Found 10 hits Enz. Inhib. hit(s) with Target = 'Hepatocyte growth factor receptor' AND taxid = 10090 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Hepatocyte growth factor receptor
(Mus musculus) | BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)(C)O)n(-c5ccccc5)c4=O)nc3)ccnc2c1 Show InChI InChI=1S/C30H29N5O5/c1-19-27(29(37)35(20-8-6-5-7-9-20)34(19)18-30(2,3)38)28(36)33-26-13-11-22(17-32-26)40-25-14-15-31-24-16-21(39-4)10-12-23(24)25/h5-17,38H,18H2,1-4H3,(H,32,33,36) | PDB
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| Article
PubMed
| 2 | -49.2 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Amgen
| Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ... |
J Med Chem 51: 3688-91 (2008)
Article DOI: 10.1021/jm800401t
BindingDB Entry DOI: 10.7270/Q2FF3QNG |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor/Nucleoprotein TPR
(Mus musculus) | BDBM163243
(US9062045, Comparator No. 1 (JNJ-38877605))Show SMILES Cn1cc(cn1)-c1ccc2nnc(n2n1)C(F)(F)c1ccc2ncccc2c1 Show InChI InChI=1S/C19H13F2N7/c1-27-11-13(10-23-27)16-6-7-17-24-25-18(28(17)26-16)19(20,21)14-4-5-15-12(9-14)3-2-8-22-15/h2-11H,1H3 | PDB
UniProtKB/SwissProt
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UniChem
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| Article
PubMed
| n/a | n/a | 8.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences (CAS)
Curated by ChEMBL
| Assay Description
Inhibition of TPR-MET in mouse BAF3 cells assessed as reduction in cell proliferation after 72 hrs by SRB or MTT assay |
Eur J Med Chem 116: 239-251 (2016)
Article DOI: 10.1016/j.ejmech.2016.03.076
BindingDB Entry DOI: 10.7270/Q2P27111 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM24470
(7-methoxy-4-({6-phenyl-[1,2,4]triazolo[4,3-a]pyrid...)Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccccc3)ccnc2c1 Show InChI InChI=1S/C22H17N5O2/c1-28-16-7-8-17-19(13-16)23-12-11-20(17)29-14-22-25-24-21-10-9-18(26-27(21)22)15-5-3-2-4-6-15/h2-13H,14H2,1H3 | PDB
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| PDB
Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
| Assay Description
The c-Met kinase activity as tested with enzyme-linked immunosorbent assays (ELISAs) as previously reported protocol [Qiang et al., Bioorg. Med. Chem... |
Bioorg Chem 70: 126-132 (2017)
Article DOI: 10.1016/j.bioorg.2016.12.002
BindingDB Entry DOI: 10.7270/Q23X85HP |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Hepatocyte growth factor receptor
(Mus musculus) | BDBM50384721
(CHEMBL2037224)Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(Nc3ccc4\C(=C\c5ccc[nH]5)C(=O)Nc4c3)c2)c1 Show InChI InChI=1S/C27H20F3N5O2/c28-27(29,30)16-4-1-5-18(12-16)33-26(37)34-20-7-2-6-19(13-20)32-21-9-10-22-23(14-17-8-3-11-31-17)25(36)35-24(22)15-21/h1-15,31-32H,(H,35,36)(H2,33,34,37)/b23-14- | PDB
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| CHEMBL
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PDB
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| Article
PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Tel-fused MET in mouse BA/F3 cells |
ACS Med Chem Lett 3: 140-145 (2012)
Article DOI: 10.1021/ml200261d
BindingDB Entry DOI: 10.7270/Q2SJ1MNM |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Mus musculus) | BDBM50384734
(CHEMBL2037211)Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1 Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18- | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Tel-fused MET in mouse BA/F3 cells |
ACS Med Chem Lett 3: 140-145 (2012)
Article DOI: 10.1021/ml200261d
BindingDB Entry DOI: 10.7270/Q2SJ1MNM |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Mus musculus) | BDBM50384727
(CHEMBL2037226)Show SMILES Cc1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1Nc1ccc2\C(=C\c3ccc[nH]3)C(=O)Nc2c1 Show InChI InChI=1S/C28H21F4N5O2/c1-15-4-6-19(35-27(39)37-25-11-16(28(30,31)32)5-9-22(25)29)13-23(15)34-18-7-8-20-21(12-17-3-2-10-33-17)26(38)36-24(20)14-18/h2-14,33-34H,1H3,(H,36,38)(H2,35,37,39)/b21-12- | PDB
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CHEMBL
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PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 5.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Tel-fused MET in mouse BA/F3 cells |
ACS Med Chem Lett 3: 140-145 (2012)
Article DOI: 10.1021/ml200261d
BindingDB Entry DOI: 10.7270/Q2SJ1MNM |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Mus musculus) | BDBM50384726
(CHEMBL2037208)Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1 Show InChI InChI=1S/C27H19F3N4O2/c28-27(29,30)17-5-1-4-16(12-17)25(35)33-20-7-2-6-19(13-20)32-21-9-10-22-23(14-18-8-3-11-31-18)26(36)34-24(22)15-21/h1-15,31-32H,(H,33,35)(H,34,36)/b23-14- | PDB
MMDB
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UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Tel-fused MET in mouse BA/F3 cells |
ACS Med Chem Lett 3: 140-145 (2012)
Article DOI: 10.1021/ml200261d
BindingDB Entry DOI: 10.7270/Q2SJ1MNM |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Mus musculus) | BDBM50384725
(CHEMBL2037209)Show SMILES Cc1cn(cn1)-c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1 Show InChI InChI=1S/C31H23F3N6O2/c1-18-16-40(17-36-18)25-11-19(10-20(12-25)31(32,33)34)29(41)38-23-5-2-4-22(13-23)37-24-7-8-26-27(14-21-6-3-9-35-21)30(42)39-28(26)15-24/h2-17,35,37H,1H3,(H,38,41)(H,39,42)/b27-14- | PDB
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UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
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PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Tel-fused MET in mouse BA/F3 cells |
ACS Med Chem Lett 3: 140-145 (2012)
Article DOI: 10.1021/ml200261d
BindingDB Entry DOI: 10.7270/Q2SJ1MNM |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM222078
(6-Chloro-3-((2-(2,4-dichlorophenyl)imidazo[1,2-a]p...)Show SMILES Clc1ccc(-c2cn3cccc(COc4nnc5ccc(Cl)nn45)c3n2)c(Cl)c1 Show InChI InChI=1S/C19H11Cl3N6O/c20-12-3-4-13(14(21)8-12)15-9-27-7-1-2-11(18(27)23-15)10-29-19-25-24-17-6-5-16(22)26-28(17)19/h1-9H,10H2 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.22E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
| Assay Description
The c-Met kinase activity as tested with enzyme-linked immunosorbent assays (ELISAs) as previously reported protocol [Qiang et al., Bioorg. Med. Chem... |
Bioorg Chem 70: 126-132 (2017)
Article DOI: 10.1016/j.bioorg.2016.12.002
BindingDB Entry DOI: 10.7270/Q23X85HP |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM222077
(6-chloro-3-((2-(2,5-dichlorophenyl)imidazo[1,2-a]p...)Show SMILES Clc1ccc(Cl)c(c1)-c1cn2cccc(COc3nnc4ccc(Cl)nn34)c2n1 Show InChI InChI=1S/C19H11Cl3N6O/c20-12-3-4-14(21)13(8-12)15-9-27-7-1-2-11(18(27)23-15)10-29-19-25-24-17-6-5-16(22)26-28(17)19/h1-9H,10H2 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.23E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
| Assay Description
The c-Met kinase activity as tested with enzyme-linked immunosorbent assays (ELISAs) as previously reported protocol [Qiang et al., Bioorg. Med. Chem... |
Bioorg Chem 70: 126-132 (2017)
Article DOI: 10.1016/j.bioorg.2016.12.002
BindingDB Entry DOI: 10.7270/Q23X85HP |
More data for this
Ligand-Target Pair | |
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