Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine palmitoyltransferase 1 (Homo sapiens (Human)) | BDBM50535848 (CHEMBL4584997) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Inhibition of human SPT1 expressed in microsomes of HEK293 cells incubated for 1hr by LC/MS analysis | J Med Chem 59: 5904-10 (2016) Article DOI: 10.1021/acs.jmedchem.5b01851 BindingDB Entry DOI: 10.7270/Q29K4FR1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine palmitoyltransferase 1 (Homo sapiens (Human)) | BDBM50325998 ((S)-2-((S,E)-1-((S)-1-carboxy-2-(4-(3-methylbut-2-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co. Ltd. Curated by ChEMBL | Assay Description Inhibition of human recombinant SPT1 activity in LCB1 transfected human HEK293 cells | Nat Chem Biol 1: 333-7 (2006) Article DOI: 10.1038/nchembio742 BindingDB Entry DOI: 10.7270/Q2MW2HC2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine palmitoyltransferase 1 (Homo sapiens (Human)) | BDBM50535847 (CHEMBL4541898) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Inhibition of human SPT1 expressed in microsomes of HEK293 cells incubated for 1hr by LC/MS analysis | J Med Chem 59: 5904-10 (2016) Article DOI: 10.1021/acs.jmedchem.5b01851 BindingDB Entry DOI: 10.7270/Q29K4FR1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine palmitoyltransferase 1 (Homo sapiens (Human)) | BDBM50461646 (CHEBI:582124 | Myriocin) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | n/a | 50 | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Inhibition of SPT1 in human MCF7 cells assessed as suppression of 14C-serine incorporation into ceramide incubated for 2 hrs in presence of 4-HPR | J Med Chem 59: 5904-10 (2016) Article DOI: 10.1021/acs.jmedchem.5b01851 BindingDB Entry DOI: 10.7270/Q29K4FR1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Serine palmitoyltransferase 1 (Homo sapiens (Human)) | BDBM50535847 (CHEMBL4541898) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 4.22E+3 | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Inhibition of SPT1 in human MCF7 cells assessed as suppression of 14C-serine incorporation into ceramide incubated for 2 hrs in presence of 4-HPR | J Med Chem 59: 5904-10 (2016) Article DOI: 10.1021/acs.jmedchem.5b01851 BindingDB Entry DOI: 10.7270/Q29K4FR1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine palmitoyltransferase 1 (Homo sapiens (Human)) | BDBM50535848 (CHEMBL4584997) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 977 | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Inhibition of SPT1 in human MCF7 cells assessed as suppression of 14C-serine incorporation into ceramide incubated for 2 hrs in presence of 4-HPR | J Med Chem 59: 5904-10 (2016) Article DOI: 10.1021/acs.jmedchem.5b01851 BindingDB Entry DOI: 10.7270/Q29K4FR1 | |||||||||||
More data for this Ligand-Target Pair |