Q2SJ1Q61
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM50545104
PNG
(CHEMBL4645636)
Show SMILES COc1cc(ccn1)-c1nc2c(cccc2[nH]1)C(N)=O
Show InChI InChI=1S/C14H12N4O2/c1-20-11-7-8(5-6-16-11)14-17-10-4-2-3-9(13(15)19)12(10)18-14/h2-7H,1H3,(H2,15,19)(H,17,18)
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 6.90E+3n/an/an/an/an/an/an/an/a



University of Sussex

Curated by ChEMBL


Assay Description
Displacement of tracer from PKN2 (unknown origin) by TR-FRET assay

Bioorg Med Chem Lett 30: (2020)


Article DOI: 10.1016/j.bmcl.2020.127040
BindingDB Entry DOI: 10.7270/Q2SJ1Q61
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM50545107
PNG
(CHEMBL4637286)
Show SMILES NC(=O)c1ccc2[nH]c(nc2c1)-c1ccncc1
Show InChI InChI=1S/C13H10N4O/c14-12(18)9-1-2-10-11(7-9)17-13(16-10)8-3-5-15-6-4-8/h1-7H,(H2,14,18)(H,16,17)
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 8.11E+3n/an/an/an/an/an/an/an/a



University of Sussex

Curated by ChEMBL


Assay Description
Displacement of tracer from PKN2 (unknown origin) by TR-FRET assay

Bioorg Med Chem Lett 30: (2020)


Article DOI: 10.1016/j.bmcl.2020.127040
BindingDB Entry DOI: 10.7270/Q2SJ1Q61
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM50545102
PNG
(CHEMBL185288)
Show SMILES NC(=O)c1cccc2[nH]c(nc12)-c1cccnc1
Show InChI InChI=1S/C13H10N4O/c14-12(18)9-4-1-5-10-11(9)17-13(16-10)8-3-2-6-15-7-8/h1-7H,(H2,14,18)(H,16,17)
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 8.19E+3n/an/an/an/an/an/an/an/a



University of Sussex

Curated by ChEMBL


Assay Description
Displacement of tracer from PKN2 (unknown origin) by TR-FRET assay

Bioorg Med Chem Lett 30: (2020)


Article DOI: 10.1016/j.bmcl.2020.127040
BindingDB Entry DOI: 10.7270/Q2SJ1Q61
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM50224883
PNG
(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Show SMILES Clc1cc2NC(=O)Nc3cnc(C#N)c(OCCCCOc2cc1NCc1cncs1)n3
Show InChI InChI=1S/C20H18ClN7O3S/c21-13-5-15-17(6-14(13)24-9-12-8-23-11-32-12)30-3-1-2-4-31-19-16(7-22)25-10-18(27-19)28-20(29)26-15/h5-6,8,10-11,24H,1-4,9H2,(H2,26,27,28,29)
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>8.20E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of PKN2

Bioorg Med Chem Lett 17: 6593-601 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.063
BindingDB Entry DOI: 10.7270/Q2X067WT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM50545112
PNG
(CHEMBL160012)
Show SMILES [O-][N+](=O)c1ccc2[nH]c(nc2c1)-c1ccncc1
Show InChI InChI=1S/C12H8N4O2/c17-16(18)9-1-2-10-11(7-9)15-12(14-10)8-3-5-13-6-4-8/h1-7H,(H,14,15)
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 1.29E+4n/an/an/an/an/an/an/an/a



University of Sussex

Curated by ChEMBL


Assay Description
Displacement of tracer from PKN2 (unknown origin) by TR-FRET assay

Bioorg Med Chem Lett 30: (2020)


Article DOI: 10.1016/j.bmcl.2020.127040
BindingDB Entry DOI: 10.7270/Q2SJ1Q61
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM50545109
PNG
(CHEMBL4632420)
Show SMILES COC(=O)c1cccc2[nH]c(nc12)-c1ccncc1
Show InChI InChI=1S/C14H11N3O2/c1-19-14(18)10-3-2-4-11-12(10)17-13(16-11)9-5-7-15-8-6-9/h2-8H,1H3,(H,16,17)
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 1.56E+4n/an/an/an/an/an/an/an/a



University of Sussex

Curated by ChEMBL


Assay Description
Displacement of tracer from PKN2 (unknown origin) by TR-FRET assay

Bioorg Med Chem Lett 30: (2020)


Article DOI: 10.1016/j.bmcl.2020.127040
BindingDB Entry DOI: 10.7270/Q2SJ1Q61
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM50545106
PNG
(CHEMBL4649365)
Show SMILES CN(C)C(=O)c1cccc2[nH]c(nc12)-c1ccncc1
Show InChI InChI=1S/C15H14N4O/c1-19(2)15(20)11-4-3-5-12-13(11)18-14(17-12)10-6-8-16-9-7-10/h3-9H,1-2H3,(H,17,18)
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 1.94E+4n/an/an/an/an/an/an/an/a



University of Sussex

Curated by ChEMBL


Assay Description
Displacement of tracer from PKN2 (unknown origin) by TR-FRET assay

Bioorg Med Chem Lett 30: (2020)


Article DOI: 10.1016/j.bmcl.2020.127040
BindingDB Entry DOI: 10.7270/Q2SJ1Q61
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM50545110
PNG
(CHEMBL4638916)
Show SMILES CCOC(=O)c1ccc2[nH]c(nc2c1)-c1ccncc1
Show InChI InChI=1S/C15H13N3O2/c1-2-20-15(19)11-3-4-12-13(9-11)18-14(17-12)10-5-7-16-8-6-10/h3-9H,2H2,1H3,(H,17,18)
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 2.11E+4n/an/an/an/an/an/an/an/a



University of Sussex

Curated by ChEMBL


Assay Description
Displacement of tracer from PKN2 (unknown origin) by TR-FRET assay

Bioorg Med Chem Lett 30: (2020)


Article DOI: 10.1016/j.bmcl.2020.127040
BindingDB Entry DOI: 10.7270/Q2SJ1Q61
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM50545103
PNG
(CHEMBL4640475)
Show SMILES NC(=O)c1cccc2[nH]c(nc12)-c1cncnc1
Show InChI InChI=1S/C12H9N5O/c13-11(18)8-2-1-3-9-10(8)17-12(16-9)7-4-14-6-15-5-7/h1-6H,(H2,13,18)(H,16,17)
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 2.38E+4n/an/an/an/an/an/an/an/a



University of Sussex

Curated by ChEMBL


Assay Description
Displacement of tracer from PKN2 (unknown origin) by TR-FRET assay

Bioorg Med Chem Lett 30: (2020)


Article DOI: 10.1016/j.bmcl.2020.127040
BindingDB Entry DOI: 10.7270/Q2SJ1Q61
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Gachon University

Curated by ChEMBL


Assay Description
Inhibition of human PKN2 using KKLNRTLSVA as substrate by [gamma-33P]-ATP assay

Eur J Med Chem 163: 453-480 (2019)


Article DOI: 10.1016/j.ejmech.2018.11.037
BindingDB Entry DOI: 10.7270/Q2TQ650N
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Gachon University

Curated by ChEMBL


Assay Description
Inhibition of human PKN2 using KKLNRTLSVA as substrate by [gamma-33P]-ATP assay

Eur J Med Chem 163: 453-480 (2019)


Article DOI: 10.1016/j.ejmech.2018.11.037
BindingDB Entry DOI: 10.7270/Q2TQ650N
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 2.20n/an/an/an/an/an/a



Southeast University

Curated by ChEMBL


Assay Description
Inhibition of PKN2 (unknown origin) incubated for 1 hr by spectrophotometric analysis

Bioorg Med Chem 24: 3483-93 (2016)


Article DOI: 10.1016/j.bmc.2016.05.057
BindingDB Entry DOI: 10.7270/Q29G5PQT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 6.10n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human PKN2 using KKLNRTLSVA as substrate by [gamma-33P]-ATP assay

Citation and Details

Article DOI: 10.1016/j.bmc.2018.02.022
BindingDB Entry DOI: 10.7270/Q2DJ5KB8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM50324316
PNG
(CHEMBL1214929 | N*1*-(3-Pyridin-4-yl[2,6]naphthyri...)
Show SMILES NCCNc1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C15H15N5/c16-4-8-19-15-13-3-7-18-10-12(13)9-14(20-15)11-1-5-17-6-2-11/h1-3,5-7,9-10H,4,8,16H2,(H,19,20)
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n/an/a 7n/an/an/an/an/an/a



Novartis Horsham Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PKN-2 using AKRRRLSSLRA as substrate after 40 mins by scintillation counting analysis

Bioorg Med Chem Lett 24: 4812-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.09.002
BindingDB Entry DOI: 10.7270/Q2MP54VV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 11.9n/an/an/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Inhibition of human PKN2 using KKLNRTLSVA as substrate by [gamma-33P]-ATP assay

Eur J Med Chem 161: 456-467 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.052
BindingDB Entry DOI: 10.7270/Q2W380MT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM50319716
PNG
((3S,4R)-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6...)
Show SMILES Clc1ccc(cc1)[C@@H]1CNC[C@H]1C(=O)Nc1cc2cc[nH]c(=O)c2cc1Cl |r|
Show InChI InChI=1S/C20H17Cl2N3O2/c21-13-3-1-11(2-4-13)15-9-23-10-16(15)20(27)25-18-7-12-5-6-24-19(26)14(12)8-17(18)22/h1-8,15-16,23H,9-10H2,(H,24,26)(H,25,27)/t15-,16+/m0/s1
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n/an/a 14n/an/an/an/an/an/a



Boehringer-Ingelheim Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of PRKCL2

Bioorg Med Chem Lett 20: 3746-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.069
BindingDB Entry DOI: 10.7270/Q2XD12MD
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM50596594
PNG
(CHEMBL5182936)
Show SMILES CCCn1c2CCNC(=O)c2cc1-c1ccncc1
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n/an/a 15n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1016/j.bmcl.2022.128588
BindingDB Entry DOI: 10.7270/Q25D8WV9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM27344
PNG
(2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyri...)
Show SMILES O=C1NCCc2[nH]c(cc12)-c1ccncc1
Show InChI InChI=1S/C12H11N3O/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12/h1-2,4-5,7,15H,3,6H2,(H,14,16)
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n/an/a 16n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1016/j.bmcl.2022.128588
BindingDB Entry DOI: 10.7270/Q25D8WV9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM27400
PNG
(1-ethyl-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,...)
Show SMILES CCn1c2CCNC(=O)c2cc1-c1ccncc1
Show InChI InChI=1S/C14H15N3O/c1-2-17-12-5-8-16-14(18)11(12)9-13(17)10-3-6-15-7-4-10/h3-4,6-7,9H,2,5,8H2,1H3,(H,16,18)
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n/an/a 16n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1016/j.bmcl.2022.128588
BindingDB Entry DOI: 10.7270/Q25D8WV9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM50391898
PNG
(CHEMBL2147538)
Show SMILES CC(C)(N)CNc1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C17H19N5/c1-17(2,18)11-21-16-14-5-8-20-10-13(14)9-15(22-16)12-3-6-19-7-4-12/h3-10H,11,18H2,1-2H3,(H,21,22)
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n/an/a 17n/an/an/an/an/an/a



Novartis Horsham Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PKN-2 using AKRRRLSSLRA as substrate after 40 mins by scintillation counting analysis

Bioorg Med Chem Lett 24: 4812-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.09.002
BindingDB Entry DOI: 10.7270/Q2MP54VV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM27401
PNG
(1-(2-hydroxyethyl)-2-(pyridin-4-yl)-1H,4H,5H,6H,7H...)
Show SMILES OCCn1c2CCNC(=O)c2cc1-c1ccncc1
Show InChI InChI=1S/C14H15N3O2/c18-8-7-17-12-3-6-16-14(19)11(12)9-13(17)10-1-4-15-5-2-10/h1-2,4-5,9,18H,3,6-8H2,(H,16,19)
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n/an/a 30n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1016/j.bmcl.2022.128588
BindingDB Entry DOI: 10.7270/Q25D8WV9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM50596601
PNG
(CHEMBL5175087)
Show SMILES O=C1NC(Cc2[nH]c(cc12)-c1ccncc1)c1ccccc1
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n/an/a 50n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1016/j.bmcl.2022.128588
BindingDB Entry DOI: 10.7270/Q25D8WV9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM50028033
PNG
(CHEMBL3338837 | US11458138, Example 312)
Show SMILES CC(C)(N)CNc1nc(nc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C16H18N6/c1-16(2,17)10-20-15-12-5-8-19-9-13(12)21-14(22-15)11-3-6-18-7-4-11/h3-9H,10,17H2,1-2H3,(H,20,21,22)
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n/an/a 58n/an/an/an/an/an/a



Novartis Horsham Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PKN-2 using AKRRRLSSLRA as substrate after 40 mins by scintillation counting analysis

Bioorg Med Chem Lett 24: 4812-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.09.002
BindingDB Entry DOI: 10.7270/Q2MP54VV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM50596600
PNG
(CHEMBL5202568)
Show SMILES O=C1CCCc2[nH]c(cc12)-c1ccncc1
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n/an/a 60n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1016/j.bmcl.2022.128588
BindingDB Entry DOI: 10.7270/Q25D8WV9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM50545100
PNG
(CHEMBL1990482)
Show SMILES NC(=O)c1cccc2[nH]c(nc12)-c1ccncc1
Show InChI InChI=1S/C13H10N4O/c14-12(18)9-2-1-3-10-11(9)17-13(16-10)8-4-6-15-7-5-8/h1-7H,(H2,14,18)(H,16,17)
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n/an/a 64n/an/an/an/an/an/a



University of Sussex

Curated by ChEMBL


Assay Description
Displacement of tracer from PKN2 (unknown origin) by TR-FRET assay

Bioorg Med Chem Lett 30: (2020)


Article DOI: 10.1016/j.bmcl.2020.127040
BindingDB Entry DOI: 10.7270/Q2SJ1Q61
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM14029
PNG
((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
Show SMILES [H][C@@]1(CC[C@@]([H])(CC1)C(=O)Nc1ccncc1)[C@@H](C)N |r,wU:4.4,1.18,17.20,wD:4.8,1.0,(1.92,.41,;1.06,-.86,;-.27,-1.63,;-1.61,-.86,;-1.61,.68,;-1.61,2.22,;-.27,1.45,;1.06,.68,;-2.94,1.45,;-2.94,2.99,;-4.27,.68,;-5.61,1.45,;-5.61,2.99,;-6.94,3.76,;-8.28,2.99,;-8.28,1.45,;-6.94,.68,;2.6,-.86,;3.37,.47,;3.37,-2.2,)|
Show InChI InChI=1S/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11-,12-/m1/s1
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n/an/a 70n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Prkcl2

Bioorg Med Chem Lett 20: 3235-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.070
BindingDB Entry DOI: 10.7270/Q21N819Z
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase N2


(Homo sapiens (Human))		BDBM50319634
PNG
(CHEMBL1084892 | N-(7-chloro-1-oxo-1,2-dihydroisoqu...)
Show SMILES CNC(C(=O)Nc1cc2cc[nH]c(=O)c2cc1Cl)c1ccccc1
Show InChI InChI=1S/C18H16ClN3O2/c1-20-16(11-5-3-2-4-6-11)18(24)22-15-9-12-7-8-21-17(23)13(12)10-14(15)19/h2-10,16,20H,1H3,(H,21,23)(H,22,24)
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n/an/a 110n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Prkcl2

Bioorg Med Chem Lett 20: 3235-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.070
BindingDB Entry DOI: 10.7270/Q21N819Z
More data for this
Ligand-Target Pair
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