Compile Data Set for Download or QSAR

Found 409 hits Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform' AND taxid = 9606   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM188124 (US9670194, Ex. 3 (S)-2-(1-((6-amino-5-(3-methyl-1,...) Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C24H21ClN8O2/c1-3-16(30-21-19(20(26)27-12-28-21)23-29-13(2)32-35-23)22-31-17-11-7-10-15(25)18(17)24(34)33(22)14-8-5-4-6-9-14/h4-12,16H,3H2,1-2H3,(H3,26,27,28,30)/t16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	25
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...				US Patent US9670194 (2017) BindingDB Entry DOI: 10.7270/Q2NS0S1D
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM189846 (US9670194, Ex. 65 (S)-2-(1-((6-amino-5-(3-methyl-1...) Show SMILES C[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C23H19ClN8O2/c1-12(28-20-18(19(25)26-11-27-20)22-29-13(2)31-34-22)21-30-16-10-6-9-15(24)17(16)23(33)32(21)14-7-4-3-5-8-14/h3-12H,1-2H3,(H3,25,26,27,28)/t12-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	25
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...				US Patent US9670194 (2017) BindingDB Entry DOI: 10.7270/Q2NS0S1D
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM188116 (US9670194, Ex. 1 (S)-2-(1-((6-amino-5-(5-methyl-1,...) Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C24H21ClN8O2/c1-3-16(29-21-19(20(26)27-12-28-21)23-32-31-13(2)35-23)22-30-17-11-7-10-15(25)18(17)24(34)33(22)14-8-5-4-6-9-14/h4-12,16H,3H2,1-2H3,(H3,26,27,28,29)/t16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	25
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...				US Patent US9670194 (2017) BindingDB Entry DOI: 10.7270/Q2NS0S1D
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM189408 (US9670194, Ex. 41 (S)-2-(1-((6-amino-5-(3-methyl-1...) Show SMILES C[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r| Show InChI InChI=1S/C20H19ClN8O2/c1-9(25-17-15(16(22)23-8-24-17)19-26-10(2)28-31-19)18-27-13-5-3-4-12(21)14(13)20(30)29(18)11-6-7-11/h3-5,8-9,11H,6-7H2,1-2H3,(H3,22,23,24,25)/t9-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	25
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...				US Patent US9670194 (2017) BindingDB Entry DOI: 10.7270/Q2NS0S1D
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM189403 (US9670194, Ex. 37 (S)-2-(1-((6-amino-5-(3-methyl-1...) Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(C)c2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C25H24N8O2/c1-4-17(30-22-20(21(26)27-13-28-22)24-29-15(3)32-35-24)23-31-18-12-8-9-14(2)19(18)25(34)33(23)16-10-6-5-7-11-16/h5-13,17H,4H2,1-3H3,(H3,26,27,28,30)/t17-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	25
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...				US Patent US9670194 (2017) BindingDB Entry DOI: 10.7270/Q2NS0S1D
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM189838 (US9670194, Ex. 57 (S)-2-(1-((6-amino-5-(3-isopropy...) Show SMILES CC(C)c1noc(n1)-c1c(N)ncnc1N[C@@H](C)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r| Show InChI InChI=1S/C22H23ClN8O2/c1-10(2)18-29-21(33-30-18)16-17(24)25-9-26-19(16)27-11(3)20-28-14-6-4-5-13(23)15(14)22(32)31(20)12-7-8-12/h4-6,9-12H,7-8H2,1-3H3,(H3,24,25,26,27)/t11-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	25
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...				US Patent US9670194 (2017) BindingDB Entry DOI: 10.7270/Q2NS0S1D
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM188145 (US9670194, Ex. 4 (S)-2-(1-((6-amino-5-(3-methyl-1,...) Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r| Show InChI InChI=1S/C21H21ClN8O2/c1-3-13(27-18-16(17(23)24-9-25-18)20-26-10(2)29-32-20)19-28-14-6-4-5-12(22)15(14)21(31)30(19)11-7-8-11/h4-6,9,11,13H,3,7-8H2,1-2H3,(H3,23,24,25,27)/t13-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	25
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...				US Patent US9670194 (2017) BindingDB Entry DOI: 10.7270/Q2NS0S1D
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM189845 (US9670194, Ex. 64 (S)-2-(1-((6-amino-5-(5-methyl-1...) Show SMILES C[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C23H19ClN8O2/c1-12(28-20-18(19(25)26-11-27-20)22-31-30-13(2)34-22)21-29-16-10-6-9-15(24)17(16)23(33)32(21)14-7-4-3-5-8-14/h3-12H,1-2H3,(H3,25,26,27,28)/t12-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	25
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...				US Patent US9670194 (2017) BindingDB Entry DOI: 10.7270/Q2NS0S1D
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM189837 (US9670194, Ex. 56 (S)-2-(1-((6-amino-5-(3-ethyl-1,...) Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nc(CC)no1)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r| Show InChI InChI=1S/C22H23ClN8O2/c1-3-13(27-19-17(18(24)25-10-26-19)21-29-15(4-2)30-33-21)20-28-14-7-5-6-12(23)16(14)22(32)31(20)11-8-9-11/h5-7,10-11,13H,3-4,8-9H2,1-2H3,(H3,24,25,26,27)/t13-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	25
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...				US Patent US9670194 (2017) BindingDB Entry DOI: 10.7270/Q2NS0S1D
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255790 (1-{1-[5-Chloro-3-(1-isopropylazetidin-3-yl)-2-meth...) Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(C)C)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C22H29ClN6O/c1-11(2)28-8-15(9-28)18-12(3)17(23)7-16(20(18)30-6)14(5)29-22-19(13(4)27-29)21(24)25-10-26-22/h7,10-11,14-15H,8-9H2,1-6H3,(H2,24,25,26)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255791 (1-{1-[3-(1-Acetylazetidin-3-yl)-5-chloro-2-methoxy...) Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(C)=O)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C21H25ClN6O2/c1-10-16(22)6-15(19(30-5)17(10)14-7-27(8-14)13(4)29)12(3)28-21-18(11(2)26-28)20(23)24-9-25-21/h6,9,12,14H,7-8H2,1-5H3,(H2,23,24,25)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255792 (1-{1-[5-Chloro-2-methoxy-4-methyl-3-(1-propionylaz...) Show SMILES CCC(=O)N1CC(C1)c1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1OC Show InChI InChI=1S/C22H27ClN6O2/c1-6-17(30)28-8-14(9-28)18-11(2)16(23)7-15(20(18)31-5)13(4)29-22-19(12(3)27-29)21(24)25-10-26-22/h7,10,13-14H,6,8-9H2,1-5H3,(H2,24,25,26)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255793 (1-(1-{5-Chloro-3-[1-(cyclopropylmethyl)azetidin-3-...) Show SMILES COc1c(cc(Cl)c(C)c1C1CN(CC2CC2)C1)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C23H29ClN6O/c1-12-18(24)7-17(14(3)30-23-20(13(2)28-30)22(25)26-11-27-23)21(31-4)19(12)16-9-29(10-16)8-15-5-6-15/h7,11,14-16H,5-6,8-10H2,1-4H3,(H2,25,26,27)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255794 (1-{1-[5-chloro-2-methoxy-4-methyl-3-(1-methylazeti...) Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C)C1)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C20H25ClN6O/c1-10-15(21)6-14(18(28-5)16(10)13-7-26(4)8-13)12(3)27-20-17(11(2)25-27)19(22)23-9-24-20/h6,9,12-13H,7-8H2,1-5H3,(H2,22,23,24)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255795 (1-{1-[5-Chloro-3-(1-ethylazetidin-3-yl)-2-methoxy-...) Show SMILES CCN1CC(C1)c1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1OC Show InChI InChI=1S/C21H27ClN6O/c1-6-27-8-14(9-27)17-11(2)16(22)7-15(19(17)29-5)13(4)28-21-18(12(3)26-28)20(23)24-10-25-21/h7,10,13-14H,6,8-9H2,1-5H3,(H2,23,24,25)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255796 (1-{1-[5-Chloro-3-(1-isobutylazetidin-3-yl)-2-metho...) Show SMILES COc1c(cc(Cl)c(C)c1C1CN(CC(C)C)C1)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C23H31ClN6O/c1-12(2)8-29-9-16(10-29)19-13(3)18(24)7-17(21(19)31-6)15(5)30-23-20(14(4)28-30)22(25)26-11-27-23/h7,11-12,15-16H,8-10H2,1-6H3,(H2,25,26,27)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255797 (1-{1-[3-(1-sec-butylazetidin-3-yl)-5-chloro-2-meth...) Show SMILES CCC(C)N1CC(C1)c1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1OC Show InChI InChI=1S/C23H31ClN6O/c1-7-12(2)29-9-16(10-29)19-13(3)18(24)8-17(21(19)31-6)15(5)30-23-20(14(4)28-30)22(25)26-11-27-23/h8,11-12,15-16H,7,9-10H2,1-6H3,(H2,25,26,27)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255798 (1-(1-{5-Chloro-2-methoxy-3-[1-(2-methoxyethyl)azet...) Show SMILES COCCN1CC(C1)c1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1OC Show InChI InChI=1S/C22H29ClN6O2/c1-12-17(23)8-16(20(31-5)18(12)15-9-28(10-15)6-7-30-4)14(3)29-22-19(13(2)27-29)21(24)25-11-26-22/h8,11,14-15H,6-7,9-10H2,1-5H3,(H2,24,25,26)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255799 (3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...) Show SMILES CNC(=O)N1CC(C1)c1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1OC Show InChI InChI=1S/C21H26ClN7O2/c1-10-15(22)6-14(18(31-5)16(10)13-7-28(8-13)21(30)24-4)12(3)29-20-17(11(2)27-29)19(23)25-9-26-20/h6,9,12-13H,7-8H2,1-5H3,(H,24,30)(H2,23,25,26)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255800 (5-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...) Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C24H26ClN7O2/c1-12-17(25)9-16(14(3)32-23-20(13(2)30-32)22(26)28-11-29-23)21(34-6)19(12)15-7-8-18(27-10-15)24(33)31(4)5/h7-11,14H,1-6H3,(H2,26,28,29)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255802 (1-{1-[5-Chloro-4-fluoro-3-(1-isopropylazetidin-3-y...) Show SMILES COc1c(cc(Cl)c(F)c1C1CN(C1)C(C)C)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C21H26ClFN6O/c1-10(2)28-7-13(8-28)17-18(23)15(22)6-14(19(17)30-5)12(4)29-21-16(11(3)27-29)20(24)25-9-26-21/h6,9-10,12-13H,7-8H2,1-5H3,(H2,24,25,26)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255803 (5-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...) Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C25H28ClN7O2/c1-7-35-22-17(15(4)33-24-21(14(3)31-33)23(27)29-12-30-24)10-18(26)13(2)20(22)16-8-9-19(28-11-16)25(34)32(5)6/h8-12,15H,7H2,1-6H3,(H2,27,29,30)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255804 (5-{3-[1-(4-Amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidi...) Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(I)c2c(N)ncnc12 Show InChI InChI=1S/C24H25ClIN7O2/c1-6-35-20-15(13(3)33-23-19(21(26)31-33)22(27)29-11-30-23)9-16(25)12(2)18(20)14-7-8-17(28-10-14)24(34)32(4)5/h7-11,13H,6H2,1-5H3,(H2,27,29,30)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255805 (4-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...) Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccnc(c1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C25H28ClN7O2/c1-7-35-22-17(15(4)33-24-21(14(3)31-33)23(27)29-12-30-24)11-18(26)13(2)20(22)16-8-9-28-19(10-16)25(34)32(5)6/h8-12,15H,7H2,1-6H3,(H2,27,29,30)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255806 (4-(3-(1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...) Show SMILES CNC(=O)c1cc(ccn1)-c1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1OC Show InChI InChI=1S/C23H24ClN7O2/c1-11-16(24)9-15(13(3)31-22-19(12(2)30-31)21(25)28-10-29-22)20(33-5)18(11)14-6-7-27-17(8-14)23(32)26-4/h6-10,13H,1-5H3,(H,26,32)(H2,25,28,29)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255807 (4-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...) Show SMILES COc1c(cc(Cl)c(C)c1-c1ccnc(c1)C(=O)NCCO)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C24H26ClN7O3/c1-12-17(25)10-16(14(3)32-23-20(13(2)31-32)22(26)29-11-30-23)21(35-4)19(12)15-5-6-27-18(9-15)24(34)28-7-8-33/h5-6,9-11,14,33H,7-8H2,1-4H3,(H,28,34)(H2,26,29,30)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255808 (4-{3-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...) Show SMILES COc1c(cc(Cl)c(C)c1-c1ccnc(c1)C(=O)N(C)CCO)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C25H28ClN7O3/c1-13-18(26)11-17(15(3)33-24-21(14(2)31-33)23(27)29-12-30-24)22(36-5)20(13)16-6-7-28-19(10-16)25(35)32(4)8-9-34/h6-7,10-12,15,34H,8-9H2,1-5H3,(H2,27,29,30)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255809 (US10376513, Example 20 | US11433071, Example 20-1 ...) Show SMILES COc1c(cc(Cl)c(C)c1-c1cnn(CCO)c1)[C@@H](C)n1nc(C)c2c(N)ncnc12 |r| Show InChI InChI=1S/C21H24ClN7O2/c1-11-16(22)7-15(19(31-4)17(11)14-8-26-28(9-14)5-6-30)13(3)29-21-18(12(2)27-29)20(23)24-10-25-21/h7-10,13,30H,5-6H2,1-4H3,(H2,23,24,25)/t13-/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255812 (3′-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]py...) Show SMILES CNC(=O)c1ccc(cc1F)-c1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1OC Show InChI InChI=1S/C24H24ClFN6O2/c1-11-17(25)9-16(13(3)32-23-20(12(2)31-32)22(27)29-10-30-23)21(34-5)19(11)14-6-7-15(18(26)8-14)24(33)28-4/h6-10,13H,1-5H3,(H,28,33)(H2,27,29,30)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255813 (5-(3-(1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...) Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)NCCO)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C24H26ClN7O3/c1-12-17(25)9-16(14(3)32-23-20(13(2)31-32)22(26)29-11-30-23)21(35-4)19(12)15-5-6-18(28-10-15)24(34)27-7-8-33/h5-6,9-11,14,33H,7-8H2,1-4H3,(H,27,34)(H2,26,29,30)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255814 (4-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...) Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)CCO)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C25H28ClN7O3/c1-13-18(26)10-17(15(3)33-24-21(14(2)31-33)23(27)29-12-30-24)22(36-5)20(13)16-6-7-19(28-11-16)25(35)32(4)8-9-34/h6-7,10-12,15,34H,8-9H2,1-5H3,(H2,27,29,30)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255816 (US10376513, Example 25-2 | US11433071, Example 25-...) Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)[C@H](C)n1ccc(=O)c2c(N)ncnc12 |r| Show InChI InChI=1S/C25H25ClN6O3/c1-13-17(26)10-16(14(2)32-9-8-19(33)21-23(27)29-12-30-24(21)32)22(35-5)20(13)15-6-7-18(28-11-15)25(34)31(3)4/h6-12,14H,1-5H3,(H2,27,29,30)/t14-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255817 (4-Amino-8-(1-{5-chloro-2-methoxy-4-methyl-3-[5-(me...) Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)S(C)(=O)=O)C(C)n1ccc(=O)c2c(N)ncnc12 Show InChI InChI=1S/C23H22ClN5O4S/c1-12-17(24)8-16(13(2)29-6-5-18(30)20-22(25)27-11-28-23(20)29)21(33-3)19(12)14-7-15(10-26-9-14)34(4,31)32/h5-11,13H,1-4H3,(H2,25,27,28)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255818 (5-{3-[1-(4-Amino-5-oxopyrido[2,3-d]pyrimidin-8(5H)...) Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)C#N)C(C)n1ccc(=O)c2c(N)ncnc12 Show InChI InChI=1S/C23H19ClN6O2/c1-12-17(24)7-16(21(32-3)19(12)15-6-14(8-25)9-27-10-15)13(2)30-5-4-18(31)20-22(26)28-11-29-23(20)30/h4-7,9-11,13H,1-3H3,(H2,26,28,29)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255820 (4-Amino-8-[1-(5-chloro-2-methoxy-4-methyl-3-pyrimi...) Show SMILES COc1c(cc(Cl)c(C)c1-c1cncnc1)C(C)n1ccc(=O)c2c(N)ncnc12 Show InChI InChI=1S/C21H19ClN6O2/c1-11-15(22)6-14(19(30-3)17(11)13-7-24-9-25-8-13)12(2)28-5-4-16(29)18-20(23)26-10-27-21(18)28/h4-10,12H,1-3H3,(H2,23,26,27)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255821 (3′-[1-(4-Amino-5-oxopyrido[2,3-d]pyrimidin-8...) Show SMILES COc1c(cc(Cl)c(C)c1-c1cccc(c1)C(=O)N(C)C)C(C)n1ccc(=O)c2c(N)ncnc12 Show InChI InChI=1S/C26H26ClN5O3/c1-14-19(27)12-18(15(2)32-10-9-20(33)22-24(28)29-13-30-25(22)32)23(35-5)21(14)16-7-6-8-17(11-16)26(34)31(3)4/h6-13,15H,1-5H3,(H2,28,29,30)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255822 (4-Amino-8-{1-[5-chloro-3-(5-fluoropyridin-3-yl)-2-...) Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(F)c1)C(C)n1ccc(=O)c2c(N)ncnc12 Show InChI InChI=1S/C22H19ClFN5O2/c1-11-16(23)7-15(20(31-3)18(11)13-6-14(24)9-26-8-13)12(2)29-5-4-17(30)19-21(25)27-10-28-22(19)29/h4-10,12H,1-3H3,(H2,25,27,28)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255823 (3′-[1-(4-Amino-5-oxopyrido[2,3-d]pyrimidin-8...) Show SMILES COc1c(cc(Cl)c(C)c1-c1cccc(c1)S(=O)(=O)N(C)C)C(C)n1ccc(=O)c2c(N)ncnc12 Show InChI InChI=1S/C25H26ClN5O4S/c1-14-19(26)12-18(15(2)31-10-9-20(32)22-24(27)28-13-29-25(22)31)23(35-5)21(14)16-7-6-8-17(11-16)36(33,34)30(3)4/h6-13,15H,1-5H3,(H2,27,28,29)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255824 (5-{3-[1-(4-amino-5-oxopyrido[2,3-d]pyrimidin-8(5H)...) Show SMILES CNC(=O)c1ccc(cn1)-c1c(C)c(Cl)cc(C(C)n2ccc(=O)c3c(N)ncnc23)c1OC Show InChI InChI=1S/C24H23ClN6O3/c1-12-16(25)9-15(13(2)31-8-7-18(32)20-22(26)29-11-30-23(20)31)21(34-4)19(12)14-5-6-17(28-10-14)24(33)27-3/h5-11,13H,1-4H3,(H,27,33)(H2,26,29,30)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255825 (4-Amino-8-{1-[5-chloro-3-(1-isopropylazetidin-3-yl...) Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(C)C)C(C)n1ccc(=O)c2c(N)ncnc12 Show InChI InChI=1S/C23H28ClN5O2/c1-12(2)28-9-15(10-28)19-13(3)17(24)8-16(21(19)31-5)14(4)29-7-6-18(30)20-22(25)26-11-27-23(20)29/h6-8,11-12,14-15H,9-10H2,1-5H3,(H2,25,26,27)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255826 (4-Amino-8-{1-[5-chloro-2-ethoxy-3-(1-isopropylazet...) Show SMILES CCOc1c(cc(Cl)c(C)c1C1CN(C1)C(C)C)C(C)n1ccc(=O)c2c(N)ncnc12 Show InChI InChI=1S/C24H30ClN5O2/c1-6-32-22-17(9-18(25)14(4)20(22)16-10-29(11-16)13(2)3)15(5)30-8-7-19(31)21-23(26)27-12-28-24(21)30/h7-9,12-13,15-16H,6,10-11H2,1-5H3,(H2,26,27,28)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255827 (5-{3-[1-(4-Amino-5-oxopyrido[2,3-d]pyrimidin-8(5H)...) Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1ccc(=O)c2c(N)ncnc12 Show InChI InChI=1S/C26H27ClN6O3/c1-6-36-23-17(15(3)33-10-9-20(34)22-24(28)30-13-31-25(22)33)11-18(27)14(2)21(23)16-7-8-19(29-12-16)26(35)32(4)5/h7-13,15H,6H2,1-5H3,(H2,28,30,31)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255828 (6-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...) Show SMILES CCNC(=O)c1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1-c1cc(F)cc(F)c1 Show InChI InChI=1S/C24H23ClF2N6O/c1-5-29-24(34)19-11(2)18(25)9-17(21(19)14-6-15(26)8-16(27)7-14)13(4)33-23-20(12(3)32-33)22(28)30-10-31-23/h6-10,13H,5H2,1-4H3,(H,29,34)(H2,28,30,31)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255800 (5-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...) Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C24H26ClN7O2/c1-12-17(25)9-16(14(3)32-23-20(13(2)30-32)22(26)28-11-29-23)21(34-6)19(12)15-7-8-18(27-10-15)24(33)31(4)5/h7-11,14H,1-6H3,(H2,26,28,29)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255835 (5-(3-(1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...) Show SMILES CCOc1c(cc(Cl)c(C#N)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C25H25ClN8O2/c1-6-36-22-16(14(3)34-24-20(13(2)32-34)23(28)30-12-31-24)9-18(26)17(10-27)21(22)15-7-8-19(29-11-15)25(35)33(4)5/h7-9,11-12,14H,6H2,1-5H3,(H2,28,30,31)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255837 (4-(1-(4-amino-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl...) Show SMILES CCOc1c(cc(Cl)c(C#N)c1-c1cncc(c1)S(C)(=O)=O)C(C)n1ccc(=O)c2c(N)ncnc12 Show InChI InChI=1S/C24H21ClN6O4S/c1-4-35-22-16(13(2)31-6-5-19(32)21-23(27)29-12-30-24(21)31)8-18(25)17(9-26)20(22)14-7-15(11-28-10-14)36(3,33)34/h5-8,10-13H,4H2,1-3H3,(H2,27,29,30)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255838 (5-(3-{1-[4-amino-3-(3-fluorophenyl)-1H-pyrazolo[3,...) Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(-c2cccc(F)c2)c2c(N)ncnc12 Show InChI InChI=1S/C30H29ClFN7O2/c1-6-41-27-21(13-22(31)16(2)24(27)19-10-11-23(34-14-19)30(40)38(4)5)17(3)39-29-25(28(33)35-15-36-29)26(37-39)18-8-7-9-20(32)12-18/h7-15,17H,6H2,1-5H3,(H2,33,35,36)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255840 (5-(3-{1-[4-amino-3-(1-methyl-1H-pyrazol-4-yl)-1H-p...) Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(-c2cnn(C)c2)c2c(N)ncnc12 Show InChI InChI=1S/C28H30ClN9O2/c1-7-40-25-19(10-20(29)15(2)22(25)17-8-9-21(31-11-17)28(39)36(4)5)16(3)38-27-23(26(30)32-14-33-27)24(35-38)18-12-34-37(6)13-18/h8-14,16H,7H2,1-6H3,(H2,30,32,33)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255842 (5-(3-{1-[4-amino-3-(1H-pyrazol-3-yl)-1H-pyrazolo[3...) Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(-c2cc[nH]n2)c2c(N)ncnc12 Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255844 (5-{3-[1-(4-amino-3-cyclopropyl-1H-pyrazolo[3,4-d]p...) Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C2CC2)c2c(N)ncnc12 Show InChI InChI=1S/C27H30ClN7O2/c1-6-37-24-18(15(3)35-26-22(25(29)31-13-32-26)23(33-35)16-7-8-16)11-19(28)14(2)21(24)17-9-10-20(30-12-17)27(36)34(4)5/h9-13,15-16H,6-8H2,1-5H3,(H2,29,31,32)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair

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