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Compile Data Set for Download or QSAR

Found 357 hits Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase 17B' AND taxid = 9606   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50166121
PNG
(CHEMBL3797480)
Show SMILES CCCCC(=O)Nc1ccc2NC(=O)\C(=C3/Nc4ccccc4/C/3=N\O)c2c1
Show InChI InChI=1S/C21H20N4O3/c1-2-3-8-17(26)22-12-9-10-16-14(11-12)18(21(27)24-16)20-19(25-28)13-6-4-5-7-15(13)23-20/h4-7,9-11,23,28H,2-3,8H2,1H3,(H,22,26)(H,24,27)/b20-18-,25-19+
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0.260n/an/an/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Competitive inhibition of DRAK2 (unknown origin) using MRLC3 peptide as substrate incubated for 2 hrs by Lineweaver-Burk plot analysis in presence of...


Bioorg Med Chem Lett 26: 2719-23 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.111
BindingDB Entry DOI: 10.7270/Q2N29ZTZ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50166121
PNG
(CHEMBL3797480)
Show SMILES CCCCC(=O)Nc1ccc2NC(=O)\C(=C3/Nc4ccccc4/C/3=N\O)c2c1
Show InChI InChI=1S/C21H20N4O3/c1-2-3-8-17(26)22-12-9-10-16-14(11-12)18(21(27)24-16)20-19(25-28)13-6-4-5-7-15(13)23-20/h4-7,9-11,23,28H,2-3,8H2,1H3,(H,22,26)(H,24,27)/b20-18-,25-19+
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n/an/a 3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of DRAK2 (unknown origin) using MRLC3 peptide as substrate incubated for 2 hrs by ADP-Glo kinase assay


Bioorg Med Chem Lett 26: 2719-23 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.111
BindingDB Entry DOI: 10.7270/Q2N29ZTZ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50559236
PNG
(CHEMBL4796519)
Show SMILES C[S+]([O-])c1ccc(cc1)-c1cc2ncnc(SCC(O)=O)c2s1
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n/an/a 7n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of N-terminal His-tagged STK17B kinase domain (25 to 329 residues) (unknown origin) expressed in Escherichia coli incubated for 90 mins by...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01174
BindingDB Entry DOI: 10.7270/Q2DB85J2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50166251
PNG
(CHEMBL3799389)
Show SMILES O\N=C1\C(\Nc2ccccc\12)=C1\C(=O)Nc2ccc(NC(=O)C3CC3)cc12
Show InChI InChI=1S/C20H16N4O3/c25-19(10-5-6-10)21-11-7-8-15-13(9-11)16(20(26)23-15)18-17(24-27)12-3-1-2-4-14(12)22-18/h1-4,7-10,22,27H,5-6H2,(H,21,25)(H,23,26)/b18-16-,24-17+
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n/an/a 8n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of DRAK2 (unknown origin) using MRLC3 peptide as substrate incubated for 2 hrs by ADP-Glo kinase assay


Bioorg Med Chem Lett 26: 2719-23 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.111
BindingDB Entry DOI: 10.7270/Q2N29ZTZ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50166076
PNG
(CHEMBL3799585)
Show SMILES CCCC(=O)Nc1ccc2NC(=O)\C(=C3/Nc4ccccc4/C/3=N\O)c2c1
Show InChI InChI=1S/C20H18N4O3/c1-2-5-16(25)21-11-8-9-15-13(10-11)17(20(26)23-15)19-18(24-27)12-6-3-4-7-14(12)22-19/h3-4,6-10,22,27H,2,5H2,1H3,(H,21,25)(H,23,26)/b19-17-,24-18+
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n/an/a 10n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of DRAK2 (unknown origin) using MRLC3 peptide as substrate incubated for 2 hrs by ADP-Glo kinase assay


Bioorg Med Chem Lett 26: 2719-23 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.111
BindingDB Entry DOI: 10.7270/Q2N29ZTZ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50559235
PNG
(CHEMBL4760126)
Show SMILES CC(=O)c1ccc(cc1)-c1cc2ncnc(SCC(O)=O)c2s1
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n/an/a 13n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of N-terminal His-tagged STK17B kinase domain (25 to 329 residues) (unknown origin) expressed in Escherichia coli incubated for 90 mins by...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01174
BindingDB Entry DOI: 10.7270/Q2DB85J2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50166254
PNG
(CHEMBL3797466)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6](=O)-[#7]-c1ccc2-[#7]-[#6](=O)\[#6](=[#6]3/[#7]-c4ccccc4/[#6]/3=[#7]\[#8])-c2c1
Show InChI InChI=1S/C21H18N4O3/c1-11(2)9-17(26)22-12-7-8-16-14(10-12)18(21(27)24-16)20-19(25-28)13-5-3-4-6-15(13)23-20/h3-10,23,28H,1-2H3,(H,22,26)(H,24,27)/b20-18-,25-19+
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n/an/a 14n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of DRAK2 (unknown origin) using MRLC3 peptide as substrate incubated for 2 hrs by ADP-Glo kinase assay


Bioorg Med Chem Lett 26: 2719-23 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.111
BindingDB Entry DOI: 10.7270/Q2N29ZTZ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50166260
PNG
(CHEMBL3799505)
Show SMILES CC(C)(C)CC(=O)Nc1ccc2NC(=O)\C(=C3/Nc4ccccc4/C/3=N\O)c2c1
Show InChI InChI=1S/C22H22N4O3/c1-22(2,3)11-17(27)23-12-8-9-16-14(10-12)18(21(28)25-16)20-19(26-29)13-6-4-5-7-15(13)24-20/h4-10,24,29H,11H2,1-3H3,(H,23,27)(H,25,28)/b20-18-,26-19+
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n/an/a 14n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of DRAK2 (unknown origin) using MRLC3 peptide as substrate incubated for 2 hrs by ADP-Glo kinase assay


Bioorg Med Chem Lett 26: 2719-23 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.111
BindingDB Entry DOI: 10.7270/Q2N29ZTZ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50559233
PNG
(CHEMBL4753926)
Show SMILES OC(=O)CSc1ncnc2cc(sc12)-c1ccc(cc1)N1CCOCC1
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n/an/a 14n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of N-terminal His-tagged STK17B kinase domain (25 to 329 residues) (unknown origin) expressed in Escherichia coli incubated for 90 mins by...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01174
BindingDB Entry DOI: 10.7270/Q2DB85J2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50559225
PNG
(CHEMBL4763132)
Show SMILES COc1ccc(cc1F)-c1cc2ncnc(SCC(O)=O)c2s1
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n/an/a 18n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of N-terminal His-tagged STK17B kinase domain (25 to 329 residues) (unknown origin) expressed in Escherichia coli incubated for 90 mins by...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01174
BindingDB Entry DOI: 10.7270/Q2DB85J2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50354565
PNG
(CHEMBL1836719)
Show SMILES CSc1ccc(cc1)-c1cc2ncnc(SCC(O)=O)c2s1
Show InChI InChI=1S/C15H12N2O2S3/c1-20-10-4-2-9(3-5-10)12-6-11-14(22-12)15(17-8-16-11)21-7-13(18)19/h2-6,8H,7H2,1H3,(H,18,19)
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n/an/a 20n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of N-terminal His-tagged STK17B kinase domain (25 to 329 residues) (unknown origin) expressed in Escherichia coli incubated for 90 mins by...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01174
BindingDB Entry DOI: 10.7270/Q2DB85J2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50166077
PNG
(CHEMBL513703)
Show SMILES CC(C)(C)C(=O)Nc1ccc2NC(=O)\C(=C3/Nc4ccccc4/C/3=N\O)c2c1
Show InChI InChI=1S/C21H20N4O3/c1-21(2,3)20(27)22-11-8-9-15-13(10-11)16(19(26)24-15)18-17(25-28)12-6-4-5-7-14(12)23-18/h4-10,23,28H,1-3H3,(H,22,27)(H,24,26)/b18-16-,25-17+
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n/an/a 21n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of DRAK2 (unknown origin) using MRLC3 peptide as substrate incubated for 2 hrs by ADP-Glo kinase assay


Bioorg Med Chem Lett 26: 2719-23 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.111
BindingDB Entry DOI: 10.7270/Q2N29ZTZ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50354559
PNG
(CHEMBL1836724)
Show SMILES CC(=O)Nc1ccc(cc1)-c1cc2ncnc(SCC(O)=O)c2s1
Show InChI InChI=1S/C16H13N3O3S2/c1-9(20)19-11-4-2-10(3-5-11)13-6-12-15(24-13)16(18-8-17-12)23-7-14(21)22/h2-6,8H,7H2,1H3,(H,19,20)(H,21,22)
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n/an/a 23n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of N-terminal His-tagged STK17B kinase domain (25 to 329 residues) (unknown origin) expressed in Escherichia coli incubated for 90 mins by...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01174
BindingDB Entry DOI: 10.7270/Q2DB85J2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 26n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Inhibition of Drak2 (unknown origin) by ADP-GLO kinase assay


Bioorg Med Chem 23: 1179-88 (2015)


Article DOI: 10.1016/j.bmc.2014.12.026
BindingDB Entry DOI: 10.7270/Q23X88F1
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50559226
PNG
(CHEMBL4754748)
Show SMILES CSc1ccc(cc1F)-c1cc2ncnc(SCC(O)=O)c2s1
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n/an/a 27n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of N-terminal His-tagged STK17B kinase domain (25 to 329 residues) (unknown origin) expressed in Escherichia coli incubated for 90 mins by...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01174
BindingDB Entry DOI: 10.7270/Q2DB85J2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50559243
PNG
(CHEMBL4794509)
Show SMILES OC(=O)CSc1ncnc2cc(sc12)-c1ccc(C=C)cc1
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n/an/a 28n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of N-terminal His-tagged STK17B kinase domain (25 to 329 residues) (unknown origin) expressed in Escherichia coli incubated for 90 mins by...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01174
BindingDB Entry DOI: 10.7270/Q2DB85J2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50239006
PNG
(CHEMBL4060481)
Show SMILES Nc1c(sc2ncc(cc12)-c1ccsc1)-c1n[nH]c(=S)o1
Show InChI InChI=1S/C13H8N4OS3/c14-9-8-3-7(6-1-2-20-5-6)4-15-12(8)21-10(9)11-16-17-13(19)18-11/h1-5H,14H2,(H,17,19)
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n/an/a 29n/an/an/an/an/an/a



East China Normal University

Curated by ChEMBL


Assay Description
Inhibition of DRAK2 (unknown origin)


Eur J Med Chem 130: 195-208 (2017)


Article DOI: 10.1016/j.ejmech.2017.02.048
BindingDB Entry DOI: 10.7270/Q2XW4N3P
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM441881
PNG
(US10647686, Example (25))
Show SMILES NCCCNc1nc(Nc2ccc(cc2)N2CCNCC2)ncc1Cl
Show InChI InChI=1S/C17H24ClN7/c18-15-12-22-17(24-16(15)21-7-1-6-19)23-13-2-4-14(5-3-13)25-10-8-20-9-11-25/h2-5,12,20H,1,6-11,19H2,(H2,21,22,23,24)
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US Patent
n/an/a 30n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)


BindingDB Entry DOI: 10.7270/Q2MS3WSB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50559224
PNG
(CHEMBL4788024)
Show SMILES OC(=O)CSc1ncnc2cc(sc12)-c1ccc(cc1)C(F)(F)F
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n/an/a 33n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of N-terminal His-tagged STK17B kinase domain (25 to 329 residues) (unknown origin) expressed in Escherichia coli incubated for 90 mins by...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01174
BindingDB Entry DOI: 10.7270/Q2DB85J2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50559222
PNG
(CHEMBL4752776)
Show SMILES OC(=O)CSc1ncnc2cc(sc12)-c1cc2ccccc2s1
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n/an/a 34n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of N-terminal His-tagged STK17B kinase domain (25 to 329 residues) (unknown origin) expressed in Escherichia coli incubated for 90 mins by...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01174
BindingDB Entry DOI: 10.7270/Q2DB85J2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50559222
PNG
(CHEMBL4752776)
Show SMILES OC(=O)CSc1ncnc2cc(sc12)-c1cc2ccccc2s1
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n/an/a 34n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human STK17B in presence of ATP at Km level


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01174
BindingDB Entry DOI: 10.7270/Q2DB85J2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50559237
PNG
(CHEMBL4747753)
Show SMILES CC(=O)Nc1cccc(c1)-c1cc2ncnc(SCC(O)=O)c2s1
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n/an/a 35n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of N-terminal His-tagged STK17B kinase domain (25 to 329 residues) (unknown origin) expressed in Escherichia coli incubated for 90 mins by...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01174
BindingDB Entry DOI: 10.7270/Q2DB85J2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50354540
PNG
(CHEMBL1836717)
Show SMILES OC(=O)CSc1ncnc2cc(sc12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C15H9N3O2S2/c16-6-9-1-3-10(4-2-9)12-5-11-14(22-12)15(18-8-17-11)21-7-13(19)20/h1-5,8H,7H2,(H,19,20)
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TBA

Assay Description
Inhibition of N-terminal His-tagged STK17B kinase domain (25 to 329 residues) (unknown origin) expressed in Escherichia coli incubated for 90 mins by...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01174
BindingDB Entry DOI: 10.7270/Q2DB85J2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50559232
PNG
(CHEMBL4740090)
Show SMILES CC(=O)c1ccc(cn1)-c1cc2ncnc(SCC(O)=O)c2s1
PDB

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TBA

Assay Description
Inhibition of N-terminal His-tagged STK17B kinase domain (25 to 329 residues) (unknown origin) expressed in Escherichia coli incubated for 90 mins by...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01174
BindingDB Entry DOI: 10.7270/Q2DB85J2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50354541
PNG
(CHEMBL1836714)
Show SMILES OC(=O)CSc1ncnc2cc(sc12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C14H9ClN2O2S2/c15-9-3-1-8(2-4-9)11-5-10-13(21-11)14(17-7-16-10)20-6-12(18)19/h1-5,7H,6H2,(H,18,19)
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TBA

Assay Description
Inhibition of N-terminal His-tagged STK17B kinase domain (25 to 329 residues) (unknown origin) expressed in Escherichia coli incubated for 90 mins by...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01174
BindingDB Entry DOI: 10.7270/Q2DB85J2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM441904
PNG
(US10647686, Comparative Example 6)
Show SMILES NCCCNc1nc(Nc2ccc(Cl)cc2)ncc1Br
Show InChI InChI=1S/C13H15BrClN5/c14-11-8-18-13(20-12(11)17-7-1-6-16)19-10-4-2-9(15)3-5-10/h2-5,8H,1,6-7,16H2,(H2,17,18,19,20)
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US Patent
n/an/a 40n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)


BindingDB Entry DOI: 10.7270/Q2MS3WSB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM441904
PNG
(US10647686, Comparative Example 6)
Show SMILES NCCCNc1nc(Nc2ccc(Cl)cc2)ncc1Br
Show InChI InChI=1S/C13H15BrClN5/c14-11-8-18-13(20-12(11)17-7-1-6-16)19-10-4-2-9(15)3-5-10/h2-5,8H,1,6-7,16H2,(H2,17,18,19,20)
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US Patent
n/an/a 40n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)


BindingDB Entry DOI: 10.7270/Q2MS3WSB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50559230
PNG
(CHEMBL4783516)
Show SMILES CCOC(=O)c1ccc(cc1)-c1cc2ncnc(SCC(O)=O)c2s1
PDB

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TBA

Assay Description
Inhibition of N-terminal His-tagged STK17B kinase domain (25 to 329 residues) (unknown origin) expressed in Escherichia coli incubated for 90 mins by...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01174
BindingDB Entry DOI: 10.7270/Q2DB85J2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50559244
PNG
(CHEMBL4753625)
Show SMILES CCc1ccc(cc1)-c1cc2ncnc(SCC(O)=O)c2s1
PDB

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TBA

Assay Description
Inhibition of N-terminal His-tagged STK17B kinase domain (25 to 329 residues) (unknown origin) expressed in Escherichia coli incubated for 90 mins by...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01174
BindingDB Entry DOI: 10.7270/Q2DB85J2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50559247
PNG
(CHEMBL4789685)
Show SMILES CSc1cccc(c1)-c1cc2ncnc(SCC(O)=O)c2s1
PDB

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TBA

Assay Description
Inhibition of N-terminal His-tagged STK17B kinase domain (25 to 329 residues) (unknown origin) expressed in Escherichia coli incubated for 90 mins by...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01174
BindingDB Entry DOI: 10.7270/Q2DB85J2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50559245
PNG
(CHEMBL4740604)
Show SMILES CC(C)Sc1ccc(cc1)-c1cc2ncnc(SCC(O)=O)c2s1
PDB

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TBA

Assay Description
Inhibition of N-terminal His-tagged STK17B kinase domain (25 to 329 residues) (unknown origin) expressed in Escherichia coli incubated for 90 mins by...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01174
BindingDB Entry DOI: 10.7270/Q2DB85J2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50559229
PNG
(CHEMBL4745018)
Show SMILES OC(=O)CSc1ncnc2cc(sc12)-c1cccc(F)c1
PDB

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TBA

Assay Description
Inhibition of N-terminal His-tagged STK17B kinase domain (25 to 329 residues) (unknown origin) expressed in Escherichia coli incubated for 90 mins by...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01174
BindingDB Entry DOI: 10.7270/Q2DB85J2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50559242
PNG
(CHEMBL4748440)
Show SMILES CC(C)c1ccc(cc1)-c1cc2ncnc(SCC(O)=O)c2s1
PDB

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n/an/a 59n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of N-terminal His-tagged STK17B kinase domain (25 to 329 residues) (unknown origin) expressed in Escherichia coli incubated for 90 mins by...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01174
BindingDB Entry DOI: 10.7270/Q2DB85J2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50559228
PNG
(CHEMBL4788886)
Show SMILES OC(=O)CSc1ncnc2cc(sc12)-c1ccccc1F
PDB

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n/an/a 60n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of N-terminal His-tagged STK17B kinase domain (25 to 329 residues) (unknown origin) expressed in Escherichia coli incubated for 90 mins by...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01174
BindingDB Entry DOI: 10.7270/Q2DB85J2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50559241
PNG
(CHEMBL4739879)
Show SMILES OC(=O)CSc1ncnc2cc(sc12)-c1ccc(cc1)C1CC1
PDB

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n/an/a 62n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of N-terminal His-tagged STK17B kinase domain (25 to 329 residues) (unknown origin) expressed in Escherichia coli incubated for 90 mins by...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01174
BindingDB Entry DOI: 10.7270/Q2DB85J2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50559231
PNG
(CHEMBL4792541)
Show SMILES OC(=O)CSc1ncnc2cc(sc12)-c1cccs1
PDB

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n/an/a 63n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of N-terminal His-tagged STK17B kinase domain (25 to 329 residues) (unknown origin) expressed in Escherichia coli incubated for 90 mins by...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01174
BindingDB Entry DOI: 10.7270/Q2DB85J2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50559227
PNG
(CHEMBL4748561)
Show SMILES OC(=O)CSc1ncnc2cc(sc12)-c1ccc(F)c(F)c1
PDB

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n/an/a 74n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of N-terminal His-tagged STK17B kinase domain (25 to 329 residues) (unknown origin) expressed in Escherichia coli incubated for 90 mins by...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01174
BindingDB Entry DOI: 10.7270/Q2DB85J2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50166271
PNG
(CHEMBL3798563)
Show SMILES O\N=C1\C(\Nc2ccccc\12)=C1\C(=O)Nc2ccc(NC(=O)c3cc(cc(c3)[N+]([O-])=O)[N+]([O-])=O)cc12
Show InChI InChI=1S/C23H14N6O7/c30-22(11-7-13(28(33)34)10-14(8-11)29(35)36)24-12-5-6-18-16(9-12)19(23(31)26-18)21-20(27-32)15-3-1-2-4-17(15)25-21/h1-10,25,32H,(H,24,30)(H,26,31)/b21-19-,27-20+
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n/an/a 77n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of DRAK2 (unknown origin) using MRLC3 peptide as substrate incubated for 2 hrs by ADP-Glo kinase assay


Bioorg Med Chem Lett 26: 2719-23 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.111
BindingDB Entry DOI: 10.7270/Q2N29ZTZ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50559234
PNG
(CHEMBL4781408)
Show SMILES OC(=O)CSc1ncnc2cc(sc12)-c1cccc(c1)N1CCOCC1
PDB

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n/an/a 83n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of N-terminal His-tagged STK17B kinase domain (25 to 329 residues) (unknown origin) expressed in Escherichia coli incubated for 90 mins by...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01174
BindingDB Entry DOI: 10.7270/Q2DB85J2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50559240
PNG
(CHEMBL4755086)
Show SMILES OC(=O)CSc1ncnc2cc(sc12)-c1ccc(Cl)c(Cl)c1
PDB

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n/an/a 92n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of N-terminal His-tagged STK17B kinase domain (25 to 329 residues) (unknown origin) expressed in Escherichia coli incubated for 90 mins by...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01174
BindingDB Entry DOI: 10.7270/Q2DB85J2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50559246
PNG
(CHEMBL4752999)
Show SMILES COc1ccccc1-c1cc2ncnc(SCC(O)=O)c2s1
PDB

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TBA

Assay Description
Inhibition of N-terminal His-tagged STK17B kinase domain (25 to 329 residues) (unknown origin) expressed in Escherichia coli incubated for 90 mins by...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01174
BindingDB Entry DOI: 10.7270/Q2DB85J2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50559239
PNG
(CHEMBL4794226)
Show SMILES OC(=O)CSc1ncnc2cc(sc12)-c1ccc(OCc2ccccc2)cc1
PDB

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n/an/a 110n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of N-terminal His-tagged STK17B kinase domain (25 to 329 residues) (unknown origin) expressed in Escherichia coli incubated for 90 mins by...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01174
BindingDB Entry DOI: 10.7270/Q2DB85J2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM441866
PNG
(US10647686, Example (13))
Show SMILES NCCCNc1nc(Nc2ccc(cc2)S(=O)(=O)c2ccc(cc2)[N+]([O-])=O)ncc1Cl
Show InChI InChI=1S/C19H19ClN6O4S/c20-17-12-23-19(25-18(17)22-11-1-10-21)24-13-2-6-15(7-3-13)31(29,30)16-8-4-14(5-9-16)26(27)28/h2-9,12H,1,10-11,21H2,(H2,22,23,24,25)
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n/an/a 110n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)


BindingDB Entry DOI: 10.7270/Q2MS3WSB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50559243
PNG
(CHEMBL4794509)
Show SMILES OC(=O)CSc1ncnc2cc(sc12)-c1ccc(C=C)cc1
PDB

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TBA

Assay Description
Binding affinity to C-terminal nano-luciferase tagged STK17B (unknown origin) expressed in HEK293 cells incubated for 2 hrs by nano-BRET assay based ...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01174
BindingDB Entry DOI: 10.7270/Q2DB85J2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50166211
PNG
(CHEMBL3798579)
Show SMILES O\N=C1\C(\Nc2ccccc\12)=C1\C(=O)Nc2ccc(NC(=O)C3CCCCC3)cc12
Show InChI InChI=1S/C23H22N4O3/c28-22(13-6-2-1-3-7-13)24-14-10-11-18-16(12-14)19(23(29)26-18)21-20(27-30)15-8-4-5-9-17(15)25-21/h4-5,8-13,25,30H,1-3,6-7H2,(H,24,28)(H,26,29)/b21-19-,27-20+
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Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of DRAK2 (unknown origin) using MRLC3 peptide as substrate incubated for 2 hrs by ADP-Glo kinase assay


Bioorg Med Chem Lett 26: 2719-23 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.111
BindingDB Entry DOI: 10.7270/Q2N29ZTZ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50166268
PNG
(CHEMBL3798680)
Show SMILES O\N=C1\C(\Nc2ccccc\12)=C1\C(=O)Nc2ccc(NC(=O)c3ccccc3C(F)(F)F)cc12
Show InChI InChI=1S/C24H15F3N4O3/c25-24(26,27)16-7-3-1-5-13(16)22(32)28-12-9-10-18-15(11-12)19(23(33)30-18)21-20(31-34)14-6-2-4-8-17(14)29-21/h1-11,29,34H,(H,28,32)(H,30,33)/b21-19-,31-20+
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n/an/a 120n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of DRAK2 (unknown origin) using MRLC3 peptide as substrate incubated for 2 hrs by ADP-Glo kinase assay


Bioorg Med Chem Lett 26: 2719-23 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.111
BindingDB Entry DOI: 10.7270/Q2N29ZTZ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM441876
PNG
(US10647686, Example (23))
Show SMILES NCCCNc1nc(Nc2ccc3CCCCc3c2)ncc1Cl
Show InChI InChI=1S/C17H22ClN5/c18-15-11-21-17(23-16(15)20-9-3-8-19)22-14-7-6-12-4-1-2-5-13(12)10-14/h6-7,10-11H,1-5,8-9,19H2,(H2,20,21,22,23)
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n/an/a 160n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)


BindingDB Entry DOI: 10.7270/Q2MS3WSB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM50585186
PNG
(CHEMBL5075360)
Show SMILES O=C(NCCCNc1ccnc(Nc2cccc(NC(=O)N3CCCC3)c2)n1)C1CCC1
PDB

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TBA

Assay Description
Inhibition of recombinant human DRAK2 using KKRPQRRYSNVF as substrate after 120 mins in presence of [gamma-33ATP] by scintillation counting based rad...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00440
BindingDB Entry DOI: 10.7270/Q27S7SND
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM441871
PNG
(US10647686, Example (18))
Show SMILES COc1ccc(Nc2ncc(Cl)c(NCCCN)n2)cc1Cl
Show InChI InChI=1S/C14H17Cl2N5O/c1-22-12-4-3-9(7-10(12)15)20-14-19-8-11(16)13(21-14)18-6-2-5-17/h3-4,7-8H,2,5-6,17H2,1H3,(H2,18,19,20,21)
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n/an/a 180n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)


BindingDB Entry DOI: 10.7270/Q2MS3WSB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 17B


(Homo sapiens (Human))
BDBM441863
PNG
(US10647686, Example (10))
Show SMILES NCCCNc1nc(Nc2ccc(Oc3ccccc3)cc2)ncc1Cl
Show InChI InChI=1S/C19H20ClN5O/c20-17-13-23-19(25-18(17)22-12-4-11-21)24-14-7-9-16(10-8-14)26-15-5-2-1-3-6-15/h1-3,5-10,13H,4,11-12,21H2,(H2,22,23,24,25)
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n/an/a 180n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

US Patent


Assay Description
To measure the DRAK1 and DRAK2 activity, the substrate MRCL3 peptide and ATP were mixed with the enzymes. After an appropriate period of time, the re...


US Patent US10647686 (2020)


BindingDB Entry DOI: 10.7270/Q2MS3WSB
More data for this
Ligand-Target Pair
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