Compile Data Set for Download or QSAR

Found 155 hits Enz. Inhib. hit(s) with Target = 'Rap guanine nucleotide exchange factor 3' AND taxid = 9606   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50511915 (CHEMBL4517829) Show SMILES COc1ccc2ccc(OCC(=O)NS(=O)(=O)c3ccc(N)cc3OC)cc2c1 Show InChI InChI=1S/C20H20N2O6S/c1-26-16-6-3-13-4-7-17(10-14(13)9-16)28-12-20(23)22-29(24,25)19-8-5-15(21)11-18(19)27-2/h3-11H,12,21H2,1-2H3,(H,22,23)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Binding affinity to GST-tagged recombinant EPAC1 CNBD (169 to 318 residues) (unknown origin) expressed in Escherichia coli BL21 Star (DE3) incubated ...				J Med Chem 63: 5159-5184 (2020) Article DOI: 10.1021/acs.jmedchem.9b02094 BindingDB Entry DOI: 10.7270/Q2M048SB
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50511914 (CHEMBL4576925) Show SMILES COc1ccc2ccc(OCC(=O)NS(=O)(=O)c3ccc4ccccc4c3)cc2c1 Show InChI InChI=1S/C23H19NO5S/c1-28-20-9-6-17-7-10-21(13-19(17)12-20)29-15-23(25)24-30(26,27)22-11-8-16-4-2-3-5-18(16)14-22/h2-14H,15H2,1H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Binding affinity to GST-tagged recombinant EPAC1 CNBD (169 to 318 residues) (unknown origin) expressed in Escherichia coli BL21 Star (DE3) incubated ...				J Med Chem 63: 5159-5184 (2020) Article DOI: 10.1021/acs.jmedchem.9b02094 BindingDB Entry DOI: 10.7270/Q2M048SB
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM517670 (NY0460 | US11124489, Compound 14) Show SMILES FC(F)(F)c1cc(NNC(C#N)C(=O)c2cc(on2)-c2ccccc2)ccc1Cl Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva...				Citation and Details BindingDB Entry DOI: 10.7270/Q2FR00SJ
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50098793 (CHEMBL3593342) Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(Cl)c(Cl)c(Cl)c1)\C#N Show InChI InChI=1S/C16H13Cl3N4O2/c1-16(2,3)13-6-11(23-25-13)15(24)12(7-20)22-21-8-4-9(17)14(19)10(18)5-8/h4-6,21H,1-3H3/b22-12+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Displacement of 8-NBD-cAMP from recombinant human EPAC1 by fluorescence assay				Bioorg Med Chem Lett 27: 1633-1639 (2017) Article DOI: 10.1016/j.bmcl.2017.02.065 BindingDB Entry DOI: 10.7270/Q2FF3VXQ
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50241941 (CHEMBL4103080) Show SMILES FC(F)(F)c1cc(N\N=C(/C#N)C(=O)c2cc(on2)-c2ccccc2)ccc1Cl Show InChI InChI=1S/C19H10ClF3N4O2/c20-14-7-6-12(8-13(14)19(21,22)23)25-26-16(10-24)18(28)15-9-17(29-27-15)11-4-2-1-3-5-11/h1-9,25H/b26-16+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Antagonist activity at recombinant human full length EPAC1 assessed as inhibition of EPAC1-mediated Rap1B (1 to 167 residues)-BODIPY GDP nucleotide e...				Eur J Med Chem 134: 62-71 (2017) Article DOI: 10.1016/j.ejmech.2017.04.001 BindingDB Entry DOI: 10.7270/Q2RR21DK
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50098719 (CHEMBL3593329) Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(Cl)cc(Cl)c1)\C#N Show InChI InChI=1S/C16H14Cl2N4O2/c1-16(2,3)14-7-12(22-24-14)15(23)13(8-19)21-20-11-5-9(17)4-10(18)6-11/h4-7,20H,1-3H3/b21-13+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activity				J Med Chem 58: 6033-47 (2015) Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50098793 (CHEMBL3593342) Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(Cl)c(Cl)c(Cl)c1)\C#N Show InChI InChI=1S/C16H13Cl3N4O2/c1-16(2,3)13-6-11(23-25-13)15(24)12(7-20)22-21-8-4-9(17)14(19)10(18)5-8/h4-6,21H,1-3H3/b22-12+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activity				J Med Chem 58: 6033-47 (2015) Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50098719 (CHEMBL3593329) Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(Cl)cc(Cl)c1)\C#N Show InChI InChI=1S/C16H14Cl2N4O2/c1-16(2,3)14-7-12(22-24-14)15(23)13(8-19)21-20-11-5-9(17)4-10(18)6-11/h4-7,20H,1-3H3/b21-13+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Displacement of 8-NBD-cAMP from recombinant human EPAC1 by fluorescence assay				Bioorg Med Chem Lett 27: 1633-1639 (2017) Article DOI: 10.1016/j.bmcl.2017.02.065 BindingDB Entry DOI: 10.7270/Q2FF3VXQ
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50098787 (CHEMBL3593468) Show SMILES Clc1cc(Cl)cc(N\N=C(/C#N)C(=O)c2cc(on2)C2CCCCC2)c1 Show InChI InChI=1S/C18H16Cl2N4O2/c19-12-6-13(20)8-14(7-12)22-23-16(10-21)18(25)15-9-17(26-24-15)11-4-2-1-3-5-11/h6-9,11,22H,1-5H2/b23-16+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activity				J Med Chem 58: 6033-47 (2015) Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50098793 (CHEMBL3593342) Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(Cl)c(Cl)c(Cl)c1)\C#N Show InChI InChI=1S/C16H13Cl3N4O2/c1-16(2,3)13-6-11(23-25-13)15(24)12(7-20)22-21-8-4-9(17)14(19)10(18)5-8/h4-6,21H,1-3H3/b22-12+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Antagonist activity at recombinant human full length EPAC1 assessed as inhibition of EPAC1-mediated Rap1B (1 to 167 residues)-BODIPY GDP nucleotide e...				Eur J Med Chem 134: 62-71 (2017) Article DOI: 10.1016/j.ejmech.2017.04.001 BindingDB Entry DOI: 10.7270/Q2RR21DK
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50241952 (CHEMBL4099528) Show SMILES FC(F)(F)c1cc(N\N=C(/C#N)C(=O)c2noc3ccccc23)ccc1Cl Show InChI InChI=1S/C17H8ClF3N4O2/c18-12-6-5-9(7-11(12)17(19,20)21)23-24-13(8-22)16(26)15-10-3-1-2-4-14(10)27-25-15/h1-7,23H/b24-13+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description In vito concentration required to displace [3H]cyclofoxy (Kd = 0.8 nM and concentration is 1.3 nM) from mu and kappa2 receptor in rat brain membranes...				Eur J Med Chem 134: 62-71 (2017) Article DOI: 10.1016/j.ejmech.2017.04.001 BindingDB Entry DOI: 10.7270/Q2RR21DK
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM517689 (NY0562 | US11124489, Compound 33) Show SMILES FC(F)(F)c1cc(NNC(C#N)C(=O)c2noc3ccccc23)ccc1Cl Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva...				Citation and Details BindingDB Entry DOI: 10.7270/Q2FR00SJ
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM517688 (NY0561 | US11124489, Compound 32) Show SMILES FC(F)(F)c1ccc(NNC(C#N)C(=O)c2noc3ccccc23)cc1Cl Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva...				Citation and Details BindingDB Entry DOI: 10.7270/Q2FR00SJ
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50241961 (CHEMBL4081514) Show SMILES FC(F)(F)c1ccc(N\N=C(/C#N)C(=O)c2noc3ccccc23)cc1Cl Show InChI InChI=1S/C17H8ClF3N4O2/c18-12-7-9(5-6-11(12)17(19,20)21)23-24-13(8-22)16(26)15-10-3-1-2-4-14(10)27-25-15/h1-7,23H/b24-13+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Antagonist activity at recombinant human full length EPAC1 assessed as inhibition of EPAC1-mediated Rap1B (1 to 167 residues)-BODIPY GDP nucleotide e...				Eur J Med Chem 134: 62-71 (2017) Article DOI: 10.1016/j.ejmech.2017.04.001 BindingDB Entry DOI: 10.7270/Q2RR21DK
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50011360 (CHEMBL3260990) Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cccc(Cl)c1)\C#N Show InChI InChI=1S/C16H15ClN4O2/c1-16(2,3)14-8-12(21-23-14)15(22)13(9-18)20-19-11-6-4-5-10(17)7-11/h4-8,19H,1-3H3/b20-13+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Inhibition of EPAC1 (unknown origin)				Bioorg Med Chem Lett 27: 1633-1639 (2017) Article DOI: 10.1016/j.bmcl.2017.02.065 BindingDB Entry DOI: 10.7270/Q2FF3VXQ
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50011360 (CHEMBL3260990) Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cccc(Cl)c1)\C#N Show InChI InChI=1S/C16H15ClN4O2/c1-16(2,3)14-8-12(21-23-14)15(22)13(9-18)20-19-11-6-4-5-10(17)7-11/h4-8,19H,1-3H3/b20-13+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Inhibition of EPAC1 (unknown origin) assessed as cAMP-mediated GEF activity				J Med Chem 57: 3651-65 (2014) Article DOI: 10.1021/jm401425e BindingDB Entry DOI: 10.7270/Q2WH2RJW
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50280395 (CHEMBL4171480) Show SMILES C[C@@H]1CCc2c(Br)c(F)c(Br)cc2N1C=O |r| Show InChI InChI=1S/C11H10Br2FNO/c1-6-2-3-7-9(15(6)5-16)4-8(12)11(14)10(7)13/h4-6H,2-3H2,1H3/t6-/m1/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute for Research in Cancer and Allied Diseases Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged EPAC1 (149 to 881 residues) expressed in Escherichia coli Rosetta 2(DE3) assessed as reduction in guanine ...				ACS Med Chem Lett 8: 1183-1187 (2017) Article DOI: 10.1021/acsmedchemlett.7b00358 BindingDB Entry DOI: 10.7270/Q20C4Z83
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50452020 (CHEMBL4213611) Show SMILES Clc1cc(Cl)cc(N\N=C(/C#N)C(=O)c2ccc3CCCCc3c2)c1 Show InChI InChI=1S/C19H15Cl2N3O/c20-15-8-16(21)10-17(9-15)23-24-18(11-22)19(25)14-6-5-12-3-1-2-4-13(12)7-14/h5-10,23H,1-4H2/b24-18+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Antagonist activity at recombinant full length EPAC1 (unknown origin) assessed as inhibition of cAMP-mediated Rap1b-BODIPY GDP nucleotide exchange ac...				Bioorg Med Chem Lett 27: 5163-5166 (2017) Article DOI: 10.1016/j.bmcl.2017.10.056 BindingDB Entry DOI: 10.7270/Q2TB19FF
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50241957 (CHEMBL4100650) Show SMILES FC(F)(F)c1cc(Cl)cc(N\N=C(/C#N)C(=O)c2cc(on2)-c2ccco2)c1 Show InChI InChI=1S/C17H8ClF3N4O3/c18-10-4-9(17(19,20)21)5-11(6-10)23-24-13(8-22)16(26)12-7-15(28-25-12)14-2-1-3-27-14/h1-7,23H/b24-13+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description In vito concentration required to displace [3H]cyclofoxy (Kd = 0.8 nM and concentration is 1.3 nM) from mu and kappa2 receptor in rat brain membranes...				Eur J Med Chem 134: 62-71 (2017) Article DOI: 10.1016/j.ejmech.2017.04.001 BindingDB Entry DOI: 10.7270/Q2RR21DK
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM517717 (US11124489, Entry 32 | ZL0524) Show SMILES Clc1cc(Cl)cc(NNC(C#N)C(=O)c2ccc3CCCCc3c2)c1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva...				Citation and Details BindingDB Entry DOI: 10.7270/Q2FR00SJ
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM517684 (NY0725 | US11124489, Compound 26) Show SMILES FC(F)(F)c1cc(Cl)cc(NNC(C#N)C(=O)c2cc(on2)-c2ccco2)c1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva...				Citation and Details BindingDB Entry DOI: 10.7270/Q2FR00SJ
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50098797 (CHEMBL3593471) Show SMILES Clc1cc(N\N=C(/C#N)C(=O)c2cc(on2)C2CCCCC2)cc(Cl)c1Cl Show InChI InChI=1S/C18H15Cl3N4O2/c19-12-6-11(7-13(20)17(12)21)23-24-15(9-22)18(26)14-8-16(27-25-14)10-4-2-1-3-5-10/h6-8,10,23H,1-5H2/b24-15+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activity				J Med Chem 58: 6033-47 (2015) Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50098796 (CHEMBL3593470) Show SMILES Clc1cc(N\N=C(/C#N)C(=O)c2cc(on2)C2CC2)cc(Cl)c1Cl Show InChI InChI=1S/C15H9Cl3N4O2/c16-9-3-8(4-10(17)14(9)18)20-21-12(6-19)15(23)11-5-13(24-22-11)7-1-2-7/h3-5,7,20H,1-2H2/b21-12+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activity				J Med Chem 58: 6033-47 (2015) Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM517685 (NY0726 | US11124489, Compound 27) Show SMILES FC(F)(F)c1cc(NNC(C#N)C(=O)c2cc(on2)-c2ccco2)ccc1Cl Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva...				Citation and Details BindingDB Entry DOI: 10.7270/Q2FR00SJ
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50241954 (CHEMBL4082655) Show SMILES FC(F)(F)c1cc(N\N=C(/C#N)C(=O)c2cc(on2)-c2ccco2)ccc1Cl Show InChI InChI=1S/C17H8ClF3N4O3/c18-11-4-3-9(6-10(11)17(19,20)21)23-24-13(8-22)16(26)12-7-15(28-25-12)14-2-1-5-27-14/h1-7,23H/b24-13+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Antagonist activity at recombinant human full length EPAC1 assessed as inhibition of EPAC1-mediated Rap1B (1 to 167 residues)-BODIPY GDP nucleotide e...				Eur J Med Chem 134: 62-71 (2017) Article DOI: 10.1016/j.ejmech.2017.04.001 BindingDB Entry DOI: 10.7270/Q2RR21DK
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50280395 (CHEMBL4171480) Show SMILES C[C@@H]1CCc2c(Br)c(F)c(Br)cc2N1C=O |r| Show InChI InChI=1S/C11H10Br2FNO/c1-6-2-3-7-9(15(6)5-16)4-8(12)11(14)10(7)13/h4-6H,2-3H2,1H3/t6-/m1/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Antagonist activity at recombinant human GST-fused EPAC1 (149 to 881 residues) expressed in Escherichia coli Rosetta (DE3) assessed as inhibition of ...				Bioorg Med Chem Lett 27: 5163-5166 (2017) Article DOI: 10.1016/j.bmcl.2017.10.056 BindingDB Entry DOI: 10.7270/Q2TB19FF
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50098794 (CHEMBL3593341) Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1ccc(c(Cl)c1)C(F)(F)F)\C#N Show InChI InChI=1S/C17H14ClF3N4O2/c1-16(2,3)14-7-12(25-27-14)15(26)13(8-22)24-23-9-4-5-10(11(18)6-9)17(19,20)21/h4-7,23H,1-3H3/b24-13+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activity				J Med Chem 58: 6033-47 (2015) Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM517687 (NY0495 | US11124489, Compound 31) Show SMILES FC(F)(F)c1cc(Cl)cc(NNC(C#N)C(=O)c2noc3ccccc23)c1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva...				Citation and Details BindingDB Entry DOI: 10.7270/Q2FR00SJ
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50241953 (CHEMBL4091792) Show SMILES FC(F)(F)c1cc(Cl)cc(N\N=C(/C#N)C(=O)c2noc3ccccc23)c1 Show InChI InChI=1S/C17H8ClF3N4O2/c18-10-5-9(17(19,20)21)6-11(7-10)23-24-13(8-22)16(26)15-12-3-1-2-4-14(12)27-25-15/h1-7,23H/b24-13+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Antagonist activity at recombinant human full length EPAC1 assessed as inhibition of EPAC1-mediated Rap1B (1 to 167 residues)-BODIPY GDP nucleotide e...				Eur J Med Chem 134: 62-71 (2017) Article DOI: 10.1016/j.ejmech.2017.04.001 BindingDB Entry DOI: 10.7270/Q2RR21DK
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50511913 (CHEMBL4459738) Show SMILES Cc1cc(Nc2ncccc2C(F)(F)F)cc(c1)S(=O)(=O)NC(=O)COc1ccc2ccccc2c1 Show InChI InChI=1S/C25H20F3N3O4S/c1-16-11-19(30-24-22(25(26,27)28)7-4-10-29-24)14-21(12-16)36(33,34)31-23(32)15-35-20-9-8-17-5-2-3-6-18(17)13-20/h2-14H,15H2,1H3,(H,29,30)(H,31,32)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Binding affinity to GST-tagged recombinant EPAC1 CNBD (169 to 318 residues) (unknown origin) expressed in Escherichia coli BL21 Star (DE3) incubated ...				J Med Chem 63: 5159-5184 (2020) Article DOI: 10.1021/acs.jmedchem.9b02094 BindingDB Entry DOI: 10.7270/Q2M048SB
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50511918 (CHEMBL4450888) Show SMILES COc1ccc(c(OC)c1)S(=O)(=O)NC(=O)COc1ccc2ccccc2c1 Show InChI InChI=1S/C20H19NO6S/c1-25-16-9-10-19(18(12-16)26-2)28(23,24)21-20(22)13-27-17-8-7-14-5-3-4-6-15(14)11-17/h3-12H,13H2,1-2H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Binding affinity to GST-tagged recombinant EPAC1 CNBD (169 to 318 residues) (unknown origin) expressed in Escherichia coli BL21 Star (DE3) incubated ...				J Med Chem 63: 5159-5184 (2020) Article DOI: 10.1021/acs.jmedchem.9b02094 BindingDB Entry DOI: 10.7270/Q2M048SB
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM517675 (NY0541 | US11124489, Compound 17b) Show SMILES FC(F)(F)c1ccc(NNC(C#N)C(=O)c2cc(on2)-c2ccccc2)cc1Cl Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva...				Citation and Details BindingDB Entry DOI: 10.7270/Q2FR00SJ
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM517696 (US11124489, Entry 11 | ZL0475) Show SMILES CC(C)(C)c1ccc(cc1)C(=O)C(NNc1cc(Cl)cc(Cl)c1)C#N Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva...				Citation and Details BindingDB Entry DOI: 10.7270/Q2FR00SJ
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50452021 (CHEMBL4210825) Show SMILES CC(C)(C)c1ccc(cc1)C(=O)C(=N\Nc1cc(Cl)cc(Cl)c1)\C#N Show InChI InChI=1S/C19H17Cl2N3O/c1-19(2,3)13-6-4-12(5-7-13)18(25)17(11-22)24-23-16-9-14(20)8-15(21)10-16/h4-10,23H,1-3H3/b24-17+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Antagonist activity at recombinant full length EPAC1 (unknown origin) assessed as inhibition of cAMP-mediated Rap1b-BODIPY GDP nucleotide exchange ac...				Bioorg Med Chem Lett 27: 5163-5166 (2017) Article DOI: 10.1016/j.bmcl.2017.10.056 BindingDB Entry DOI: 10.7270/Q2TB19FF
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM517701 (US11124489, Entry 15 | ZL0479) Show SMILES CC(C)(C)c1ccc(cc1)C(=O)C(NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C#N Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva...				Citation and Details BindingDB Entry DOI: 10.7270/Q2FR00SJ
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50280395 (CHEMBL4171480) Show SMILES C[C@@H]1CCc2c(Br)c(F)c(Br)cc2N1C=O |r| Show InChI InChI=1S/C11H10Br2FNO/c1-6-2-3-7-9(15(6)5-16)4-8(12)11(14)10(7)13/h4-6H,2-3H2,1H3/t6-/m1/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Antagonist activity at recombinant full length EPAC1 (unknown origin) assessed as inhibition of cAMP-mediated Rap1b-BODIPY GDP nucleotide exchange ac...				Bioorg Med Chem Lett 27: 5163-5166 (2017) Article DOI: 10.1016/j.bmcl.2017.10.056 BindingDB Entry DOI: 10.7270/Q2TB19FF
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50452009 (CHEMBL4205201) Show SMILES CC(C)(C)c1ccc(cc1)C(=O)C(=N\Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F)\C#N Show InChI InChI=1S/C21H17F6N3O/c1-19(2,3)13-6-4-12(5-7-13)18(31)17(11-28)30-29-16-9-14(20(22,23)24)8-15(10-16)21(25,26)27/h4-10,29H,1-3H3/b30-17+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Antagonist activity at recombinant full length EPAC1 (unknown origin) assessed as inhibition of cAMP-mediated Rap1b-BODIPY GDP nucleotide exchange ac...				Bioorg Med Chem Lett 27: 5163-5166 (2017) Article DOI: 10.1016/j.bmcl.2017.10.056 BindingDB Entry DOI: 10.7270/Q2TB19FF
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50241958 (CHEMBL4063555) Show SMILES COc1ccc(cc1)-c1cc(no1)C(=O)C(=N\Nc1ccc(Cl)c(c1)C(F)(F)F)\C#N Show InChI InChI=1S/C20H12ClF3N4O3/c1-30-13-5-2-11(3-6-13)18-9-16(28-31-18)19(29)17(10-25)27-26-12-4-7-15(21)14(8-12)20(22,23)24/h2-9,26H,1H3/b27-17+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Antagonist activity at recombinant human full length EPAC1 assessed as inhibition of EPAC1-mediated Rap1B (1 to 167 residues)-BODIPY GDP nucleotide e...				Eur J Med Chem 134: 62-71 (2017) Article DOI: 10.1016/j.ejmech.2017.04.001 BindingDB Entry DOI: 10.7270/Q2RR21DK
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM517681 (NY0654 | US11124489, Compound 23) Show SMILES COc1ccc(cc1)-c1cc(no1)C(=O)C(NNc1ccc(Cl)c(c1)C(F)(F)F)C#N Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva...				Citation and Details BindingDB Entry DOI: 10.7270/Q2FR00SJ
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50451965 (CHEMBL4217436) Show SMILES CC(C)(C)c1ccc(cc1)C(=O)C(=N\Nc1cc(Cl)cc(c1)C(F)(F)F)\C#N Show InChI InChI=1S/C20H17ClF3N3O/c1-19(2,3)13-6-4-12(5-7-13)18(28)17(11-25)27-26-16-9-14(20(22,23)24)8-15(21)10-16/h4-10,26H,1-3H3/b27-17+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Antagonist activity at recombinant full length EPAC1 (unknown origin) assessed as inhibition of cAMP-mediated Rap1b-BODIPY GDP nucleotide exchange ac...				Bioorg Med Chem Lett 27: 5163-5166 (2017) Article DOI: 10.1016/j.bmcl.2017.10.056 BindingDB Entry DOI: 10.7270/Q2TB19FF
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM517704 (US11124489, Entry 17 | ZL0560) Show SMILES CC(C)(C)c1ccc(cc1)C(=O)C(NNc1cc(Cl)cc(c1)C(F)(F)F)C#N Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva...				Citation and Details BindingDB Entry DOI: 10.7270/Q2FR00SJ
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM517682 (NY0655 | US11124489, Compound 24) Show SMILES COc1ccc(cc1)-c1cc(no1)C(=O)C(NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C#N Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva...				Citation and Details BindingDB Entry DOI: 10.7270/Q2FR00SJ
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50241966 (CHEMBL4092921) Show SMILES COc1ccc(cc1)-c1cc(no1)C(=O)C(=N\Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F)\C#N Show InChI InChI=1S/C21H12F6N4O3/c1-33-15-4-2-11(3-5-15)18-9-16(31-34-18)19(32)17(10-28)30-29-14-7-12(20(22,23)24)6-13(8-14)21(25,26)27/h2-9,29H,1H3/b30-17+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Antagonist activity at recombinant human full length EPAC1 assessed as inhibition of EPAC1-mediated Rap1B (1 to 167 residues)-BODIPY GDP nucleotide e...				Eur J Med Chem 134: 62-71 (2017) Article DOI: 10.1016/j.ejmech.2017.04.001 BindingDB Entry DOI: 10.7270/Q2RR21DK
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50098716 (CHEMBL3593332) Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F)\C#N Show InChI InChI=1S/C18H14F6N4O2/c1-16(2,3)14-7-12(28-30-14)15(29)13(8-25)27-26-11-5-9(17(19,20)21)4-10(6-11)18(22,23)24/h4-7,26H,1-3H3/b27-13+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activity				J Med Chem 58: 6033-47 (2015) Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50098713 (CHEMBL3593335) Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(Cl)cc(c1)C(F)(F)F)\C#N Show InChI InChI=1S/C17H14ClF3N4O2/c1-16(2,3)14-7-12(25-27-14)15(26)13(8-22)24-23-11-5-9(17(19,20)21)4-10(18)6-11/h4-7,23H,1-3H3/b24-13+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activity				J Med Chem 58: 6033-47 (2015) Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM517702 (US11124489, Entry 16 | ZL0559) Show SMILES CC(C)(C)c1ccc(cc1)C(=O)C(NNc1ccc(Cl)c(c1)C(F)(F)F)C#N Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva...				Citation and Details BindingDB Entry DOI: 10.7270/Q2FR00SJ
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50451966 (CHEMBL4205731) Show SMILES CC(C)(C)c1ccc(cc1)C(=O)C(=N\Nc1ccc(Cl)c(c1)C(F)(F)F)\C#N Show InChI InChI=1S/C20H17ClF3N3O/c1-19(2,3)13-6-4-12(5-7-13)18(28)17(11-25)27-26-14-8-9-16(21)15(10-14)20(22,23)24/h4-10,26H,1-3H3/b27-17+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Antagonist activity at recombinant full length EPAC1 (unknown origin) assessed as inhibition of cAMP-mediated Rap1b-BODIPY GDP nucleotide exchange ac...				Bioorg Med Chem Lett 27: 5163-5166 (2017) Article DOI: 10.1016/j.bmcl.2017.10.056 BindingDB Entry DOI: 10.7270/Q2TB19FF
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM517698 (US11124489, Entry 13 | ZL0477) Show SMILES CC(C)(C)c1ccc(cc1)C(=O)C(NNc1cc(F)cc(Cl)c1)C#N Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva...				Citation and Details BindingDB Entry DOI: 10.7270/Q2FR00SJ
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50452010 (CHEMBL4209582) Show SMILES CC(C)(C)c1ccc(cc1)C(=O)C(=N\Nc1cc(F)cc(Cl)c1)\C#N Show InChI InChI=1S/C19H17ClFN3O/c1-19(2,3)13-6-4-12(5-7-13)18(25)17(11-22)24-23-16-9-14(20)8-15(21)10-16/h4-10,23H,1-3H3/b24-17+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Antagonist activity at recombinant full length EPAC1 (unknown origin) assessed as inhibition of cAMP-mediated Rap1b-BODIPY GDP nucleotide exchange ac...				Bioorg Med Chem Lett 27: 5163-5166 (2017) Article DOI: 10.1016/j.bmcl.2017.10.056 BindingDB Entry DOI: 10.7270/Q2TB19FF
					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM517692 (NY0563 | US11124489, Compound 36) Show SMILES FC(F)(F)c1cc(NNC(C#N)C(=O)c2noc3ccccc23)cc(c1)C(F)(F)F Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva...				Citation and Details BindingDB Entry DOI: 10.7270/Q2FR00SJ
					More data for this Ligand-Target Pair

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