Compile Data Set for Download or QSAR

Found 14 hits Enz. Inhib. hit(s) with Target = 'RNA polymerase II subunit A C-terminal domain phosphatase SSU72' AND taxid = 9606   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (Homo sapiens (Human))	BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) Show SMILES Cn1c(c(I)c2cc(C(O)=O)c(O)cc12)-c1cccc(NC(=O)C(=O)Nc2ccc(cc2)-c2ccsc2)c1 Show InChI InChI=1S/C28H20IN3O5S/c1-32-22-13-23(33)21(28(36)37)12-20(22)24(29)25(32)16-3-2-4-19(11-16)31-27(35)26(34)30-18-7-5-15(6-8-18)17-9-10-38-14-17/h2-14,33H,1H3,(H,30,34)(H,31,35)(H,36,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University School of Medicine Curated by ChEMBL					Assay Description Inhibition of Ssu72 (unknown origin)				J Med Chem 57: 6594-609 (2014) Article DOI: 10.1021/jm5006176 BindingDB Entry DOI: 10.7270/Q24X59FM
					More data for this Ligand-Target Pair
RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (Homo sapiens (Human))	BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) Show SMILES Cn1c(c(I)c2cc(C(O)=O)c(O)cc12)-c1cccc(NC(=O)C(=O)Nc2ccc(cc2)-c2ccsc2)c1 Show InChI InChI=1S/C28H20IN3O5S/c1-32-22-13-23(33)21(28(36)37)12-20(22)24(29)25(32)16-3-2-4-19(11-16)31-27(35)26(34)30-18-7-5-15(6-8-18)17-9-10-38-14-17/h2-14,33H,1H3,(H,30,34)(H,31,35)(H,36,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University Research and Technology Corporation US Patent					Assay Description For selectivity studies, the PTPs, including LYP, mPTPA, SHP1-D1C, PTP1B, LMPTP, VHR, Laforin and PTPα-D1D2 were expressed and purified from E. ...				US Patent US9522881 (2016) BindingDB Entry DOI: 10.7270/Q2DN4402
					More data for this Ligand-Target Pair
RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (Homo sapiens (Human))	BDBM50607111 (CHEMBL5218807) Show SMILES Cc1c(Br)cc(NC(=O)NS(O)(=O)=O)cc1Br Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c01143 BindingDB Entry DOI: 10.7270/Q2BK1HGF
					More data for this Ligand-Target Pair
RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (Homo sapiens (Human))	BDBM50558487 (CHEMBL4786243) Show SMILES OS(=O)(=O)C(C(=O)Nc1ccc(OCc2ccccc2)c(Cl)c1)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.66E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of His-tagged SSu72 (unknown origin) expressed in Escherichia coli BL21 cells using para-nitrophenyl phosphate as substrate incubated for ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00993 BindingDB Entry DOI: 10.7270/Q2DN48Q4
					More data for this Ligand-Target Pair
RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (Homo sapiens (Human))	BDBM50558482 (CHEMBL4742123) Show SMILES OS(=O)(=O)C(C(=O)Nc1nc2ccccc2s1)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	6.99E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of His-tagged SSu72 (unknown origin) expressed in Escherichia coli BL21 cells using para-nitrophenyl phosphate as substrate incubated for ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00993 BindingDB Entry DOI: 10.7270/Q2DN48Q4
					More data for this Ligand-Target Pair
RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (Homo sapiens (Human))	BDBM50558481 (CHEMBL4783639) Show SMILES OS(=O)(=O)C(C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of His-tagged SSu72 (unknown origin) expressed in Escherichia coli BL21 cells using para-nitrophenyl phosphate as substrate incubated for ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00993 BindingDB Entry DOI: 10.7270/Q2DN48Q4
					More data for this Ligand-Target Pair
RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (Homo sapiens (Human))	BDBM50607110 (CHEMBL5219519) Show SMILES Cc1c(Br)cc(NC(=O)CS(O)(=O)=O)cc1Br Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c01143 BindingDB Entry DOI: 10.7270/Q2BK1HGF
					More data for this Ligand-Target Pair
RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (Homo sapiens (Human))	BDBM50558485 (CHEMBL4800195) Show SMILES OS(=O)(=O)C(C(=O)Nc1ccc(cc1)-n1ccnc1)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of His-tagged SSu72 (unknown origin) expressed in Escherichia coli BL21 cells using para-nitrophenyl phosphate as substrate incubated for ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00993 BindingDB Entry DOI: 10.7270/Q2DN48Q4
					More data for this Ligand-Target Pair
RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (Homo sapiens (Human))	BDBM50558461 (CHEMBL4760367) Show SMILES OS(=O)(=O)C(C(=O)Nc1nc2ccc(cc2s1)[N+]([O-])=O)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of His-tagged SSu72 (unknown origin) expressed in Escherichia coli BL21 cells using para-nitrophenyl phosphate as substrate incubated for ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00993 BindingDB Entry DOI: 10.7270/Q2DN48Q4
					More data for this Ligand-Target Pair
RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (Homo sapiens (Human))	BDBM50558488 (CHEMBL4794972) Show SMILES Cc1c(Br)cc(NC(=O)C(c2ccccc2)S(O)(=O)=O)cc1Br Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of His-tagged SSu72 (unknown origin) expressed in Escherichia coli BL21 cells using para-nitrophenyl phosphate as substrate incubated for ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00993 BindingDB Entry DOI: 10.7270/Q2DN48Q4
					More data for this Ligand-Target Pair
RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (Homo sapiens (Human))	BDBM50558486 (CHEMBL4797766) Show SMILES OS(=O)(=O)C(C(=O)Nc1ccc2nc([nH]c2c1)C(F)(F)F)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of His-tagged SSu72 (unknown origin) expressed in Escherichia coli BL21 cells using para-nitrophenyl phosphate as substrate incubated for ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00993 BindingDB Entry DOI: 10.7270/Q2DN48Q4
					More data for this Ligand-Target Pair
RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (Homo sapiens (Human))	BDBM50558488 (CHEMBL4794972) Show SMILES Cc1c(Br)cc(NC(=O)C(c2ccccc2)S(O)(=O)=O)cc1Br Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c01143 BindingDB Entry DOI: 10.7270/Q2BK1HGF
					More data for this Ligand-Target Pair
RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (Homo sapiens (Human))	BDBM50558483 (CHEMBL4778085) Show SMILES OS(=O)(=O)C(C(=O)Nc1cnc2ccccc2c1)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of His-tagged SSu72 (unknown origin) expressed in Escherichia coli BL21 cells using para-nitrophenyl phosphate as substrate incubated for ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00993 BindingDB Entry DOI: 10.7270/Q2DN48Q4
					More data for this Ligand-Target Pair
RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (Homo sapiens (Human))	BDBM50558484 (CHEMBL4748824) Show SMILES OS(=O)(=O)C(C(=O)Nc1ccc(cc1)N1CCOCC1)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of His-tagged SSu72 (unknown origin) expressed in Escherichia coli BL21 cells using para-nitrophenyl phosphate as substrate incubated for ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00993 BindingDB Entry DOI: 10.7270/Q2DN48Q4
					More data for this Ligand-Target Pair