BindingDB PrimarySearch

Found 13 hits Enz. Inhib. hit(s) with Target = '5-hydroxytryptamine receptor 4' AND taxid = 9823
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
5-hydroxytryptamine receptor 4 (Sus scrofa)	BDBM50421360 (CHEMBL358119 \| SB-207058) Show SMILES Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	0.0631	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound was evaluated for its ability to inhibit the binding of 5-HT4 receptor radioligand [125I]SB 207710 to piglet hippocampal membrane				Citation and Details Article DOI: 10.1016/S0960-894X(01)80176-1 BindingDB Entry DOI: 10.7270/Q25T3MSB
TBA					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 4 (Sus scrofa)	BDBM50421359 (CHEMBL145075) Show SMILES CCCCN1CCC(COC(=O)c2c3OCCn3c3ccccc23)CC1 Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	0.0794	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound was evaluated for its ability to inhibit the binding of 5-HT4 receptor radioligand [125I]SB 207710 to piglet hippocampal membrane				Citation and Details Article DOI: 10.1016/S0960-894X(01)80176-1 BindingDB Entry DOI: 10.7270/Q25T3MSB
TBA					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 4 (Sus scrofa)	BDBM82505 (CAS_121881 \| NSC_121881 \| SB204070) Show SMILES Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article	0.126	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound was evaluated for its ability to inhibit the binding of 5-HT4 receptor radioligand [125I]SB 207710 to piglet hippocampal membrane				Citation and Details Article DOI: 10.1016/S0960-894X(01)80176-1 BindingDB Entry DOI: 10.7270/Q25T3MSB
TBA					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 4 (Sus scrofa)	BDBM50421362 (CHEMBL143862) Show SMILES Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	0.200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound was evaluated for its ability to inhibit the binding of 5-HT4 receptor radioligand [125I]SB 207710 to piglet hippocampal membrane				Citation and Details Article DOI: 10.1016/S0960-894X(01)80176-1 BindingDB Entry DOI: 10.7270/Q25T3MSB
TBA					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 4 (Sus scrofa)	BDBM50421361 (CHEMBL143426) Show SMILES CCCCN1CCC(COC(=O)c2c[nH]c3ccccc23)CC1 Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	2.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound was evaluated for its ability to inhibit the binding of 5-HT4 receptor radioligand [125I]SB 207710 to piglet hippocampal membrane				Citation and Details Article DOI: 10.1016/S0960-894X(01)80176-1 BindingDB Entry DOI: 10.7270/Q25T3MSB
TBA					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 4 (PIGLET)	BDBM50003359 (5-(4-Hexyloxy-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2...) Show SMILES CCCCCCOc1nsnc1C1=CCCN(C)C1 \|t:13\| Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	251	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SmithKline Beecham Pharmaceuticals Curated by PDSP K_i Database									Br J Pharmacol 125: 1413-20 (1998) Article DOI: 10.1038/sj.bjp.0702201 BindingDB Entry DOI: 10.7270/Q2HM56ZD
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 4 (Sus scrofa)	BDBM50079939 ((7-Chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)...) Show SMILES Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Knoll Pharmaceuticals Curated by ChEMBL					Assay Description The compound was tested for binding affinity against 5-hydroxytryptamine 4 receptor				J Med Chem 42: 3342-55 (1999) Article DOI: 10.1021/jm9910122 BindingDB Entry DOI: 10.7270/Q2WH2P6K
Knoll Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 4 (Sus scrofa)	BDBM50084959 (11'-Methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadia...) Show SMILES Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SmithKline Beecham Pharmaceuticals Curated by ChEMBL					Assay Description Compound was tested for binding affinity against piglet hippocampus 5-hydroxytryptamine 4 receptor				J Med Chem 41: 1218-35 (1998) Article DOI: 10.1021/jm970457s BindingDB Entry DOI: 10.7270/Q2XS5WMN
SmithKline Beecham Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 4 (PIGLET)	BDBM85097 (CAS_181632-25-7 \| CHEMBL14563 \| SB 242084) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	3.16E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SmithKline Beecham Pharmaceuticals Curated by PDSP K_i Database									Neuropharmacology 36: 609-20 (1997) Article DOI: 10.1016/s0028-3908(97)00038-5 BindingDB Entry DOI: 10.7270/Q2SN07GG
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 4 (PIGLET)	BDBM84991 (CAS_3277600 \| NSC_3277600 \| SB204741) Show SMILES Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1 Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SmithKline Beecham Pharmaceuticals Curated by PDSP K_i Database									Behav Brain Res 73: 149-52 (1996) Article DOI: 10.1016/0166-4328(96)00087-3 BindingDB Entry DOI: 10.7270/Q2RX99ND
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 4 (PIGLET)	BDBM82472 (BW-723C86 \| CAS_5311036 \| NSC_5311036) Show SMILES CC(N)Cc1c[nH]c2ccc(OCc3cccs3)cc12 Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SmithKline Beecham Pharmaceuticals Curated by PDSP K_i Database									Behav Brain Res 73: 149-52 (1996) Article DOI: 10.1016/0166-4328(96)00087-3 BindingDB Entry DOI: 10.7270/Q2RX99ND
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 4 (Sus scrofa)	BDBM50327858 ((1-Butylpiperidin-4-yl)methyl 8-amino-7-iodo-2,3-d...) Show SMILES Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	0.0800	n/a	n/a	n/a	n/a	n/a
Molecular NeuroImaging LLC Curated by ChEMBL					Assay Description Binding affinity to 5HT4 receptor in pig striatal membranes				Bioorg Med Chem Lett 23: 6243-7 (2013) Article DOI: 10.1016/j.bmcl.2013.09.097 BindingDB Entry DOI: 10.7270/Q2RJ4KZ2
Molecular NeuroImaging LLC Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 4 (Sus scrofa)	BDBM50448450 (CHEMBL3126112) Show SMILES CN1CCC(COC(=O)c2cc(Cl)c(N)c3OCCOc23)CC1 Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	0.0800	n/a	n/a	n/a	n/a	n/a
Molecular NeuroImaging LLC Curated by ChEMBL					Assay Description Binding affinity to 5HT4 receptor in pig striatal membranes				Bioorg Med Chem Lett 23: 6243-7 (2013) Article DOI: 10.1016/j.bmcl.2013.09.097 BindingDB Entry DOI: 10.7270/Q2RJ4KZ2
Molecular NeuroImaging LLC Curated by ChEMBL					More data for this Ligand-Target Pair