Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM50559599 (CHEMBL4764496) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human TRPC6 channel transfected in HEK293 cells assessed as intracellular calcium level by FLIPR assay | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00056 BindingDB Entry DOI: 10.7270/Q2J106W2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM50559602 (CHEMBL4741505) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human TRPC6 channel transfected in HEK293 cells assessed as intracellular calcium level by FLIPR assay | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00056 BindingDB Entry DOI: 10.7270/Q2J106W2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM50559600 (CHEMBL4752852) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human TRPC6 channel transfected in HEK293 cells assessed as intracellular calcium level by FLIPR assay | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00056 BindingDB Entry DOI: 10.7270/Q2J106W2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM50559598 (CHEMBL4753871) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human TRPC6 channel transfected in HEK293 cells assessed as intracellular calcium level by FLIPR assay | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00056 BindingDB Entry DOI: 10.7270/Q2J106W2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM50559601 (CHEMBL4746182) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human TRPC6 channel transfected in HEK293 cells assessed as intracellular calcium level by FLIPR assay | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00056 BindingDB Entry DOI: 10.7270/Q2J106W2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM50559597 (CHEMBL4776935) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human TRPC6 channel transfected in HEK293 cells assessed as intracellular calcium level by FLIPR assay | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00056 BindingDB Entry DOI: 10.7270/Q2J106W2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM542437 (1-[4-(4-fluorophenyl)-2-pyrazol-1-yl-cyclopentyl] ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM50273013 (CHEMBL4129456) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd Curated by ChEMBL | Assay Description Inhibition of human TRPC6 expressed in HEK293 cells assessed as decrease in intracellular calcium level after 24 hrs by Fluo-4 dye-based FLIPR assay | Bioorg Med Chem Lett 28: 2222-2227 (2018) Article DOI: 10.1016/j.bmcl.2018.03.056 BindingDB Entry DOI: 10.7270/Q2CF9SMH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM542002 (1-[4-(4-fluorophenyl)-2-(triazol-2-yl)cyclopentyl]...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.37 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM542439 (5-fluoro-1-[4-(4-fluorophenyl)-2-pyrazol-1-yl-cycl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM542462 (5-fluoro-1-[4-(4-fluorophenyl)-2-pyrimidin-4-yloxy...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.44 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM542143 (1-[2-(3-amino-1-piperidyl)-4-(4-fluorophenyl)cyclo...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.78 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM50439218 (CHEMBL2418809) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay | Bioorg Med Chem Lett 23: 4979-84 (2013) Article DOI: 10.1016/j.bmcl.2013.06.047 BindingDB Entry DOI: 10.7270/Q2319X9H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM542199 (1-[2-(3-amino-5-fluoro-1-piperidyl)-4-(4-fluorophe...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.06 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM542121 (1-[2-(3-amino-1-piperidyl)-4-(4-fluorophenyl)cyclo...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.31 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM542456 (1-[2-(4-chloropyridazin-3-yl)oxy-4-(4-fluorophenyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.56 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM542446 (1-[2-(3-amino-1-piperidyl)-4-(4-fluorophenyl)cyclo...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM50273009 (CHEMBL4129809) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center Curated by ChEMBL | Assay Description Inhibition of human TRPC6 expressed in HEK293 cells assessed as reduction in TRPC6-induced current by Whole-cell patch-clamp | J Med Chem 62: 7589-7602 (2019) Article DOI: 10.1021/acs.jmedchem.8b01954 BindingDB Entry DOI: 10.7270/Q2XS5ZR8 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM542111 (1-[2-(3-amino-1-piperidyl)-4-(4-fluorophenyl)cyclo...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7.97 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM50273116 (CHEMBL4129805) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd Curated by ChEMBL | Assay Description Inhibition of human TRPC6 expressed in HEK293 cells assessed as decrease in intracellular calcium level after 24 hrs by Fluo-4 dye-based FLIPR assay | Bioorg Med Chem Lett 28: 2222-2227 (2018) Article DOI: 10.1016/j.bmcl.2018.03.056 BindingDB Entry DOI: 10.7270/Q2CF9SMH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM50273009 (CHEMBL4129809) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 9.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd Curated by ChEMBL | Assay Description Inhibition of human TRPC6 expressed in HEK293 cells assessed as decrease in intracellular calcium level after 24 hrs by Fluo-4 dye-based FLIPR assay | Bioorg Med Chem Lett 28: 2222-2227 (2018) Article DOI: 10.1016/j.bmcl.2018.03.056 BindingDB Entry DOI: 10.7270/Q2CF9SMH | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM50273009 (CHEMBL4129809) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 9.5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center Curated by ChEMBL | Assay Description Inhibition of human TRPC6 expressed in HEK293 cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR as... | J Med Chem 62: 7589-7602 (2019) Article DOI: 10.1021/acs.jmedchem.8b01954 BindingDB Entry DOI: 10.7270/Q2XS5ZR8 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM542459 (6-[2-(3-amino-1-piperidyl)-4-(4-fluorophenyl) cycl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 9.51 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM542448 (4-[2-(3-amino-1-piperidyl)-4-(4-fluoro-3-methoxy-p...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 9.51 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM542458 (US11274091, Example 25 | l-[4-(4-fluorophenyl)-2-(...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 9.93 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM542444 (5-fluoro-1-[4-(4-fluorophenyl)-2-(tetrazol-2-yl) c...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 10.6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM542465 (5-[2-(3-amino-1-piperidyl)-4-(4-fluorophenyl) cycl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 10.6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM50273012 (CHEMBL4127600) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd Curated by ChEMBL | Assay Description Inhibition of human TRPC6 expressed in HEK293 cells assessed as decrease in intracellular calcium level after 24 hrs by Fluo-4 dye-based FLIPR assay | Bioorg Med Chem Lett 28: 2222-2227 (2018) Article DOI: 10.1016/j.bmcl.2018.03.056 BindingDB Entry DOI: 10.7270/Q2CF9SMH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM542463 (2-[2-(3-amino-1-piperidyl)-4-(4-fluorophenyl) cycl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 11.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM542457 (6-[2-(3-amino-5-fluoro-1-piperidyl)-4-(4-fluorophe...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >11.8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM542464 (5-[2-(3-amino-1-piperidyl)-4-(4-fluorophenyl) cycl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 13.7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM542453 (2-[2-(3-amino-1-piperidyl)-4-phenyl-cyclopentoxy] ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 14.1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM50439217 (CHEMBL2418811) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay | Bioorg Med Chem Lett 23: 4979-84 (2013) Article DOI: 10.1016/j.bmcl.2013.06.047 BindingDB Entry DOI: 10.7270/Q2319X9H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM50439220 (CHEMBL2418807) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay | Bioorg Med Chem Lett 23: 4979-84 (2013) Article DOI: 10.1016/j.bmcl.2013.06.047 BindingDB Entry DOI: 10.7270/Q2319X9H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM542201 (1-[2-(3-amino-4,4-difluoro-1-piperidyl)-4-(4-fluor...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 16.2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM542447 (4-[2-(3-amino-1-piperidyl)-4-(4-fluoro-3-hydroxy-p...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 17.4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM542454 (4-[2-(3-amino-1-piperidyl)-4-phenyl-cyclopentoxy]-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 17.4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM542461 (1-[4-(4-fluorophenyl)-2-pyridazin-3-yloxy-cyclopen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 17.8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM542449 (4-[2-(3-amino-1-piperidyl)-4-(3-fluorophenyl) cycl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 19.3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM542119 (1-[2-(3-amino-1-piperidyl)-4-(4-fluorophenyl)cyclo...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <19.9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM542450 (4-[2-(3-amino-4,4-difluoro-1-piperidyl)-4-(4-fluor...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 20.7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM542460 (6-[2-(3-amino-1-piperidyl)-4-(4-fluorophenyl) cycl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM50273111 (CHEMBL4126041) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd Curated by ChEMBL | Assay Description Inhibition of human TRPC6 expressed in HEK293 cells assessed as decrease in intracellular calcium level after 24 hrs by Fluo-4 dye-based FLIPR assay | Bioorg Med Chem Lett 28: 2222-2227 (2018) Article DOI: 10.1016/j.bmcl.2018.03.056 BindingDB Entry DOI: 10.7270/Q2CF9SMH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM50439219 (CHEMBL2418808) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay | Bioorg Med Chem Lett 23: 4979-84 (2013) Article DOI: 10.1016/j.bmcl.2013.06.047 BindingDB Entry DOI: 10.7270/Q2319X9H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM542452 (4-[2-(3-amino-1-piperidyl)-4-(4-fluorophenyl) cycl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 25.1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM542445 (1-[4-(4-fluorophenyl)-2-(tetrazol-2-yl)cyclopentyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 26.7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM466594 ((6-Amino-4-methyl-3',4',5',6'- tetrahydro-2'H-[3,4...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC US Patent | Assay Description This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o... | US Patent US10800757 (2020) BindingDB Entry DOI: 10.7270/Q2PV6PDC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM466595 (US10800757, Compound 11 | US10889568, Compound 11 ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC US Patent | Assay Description This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o... | US Patent US10800757 (2020) BindingDB Entry DOI: 10.7270/Q2PV6PDC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM466596 (US10800757, Compound 12 | US10889568, Compound 12 ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC US Patent | Assay Description This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o... | US Patent US10800757 (2020) BindingDB Entry DOI: 10.7270/Q2PV6PDC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 6 (Homo sapiens (Human)) | BDBM466597 (US10800757, Compound 13 | US10889568, Compound 13 ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC US Patent | Assay Description This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o... | US Patent US10800757 (2020) BindingDB Entry DOI: 10.7270/Q2PV6PDC | |||||||||||
More data for this Ligand-Target Pair |
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